{"id":"https://openalex.org/W2062223218","doi":"https://doi.org/10.1253/circj.71.1250","title":"Efficacy and Safety of the Additional Bepridil Treatment in Patients With Atrial Fibrillation Refractory to Class I Antiarrhythmic Drugs","display_name":"Efficacy and Safety of the Additional Bepridil Treatment in Patients With Atrial Fibrillation Refractory to Class I Antiarrhythmic Drugs","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2062223218","doi":"https://doi.org/10.1253/circj.71.1250","mag":"2062223218","pmid":"https://pubmed.ncbi.nlm.nih.gov/17652890"},"language":"en","primary_location":{"id":"doi:10.1253/circj.71.1250","doi":"https://doi.org/10.1253/circj.71.1250","is_oa":true,"landing_page_url":"https://doi.org/10.1253/circj.71.1250","pdf_url":"https://www.jstage.jst.go.jp/article/circj/71/8/71_8_1250/_pdf","source":{"id":"https://openalex.org/S4210176241","display_name":"Circulation Journal","issn_l":"1346-9843","issn":["1346-9843","1347-4820"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/circj/71/8/71_8_1250/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112563329","display_name":"Kohei Miyaji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohei Miyaji","raw_affiliation_strings":["Department of Cardiovascular Medicine, Okayama University Graduated School of Medicine, Density and Pharmaceutical Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Okayama University Graduated School of Medicine, Density and Pharmaceutical Science","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044821062","display_name":"Hiroshi Tada","orcid":"https://orcid.org/0000-0001-8578-2328","observed_orcids":["https://orcid.org/0000-0001-8578-2328"]},"institutions":[{"id":"https://openalex.org/I4210129341","display_name":"Gunma Prefectural Cardiovascular Center","ror":"https://ror.org/037403209","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210129341"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Tada","raw_affiliation_strings":["Division of Cardiology, Gunma Prefectural Cardiovascular Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Gunma Prefectural Cardiovascular Center","institution_ids":["https://openalex.org/I4210129341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064721178","display_name":"KENGO FUKUSHIMA KUSANO","orcid":"https://orcid.org/0000-0002-5760-9285","observed_orcids":["https://orcid.org/0000-0002-5760-9285"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kengo Fukushima Kusano","raw_affiliation_strings":["Department of Cardiovascular Medicine, Okayama University Graduated School of Medicine, Density and Pharmaceutical Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Okayama University Graduated School of Medicine, Density and Pharmaceutical Science","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111620089","display_name":"Tohru Hashimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129341","display_name":"Gunma Prefectural Cardiovascular Center","ror":"https://ror.org/037403209","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210129341"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tohru Hashimoto","raw_affiliation_strings":["Division of Cardiology, Gunma Prefectural Cardiovascular Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Gunma Prefectural Cardiovascular Center","institution_ids":["https://openalex.org/I4210129341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004224199","display_name":"Kenichi Kaseno","orcid":"https://orcid.org/0000-0002-0452-0578","observed_orcids":["https://orcid.org/0000-0002-0452-0578"]},"institutions":[{"id":"https://openalex.org/I4210129341","display_name":"Gunma Prefectural Cardiovascular Center","ror":"https://ror.org/037403209","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210129341"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichi Kaseno","raw_affiliation_strings":["Division of Cardiology, Gunma Prefectural Cardiovascular Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Gunma Prefectural Cardiovascular Center","institution_ids":["https://openalex.org/I4210129341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018326563","display_name":"Shigeki Hiramatsu","orcid":"https://orcid.org/0000-0002-3553-1843","observed_orcids":["https://orcid.org/0000-0002-3553-1843"]},"institutions":[{"id":"https://openalex.org/I4210129341","display_name":"Gunma Prefectural Cardiovascular Center","ror":"https://ror.org/037403209","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210129341"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeki Hiramatsu","raw_affiliation_strings":["Division of Cardiology, Gunma Prefectural Cardiovascular Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Gunma Prefectural Cardiovascular Center","institution_ids":["https://openalex.org/I4210129341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067954575","display_name":"Kazuyoshi Tadokoro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129341","display_name":"Gunma Prefectural Cardiovascular Center","ror":"https://ror.org/037403209","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210129341"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuyoshi Tadokoro","raw_affiliation_strings":["Division of Cardiology, Gunma Prefectural Cardiovascular Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Gunma Prefectural Cardiovascular Center","institution_ids":["https://openalex.org/I4210129341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084857058","display_name":"Shigeto Naito","orcid":"https://orcid.org/0009-0006-7092-0445","observed_orcids":["https://orcid.org/0009-0006-7092-0445"]},"institutions":[{"id":"https://openalex.org/I4210129341","display_name":"Gunma Prefectural Cardiovascular Center","ror":"https://ror.org/037403209","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210129341"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeto Naito","raw_affiliation_strings":["Division of Cardiology, Gunma Prefectural Cardiovascular Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Gunma Prefectural Cardiovascular Center","institution_ids":["https://openalex.org/I4210129341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038761025","display_name":"Kazufumi Nakamura","orcid":"https://orcid.org/0000-0001-8845-3626","observed_orcids":["https://orcid.org/0000-0001-8845-3626"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazufumi Nakamura","raw_affiliation_strings":["Department of Cardiovascular Medicine, Okayama University Graduated School of Medicine, Density and Pharmaceutical Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Okayama University Graduated School of Medicine, Density and Pharmaceutical Science","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064010379","display_name":"Shigeru Oshima","orcid":"https://orcid.org/0000-0003-1186-9177","observed_orcids":["https://orcid.org/0000-0003-1186-9177","https://orcid.org/0000-0001-9929-5336"]},"institutions":[{"id":"https://openalex.org/I4210129341","display_name":"Gunma Prefectural Cardiovascular Center","ror":"https://ror.org/037403209","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210129341"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Oshima","raw_affiliation_strings":["Division of Cardiology, Gunma Prefectural Cardiovascular Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Gunma Prefectural Cardiovascular Center","institution_ids":["https://openalex.org/I4210129341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100892512","display_name":"Koichi Taniguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129341","display_name":"Gunma Prefectural Cardiovascular Center","ror":"https://ror.org/037403209","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210129341"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Taniguchi","raw_affiliation_strings":["Division of Cardiology, Gunma Prefectural Cardiovascular Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Gunma Prefectural Cardiovascular Center","institution_ids":["https://openalex.org/I4210129341"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020751983","display_name":"Tohru Ohe","orcid":"https://orcid.org/0000-0001-5092-1893","observed_orcids":["https://orcid.org/0000-0001-5092-1893"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tohru Ohe","raw_affiliation_strings":["Department of Cardiovascular Medicine, Okayama University Graduated School of Medicine, Density and Pharmaceutical Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Okayama University Graduated School of Medicine, Density and Pharmaceutical Science","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6781,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.9071694,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"71","issue":"8","first_page":"1250","last_page":"1257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bepridil","display_name":"bepridil","score":1.0},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.996999979019165},{"id":"https://openalex.org/keywords/class-i-antiarrhythmic-drugs","display_name":"class I antiarrhythmic drugs","score":0.9710000157356262},{"id":"https://openalex.org/keywords/refractory-atrial-fibrillation","display_name":"refractory atrial fibrillation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/paroxysmal-atrial-fibrillation","display_name":"paroxysmal atrial fibrillation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/persistent-atrial-fibrillation","display_name":"persistent atrial fibrillation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/qt-interval-prolongation","display_name":"QT prolongation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/torsades-de-pointes","display_name":"torsades de pointes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/sinus-rhythm-restoration","display_name":"sinus rhythm restoration","score":0.7540000081062317},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5320000052452087},{"id":"https://openalex.org/keywords/ion-channel-blockers","display_name":"ion channel blockers","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C2778937662","wikidata":"https://www.wikidata.org/wiki/Q4890934","display_name":"Bepridil","level":4,"score":0.9918848872184753},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8317434191703796},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.701256513595581},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6259924173355103},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6054837703704834},{"id":"https://openalex.org/C2775914520","wikidata":"https://www.wikidata.org/wiki/Q12335414","display_name":"Sinus rhythm","level":3,"score":0.573194146156311},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.5488697290420532},{"id":"https://openalex.org/C2780486423","wikidata":"https://www.wikidata.org/wiki/Q1625433","display_name":"Torsades de pointes","level":3,"score":0.5260058641433716},{"id":"https://openalex.org/C189327125","wikidata":"https://www.wikidata.org/wiki/Q5347276","display_name":"Effective refractory period","level":3,"score":0.49036669731140137},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.4752920866012573},{"id":"https://openalex.org/C70616116","wikidata":"https://www.wikidata.org/wiki/Q1736732","display_name":"Refractory period","level":2,"score":0.46370014548301697},{"id":"https://openalex.org/C2779837460","wikidata":"https://www.wikidata.org/wiki/Q421381","display_name":"Flecainide","level":3,"score":0.42353951930999756},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3684350252151489},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.07642340660095215},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2777022698","wikidata":"https://www.wikidata.org/wiki/Q410291","display_name":"Verapamil","level":3,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008133","descriptor_name":"Long QT Syndrome","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015764","descriptor_name":"Bepridil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016171","descriptor_name":"Torsades de Pointes","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D016879","descriptor_name":"Salvage Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1253/circj.71.1250","doi":"https://doi.org/10.1253/circj.71.1250","is_oa":true,"landing_page_url":"https://doi.org/10.1253/circj.71.1250","pdf_url":"https://www.jstage.jst.go.jp/article/circj/71/8/71_8_1250/_pdf","source":{"id":"https://openalex.org/S4210176241","display_name":"Circulation Journal","issn_l":"1346-9843","issn":["1346-9843","1347-4820"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Journal","raw_type":"journal-article"},{"id":"pmid:17652890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17652890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation journal : official journal of the Japanese Circulation Society","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1253/circj.71.1250","doi":"https://doi.org/10.1253/circj.71.1250","is_oa":true,"landing_page_url":"https://doi.org/10.1253/circj.71.1250","pdf_url":"https://www.jstage.jst.go.jp/article/circj/71/8/71_8_1250/_pdf","source":{"id":"https://openalex.org/S4210176241","display_name":"Circulation Journal","issn_l":"1346-9843","issn":["1346-9843","1347-4820"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2062223218.pdf","grobid_xml":"https://content.openalex.org/works/W2062223218.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W597568603","https://openalex.org/W982400188","https://openalex.org/W1841210729","https://openalex.org/W1969812057","https://openalex.org/W2004086269","https://openalex.org/W2010550566","https://openalex.org/W2015477314","https://openalex.org/W2015631858","https://openalex.org/W2016769386","https://openalex.org/W2020282416","https://openalex.org/W2032460077","https://openalex.org/W2033449081","https://openalex.org/W2033707486","https://openalex.org/W2040299893","https://openalex.org/W2043687040","https://openalex.org/W2047460539","https://openalex.org/W2050335927","https://openalex.org/W2057808261","https://openalex.org/W2070841636","https://openalex.org/W2070952976","https://openalex.org/W2074502478","https://openalex.org/W2078125895","https://openalex.org/W2093894528","https://openalex.org/W2108677822","https://openalex.org/W2130114624","https://openalex.org/W2154312522","https://openalex.org/W2170290111","https://openalex.org/W2170313402","https://openalex.org/W2284531888","https://openalex.org/W2326579808","https://openalex.org/W2399665478","https://openalex.org/W2463417997"],"related_works":["https://openalex.org/W7144412213","https://openalex.org/W1993960872","https://openalex.org/W2059846626","https://openalex.org/W1969812057","https://openalex.org/W2768540316","https://openalex.org/W2059979813","https://openalex.org/W1998408498","https://openalex.org/W2154312522","https://openalex.org/W2107536758","https://openalex.org/W2315887706"],"abstract_inverted_index":{"BACKGROUND:":[0],"Bepridil":[1,52],"has":[2],"multiple":[3],"ion-channel":[4],"blocking":[5],"effects":[6],"and":[7,28,108,116,170],"is":[8,168,181],"expected":[9],"to":[10,24,57,81,97,135,164],"be":[11],"useful":[12],"for":[13,172,183],"managing":[14],"atrial":[15],"fibrillation":[16],"(AF).":[17],"The":[18,160],"purpose":[19],"of":[20,30,88,92,140,147,156,162],"this":[21],"study":[22],"was":[23,55,111,129],"clarify":[25],"the":[26,83,86,90,119,157],"efficacy":[27],"safety":[29],"additional":[31],"treatment":[32],"with":[33,37,43,60,73,105,125,132],"bepridil":[34,163],"in":[35,101,121,154],"patients":[36,59,69,104,124],"AF":[38,66,94],"who":[39],"had":[40,70],"been":[41,71],"treated":[42,72],"class":[44,74,165],"I":[45,75,166],"antiarrhythmic":[46],"drugs":[47],"(AADs).":[48],"METHODS":[49],"AND":[50],"RESULTS:":[51],"(50-200":[53],"mg/day)":[54,139],"given":[56],"76":[58],"either":[61],"paroxysmal":[62,106],"(n=49)":[63],"or":[64],"persistent":[65,126],"(n=27).":[67],"All":[68],"AADs":[76,167],"(1.9+/-0.9":[77],"drugs/patient)":[78],"that":[79],"failed":[80],"control":[82],"AF.":[84,127],"With":[85],"addition":[87,161],"bepridil,":[89],"frequency":[91],"symptomatic":[93],"episodes":[95],"decreased":[96],"less":[98],"than":[99],"10%":[100],"38":[102],"(78%)":[103],"AF,":[107,173],"sinus":[109],"rhythm":[110],"restored":[112],"within":[113],"3":[114],"months":[115],"maintained":[117],"during":[118],"follow-up":[120,145],"20":[122],"(74%)":[123],"Efficacy":[128],"usually":[130],"obtained":[131],"a":[133,143],"small":[134],"moderate":[136],"dose":[137],"(50-150":[138],"bepridil.":[141],"During":[142],"mean":[144],"period":[146],"27+/-22":[148],"months,":[149],"no":[150],"potential":[151],"complications":[152],"occurred":[153],"any":[155],"patients.":[158],"CONCLUSIONS:":[159],"effective":[169],"safe":[171],"but":[174],"careful":[175],"observation":[176],"using":[177],"periodic":[178],"ECG":[179],"recordings":[180],"essential":[182],"avoiding":[184],"torsades":[185],"de":[186],"pointes":[187],"caused":[188],"by":[189],"QT":[190],"prolongation.":[191]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
