{"id":"https://openalex.org/W2062222985","doi":"https://doi.org/10.1517/14728222.8.5.409","title":"STAT proteins as novel targets for cancer drug discovery","display_name":"STAT proteins as novel targets for cancer drug discovery","publication_year":2004,"publication_date":"2004-10-01","ids":{"openalex":"https://openalex.org/W2062222985","doi":"https://doi.org/10.1517/14728222.8.5.409","mag":"2062222985","pmid":"https://pubmed.ncbi.nlm.nih.gov/15469392"},"language":"en","primary_location":{"id":"doi:10.1517/14728222.8.5.409","doi":"https://doi.org/10.1517/14728222.8.5.409","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14728222.8.5.409","pdf_url":null,"source":{"id":"https://openalex.org/S149756942","display_name":"Expert Opinion on Therapeutic Targets","issn_l":"1472-8222","issn":["1472-8222","1744-7631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Targets","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087339928","display_name":"James Turkson","orcid":"https://orcid.org/0000-0002-6964-1602","observed_orcids":["https://orcid.org/0000-0002-6964-1602"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James Turkson","raw_affiliation_strings":["Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, SRB 22214, Tampa, FL 33612, USA. turksonj@moffitt.usf.edu","H. Lee Moffitt Cancer Center and Research Institute, Molecular Oncology Program, 12902 Magnolia Drive, SRB 22214, Tampa, FL 33612, USA. turksonj@moffitt.usf.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, SRB 22214, Tampa, FL 33612, USA. turksonj@moffitt.usf.edu","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute, Molecular Oncology Program, 12902 Magnolia Drive, SRB 22214, Tampa, FL 33612, USA. turksonj@moffitt.usf.edu","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087339928"],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":null,"apc_paid":null,"fwci":1.3801,"has_fulltext":false,"cited_by_count":299,"citation_normalized_percentile":{"value":0.81204819,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"8","issue":"5","first_page":"409","last_page":"422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat-proteins","display_name":"STAT proteins","score":0.9789999723434448},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9539999961853027},{"id":"https://openalex.org/keywords/stat5","display_name":"STAT5","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cancer-drug-targets","display_name":"cancer drug targets","score":0.7149999737739563},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.9160000085830688},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.7329999804496765},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9399999976158142},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.8830000162124634},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tyrosine-kinase-signaling","display_name":"tyrosine kinase signaling","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.6940414905548096},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.6722844243049622},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6233164072036743},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5739608407020569},{"id":"https://openalex.org/C2779391668","wikidata":"https://www.wikidata.org/wiki/Q4210018","display_name":"STAT5","level":3,"score":0.5643167495727539},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4981660842895508},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4952203333377838},{"id":"https://openalex.org/C157333092","wikidata":"https://www.wikidata.org/wiki/Q902835","display_name":"JAK-STAT signaling pathway","level":4,"score":0.468289315700531},{"id":"https://openalex.org/C2778277574","wikidata":"https://www.wikidata.org/wiki/Q665327","display_name":"stat","level":4,"score":0.4421728253364563},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4199150800704956},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.418337881565094},{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.4133346974849701},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.4130135178565979},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.39872512221336365},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38166600465774536},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.36000990867614746},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.1597742736339569},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0948624312877655}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008894","descriptor_name":"Milk Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D008894","descriptor_name":"Milk Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050795","descriptor_name":"STAT2 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050797","descriptor_name":"STAT4 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050799","descriptor_name":"STAT5 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050800","descriptor_name":"STAT6 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1517/14728222.8.5.409","doi":"https://doi.org/10.1517/14728222.8.5.409","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14728222.8.5.409","pdf_url":null,"source":{"id":"https://openalex.org/S149756942","display_name":"Expert Opinion on Therapeutic Targets","issn_l":"1472-8222","issn":["1472-8222","1744-7631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Targets","raw_type":"journal-article"},{"id":"pmid:15469392","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15469392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on therapeutic targets","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311073","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":147,"referenced_works":["https://openalex.org/W168754456","https://openalex.org/W195636202","https://openalex.org/W1483520515","https://openalex.org/W1547495699","https://openalex.org/W1548640328","https://openalex.org/W1550156431","https://openalex.org/W1556315117","https://openalex.org/W1558123369","https://openalex.org/W1558580388","https://openalex.org/W1563819414","https://openalex.org/W1584223654","https://openalex.org/W1803183847","https://openalex.org/W1848898216","https://openalex.org/W1884415617","https://openalex.org/W1889152575","https://openalex.org/W1913007537","https://openalex.org/W1917630072","https://openalex.org/W1933735120","https://openalex.org/W1943783753","https://openalex.org/W1946894092","https://openalex.org/W1953156122","https://openalex.org/W1964321121","https://openalex.org/W1964419220","https://openalex.org/W1965830315","https://openalex.org/W1966597019","https://openalex.org/W1968292745","https://openalex.org/W1972755060","https://openalex.org/W1975225141","https://openalex.org/W1976259288","https://openalex.org/W1976665551","https://openalex.org/W1977681992","https://openalex.org/W1978583563","https://openalex.org/W1982703106","https://openalex.org/W1982852897","https://openalex.org/W1983974405","https://openalex.org/W1986081926","https://openalex.org/W1988719795","https://openalex.org/W1992965385","https://openalex.org/W1994798501","https://openalex.org/W1995997868","https://openalex.org/W1996112634","https://openalex.org/W1999468766","https://openalex.org/W2000193607","https://openalex.org/W2000487932","https://openalex.org/W2003525895","https://openalex.org/W2004029306","https://openalex.org/W2004175299","https://openalex.org/W2004593694","https://openalex.org/W2006379003","https://openalex.org/W2007897471","https://openalex.org/W2009228236","https://openalex.org/W2012558233","https://openalex.org/W2016116775","https://openalex.org/W2020365958","https://openalex.org/W2021029373","https://openalex.org/W2022215206","https://openalex.org/W2023354216","https://openalex.org/W2024282024","https://openalex.org/W2032674547","https://openalex.org/W2033485661","https://openalex.org/W2034286443","https://openalex.org/W2035540327","https://openalex.org/W2036861892","https://openalex.org/W2040712355","https://openalex.org/W2041187882","https://openalex.org/W2041204531","https://openalex.org/W2041294102","https://openalex.org/W2042386826","https://openalex.org/W2042504507","https://openalex.org/W2043803403","https://openalex.org/W2044991100","https://openalex.org/W2045429389","https://openalex.org/W2046604039","https://openalex.org/W2049386412","https://openalex.org/W2051638902","https://openalex.org/W2052344543","https://openalex.org/W2053222369","https://openalex.org/W2056961869","https://openalex.org/W2058347762","https://openalex.org/W2058584950","https://openalex.org/W2058792197","https://openalex.org/W2061466636","https://openalex.org/W2063783803","https://openalex.org/W2064540997","https://openalex.org/W2064840117","https://openalex.org/W2067894718","https://openalex.org/W2069657245","https://openalex.org/W2071900493","https://openalex.org/W2072171359","https://openalex.org/W2072493113","https://openalex.org/W2074356752","https://openalex.org/W2077721448","https://openalex.org/W2080476012","https://openalex.org/W2081003617","https://openalex.org/W2081080444","https://openalex.org/W2083189092","https://openalex.org/W2083446462","https://openalex.org/W2083802827","https://openalex.org/W2087471989","https://openalex.org/W2088357471","https://openalex.org/W2092646816","https://openalex.org/W2092970174","https://openalex.org/W2097166235","https://openalex.org/W2097765112","https://openalex.org/W2099494462","https://openalex.org/W2099792017","https://openalex.org/W2100429833","https://openalex.org/W2101472630","https://openalex.org/W2103565638","https://openalex.org/W2107631090","https://openalex.org/W2108758247","https://openalex.org/W2110754651","https://openalex.org/W2110807341","https://openalex.org/W2112127173","https://openalex.org/W2113898952","https://openalex.org/W2115477226","https://openalex.org/W2115744231","https://openalex.org/W2116401711","https://openalex.org/W2116426194","https://openalex.org/W2118310862","https://openalex.org/W2120286360","https://openalex.org/W2124043243","https://openalex.org/W2131073503","https://openalex.org/W2134661616","https://openalex.org/W2141016223","https://openalex.org/W2143812692","https://openalex.org/W2150576033","https://openalex.org/W2150627722","https://openalex.org/W2152000177","https://openalex.org/W2159730182","https://openalex.org/W2162082382","https://openalex.org/W2170189698","https://openalex.org/W2173560213","https://openalex.org/W2185197313","https://openalex.org/W2224782492","https://openalex.org/W2312555199","https://openalex.org/W2312687639","https://openalex.org/W2312705964","https://openalex.org/W2318884910","https://openalex.org/W2320125856","https://openalex.org/W2321599954","https://openalex.org/W2323400003","https://openalex.org/W2330829715","https://openalex.org/W2410770797","https://openalex.org/W2414945450","https://openalex.org/W2799941631","https://openalex.org/W4323053376"],"related_works":["https://openalex.org/W2056961869","https://openalex.org/W622442334","https://openalex.org/W2365971279","https://openalex.org/W2064117666","https://openalex.org/W2312555199","https://openalex.org/W2159730182","https://openalex.org/W2028792884","https://openalex.org/W4393356584","https://openalex.org/W1971189052","https://openalex.org/W2410073144"],"abstract_inverted_index":{"Signal":[0],"transducer":[1],"and":[2,21,50,65,74,110,123,126,150,172,199],"activator":[3],"of":[4,19,59,63,94,114,144,156,192,209],"transcription":[5,11],"(STAT)":[6],"proteins":[7],"are":[8],"latent":[9],"cytoplasmic":[10],"factors":[12],"that":[13,79,88,98,135],"were":[14],"discovered":[15],"in":[16,36,69,103,154,196],"the":[17,95,175,189,201,206,218],"context":[18],"cytokine":[20],"growth":[22,109,147],"factor":[23,148],"signalling.":[24],"Normal":[25],"STAT":[26,44,60,194],"signalling":[27,83,195],"is":[28,35,51,67,86,92],"tightly":[29],"controlled":[30],"with":[31,38,54],"finite":[32],"kinetics,":[33],"which":[34],"keeping":[37],"standard":[39],"cellular":[40],"responses.":[41],"However,":[42],"persistent":[43],"activation":[45,58],"has":[46,99],"also":[47,229],"been":[48],"observed":[49],"frequently":[52],"associated":[53],"malignant":[55,197],"transformation.":[56],"Constitutive":[57],"proteins,":[61],"notably":[62],"Stat3":[64,91,106,138,164,180,210,223],"Stat5,":[66],"detected":[68],"many":[70],"human":[71],"tumour":[72,140,157],"cells":[73,75],"transformed":[76],"by":[77,142],"oncoproteins":[78],"activate":[80],"tyrosine":[81],"kinase":[82],"pathways.":[84],"It":[85],"well-established":[87],"constitutively":[89],"active":[90,137],"one":[93],"molecular":[96],"abnormalities":[97],"a":[100,166,212],"causal":[101],"role":[102,191],"oncogenesis.":[104,130],"Aberrant":[105],"promotes":[107],"uncontrolled":[108],"survival":[111],"through":[112],"dysregulation":[113],"gene":[115],"expression,":[116],"including":[117],"cyclin":[118],"D1,":[119],"c-Myc,":[120],"Bcl-xL,":[121],"Mcl-1":[122],"survivin":[124],"genes,":[125],"thereby":[127],"contributes":[128],"to":[129,220],"Moreover,":[131],"recent":[132],"studies":[133,161],"reveal":[134],"persistently":[136],"induces":[139],"angiogenesis":[141],"upregulation":[143],"vascular":[145],"endothelial":[146],"induction,":[149],"modulates":[151],"immune":[152,158],"functions":[153],"favour":[155],"evasion.":[159],"Overall,":[160],"have":[162],"validated":[163],"as":[165,203,205,211],"novel":[167,222],"target":[168],"for":[169,177,188,225],"cancer":[170,213],"therapy,":[171],"hence":[173],"provided":[174],"rationale":[176],"developing":[178],"small-molecule":[179],"inhibitors.":[181],"This":[182],"review":[183],"will":[184,228],"discuss":[185],"current":[186],"evidence":[187],"critical":[190],"aberrant":[193],"transformation,":[198],"examine":[200],"validity":[202],"well":[204],"therapeutic":[207,226],"potential":[208],"target.":[214],"An":[215],"update":[216],"on":[217],"efforts":[219],"develop":[221],"inhibitors":[224],"application":[227],"be":[230],"provided.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":25}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
