{"id":"https://openalex.org/W2062147992","doi":"https://doi.org/10.1002/jmri.22869","title":"Gadofluorine M enhanced MRI in experimental glioma: Superior and persistent intracellular tumor enhancement compared with conventional MRI","display_name":"Gadofluorine M enhanced MRI in experimental glioma: Superior and persistent intracellular tumor enhancement compared with conventional MRI","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2062147992","doi":"https://doi.org/10.1002/jmri.22869","mag":"2062147992","pmid":"https://pubmed.ncbi.nlm.nih.gov/22045630"},"language":"en","primary_location":{"id":"doi:10.1002/jmri.22869","doi":"https://doi.org/10.1002/jmri.22869","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jmri.22869","pdf_url":null,"source":{"id":"https://openalex.org/S132538424","display_name":"Journal of Magnetic Resonance Imaging","issn_l":"1053-1807","issn":["1053-1807","1522-2586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Magnetic Resonance Imaging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069804767","display_name":"Leonie Jestaedt","orcid":"https://orcid.org/0009-0006-6114-8449","observed_orcids":["https://orcid.org/0009-0006-6114-8449"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Leonie Jestaedt","raw_affiliation_strings":["Department of Neuroradiology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany. leonie.jestaedt@med.uni-heidelberg.de","Department of Neuroradiology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroradiology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany. leonie.jestaedt@med.uni-heidelberg.de","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Department of Neuroradiology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042545972","display_name":"Dieter Lemke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dieter Lemke","raw_affiliation_strings":["Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany","Department of Neurooncology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany","L.J. and D.L. contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Department of Neurooncology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"L.J. and D.L. contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043733377","display_name":"Markus Weiler","orcid":"https://orcid.org/0000-0002-8942-7662","observed_orcids":["https://orcid.org/0000-0002-8942-7662"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Weiler","raw_affiliation_strings":["Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany","Department of Neurooncology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Department of Neurooncology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056275665","display_name":"Philipp\u2010Niclas Pfenning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp\u2010Niclas Pfenning","raw_affiliation_strings":["Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079482117","display_name":"Sabine Heiland","orcid":"https://orcid.org/0000-0002-2796-3451","observed_orcids":["https://orcid.org/0000-0002-2796-3451"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Heiland","raw_affiliation_strings":["Department of Neuroradiology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroradiology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080482957","display_name":"Wolfgang Wick","orcid":"https://orcid.org/0000-0002-6171-634X","observed_orcids":["https://orcid.org/0000-0002-6171-634X"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Wick","raw_affiliation_strings":["Department of Neurooncology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurooncology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019876508","display_name":"Martin Bendszus","orcid":"https://orcid.org/0000-0002-9094-6769","observed_orcids":["https://orcid.org/0000-0002-9094-6769"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Bendszus","raw_affiliation_strings":["Department of Neuroradiology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroradiology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069804767"],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.16841642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"35","issue":"3","first_page":"551","last_page":"560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.1264999955892563,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.11659999936819077,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mri-contrast-agents","display_name":"MRI contrast agents","score":0.6830000281333923},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9039999842643738},{"id":"https://openalex.org/keywords/murine-glioma-model","display_name":"murine glioma model","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tumor-delineation","display_name":"tumor delineation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/gd-dtpa","display_name":"Gd-DTPA","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tumor-growth-monitoring","display_name":"tumor growth monitoring","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.7050033807754517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6443966627120972},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6033812761306763},{"id":"https://openalex.org/C557651011","wikidata":"https://www.wikidata.org/wiki/Q1832","display_name":"Gadolinium","level":2,"score":0.5746796131134033},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.45478782057762146},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4314885139465332},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.40068066120147705},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.12802687287330627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1000528335571289},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.08185213804244995},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005466","descriptor_name":"Fluorocarbons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jmri.22869","doi":"https://doi.org/10.1002/jmri.22869","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jmri.22869","pdf_url":null,"source":{"id":"https://openalex.org/S132538424","display_name":"Journal of Magnetic Resonance Imaging","issn_l":"1053-1807","issn":["1053-1807","1522-2586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Magnetic Resonance Imaging","raw_type":"journal-article"},{"id":"pmid:22045630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22045630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of magnetic resonance imaging : JMRI","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1701002662","https://openalex.org/W1897881764","https://openalex.org/W1968601707","https://openalex.org/W1984226345","https://openalex.org/W1993237034","https://openalex.org/W2026449810","https://openalex.org/W2033987226","https://openalex.org/W2034301876","https://openalex.org/W2039881069","https://openalex.org/W2059864970","https://openalex.org/W2079256860","https://openalex.org/W2086434876","https://openalex.org/W2089469570","https://openalex.org/W2101619182","https://openalex.org/W2109929731","https://openalex.org/W2125372543","https://openalex.org/W2133983348","https://openalex.org/W2134391076","https://openalex.org/W2147446468","https://openalex.org/W2160271782","https://openalex.org/W4255289481"],"related_works":["https://openalex.org/W2309607996","https://openalex.org/W1994529523","https://openalex.org/W2089469570","https://openalex.org/W2160138169","https://openalex.org/W2018811656","https://openalex.org/W179864608","https://openalex.org/W2178002579","https://openalex.org/W2121347527","https://openalex.org/W2008182592","https://openalex.org/W2045607308"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"compare":[2],"conventional":[3,53,118,126,181],"magnetic":[4],"resonance":[5],"imaging":[6],"(MRI)":[7],"techniques":[8,128],"(T2-w":[9],"and":[10,14,94,114,125],"Gadolinium-DTPA-enhanced":[11],"T1-w":[12],"images)":[13],"Gadofluorine-M":[15],"(GfM),":[16],"a":[17,40,72,164,187],"novel":[18],"contrast":[19,87],"agent":[20],"in":[21,23,35,68,148,173,190],"MRI,":[22],"murine":[24,32],"gliomas.":[25],"MATERIALS":[26],"AND":[27],"METHODS:":[28],"Growth":[29],"monitoring":[30],"of":[31,66,77,86,131,142,146,170,176],"gliomas":[33],"(induced":[34],"mice)":[36],"was":[37,60,81],"performed":[38,82],"on":[39],"2.3":[41],"Tesla":[42],"Bruker":[43],"Biospec":[44],"MRI":[45,54,80,119,127,138,182],"unit.":[46],"First":[47],"all":[48],"animals":[49],"were":[50,97,100],"investigated":[51],"with":[52,180],"techniques.":[55,120,183],"In":[56,106],"group":[57,69],"I":[58],"GfM":[59,78,109,124,143,147,162,171,185],"applied":[61],"at":[62,71,133],"an":[63],"early":[64],"stage":[65],"disease,":[67],"II":[70],"later":[73],"stage.":[74],"After":[75],"injection":[76,85,141],"follow-up":[79],"without":[83],"further":[84],"agent.":[88],"On":[89,151],"MR":[90],"images":[91],"tumor":[92,111,135,149,160],"size":[93],"signal":[95],"intensities":[96],"assessed.":[98],"Animals":[99],"killed":[101],"for":[102],"histological":[103],"evaluation.":[104],"RESULTS:":[105],"both":[107,134],"groups":[108],"delineated":[110],"extents":[112],"larger":[113],"more":[115],"precisely":[116],"than":[117],"The":[121],"difference":[122],"between":[123],"reached":[129],"level":[130],"significance":[132],"stages.":[136],"Follow-up":[137],"after":[139],"singular":[140],"showed":[144,163],"persistence":[145],"tissue.":[150,161],"tissue":[152],"sections":[153],"GfM-enhancing":[154],"areas":[155],"corresponded":[156],"closely":[157],"to":[158],"vital":[159],"mainly":[165],"intracellular":[166],"accumulation.":[167],"CONCLUSION:":[168],"Application":[169],"resulted":[172],"superior":[174],"delineation":[175],"experimental":[177],"glioma":[178],"compared":[179],"Thus,":[184],"bears":[186],"high":[188],"potential":[189],"clinical":[191],"application.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}