{"id":"https://openalex.org/W2062074249","doi":"https://doi.org/10.1021/ol301490h","title":"Design, Synthesis, and Photochemical Validation of Peptide Linchpins Containing the S,S-Tetrazine Phototrigger","display_name":"Design, Synthesis, and Photochemical Validation of Peptide Linchpins Containing the S,S-Tetrazine Phototrigger","publication_year":2012,"publication_date":"2012-06-26","ids":{"openalex":"https://openalex.org/W2062074249","doi":"https://doi.org/10.1021/ol301490h","mag":"2062074249","pmid":"https://pubmed.ncbi.nlm.nih.gov/22731895","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3397404"},"language":"en","primary_location":{"id":"doi:10.1021/ol301490h","doi":"https://doi.org/10.1021/ol301490h","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ol301490h","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3397404","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091829114","display_name":"Mohannad Abdo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohannad Abdo","raw_affiliation_strings":["Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States","Department of Chemistry, University of Pennsylvania, Philadelphia,#R#Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania, Philadelphia,#R#Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102066766","display_name":"Stephen P. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen P. Brown","raw_affiliation_strings":["Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States","Department of Chemistry, University of Pennsylvania, Philadelphia,#R#Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania, Philadelphia,#R#Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010023555","display_name":"Joel R. Courter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel R. Courter","raw_affiliation_strings":["Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States","Department of Chemistry, University of Pennsylvania, Philadelphia,#R#Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania, Philadelphia,#R#Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086404347","display_name":"Matthew J. Tucker","orcid":"https://orcid.org/0000-0001-9724-4455","observed_orcids":["https://orcid.org/0000-0001-9724-4455"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J. Tucker","raw_affiliation_strings":["Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States","Department of Chemistry, University of Pennsylvania, Philadelphia,#R#Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania, Philadelphia,#R#Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026551999","display_name":"Robin M. Hochstrasser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robin M. Hochstrasser","raw_affiliation_strings":["Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States","Department of Chemistry, University of Pennsylvania, Philadelphia,#R#Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania, Philadelphia,#R#Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066527875","display_name":"Amos B. Smith","orcid":"https://orcid.org/0000-0002-1712-8567","observed_orcids":["https://orcid.org/0000-0002-1712-8567"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amos B. Smith","raw_affiliation_strings":["Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States","Department of Chemistry, University of Pennsylvania, Philadelphia,#R#Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania, Philadelphia,#R#Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026551999","https://openalex.org/A5066527875"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.0275,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.73906235,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"14","issue":"13","first_page":"3518","last_page":"3521"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11708","display_name":"Photochromic and Fluorescence Chemistry","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phototriggers","display_name":"phototriggers","score":0.9229999780654907},{"id":"https://openalex.org/keywords/photodissociation","display_name":"photodissociation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/constrained-peptides","display_name":"constrained peptides","score":0.7450000047683716},{"id":"https://openalex.org/keywords/solid-phase-peptide-synthesis","display_name":"solid-phase peptide synthesis","score":0.7549999952316284},{"id":"https://openalex.org/keywords/femtosecond-laser-irradiation","display_name":"femtosecond laser irradiation","score":0.722000002861023},{"id":"https://openalex.org/keywords/peptide-conformational-dynamics","display_name":"peptide conformational dynamics","score":0.7459999918937683},{"id":"https://openalex.org/keywords/photochemical-release","display_name":"photochemical release","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C2778754187","wikidata":"https://www.wikidata.org/wiki/Q417549","display_name":"Tetrazine","level":2,"score":0.89225172996521},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8748171329498291},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7638787627220154},{"id":"https://openalex.org/C167735695","wikidata":"https://www.wikidata.org/wiki/Q1777507","display_name":"Femtosecond","level":3,"score":0.5450515747070312},{"id":"https://openalex.org/C2779809887","wikidata":"https://www.wikidata.org/wiki/Q14864278","display_name":"Peptide synthesis","level":3,"score":0.5378578901290894},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4627189040184021},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.426705539226532},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.37766438722610474},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3206656575202942},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.27916112542152405},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13822335004806519},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13782945275306702},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055668","descriptor_name":"Photochemical Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/ol301490h","doi":"https://doi.org/10.1021/ol301490h","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ol301490h","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},{"id":"pmid:22731895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22731895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic letters","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2697648","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3397404","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3397404","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3397404","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Org Lett","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2697648","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3397404","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1069440171","display_name":null,"funder_award_id":"GM 12694","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G255748793","display_name":null,"funder_award_id":"P41-RR001348","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G45257206","display_name":"ULTRAFAST OPTICAL PROCESSES LABORATORY","funder_award_id":"5p41rr001348-28","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1977462247","https://openalex.org/W1984854670","https://openalex.org/W1988131005","https://openalex.org/W1992386603","https://openalex.org/W1995723106","https://openalex.org/W2002212053","https://openalex.org/W2002520350","https://openalex.org/W2006885501","https://openalex.org/W2016206751","https://openalex.org/W2017398116","https://openalex.org/W2028909116","https://openalex.org/W2035879189","https://openalex.org/W2048276709","https://openalex.org/W2054762483","https://openalex.org/W2057193323","https://openalex.org/W2058006670","https://openalex.org/W2065120136","https://openalex.org/W2066823500","https://openalex.org/W2067236515","https://openalex.org/W2078021320","https://openalex.org/W2081536788","https://openalex.org/W2085082978","https://openalex.org/W2089199447","https://openalex.org/W2150614072","https://openalex.org/W2155156999","https://openalex.org/W2163161088"],"related_works":["https://openalex.org/W2155156999","https://openalex.org/W2002520350","https://openalex.org/W2050205264","https://openalex.org/W2339033561","https://openalex.org/W2043766604","https://openalex.org/W2259253746","https://openalex.org/W2502252231","https://openalex.org/W2168355713","https://openalex.org/W2094908161","https://openalex.org/W2056766638"],"abstract_inverted_index":{"The":[0],"design,":[1],"solid-phase":[2],"synthesis,":[3],"and":[4,35],"photochemical":[5,58],"validation":[6],"of":[7,30,49],"diverse":[8,41],"peptide":[9,43],"linchpins,":[10],"containing":[11],"the":[12,33,47],"S,S-tetrazine":[13],"phototrigger,":[14],"have":[15],"been":[16],"achieved.":[17],"Steady":[18],"state":[19],"irradiation":[20],"or":[21],"femtosecond":[22],"laser":[23],"pulses":[24],"confirm":[25],"their":[26],"rapid":[27],"photofragmentation.":[28],"Attachment":[29],"peptides":[31],"to":[32,40],"C-":[34],"N-termini":[36],"will":[37],"provide":[38],"access":[39],"constrained":[42],"constructs":[44],"that":[45],"hold":[46],"promise":[48],"providing":[50],"information":[51],"about":[52],"early":[53],"peptide/protein":[54],"conformational":[55],"dynamics":[56],"upon":[57],"release.":[59]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}