{"id":"https://openalex.org/W2062010938","doi":"https://doi.org/10.1001/jama.2011.747","title":"Long-term Risks of Subsequent Primary Neoplasms Among Survivors of Childhood Cancer","display_name":"Long-term Risks of Subsequent Primary Neoplasms Among Survivors of Childhood Cancer","publication_year":2011,"publication_date":"2011-06-04","ids":{"openalex":"https://openalex.org/W2062010938","doi":"https://doi.org/10.1001/jama.2011.747","mag":"2062010938","pmid":"https://pubmed.ncbi.nlm.nih.gov/21642683"},"language":"en","primary_location":{"id":"doi:10.1001/jama.2011.747","doi":"https://doi.org/10.1001/jama.2011.747","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.2011.747","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2062010938"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016823196","display_name":"Raoul C. Reulen","orcid":"https://orcid.org/0000-0002-7328-0467","observed_orcids":["https://orcid.org/0000-0002-7328-0467"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Raoul C. Reulen","raw_affiliation_strings":["Centre for Childhood Cancer Survivor Studies, School of Health and Population Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom. r.c.reulen@bham.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Childhood Cancer Survivor Studies, School of Health and Population Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom. r.c.reulen@bham.ac.uk","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049006929","display_name":"Clare Frobisher","orcid":"https://orcid.org/0000-0003-1099-163X","observed_orcids":["https://orcid.org/0000-0003-1099-163X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clare Frobisher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161969072","display_name":"David L Winter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David L Winter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158124598","display_name":"Julie Kelly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Kelly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108044755","display_name":"Emma R. Lancashire","orcid":"https://orcid.org/0000-0001-8601-4400","observed_orcids":["https://orcid.org/0000-0001-8601-4400"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emma R Lancashire","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082467051","display_name":"Charles A. Stiller","orcid":"https://orcid.org/0000-0002-3006-7869","observed_orcids":["https://orcid.org/0000-0002-3006-7869"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles A Stiller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161831678","display_name":"Kathryn Pritchard-Jones","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathryn Pritchard-Jones","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074742139","display_name":"Helen C. Jenkinson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen C Jenkinson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5161935927","display_name":"Michael M Hawkins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael M Hawkins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016823196"],"corresponding_institution_ids":["https://openalex.org/I79619799"],"apc_list":null,"apc_paid":null,"fwci":16.2063,"has_fulltext":false,"cited_by_count":344,"citation_normalized_percentile":{"value":0.99645798,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"305","issue":"22","first_page":"2311","last_page":"2311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11141","display_name":"Childhood Cancer Survivors' Quality of Life","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-cancer-survivors","display_name":"childhood cancer survivors","score":0.9909999966621399},{"id":"https://openalex.org/keywords/second-primary-neoplasms","display_name":"second primary neoplasms","score":0.8330000042915344},{"id":"https://openalex.org/keywords/long-term-cancer-risk","display_name":"long-term cancer risk","score":0.828000009059906},{"id":"https://openalex.org/keywords/central-nervous-system-tumors","display_name":"central nervous system tumors","score":0.7129999995231628},{"id":"https://openalex.org/keywords/non-melanoma-skin-cancer","display_name":"non-melanoma skin cancer","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gastrointestinal-cancer","display_name":"gastrointestinal cancer","score":0.5400000214576721},{"id":"https://openalex.org/keywords/urological-cancer","display_name":"genitourinary cancer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.875},{"id":"https://openalex.org/keywords/bone-cancer","display_name":"bone cancer","score":0.8119999766349792},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.7409999966621399},{"id":"https://openalex.org/keywords/cumulative-incidence","display_name":"cumulative incidence","score":0.5270000100135803},{"id":"https://openalex.org/keywords/standardized-incidence-ratio","display_name":"standardized incidence ratio","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9441906213760376},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5868715643882751},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.581806480884552},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5418421030044556},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5371713042259216},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5130754709243774},{"id":"https://openalex.org/C120195587","wikidata":"https://www.wikidata.org/wiki/Q2138790","display_name":"Absolute risk reduction","level":3,"score":0.5048533082008362},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.49733784794807434},{"id":"https://openalex.org/C2778527826","wikidata":"https://www.wikidata.org/wiki/Q1787017","display_name":"Cancer registry","level":3,"score":0.477914422750473},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.4679053723812103},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.4564436078071594},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4402020573616028},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4264141917228699},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.42199116945266724},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4165748357772827},{"id":"https://openalex.org/C133507102","wikidata":"https://www.wikidata.org/wiki/Q4712977","display_name":"Genitourinary system","level":2,"score":0.41343599557876587},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.07340902090072632},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D017741","descriptor_name":"Survivors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1001/jama.2011.747","doi":"https://doi.org/10.1001/jama.2011.747","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.2011.747","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},{"id":"pmid:21642683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21642683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1315126","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1315126/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JAMA-J AM MED ASSOC , 305 (22) 2311 - 2319. (2011)","raw_type":"Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/edea65d5-73fb-4541-8e75-49c8f7212533","doi":null,"is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/edea65d5-73fb-4541-8e75-49c8f7212533","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Reulen, R, Frobisher, C, Winter, D, Kelly, J, Lancashire, E, Stiller, CA, Pritchard-Jones, K, Jenkinson, H & Hawkins, M 2011, 'Long-term Risks of Subsequent Primary Neoplasms Among Survivors of Childhood Cancer', JAMA The Journal of the American Medical Association, vol. 305, no. 22, pp. 2311-2319. https://doi.org/10.1001/jama.2011.747","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:publications/edea65d5-73fb-4541-8e75-49c8f7212533","doi":null,"is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/portal/en/publications/longterm-risks-of-subsequent-primary-neoplasms-among-survivors-of-childhood-cancer(edea65d5-73fb-4541-8e75-49c8f7212533).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Reulen , R , Frobisher , C , Winter , D , Kelly , J , Lancashire , E , Stiller , CA , Pritchard-Jones , K , Jenkinson , H & Hawkins , M 2011 , ' Long-term Risks of Subsequent Primary Neoplasms Among Survivors of Childhood Cancer ' , JAMA The Journal of the American Medical Association , vol. 305 , no. 22 , pp. 2311-2319 . https://doi.org/10.1001/jama.2011.747","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1521660172","https://openalex.org/W1570622790","https://openalex.org/W1973617793","https://openalex.org/W1979955428","https://openalex.org/W1989971315","https://openalex.org/W1991476269","https://openalex.org/W2018538091","https://openalex.org/W2021460638","https://openalex.org/W2029080157","https://openalex.org/W2051789604","https://openalex.org/W2068672589","https://openalex.org/W2074447809","https://openalex.org/W2085512305","https://openalex.org/W2085657754","https://openalex.org/W2097786984","https://openalex.org/W2118489721","https://openalex.org/W2122245945","https://openalex.org/W2132628053","https://openalex.org/W2147416239","https://openalex.org/W2152710213","https://openalex.org/W2158922990","https://openalex.org/W2161951565","https://openalex.org/W2168571815","https://openalex.org/W2344750083","https://openalex.org/W2407730988","https://openalex.org/W2465410240","https://openalex.org/W2621720915","https://openalex.org/W4394745208"],"related_works":["https://openalex.org/W2164019592","https://openalex.org/W2127719600","https://openalex.org/W2144906623","https://openalex.org/W2111386972","https://openalex.org/W2135137207","https://openalex.org/W2152710213","https://openalex.org/W2603845577","https://openalex.org/W7154036414","https://openalex.org/W4391402960","https://openalex.org/W2320043670"],"abstract_inverted_index":{"CONTEXT:":[0],"Survivors":[1],"of":[2,9,25,31,49,55,76,80,117,127,226,242,282],"childhood":[3,32,81,284],"cancer":[4,82,85,153,244,285],"are":[5,18],"at":[6,51,86,197,269,296],"excess":[7,43,111,289],"risk":[8,54,265,290],"developing":[10],"subsequent":[11,26,57,118,135,208,235,293],"primary":[12,27,58,119,136,209,236,294],"neoplasms":[13,28,59,137,210,295],"but":[14],"the":[15,36,140,227,263,287],"long-term":[16,23,42],"risks":[17,24,112],"uncertain.":[19],"OBJECTIVES:":[20],"To":[21],"investigate":[22],"in":[29,95,266],"survivors":[30,50,79,246],"cancer,":[33],"to":[34,41,46,232],"identify":[35,47],"types":[37],"that":[38,60],"contribute":[39],"most":[40,141],"risk,":[44],"and":[45,93,114,169,206,216,304],"subgroups":[48],"substantially":[52],"increased":[53],"particular":[56],"may":[61],"require":[62],"specific":[63],"interventions.":[64],"DESIGN,":[65],"SETTING,":[66],"AND":[67],"PARTICIPANTS:":[68],"British":[69,283],"Childhood":[70],"Cancer":[71],"Survivor":[72],"Study--a":[73],"population-based":[74],"cohort":[75,281],"17,981":[77],"5-year":[78],"diagnosed":[83],"with":[84,248,262,268,292],"younger":[87],"than":[88,181,199,298],"15":[89],"years":[90,129,201,300],"between":[91],"1940":[92],"1991":[94],"Great":[96],"Britain,":[97],"followed":[98],"up":[99],"through":[100],"December":[101],"2006.":[102],"MAIN":[103],"OUTCOME":[104],"MEASURES:":[105],"Standardized":[106],"incidence":[107,116,241],"ratios":[108],"(SIRs),":[109],"absolute":[110],"(AERs),":[113],"cumulative":[115,240],"neoplasms.":[120,306],"RESULTS:":[121],"After":[122],"a":[123,280],"median":[124],"follow-up":[125],"time":[126],"24.3":[128],"(mean":[130],"=":[131,149,155,159,163,167,172],"25.6":[132],"years),":[133],"1354":[134],"were":[138],"ascertained;":[139],"frequently":[142],"observed":[143],"being":[144],"central":[145],"nervous":[146],"system":[147],"(n":[148,154,158,162,166,171],"344),":[150],"nonmelanoma":[151],"skin":[152],"278),":[156],"digestive":[157,205,303],"105),":[160],"genitourinary":[161,207,305],"100),":[164],"breast":[165],"97),":[168],"bone":[170],"94).":[173],"The":[174,195,239],"overall":[175],"SIR":[176],"was":[177,202,230,252,301],"4":[178],"times":[179],"more":[180],"expected":[182],"(SIR,":[183],"3.9;":[184],"95%":[185],"confidence":[186],"interval":[187],"[CI],":[188],"3.6-4.2;":[189],"AER,":[190,217],"16.8":[191],"per":[192,221],"10,000":[193,222],"person-years).":[194],"AER":[196,229],"older":[198,297],"40":[200,299],"highest":[203],"for":[204,245,302],"(AER,":[211],"5.9":[212],"[95%":[213],"CI,":[214,255],"2.5-9.3];":[215],"6.0":[218],"[95%CI,":[219],"2.3-9.6]":[220],"person-years,":[223],"respectively);":[224],"36%":[225],"total":[228],"attributable":[231],"these":[233],"2":[234,271],"neoplasm":[237],"sites.":[238],"colorectal":[243,276],"treated":[247],"direct":[249],"abdominopelvic":[250],"irradiation":[251],"1.4%":[253],"(95%":[254],"0.7%-2.6%)":[256],"by":[257,275],"age":[258],"50":[259],"years,":[260],"comparable":[261],"1.2%":[264],"individuals":[267],"least":[270],"first-degree":[272],"relatives":[273],"affected":[274],"cancer.":[277],"CONCLUSION:":[278],"Among":[279],"survivors,":[286],"greatest":[288],"associated":[291]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":31},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":33},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":24}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}