{"id":"https://openalex.org/W2061972001","doi":"https://doi.org/10.1074/jbc.m111.336545","title":"Activated Apoptotic Cells Induce Dendritic Cell Maturation via Engagement of Toll-like Receptor 4 (TLR4), Dendritic Cell-specific Intercellular Adhesion Molecule 3 (ICAM-3)-grabbing Nonintegrin (DC-SIGN), and \u03b22 Integrins","display_name":"Activated Apoptotic Cells Induce Dendritic Cell Maturation via Engagement of Toll-like Receptor 4 (TLR4), Dendritic Cell-specific Intercellular Adhesion Molecule 3 (ICAM-3)-grabbing Nonintegrin (DC-SIGN), and \u03b22 Integrins","publication_year":2012,"publication_date":"2012-03-07","ids":{"openalex":"https://openalex.org/W2061972001","doi":"https://doi.org/10.1074/jbc.m111.336545","mag":"2061972001","pmid":"https://pubmed.ncbi.nlm.nih.gov/22396536","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3340136"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111.336545","doi":"https://doi.org/10.1074/jbc.m111.336545","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.336545","pdf_url":"http://www.jbc.org/article/S0021925820529463/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820529463/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027966596","display_name":"Sushil Kumar Pathak","orcid":"https://orcid.org/0009-0005-9075-9006","observed_orcids":["https://orcid.org/0009-0005-9075-9006"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Sushil Kumar Pathak","raw_affiliation_strings":["Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078024614","display_name":"Annette E. Sk\u00f6ld","orcid":"https://orcid.org/0000-0002-5309-8860","observed_orcids":["https://orcid.org/0000-0002-5309-8860"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Annette E. Sk\u00f6ld","raw_affiliation_strings":["Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043813969","display_name":"Venkatramanan Mohanram","orcid":"https://orcid.org/0000-0002-8221-5982","observed_orcids":["https://orcid.org/0000-0002-8221-5982"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Venkatramanan Mohanram","raw_affiliation_strings":["Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037259959","display_name":"Catrine M. Persson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Catrine Persson","raw_affiliation_strings":["Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036659517","display_name":"Ulrika Johansson","orcid":"https://orcid.org/0000-0003-0743-7400","observed_orcids":["https://orcid.org/0000-0003-0743-7400"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ulrika Johansson","raw_affiliation_strings":["Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027200440","display_name":"Anna\u2010Lena Spetz","orcid":"https://orcid.org/0000-0003-3964-9512","observed_orcids":["https://orcid.org/0000-0003-3964-9512"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Anna-Lena Spetz","raw_affiliation_strings":["Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027200440","https://openalex.org/A5027966596"],"corresponding_institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.6892,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.82547351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"287","issue":"17","first_page":"13731","last_page":"13742"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.996999979019165},{"id":"https://openalex.org/keywords/apoptotic-cells","display_name":"apoptotic cells","score":0.7680000066757202},{"id":"https://openalex.org/keywords/immunogenic-cell-death","display_name":"immunogenic cell death","score":0.8460000157356262},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dc-sign","display_name":"DC-SIGN","score":0.9959999918937683},{"id":"https://openalex.org/keywords/beta2-integrins","display_name":"beta2 integrins","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cd80","display_name":"CD80","score":0.6930000185966492},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":1.0},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cell-cell-contact-signaling","display_name":"cell-cell contact signaling","score":0.7730000019073486},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.7239999771118164},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9810000061988831},{"id":"https://openalex.org/keywords/pi3k-akt","display_name":"PI3K/Akt","score":0.8870000243186951},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.9190000295639038},{"id":"https://openalex.org/keywords/nf-kappab-p65","display_name":"NF-\u03baB p65","score":0.9200000166893005},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.7609999775886536},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.996999979019165},{"id":"https://openalex.org/keywords/monocyte-derived-dendritic-cells","display_name":"monocyte-derived dendritic cells","score":0.8560000061988831},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7221963405609131},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.6183999180793762},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.6172900795936584},{"id":"https://openalex.org/C2778297628","wikidata":"https://www.wikidata.org/wiki/Q5009843","display_name":"CD80","level":5,"score":0.6042559146881104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5818753838539124},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.4946081340312958},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.44324126839637756},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.41605132818222046},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3658360540866852},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.30261102318763733},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2744958996772766},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.27225106954574585},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.23948949575424194},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.173326313495636},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.13735529780387878},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.12978428602218628},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099215","descriptor_name":"DC-Specific ICAM-3 Grabbing Nonintegrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018821","descriptor_name":"CD18 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018950","descriptor_name":"Lipopolysaccharide Receptors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1074/jbc.m111.336545","doi":"https://doi.org/10.1074/jbc.m111.336545","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.336545","pdf_url":"http://www.jbc.org/article/S0021925820529463/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2622834","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3340136","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:22396536","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22396536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3340136","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3340136/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/108425","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/108425","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ncbi.nlm.nih.gov/pubmed/22396536","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/108425","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/108425","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biological Chemistry, 287, 13731 - 42","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m111.336545","doi":"https://doi.org/10.1074/jbc.m111.336545","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.336545","pdf_url":"http://www.jbc.org/article/S0021925820529463/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320940","display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning","ror":"https://ror.org/044wr7g58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2061972001.pdf","grobid_xml":"https://content.openalex.org/works/W2061972001.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1499902555","https://openalex.org/W1504924831","https://openalex.org/W1520778627","https://openalex.org/W1525166884","https://openalex.org/W1545740310","https://openalex.org/W1580809446","https://openalex.org/W1661544713","https://openalex.org/W1722018986","https://openalex.org/W1931655778","https://openalex.org/W1961222220","https://openalex.org/W1969432457","https://openalex.org/W1972489295","https://openalex.org/W1972715229","https://openalex.org/W1980295353","https://openalex.org/W1981230452","https://openalex.org/W1991536229","https://openalex.org/W1996230397","https://openalex.org/W2000785864","https://openalex.org/W2004266769","https://openalex.org/W2009840433","https://openalex.org/W2015784912","https://openalex.org/W2016612145","https://openalex.org/W2030489912","https://openalex.org/W2034515469","https://openalex.org/W2038663100","https://openalex.org/W2040287935","https://openalex.org/W2042851093","https://openalex.org/W2047046033","https://openalex.org/W2048685286","https://openalex.org/W2052914449","https://openalex.org/W2053849689","https://openalex.org/W2055132644","https://openalex.org/W2083032546","https://openalex.org/W2084006363","https://openalex.org/W2086685130","https://openalex.org/W2088977113","https://openalex.org/W2092946137","https://openalex.org/W2100446366","https://openalex.org/W2103301134","https://openalex.org/W2112222308","https://openalex.org/W2113158278","https://openalex.org/W2116372484","https://openalex.org/W2117817795","https://openalex.org/W2128519954","https://openalex.org/W2129374849","https://openalex.org/W2129589052","https://openalex.org/W2130590529","https://openalex.org/W2130878425","https://openalex.org/W2132957546","https://openalex.org/W2135649725","https://openalex.org/W2136883776","https://openalex.org/W2141778744","https://openalex.org/W2142153200","https://openalex.org/W2143516276","https://openalex.org/W2143998429","https://openalex.org/W2148345765","https://openalex.org/W2155742637","https://openalex.org/W2161367998","https://openalex.org/W2161489704","https://openalex.org/W2166222304","https://openalex.org/W2166495164","https://openalex.org/W2341467666"],"related_works":["https://openalex.org/W4313331874","https://openalex.org/W2126678018","https://openalex.org/W1525166884","https://openalex.org/W2121004230","https://openalex.org/W7100220113","https://openalex.org/W2123008121","https://openalex.org/W2289263596","https://openalex.org/W4313331452","https://openalex.org/W7096530330","https://openalex.org/W2149079955"],"abstract_inverted_index":{"Dendritic":[0],"cells":[1,6,239],"(DCs)":[2],"are":[3,79],"professional":[4],"antigen-presenting":[5,35],"playing":[7],"a":[8,32],"central":[9],"role":[10,147],"in":[11,65,93,130,157,179,192],"connecting":[12],"innate":[13],"and":[14,27,62,74,87,115,125,140,189,207,214,223],"adaptive":[15],"immunity.":[16],"Maturation":[17],"signals":[18,48],"are,":[19],"however,":[20],"required":[21,80],"for":[22,81],"DCs":[23,193,235],"to":[24,30,49],"undergo":[25],"phenotypic":[26],"functional":[28],"changes":[29],"acquire":[31],"fully":[33],"competent":[34],"capacity.":[36],"We":[37,69,182],"previously":[38],"reported":[39],"that":[40,71],"activated":[41,167],"apoptotic":[42,168],"peripheral":[43],"lymphocytes":[44],"(ActApo)":[45],"provide":[46,227],"activation/maturation":[47],"human":[50,176],"monocyte-derived":[51],"DCs.":[52,158,224],"In":[53,159],"this":[54],"paper,":[55],"we":[56],"have":[57],"characterized":[58],"the":[59,94,121,131,161,217,232],"signaling":[60,106,187],"pathways":[61,188],"molecules":[63],"involved":[64,107],"ActApo-mediated":[66],"DC":[67,82],"maturation.":[68],"found":[70],"both":[72],"cellular":[73],"supernatant":[75],"fractions":[76],"from":[77],"ActApo":[78,222],"maturation":[83,122],"signaling.":[84],"ActApoSup-induced":[85],"CD80":[86,124],"CD86":[88,126],"expression":[89],"was":[90,127,150,171],"significantly":[91,128],"blocked":[92],"presence":[95,132],"of":[96,120,133,148,155,185,234],"neutralizing":[97,134],"antibodies":[98,135],"against":[99,136],"tumor":[100],"necrosis":[101],"factor-\u03b1":[102],"(TNF-\u03b1).":[103],"Cell-cell":[104],"contact-dependent":[105],"\u03b22":[108],"integrins,":[109],"dendritic":[110],"cell-specific":[111],"ICAM-3-grabbing":[112],"nonintegrin":[113],"(DC-SIGN),":[114],"TLR4":[116,149,156],"because":[117],"ActApo-induced":[118],"up-regulation":[119],"markers":[123],"inhibited":[129],"CD18,":[137],"CD11a,":[138],"CD11b,":[139],"DC-SIGN":[141],"as":[142,144],"well":[143],"TLR4.":[145],"The":[146],"further":[151],"confirmed":[152],"by":[153,166],"silencing":[154],"addition,":[160],"endogenous":[162],"adjuvant":[163],"effect":[164],"exerted":[165],"splenocytes":[169],"(ActApoSp)":[170],"reduced":[172],"after":[173],"immunization":[174],"with":[175,196,238],"serum":[177],"albumin":[178],"TLR4(-/-)":[180],"mice.":[181],"detected":[183],"activation":[184],"multiple":[186],"transcription":[190,209],"factors":[191],"upon":[194],"co-culture":[195],"ActApo,":[197],"including":[198],"p38,":[199],"JNK,":[200],"PI3K-Akt,":[201],"Src":[202],"family":[203,211],"kinases,":[204],"NF\u03baB":[205],"p65,":[206],"AP1":[208],"factor":[210],"members":[212],"c-Jun":[213],"c-Fos,":[215],"demonstrating":[216],"complex":[218],"interactions":[219],"occurring":[220],"between":[221],"These":[225],"studies":[226],"important":[228],"mechanistic":[229],"insight":[230],"into":[231],"responses":[233],"during":[236],"encounter":[237],"undergoing":[240],"immunogenic":[241],"cell":[242],"death.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}