{"id":"https://openalex.org/W2061962063","doi":"https://doi.org/10.2174/1568006053005056","title":"Hyaluronan and Hyaluronan Synthases: Potential Therapeutic Targets in Cancer","display_name":"Hyaluronan and Hyaluronan Synthases: Potential Therapeutic Targets in Cancer","publication_year":2005,"publication_date":"2005-02-01","ids":{"openalex":"https://openalex.org/W2061962063","doi":"https://doi.org/10.2174/1568006053005056","mag":"2061962063","pmid":"https://pubmed.ncbi.nlm.nih.gov/15720220"},"language":"en","primary_location":{"id":"doi:10.2174/1568006053005056","doi":"https://doi.org/10.2174/1568006053005056","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1568006053005056","pdf_url":null,"source":{"id":"https://openalex.org/S2764548042","display_name":"Cardiovascular & Haematological Disorders - Drug Targets","issn_l":"1568-0061","issn":["1568-0061","1871-529X","1875-5895","2212-4063"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Target -Cardiovascular & Hematological Disorders","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056530572","display_name":"Sophia Adamia","orcid":"https://orcid.org/0000-0001-5704-6040","observed_orcids":["https://orcid.org/0000-0001-5704-6040"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]},{"id":"https://openalex.org/I4405258411","display_name":"Cross Cancer Institute","ror":"https://ror.org/00m3k3802","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405258411"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sophia Adamia","raw_affiliation_strings":["Department of Oncology, University of Alberta & Cross Cancer Institute, Edmonton, 11560 University Avenue, Edmonton, Alberta, Canada T6G 1Z2. sadamia@ualberta.ca","Department of Oncology, University of Alberta & Cross Cancer Institute, Edmonton, 11560 University Avenue, Edmonton, Alberta, Canada T6G 1Z2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University of Alberta & Cross Cancer Institute, Edmonton, 11560 University Avenue, Edmonton, Alberta, Canada T6G 1Z2. sadamia@ualberta.ca","institution_ids":["https://openalex.org/I154425047","https://openalex.org/I4405258411"]},{"raw_affiliation_string":"Department of Oncology, University of Alberta & Cross Cancer Institute, Edmonton, 11560 University Avenue, Edmonton, Alberta, Canada T6G 1Z2","institution_ids":["https://openalex.org/I154425047","https://openalex.org/I4405258411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058042409","display_name":"Christopher A. Maxwell","orcid":"https://orcid.org/0000-0002-0713-7136","observed_orcids":["https://orcid.org/0000-0002-0713-7136"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Maxwell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103507326","display_name":"Linda M. Pilarski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]},{"id":"https://openalex.org/I4405258411","display_name":"Cross Cancer Institute","ror":"https://ror.org/00m3k3802","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405258411"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Linda Pilarski","raw_affiliation_strings":["Department of Oncology, University of Alberta&Cross Cancer Institute Edmonton, 11560 UniversityAvenue, Edmonton, Alberta, Canada T6G 1Z2.,Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University of Alberta&Cross Cancer Institute Edmonton, 11560 UniversityAvenue, Edmonton, Alberta, Canada T6G 1Z2.,Canada","institution_ids":["https://openalex.org/I154425047","https://openalex.org/I4405258411"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103507326"],"corresponding_institution_ids":["https://openalex.org/I154425047","https://openalex.org/I4405258411"],"apc_list":null,"apc_paid":null,"fwci":4.1492,"has_fulltext":false,"cited_by_count":169,"citation_normalized_percentile":{"value":0.94775152,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"3","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":1.0},{"id":"https://openalex.org/keywords/hyaluronan-synthase","display_name":"hyaluronan synthase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/has1","display_name":"HAS1","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hyaluronan-synthase-2","display_name":"HAS2","score":1.0},{"id":"https://openalex.org/keywords/has3","display_name":"HAS3","score":1.0},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9729999899864197},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5339999794960022},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7820000052452087},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8679999709129333},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7319999933242798},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7231349945068359},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6856263875961304},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6159851551055908},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5977652072906494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5264939665794373},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.49932122230529785},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.47293782234191895},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.46192237734794617},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.4551832377910614},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41227757930755615},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3968627452850342},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34092026948928833},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1245637834072113},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09473517537117004},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000076002","descriptor_name":"Hyaluronan Synthases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014166","descriptor_name":"Transferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014453","descriptor_name":"Glucuronosyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2174/1568006053005056","doi":"https://doi.org/10.2174/1568006053005056","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1568006053005056","pdf_url":null,"source":{"id":"https://openalex.org/S2764548042","display_name":"Cardiovascular & Haematological Disorders - Drug Targets","issn_l":"1568-0061","issn":["1568-0061","1871-529X","1875-5895","2212-4063"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Target -Cardiovascular & Hematological Disorders","raw_type":"journal-article"},{"id":"pmid:15720220","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15720220","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current drug targets. Cardiovascular & haematological disorders","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.335.6177","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.6177","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.benthamscience.com/cdtchd/sample/cdtchd5-1/0002X.pdf","raw_type":"text"},{"id":"pmh:oai:cisti-icist.nrc-cnrc.ca:cistinparc:8926408","doi":null,"is_oa":false,"landing_page_url":"https://nrc-publications.canada.ca/fra/voir/objet/?id=9882ca37-092d-429c-9fb6-7f7abf5da7c1","pdf_url":null,"source":{"id":"https://openalex.org/S7407055245","display_name":"NPARC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2004326672","display_name":"The malignant stem cell in multiple myeloma","funder_award_id":"R01CA080963","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320321767","display_name":"Alberta Heritage Foundation for Medical Research","ror":"https://ror.org/0160cpw27"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W91710746","https://openalex.org/W147069033","https://openalex.org/W155864078","https://openalex.org/W815233466","https://openalex.org/W1493591863","https://openalex.org/W1545715882","https://openalex.org/W1552949608","https://openalex.org/W1567493631","https://openalex.org/W1574987094","https://openalex.org/W1587249246","https://openalex.org/W1595631714","https://openalex.org/W1657157395","https://openalex.org/W1896714038","https://openalex.org/W1909809324","https://openalex.org/W1941651480","https://openalex.org/W1964253746","https://openalex.org/W1968952749","https://openalex.org/W1977409409","https://openalex.org/W1988968874","https://openalex.org/W1990317973","https://openalex.org/W1991189072","https://openalex.org/W1991690400","https://openalex.org/W1991948593","https://openalex.org/W1997504682","https://openalex.org/W1998531407","https://openalex.org/W2001217834","https://openalex.org/W2004522957","https://openalex.org/W2005621119","https://openalex.org/W2008678914","https://openalex.org/W2008712731","https://openalex.org/W2010069724","https://openalex.org/W2010512481","https://openalex.org/W2013782445","https://openalex.org/W2014226393","https://openalex.org/W2017437930","https://openalex.org/W2023153142","https://openalex.org/W2026024971","https://openalex.org/W2026718707","https://openalex.org/W2028957277","https://openalex.org/W2029706883","https://openalex.org/W2029947874","https://openalex.org/W2030605936","https://openalex.org/W2032511595","https://openalex.org/W2034269086","https://openalex.org/W2034384394","https://openalex.org/W2036391446","https://openalex.org/W2047025323","https://openalex.org/W2047516844","https://openalex.org/W2049508142","https://openalex.org/W2051603299","https://openalex.org/W2052015840","https://openalex.org/W2054087284","https://openalex.org/W2061095488","https://openalex.org/W2062413975","https://openalex.org/W2064326439","https://openalex.org/W2067956542","https://openalex.org/W2070088612","https://openalex.org/W2074340276","https://openalex.org/W2075905225","https://openalex.org/W2077007440","https://openalex.org/W2077723522","https://openalex.org/W2081496297","https://openalex.org/W2084649332","https://openalex.org/W2085665189","https://openalex.org/W2088719923","https://openalex.org/W2093549611","https://openalex.org/W2095204857","https://openalex.org/W2095656992","https://openalex.org/W2103961160","https://openalex.org/W2104512411","https://openalex.org/W2105159223","https://openalex.org/W2105298685","https://openalex.org/W2105865292","https://openalex.org/W2110503511","https://openalex.org/W2111914361","https://openalex.org/W2112327424","https://openalex.org/W2113805143","https://openalex.org/W2116672705","https://openalex.org/W2117976997","https://openalex.org/W2118027609","https://openalex.org/W2118121278","https://openalex.org/W2119577416","https://openalex.org/W2123283925","https://openalex.org/W2125153566","https://openalex.org/W2126777575","https://openalex.org/W2128466784","https://openalex.org/W2129081579","https://openalex.org/W2130725713","https://openalex.org/W2131095105","https://openalex.org/W2134995897","https://openalex.org/W2135264351","https://openalex.org/W2135325995","https://openalex.org/W2140526338","https://openalex.org/W2140557275","https://openalex.org/W2142730893","https://openalex.org/W2149249386","https://openalex.org/W2150174045","https://openalex.org/W2150468943","https://openalex.org/W2151339663","https://openalex.org/W2151615110","https://openalex.org/W2153151063","https://openalex.org/W2157028830","https://openalex.org/W2158160769","https://openalex.org/W2158939062","https://openalex.org/W2159847432","https://openalex.org/W2162563495","https://openalex.org/W2163344769","https://openalex.org/W2163753400","https://openalex.org/W2167704983","https://openalex.org/W2172114097","https://openalex.org/W2181856912","https://openalex.org/W2220491495","https://openalex.org/W2285037228","https://openalex.org/W2395572556","https://openalex.org/W2409125979","https://openalex.org/W2410326628","https://openalex.org/W2415781863","https://openalex.org/W2416624154","https://openalex.org/W2417808907","https://openalex.org/W3157219154"],"related_works":["https://openalex.org/W7095421408","https://openalex.org/W3023562651","https://openalex.org/W2939841075","https://openalex.org/W935121131","https://openalex.org/W2958685672","https://openalex.org/W2770229360","https://openalex.org/W2800749615","https://openalex.org/W4229716791","https://openalex.org/W296648604","https://openalex.org/W4296995255"],"abstract_inverted_index":{"Current":[0],"models":[1],"of":[2,9,25,40,90,93,105,114,122,148,154,165,201,208,212,223,238,273,279,295,303,312],"oncogenesis":[3],"describe":[4],"cancer":[5,155],"as":[6,217],"a":[7,13,22,32,44,145,234],"progression":[8],"genetic":[10],"mutations":[11],"in":[12,117,174,205,243,270,285],"tumor":[14,45,77,80],"cell":[15,49,106,129,175,228,253,259,286],"mass.":[16],"However,":[17,275],"tumors":[18],"are":[19,29,85,190],"more":[20],"than":[21],"clonal":[23],"expansion":[24],"malignant":[26,268],"cells.":[27],"Tumors":[28],"heterogeneous,":[30],"with":[31,52,56,68],"complex":[33],"3D":[34],"structure,":[35],"analogous":[36],"to":[37,103,151,158,226,265,289,307],"organs":[38],"comprised":[39],"different":[41],"tissues.":[42],"In":[43,136],"mass,":[46],"the":[47,69,88,115,120,267,276,301],"component":[48,147],"types":[50,153,272],"interact":[51],"each":[53],"other":[54,132],"and":[55,82,109,131,162,184,197,210,219,229,245,249,255,261,282,297],"their":[57,283],"microenvironment":[58],"by":[59,192],"exchanging":[60],"information":[61],"through":[62,66,87,252],"cell-cell":[63],"interactions":[64,67,75],"and/or":[65,98],"extracellular":[70,159],"matrix":[71],"(ECM).":[72],"These":[73],"synergetic":[74],"facilitate":[76,186,300],"progression.":[78],"Furthermore,":[79],"invasion":[81],"metastatic":[83],"development":[84,251],"accomplished":[86],"breakdown":[89],"ECM.":[91],"Disruption":[92],"ECM":[94,116],"promotes":[95,119],"abnormal":[96,206,213],"inter-":[97],"intra-":[99],"cellular":[100],"signaling,":[101,176],"leading":[102],"dysregulation":[104],"proliferation,":[107],"growth":[108,123],"cytoskeleton":[110],"reorganization.":[111],"The":[112,221],"disruption":[113],"turn":[118],"overproduction":[121],"factors,":[124],"which":[125],"induce":[126],"elevated":[127],"epithelial":[128],"proliferation":[130,260],"abnormalities":[133],"including":[134],"carcinogenesis.":[135],"this":[137],"review":[138],"we":[139],"will":[140],"demonstrate":[141],"that":[142],"hyaluronan":[143,193],"(HA),":[144],"core":[146],"ECM,":[149],"contributes":[150],"certain":[152],"development.":[156],"Additional":[157],"HA,":[160],"intracellular":[161],"nuclear":[163,178],"forms":[164],"HA":[166,171,179,188,209,296],"have":[167],"been":[168],"detected.":[169],"Intracellular":[170],"is":[172,241],"involved":[173,242],"whereas":[177],"could":[180],"promote":[181],"chromatin":[182],"condensation":[183],"thus":[185],"mitosis.":[187],"molecules":[189],"synthesized":[191],"synthases":[194],"(HASs)-HAS1,":[195],"HAS2":[196,240,257],"HAS3":[198,263],"enzymes.":[199],"Dysregulation":[200],"HAS":[202,280],"genes":[203],"results":[204],"production":[207],"promotion":[211],"biological":[214],"processes":[215],"such":[216],"transformation":[218],"metastasis.":[220],"function":[222,278],"HASs":[224,298],"appears":[225,264],"be":[227,290],"tissue":[230],"specific.":[231],"HAS1":[232],"maintains":[233],"low,":[235],"basal":[236],"level":[237],"HA.":[239],"embryonic":[244],"cardiac":[246],"cushion":[247],"morphogenesis":[248],"subsequent":[250],"migration":[254],"invasion.":[256],"stimulates":[258],"angiogenesis.":[262],"favor":[266],"phenotype":[269],"many":[271],"malignancies.":[274],"exact":[277],"isoenzymes":[281],"role":[284],"signaling":[287],"remains":[288],"elucidated.":[291],"A":[292],"better":[293],"understanding":[294],"may":[299],"design":[302],"novel":[304],"therapeutic":[305],"strategies":[306],"counter":[308],"presumptive":[309],"cancer-promoting":[310],"effects":[311],"microenvironmental":[313],"components.":[314]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}