{"id":"https://openalex.org/W2061857101","doi":"https://doi.org/10.1111/j.1527-5299.2002.00300.x","title":"Free Radicals in Heart Failure: Therapeutic Targets for Old and New Drugs","display_name":"Free Radicals in Heart Failure: Therapeutic Targets for Old and New Drugs","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W2061857101","doi":"https://doi.org/10.1111/j.1527-5299.2002.00300.x","mag":"2061857101","pmid":"https://pubmed.ncbi.nlm.nih.gov/12045380"},"language":"en","primary_location":{"id":"doi:10.1111/j.1527-5299.2002.00300.x","doi":"https://doi.org/10.1111/j.1527-5299.2002.00300.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1527-5299.2002.00300.x","pdf_url":null,"source":{"id":"https://openalex.org/S26432035","display_name":"Congestive Heart Failure","issn_l":"1527-5299","issn":["1527-5299","1751-7133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Congestive Heart Failure","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090603814","display_name":"Abarmard Maziar Zafari","orcid":"https://orcid.org/0000-0001-9281-7197","observed_orcids":["https://orcid.org/0000-0001-9281-7197"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. Maziar Zafari","raw_affiliation_strings":["Emory University School of Medicine, Department of Medicine, Division of Cardiology, Atlanta, GA 30322, USA. azafari@emory.edu","From Emory University School of Medicine, Department of Medicine, Division of Cardiology, Atlanta, GA, and Atlanta Veterans Administration Medical Center, Division of Cardiology, Decatur, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, Department of Medicine, Division of Cardiology, Atlanta, GA 30322, USA. azafari@emory.edu","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"From Emory University School of Medicine, Department of Medicine, Division of Cardiology, Atlanta, GA, and Atlanta Veterans Administration Medical Center, Division of Cardiology, Decatur, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210152539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011627807","display_name":"David Glenn Harrison","orcid":"https://orcid.org/0000-0001-9363-6451","observed_orcids":["https://orcid.org/0000-0001-9363-6451"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G. Harrison","raw_affiliation_strings":["From Emory University School of Medicine, Department of Medicine, Division of Cardiology, Atlanta, GA, and Atlanta Veterans Administration Medical Center, Division of Cardiology, Decatur, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Emory University School of Medicine, Department of Medicine, Division of Cardiology, Atlanta, GA, and Atlanta Veterans Administration Medical Center, Division of Cardiology, Decatur, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210152539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090603814"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210152539"],"apc_list":null,"apc_paid":null,"fwci":0.2019,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.57194958,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"3","first_page":"129","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8460000157356262},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.8659999966621399},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.972000002861023},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9620000123977661},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.8019999861717224},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.8679999709129333},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8640000224113464},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.859000027179718},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9769999980926514},{"id":"https://openalex.org/keywords/8-isoprostane","display_name":"8-isoprostane","score":0.7289999723434448},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.7900000214576721},{"id":"https://openalex.org/keywords/systemic-vascular-resistance","display_name":"systemic vascular resistance","score":0.7329999804496765},{"id":"https://openalex.org/keywords/afterload","display_name":"afterload","score":0.753000020980835},{"id":"https://openalex.org/keywords/exercise-intolerance","display_name":"exercise intolerance","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.8552179336547852},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7039943933486938},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.6977442502975464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5798476934432983},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5643866658210754},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.5328578948974609},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5202704071998596},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.505896270275116},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4841657280921936},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.43406111001968384},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.42818576097488403},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4233565330505371},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.4135393798351288},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4017540514469147},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.39778032898902893},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3460097908973694},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.22586703300476074},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1413288414478302},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13475659489631653},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1527-5299.2002.00300.x","doi":"https://doi.org/10.1111/j.1527-5299.2002.00300.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1527-5299.2002.00300.x","pdf_url":null,"source":{"id":"https://openalex.org/S26432035","display_name":"Congestive Heart Failure","issn_l":"1527-5299","issn":["1527-5299","1751-7133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Congestive Heart Failure","raw_type":"journal-article"},{"id":"pmid:12045380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12045380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Congestive heart failure (Greenwich, Conn.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1483108854","https://openalex.org/W1967682330","https://openalex.org/W1972253696","https://openalex.org/W1976555160","https://openalex.org/W1984260056","https://openalex.org/W2007439206","https://openalex.org/W2011934184","https://openalex.org/W2018010106","https://openalex.org/W2032647797","https://openalex.org/W2041285286","https://openalex.org/W2049636133","https://openalex.org/W2053987168","https://openalex.org/W2059407166","https://openalex.org/W2063478996","https://openalex.org/W2063775163","https://openalex.org/W2079757467","https://openalex.org/W2093857799","https://openalex.org/W2095878354"],"related_works":["https://openalex.org/W2041285286","https://openalex.org/W2183605994","https://openalex.org/W2063478996","https://openalex.org/W2010032368","https://openalex.org/W1996783916","https://openalex.org/W2115538102","https://openalex.org/W2093369326","https://openalex.org/W2017920431","https://openalex.org/W2130819422","https://openalex.org/W1966408926"],"abstract_inverted_index":{"Increased":[0],"peripheral":[1,458],"vascular":[2,98,117,524,554],"resistance":[3,99],"is":[4,55,90,109,133,214,224,327,505,582],"a":[5,75,92,328,350,412,461,483,559,602,632],"hallmark":[6],"of":[7,26,34,40,72,81,86,95,113,127,147,151,162,181,185,217,229,260,266,281,291,299,314,322,341,386,389,402,414,451,468,481,523,534,543,553,562,589,594,605,619,634],"advanced":[8],"chronic":[9,622],"congestive":[10],"heart":[11,103,140,201,212,241,271,292,323,342,363,403,418,469,518,544],"failure":[12,213,242,419,504,519],"(CHF).":[13],"Multiple":[14],"factors":[15],"probably":[16,91],"underlie":[17],"this":[18,376,567,628],"phenomenon,":[19],"including":[20,608],"increased":[21,29,32,56,96,247,306,408],"water":[22],"and":[23,37,61,100,116,119,160,167,175,187,200,243,251,262,288,334,337,359,379,400,436,446,457,466,471,496,526,557,574,613],"sodium":[24],"content":[25],"the":[27,41,44,79,84,110,130,143,148,158,178,190,233,237,254,258,279,319,338,396,449,478,617],"vasculature,":[28],"neurohormonal":[30],"activation,":[31],"levels":[33,298,313,336],"proinflammatory":[35],"cytokines,":[36],"intrinsic":[38],"abnormalities":[39],"vasculature.1":[42],"During":[43],"past":[45],"decade,":[46],"it":[47],"has":[48,420],"also":[49,520],"been":[50,421],"shown":[51],"that":[52,69,124,366,426,489,517,527,577],"oxidative":[53,248,282,373,393,409],"stress":[54,283,374,394,410],"in":[57,78,102,139,197,211,240,264,270,284,362,375,384,395,417,438,454,499,541,580,584,616],"both":[58,434,455],"experimental":[59],"models":[60],"humans":[62,581],"with":[63,246,296,305,318,428,440,501,621],"depressed":[64],"cardiac":[65,497,535],"function.2,":[66],"3":[67],"Given":[68],"endothelial":[70,114,137,209,218,415,432,452],"regulation":[71],"vasomotion":[73],"plays":[74],"major":[76,93,111],"role":[77,161,259,280,450],"control":[80],"systemic":[82,97],"hemodynamics,":[83],"phenomenon":[85],"abnormal,":[87],"endothelium-dependent":[88],"vasodilation":[89],"cause":[94],"afterload":[101],"failure.":[104,141,272,293,404],"Endothelium-derived":[105],"nitric":[106],"oxide":[107],"(NO)":[108],"regulator":[112],"function":[115,138,171,210,525,599],"tone,":[118],"several":[120],"studies":[121,424,515],"have":[122],"suggested":[123],"enhanced":[125],"biodegradation":[126],"NO":[128,168,220,238,263],"by":[129,309,423,511,551,586],"superoxide":[131,186,356,555],"anion":[132],"responsible":[134,206,226],"for":[135,207,227,398,407],"impaired":[136,208],"In":[142,294,344,442],"first":[144],"three":[145,275],"papers":[146,277],"current":[149,234,382],"issue":[150],"Congestive":[152],"Heart":[153,503],"Failure,":[154],"basic":[155],"data":[156,383],"regarding":[157,236],"source":[159,184],"reactive":[163],"oxygen":[164],"species":[165],"(ROS)":[166],"on":[169,597],"cardiovascular":[170],"are":[172,302],"reviewed.":[173],"Sorescu":[174],"Griendling":[176],"discuss":[177,253,278,448],"potential":[179,592],"relevance":[180],"one":[182],"important":[183],"other":[188],"ROS,":[189],"nicotinamide":[191],"adenine":[192],"dinucleotide":[193],"phosphate":[194],"(NAD[P]H)":[195],"oxidases,":[196],"ventricular":[198,494,598],"hypertrophy":[199],"failure.4":[202],"A":[203],"second":[204],"mechanism":[205,629],"reduced":[215],"expression":[216],"cell":[219],"synthase":[221],"(eNOS),":[222],"which":[223],"ultimately":[225,472],"production":[228],"NO.":[230],"Searles5":[231],"discusses":[232,477],"evidence":[235,255,406],"pathway":[239],"its":[244],"relationship":[245,352],"stress.":[249],"Choudhary":[250],"Dudley6":[252],"pointing":[256],"toward":[257],"ROS":[261,528],"modulation":[265],"myocardial":[267,512],"ion":[268],"channels":[269],"The":[273,591],"next":[274],"clinical":[276,339],"relation":[285],"to":[286,348,372,392,463,508,532,626],"diagnostic":[287],"therapeutic":[289,539],"aspects":[290],"patients":[295,439,500,620],"CHF,":[297],"malondialdehyde":[300],"(MDA)":[301],"increased,":[303],"compatible":[304],"lipid":[307,332],"peroxidation":[308],"ROS.7":[310],"Furthermore,":[311],"pericardial":[312],"8-iso-prostaglandin":[315],"F2-\u03b1":[316],"correlate":[317],"functional":[320],"severity":[321,465],"failure.8":[324],"Also,":[325],"there":[326,346],"correlation":[329],"between":[330,353],"plasma":[331],"peroxide":[333],"MDA":[335],"class":[340],"failure.9":[343],"addition,":[345],"seems":[347],"be":[349,370,509,601],"close":[351],"exercise-induced":[354],"MDA,":[355],"dismutase":[357],"activity,":[358],"exercise":[360,367],"capacity":[361],"failure,":[364,470,545],"suggesting":[365],"intolerance":[368],"may":[369,565,600],"related":[371,391],"condition.10":[377],"Alameddine":[378],"Zafari11":[380],"summarize":[381],"support":[385],"various":[387],"polymorphisms":[388],"genes":[390],"susceptibility":[397],"development":[399],"progression":[401,467],"Indirect":[405],"as":[411,460,547],"determinant":[413],"dysfunction":[416,433,453],"provided":[422],"demonstrating":[425],"treatment":[427,542,618],"vitamin":[429],"C":[430],"improved":[431],"short":[435],"long-term":[437],"CHF.12":[441],"their":[443],"review,":[444],"Sharma":[445],"Davidoff13":[447],"coronary":[456],"circulation":[459],"tool":[462],"diagnose":[464],"target":[473,604,633],"therapy.":[474],"Finally,":[475],"Book14":[476],"antioxidant":[479],"properties":[480],"carvedilol,":[482],"unique,":[484],"nonselective":[485],"\u03b2":[486,614],"blocking":[487],"agent":[488],"significantly":[490],"reduces":[491],"disease":[492],"progression,":[493],"remodeling,":[495],"mortality":[498],"CHF.":[502,623],"generally":[506],"considered":[507],"caused":[510],"dysfunction.":[513],"Numerous":[514],"suggest":[516],"involves":[521],"perturbations":[522],"most":[529],"likely":[530],"contribute":[531],"deterioration":[533],"function.":[536],"Well":[537],"established":[538],"strategies":[540,625],"such":[546],"angiotensin-converting":[548,609],"enzyme":[549,610],"inhibition,":[550],"reduction":[552],"production,":[556],"hydralazine,":[558,612],"potent":[560],"inhibitor":[561],"NADH":[563],"oxidase,":[564],"modulate":[566,627],"maladaptive":[568],"response.15,":[569],"16":[570],"Most":[571],"recently,":[572],"Mak":[573],"Newton17":[575],"found":[576],"\u03b2-adrenergic-mediated":[578],"contractility":[579],"modulated":[583],"part":[585],"basal":[587],"activity":[588],"ROS.":[590],"impact":[593],"redox":[595],"manipulation":[596],"common":[603],"proven":[606],"pharmacotherapy,":[607],"inhibitors,":[611],"blockers,":[615],"Therapeutic":[624],"should":[630],"become":[631],"future":[635],"research.":[636]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
