{"id":"https://openalex.org/W2061803112","doi":"https://doi.org/10.1074/jbc.274.20.14107","title":"Molecular Cloning and Tissue-specific Expression of a Novel Murine Laminin \u03b33 Chain","display_name":"Molecular Cloning and Tissue-specific Expression of a Novel Murine Laminin \u03b33 Chain","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W2061803112","doi":"https://doi.org/10.1074/jbc.274.20.14107","mag":"2061803112","pmid":"https://pubmed.ncbi.nlm.nih.gov/10318827"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.274.20.14107","doi":"https://doi.org/10.1074/jbc.274.20.14107","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.20.14107","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.274.20.14107","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091865898","display_name":"Antti Iivanainen","orcid":"https://orcid.org/0000-0003-1002-3225","observed_orcids":["https://orcid.org/0000-0003-1002-3225"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"Antti Iivanainen","raw_affiliation_strings":["Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S-17177 Stockholm, Sweden","Department of Basic Veterinary Sciences, Division of Anatomy, University of Helsinki, FIN-00014 Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S-17177 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Basic Veterinary Sciences, Division of Anatomy, University of Helsinki, FIN-00014 Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takako Morita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Takako Morita","raw_affiliation_strings":["Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S-17177 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S-17177 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000224317","display_name":"Karl Tryggvason","orcid":"https://orcid.org/0000-0002-0879-3290","observed_orcids":["https://orcid.org/0000-0002-0879-3290","https://orcid.org/0000-0003-1292-9266"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Karl Tryggvason","raw_affiliation_strings":["Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S-17177 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S-17177 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.7756,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.93399784,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"274","issue":"20","first_page":"14107","last_page":"14111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.7509999871253967},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.7760000228881836},{"id":"https://openalex.org/keywords/tissue-specific-expression","display_name":"tissue-specific gene expression","score":0.8809999823570251},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nidogen","display_name":"nidogen","score":0.6729999780654907},{"id":"https://openalex.org/keywords/signal-peptide","display_name":"signal peptide","score":0.7509999871253967},{"id":"https://openalex.org/keywords/leydig-cells","display_name":"Leydig cells","score":0.9559999704360962},{"id":"https://openalex.org/keywords/testis","display_name":"testis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/expressed-sequence-tags","display_name":"expressed sequence tags","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.8516902923583984},{"id":"https://openalex.org/C10858879","wikidata":"https://www.wikidata.org/wiki/Q899790","display_name":"Signal peptide","level":4,"score":0.6282697916030884},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.622998833656311},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.5949677228927612},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.5915868282318115},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5242835879325867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5232133865356445},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49025729298591614},{"id":"https://openalex.org/C121050878","wikidata":"https://www.wikidata.org/wiki/Q5135020","display_name":"Cloning (programming)","level":2,"score":0.46445298194885254},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4470410943031311},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.4377758502960205},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3755156993865967},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3591555953025818},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3143043518066406},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3107779026031494},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3102627992630005},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29189229011535645},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020224","descriptor_name":"Expressed Sequence Tags","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.274.20.14107","doi":"https://doi.org/10.1074/jbc.274.20.14107","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.20.14107","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:10318827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10318827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1074/jbc.274.20.14107","doi":"https://doi.org/10.1074/jbc.274.20.14107","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.20.14107","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W126401282","https://openalex.org/W157395064","https://openalex.org/W1496520030","https://openalex.org/W1496915816","https://openalex.org/W1509167979","https://openalex.org/W1511364800","https://openalex.org/W1554401266","https://openalex.org/W1560452279","https://openalex.org/W1567770297","https://openalex.org/W1575319966","https://openalex.org/W1597094163","https://openalex.org/W1628719417","https://openalex.org/W1659616673","https://openalex.org/W1764824114","https://openalex.org/W1832431561","https://openalex.org/W1933015809","https://openalex.org/W1951218128","https://openalex.org/W1966695696","https://openalex.org/W1973064020","https://openalex.org/W1980020840","https://openalex.org/W1982387497","https://openalex.org/W1989384629","https://openalex.org/W1989881773","https://openalex.org/W1992145299","https://openalex.org/W2001991657","https://openalex.org/W2009090056","https://openalex.org/W2020128511","https://openalex.org/W2024005915","https://openalex.org/W2024645073","https://openalex.org/W2027536585","https://openalex.org/W2027745468","https://openalex.org/W2031780222","https://openalex.org/W2037973638","https://openalex.org/W2040413836","https://openalex.org/W2041429746","https://openalex.org/W2041956242","https://openalex.org/W2048907346","https://openalex.org/W2050018598","https://openalex.org/W2053929376","https://openalex.org/W2054307558","https://openalex.org/W2055043387","https://openalex.org/W2055290772","https://openalex.org/W2057958444","https://openalex.org/W2060956856","https://openalex.org/W2066101080","https://openalex.org/W2070053893","https://openalex.org/W2071090580","https://openalex.org/W2072041699","https://openalex.org/W2075965099","https://openalex.org/W2076166690","https://openalex.org/W2085566447","https://openalex.org/W2090206479","https://openalex.org/W2091970430","https://openalex.org/W2093514870","https://openalex.org/W2104206565","https://openalex.org/W2105273730","https://openalex.org/W2111786954","https://openalex.org/W2119622097","https://openalex.org/W2126741390","https://openalex.org/W2138316626","https://openalex.org/W2138879032","https://openalex.org/W2143987989","https://openalex.org/W2144615694","https://openalex.org/W2166475130","https://openalex.org/W2167970431","https://openalex.org/W2168058510","https://openalex.org/W2184761538","https://openalex.org/W2314225431","https://openalex.org/W4255596106"],"related_works":["https://openalex.org/W2076667246","https://openalex.org/W2107564206","https://openalex.org/W7098435056","https://openalex.org/W2022356114","https://openalex.org/W2027536585","https://openalex.org/W2065130831","https://openalex.org/W1878446582","https://openalex.org/W2119622097","https://openalex.org/W7146113969","https://openalex.org/W2014201402"],"abstract_inverted_index":{"A":[0,21],"novel":[1],"laminin":[2,43,75],"gamma3":[3,66,104],"chain":[4,45,105],"was":[5],"identified":[6],"from":[7],"the":[8,15,42,48,57,74,87,103],"expressed":[9],"sequence":[10,25],"tag":[11],"data":[12],"base":[13],"at":[14],"National":[16],"Center":[17],"for":[18],"Biotechnology":[19],"Information.":[20],"complete":[22],"cDNAderived":[23],"peptide":[24],"reveals":[26],"a":[27,34],"1592-amino":[28],"acid-long":[29,37],"primary":[30],"translation":[31],"product,":[32],"including":[33],"tentative":[35],"33-amino":[36],"signal":[38],"peptide.":[39],"Comparison":[40],"with":[41],"gamma1":[44],"predicts":[46],"that":[47,65,100],"two":[49],"polypeptides":[50],"have":[51],"equal":[52],"spatial":[53],"dimensions.":[54],"In":[55],"addition,":[56],"well":[58,121],"conserved":[59],"domains":[60],"VI":[61],"and":[62,77,94,109,116],"III(LE4)":[63],"predict":[64],"containing":[67],"laminins":[68],"are":[69],"able":[70],"to":[71,73,82],"integrate":[72],"network":[76],"also":[78],"via":[79],"nidogen":[80],"connect":[81],"other":[83],"protein":[84],"networks":[85],"in":[86,95,114,123],"basement":[88],"membranes.":[89],"Combination":[90],"of":[91,102,118,127],"Northern":[92],"analysis":[93],"situ":[96],"hybridization":[97],"experiments":[98],"indicate":[99],"expression":[101],"is":[106],"highly":[107],"tissue-":[108],"cell-specific,":[110],"being":[111],"significantly":[112],"strong":[113],"capillaries":[115],"arterioles":[117],"kidney":[119],"as":[120,122],"interstitial":[124],"Leydig":[125],"cells":[126],"testis.":[128]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}