{"id":"https://openalex.org/W2061748744","doi":"https://doi.org/10.1136/adc.61.2.153","title":"Immunoregulatory treatment for minimal change nephrotic syndrome.","display_name":"Immunoregulatory treatment for minimal change nephrotic syndrome.","publication_year":1986,"publication_date":"1986-02-01","ids":{"openalex":"https://openalex.org/W2061748744","doi":"https://doi.org/10.1136/adc.61.2.153","mag":"2061748744","pmid":"https://pubmed.ncbi.nlm.nih.gov/3485404","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1777577"},"language":"en","primary_location":{"id":"doi:10.1136/adc.61.2.153","doi":"https://doi.org/10.1136/adc.61.2.153","is_oa":true,"landing_page_url":"https://doi.org/10.1136/adc.61.2.153","pdf_url":"https://adc.bmj.com/content/archdischild/61/2/153.full.pdf","source":{"id":"https://openalex.org/S207294652","display_name":"Archives of Disease in Childhood","issn_l":"0003-9888","issn":["0003-9888","1468-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Disease in Childhood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://adc.bmj.com/content/archdischild/61/2/153.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112182527","display_name":"K P Mehta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111325","display_name":"Bai Jerbai Wadia Hospital for Children","ror":"https://ror.org/02rw2zs46","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210111325"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"K P Mehta","raw_affiliation_strings":["Nephrology Division and Research Laboratory, Bai Jerbai Wadia Hospital for Children, Parel, Bombay, India","The Nephrology Division. Bai Jerbai Wadia Hospital for Children, Institute of Child Health and Research Centre, Parel, Bombay 400 012, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Division and Research Laboratory, Bai Jerbai Wadia Hospital for Children, Parel, Bombay, India","institution_ids":["https://openalex.org/I4210111325"]},{"raw_affiliation_string":"The Nephrology Division. Bai Jerbai Wadia Hospital for Children, Institute of Child Health and Research Centre, Parel, Bombay 400 012, India","institution_ids":["https://openalex.org/I4210111325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085455496","display_name":"Uma Ali","orcid":"https://orcid.org/0000-0003-1491-9950","observed_orcids":["https://orcid.org/0000-0003-1491-9950"]},"institutions":[{"id":"https://openalex.org/I4210111325","display_name":"Bai Jerbai Wadia Hospital for Children","ror":"https://ror.org/02rw2zs46","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210111325"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"U Ali","raw_affiliation_strings":["Nephrology Division and Research Laboratory, Bai Jerbai Wadia Hospital for Children, Parel, Bombay, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Division and Research Laboratory, Bai Jerbai Wadia Hospital for Children, Parel, Bombay, India","institution_ids":["https://openalex.org/I4210111325"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Kutty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111325","display_name":"Bai Jerbai Wadia Hospital for Children","ror":"https://ror.org/02rw2zs46","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210111325"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M Kutty","raw_affiliation_strings":["Nephrology Division and Research Laboratory, Bai Jerbai Wadia Hospital for Children, Parel, Bombay, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Division and Research Laboratory, Bai Jerbai Wadia Hospital for Children, Parel, Bombay, India","institution_ids":["https://openalex.org/I4210111325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032083543","display_name":"U. V. Kolhatkar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111325","display_name":"Bai Jerbai Wadia Hospital for Children","ror":"https://ror.org/02rw2zs46","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210111325"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"U Kolhatkar","raw_affiliation_strings":["Nephrology Division and Research Laboratory, Bai Jerbai Wadia Hospital for Children, Parel, Bombay, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Division and Research Laboratory, Bai Jerbai Wadia Hospital for Children, Parel, Bombay, India","institution_ids":["https://openalex.org/I4210111325"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210111325"],"apc_list":null,"apc_paid":null,"fwci":2.9855,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.90647482,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"61","issue":"2","first_page":"153","last_page":"158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/minimal-change-disease","display_name":"minimal change disease","score":0.8339999914169312},{"id":"https://openalex.org/keywords/nephrotic-syndrome","display_name":"nephrotic syndrome","score":0.9940000176429749},{"id":"https://openalex.org/keywords/levamisole","display_name":"levamisole","score":0.7760000228881836},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.824999988079071},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.906000018119812},{"id":"https://openalex.org/keywords/lymphocyte-dysfunction","display_name":"lymphocyte dysfunction","score":0.75},{"id":"https://openalex.org/keywords/dinitrochlorobenzene-skin-test","display_name":"dinitrochlorobenzene skin test","score":0.843999981880188},{"id":"https://openalex.org/keywords/serum-igg","display_name":"serum IgG","score":0.7919999957084656},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.6549999713897705},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.9599999785423279},{"id":"https://openalex.org/keywords/pediatric-nephrology","display_name":"pediatric nephrology","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9177481532096863},{"id":"https://openalex.org/C2781325985","wikidata":"https://www.wikidata.org/wiki/Q417097","display_name":"Levamisole","level":2,"score":0.8269711136817932},{"id":"https://openalex.org/C2780050583","wikidata":"https://www.wikidata.org/wiki/Q2702796","display_name":"Phytohaemagglutinin","level":3,"score":0.8068790435791016},{"id":"https://openalex.org/C3018657049","wikidata":"https://www.wikidata.org/wiki/Q1595418","display_name":"Complete remission","level":3,"score":0.6578001379966736},{"id":"https://openalex.org/C2776434150","wikidata":"https://www.wikidata.org/wiki/Q1639997","display_name":"Spontaneous remission","level":3,"score":0.6117451190948486},{"id":"https://openalex.org/C2778930706","wikidata":"https://www.wikidata.org/wiki/Q504790","display_name":"Nephrotic syndrome","level":2,"score":0.5893141031265259},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5825707912445068},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5489091873168945},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.43292760848999023},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4128866195678711},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36711227893829346},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21392223238945007},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.141382098197937},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12017020583152771},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007978","descriptor_name":"Levamisole","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007978","descriptor_name":"Levamisole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009402","descriptor_name":"Nephrosis, Lipoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009402","descriptor_name":"Nephrosis, Lipoid","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010835","descriptor_name":"Phytohemagglutinins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1136/adc.61.2.153","doi":"https://doi.org/10.1136/adc.61.2.153","is_oa":true,"landing_page_url":"https://doi.org/10.1136/adc.61.2.153","pdf_url":"https://adc.bmj.com/content/archdischild/61/2/153.full.pdf","source":{"id":"https://openalex.org/S207294652","display_name":"Archives of Disease in Childhood","issn_l":"0003-9888","issn":["0003-9888","1468-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Disease in Childhood","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1423431","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1777577","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1777577","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1777577","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arch Dis Child","raw_type":"Text"},{"id":"pmid:3485404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3485404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of disease in childhood","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.908.6928","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.908.6928","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://adc.bmj.com/content/61/2/153.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1136/adc.61.2.153","doi":"https://doi.org/10.1136/adc.61.2.153","is_oa":true,"landing_page_url":"https://doi.org/10.1136/adc.61.2.153","pdf_url":"https://adc.bmj.com/content/archdischild/61/2/153.full.pdf","source":{"id":"https://openalex.org/S207294652","display_name":"Archives of Disease in Childhood","issn_l":"0003-9888","issn":["0003-9888","1468-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Disease in Childhood","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2061748744.pdf","grobid_xml":"https://content.openalex.org/works/W2061748744.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1829622128","https://openalex.org/W1965462370","https://openalex.org/W1982349255","https://openalex.org/W2008137852","https://openalex.org/W2014786244","https://openalex.org/W2058313702","https://openalex.org/W2070755494","https://openalex.org/W2073069969","https://openalex.org/W2092182992","https://openalex.org/W2098361930","https://openalex.org/W2101875709","https://openalex.org/W2158614836","https://openalex.org/W2411532507","https://openalex.org/W2418238307","https://openalex.org/W4231203550"],"related_works":["https://openalex.org/W2981464513","https://openalex.org/W2008137852","https://openalex.org/W2411792090","https://openalex.org/W2092182992","https://openalex.org/W2065858312","https://openalex.org/W3141114429","https://openalex.org/W7097627613","https://openalex.org/W2374915476","https://openalex.org/W2411922037","https://openalex.org/W96995753"],"abstract_inverted_index":{"Immunological":[0],"studies":[1],"were":[2,76,94],"performed":[3],"in":[4,19,43,73,180],"18":[5,25,59],"children":[6,26],"with":[7,56,91,96],"minimal":[8],"change":[9],"nephrotic":[10,92],"syndrome":[11,93],"proved":[12],"by":[13,35],"biopsy":[14],"examination":[15],"during":[16],"relapse":[17],"and":[18,48,70,156,183],"15":[20],"age":[21],"matched":[22],"controls.":[23,57],"All":[24,58],"showed":[27],"dysfunction":[28],"of":[29,84,105,117,142],"cell":[30,86],"mediated":[31,87],"immunity":[32],"as":[33],"evidenced":[34],"low":[36,40,62],"absolute":[37],"lymphocyte":[38],"count,":[39],"blastogenesis":[41],"index":[42],"response":[44],"to":[45,52,136,152,178],"phytohaemagglutinin":[46],"stimulation,":[47],"reduced":[49],"skin":[50],"sensitivity":[51],"dinitrochlorobenzene":[53],"when":[54],"compared":[55],"patients":[60,90,109,122,145,166],"had":[61],"serum":[63,75],"IgG":[64],"concentrations,":[65],"while":[66,127],"the":[67,74,82,143,154,164],"IgA,":[68],"IgM,":[69],"C3":[71],"concentrations":[72],"within":[77,114],"normal":[78],"limits.":[79],"Based":[80],"on":[81],"evidence":[83],"depressed":[85],"immunity,":[88],"14":[89],"treated":[95],"an":[97],"immunoregulatory":[98],"drug":[99],"l-tetramisole":[100],"(levamisole)":[101],"for":[102],"a":[103,119],"period":[104],"20-24":[106],"weeks.":[107],"Six":[108],"went":[110,123,172],"into":[111,124,173],"complete":[112,148,174],"remission":[113],"4-20":[115],"weeks":[116],"treatment,":[118],"further":[120],"six":[121,144,161,165],"partial":[125,169,181],"remission,":[126,149,170,175,182],"two":[128,157,171,176,184],"did":[129],"not":[130],"respond.":[131],"On":[132],"follow":[133],"up":[134],"(six":[135],"24":[137],"months":[138],"after":[139,159],"stopping":[140],"levamisole),":[141],"who":[146,167],"achieved":[147,168],"four":[150],"continued":[151,177],"maintain":[153],"state":[155],"relapsed":[158],"roughly":[160],"months.":[162],"Of":[163],"be":[179],"relapsed.":[185]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
