{"id":"https://openalex.org/W2061679424","doi":"https://doi.org/10.1081/ncn-200059772","title":"ANTIVIRAL POTENTIAL OF A NEW GENERATION OF ACYCLIC NUCLEOSIDE PHOSPHONATES, THE 6-[2-(PHOSPHONOMETHOXY)ALKOXY]-2,4-DIAMINOPYRIMIDINES","display_name":"ANTIVIRAL POTENTIAL OF A NEW GENERATION OF ACYCLIC NUCLEOSIDE PHOSPHONATES, THE 6-[2-(PHOSPHONOMETHOXY)ALKOXY]-2,4-DIAMINOPYRIMIDINES","publication_year":2005,"publication_date":"2005-04-01","ids":{"openalex":"https://openalex.org/W2061679424","doi":"https://doi.org/10.1081/ncn-200059772","mag":"2061679424","pmid":"https://pubmed.ncbi.nlm.nih.gov/16247948"},"language":"en","primary_location":{"id":"doi:10.1081/ncn-200059772","doi":"https://doi.org/10.1081/ncn-200059772","is_oa":false,"landing_page_url":"https://doi.org/10.1081/ncn-200059772","pdf_url":null,"source":{"id":"https://openalex.org/S111464279","display_name":"Nucleosides Nucleotides & Nucleic Acids","issn_l":"1525-7770","issn":["1525-7770","1532-2335"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides, Nucleotides & Nucleic Acids","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040662398","display_name":"Erik De Clercq","orcid":"https://orcid.org/0000-0002-2985-8890","observed_orcids":["https://orcid.org/0000-0002-2985-8890"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Erik De Clercq","raw_affiliation_strings":["a  Rega Institute for Medical Research , Leuven,  Belgium","Rega Institute for Medical Research , Leuven , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  Rega Institute for Medical Research , Leuven,  Belgium","institution_ids":["https://openalex.org/I24156275"]},{"raw_affiliation_string":"Rega Institute for Medical Research , Leuven , Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030479730","display_name":"Graciela Andre\u00ef","orcid":"https://orcid.org/0000-0003-2609-4896","observed_orcids":["https://orcid.org/0000-0003-2609-4896"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"G. Andrei","raw_affiliation_strings":["a  Rega Institute for Medical Research , Leuven,  Belgium","Rega Institute for Medical Research , Leuven , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  Rega Institute for Medical Research , Leuven,  Belgium","institution_ids":["https://openalex.org/I24156275"]},{"raw_affiliation_string":"Rega Institute for Medical Research , Leuven , Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038319371","display_name":"Jan M. Balzarini","orcid":"https://orcid.org/0000-0003-2240-3321","observed_orcids":["https://orcid.org/0000-0003-2240-3321","https://orcid.org/0000-0003-1144-1808"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J. Balzarini","raw_affiliation_strings":["a  Rega Institute for Medical Research , Leuven,  Belgium","Rega Institute for Medical Research , Leuven , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  Rega Institute for Medical Research , Leuven,  Belgium","institution_ids":["https://openalex.org/I24156275"]},{"raw_affiliation_string":"Rega Institute for Medical Research , Leuven , Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036860979","display_name":"Pieter Leyssen","orcid":"https://orcid.org/0000-0002-7537-1688","observed_orcids":["https://orcid.org/0000-0002-7537-1688"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"P. Leyssen","raw_affiliation_strings":["a  Rega Institute for Medical Research , Leuven,  Belgium","Rega Institute for Medical Research , Leuven , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  Rega Institute for Medical Research , Leuven,  Belgium","institution_ids":["https://openalex.org/I24156275"]},{"raw_affiliation_string":"Rega Institute for Medical Research , Leuven , Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081640914","display_name":"Lieve M. J. Naesens","orcid":"https://orcid.org/0000-0001-9742-9302","observed_orcids":["https://orcid.org/0000-0001-9742-9302"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"L. Naesens","raw_affiliation_strings":["a  Rega Institute for Medical Research , Leuven,  Belgium","Rega Institute for Medical Research , Leuven , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  Rega Institute for Medical Research , Leuven,  Belgium","institution_ids":["https://openalex.org/I24156275"]},{"raw_affiliation_string":"Rega Institute for Medical Research , Leuven , Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089010495","display_name":"Johan H. Neyts","orcid":"https://orcid.org/0000-0002-0033-7514","observed_orcids":["https://orcid.org/0000-0002-0033-7514"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J. Neyts","raw_affiliation_strings":["a  Rega Institute for Medical Research , Leuven,  Belgium","Rega Institute for Medical Research , Leuven , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  Rega Institute for Medical Research , Leuven,  Belgium","institution_ids":["https://openalex.org/I24156275"]},{"raw_affiliation_string":"Rega Institute for Medical Research , Leuven , Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016741562","display_name":"Christophe C. Pannecouque","orcid":"https://orcid.org/0000-0002-1254-4473","observed_orcids":["https://orcid.org/0000-0002-1254-4473"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"C. Pannecouque","raw_affiliation_strings":["a  Rega Institute for Medical Research , Leuven,  Belgium","Rega Institute for Medical Research , Leuven , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  Rega Institute for Medical Research , Leuven,  Belgium","institution_ids":["https://openalex.org/I24156275"]},{"raw_affiliation_string":"Rega Institute for Medical Research , Leuven , Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085228034","display_name":"Robert Snoeck","orcid":"https://orcid.org/0000-0002-7586-5434","observed_orcids":["https://orcid.org/0000-0002-7586-5434"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"R. Snoeck","raw_affiliation_strings":["a  Rega Institute for Medical Research , Leuven,  Belgium","Rega Institute for Medical Research , Leuven , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  Rega Institute for Medical Research , Leuven,  Belgium","institution_ids":["https://openalex.org/I24156275"]},{"raw_affiliation_string":"Rega Institute for Medical Research , Leuven , Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111174716","display_name":"C. Ying","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"C. Ying","raw_affiliation_strings":["a  Rega Institute for Medical Research , Leuven,  Belgium","Rega Institute for Medical Research , Leuven , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  Rega Institute for Medical Research , Leuven,  Belgium","institution_ids":["https://openalex.org/I24156275"]},{"raw_affiliation_string":"Rega Institute for Medical Research , Leuven , Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072438230","display_name":"Dana Hockov\u00e1","orcid":"https://orcid.org/0000-0003-1673-8694","observed_orcids":["https://orcid.org/0000-0003-1673-8694"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210145889","display_name":"Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry","ror":"https://ror.org/04nfjn472","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"D. Hockov\u00e1","raw_affiliation_strings":["b  Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Praha 6,  Czech Republic","Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Praha 6, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b  Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Praha 6,  Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]},{"raw_affiliation_string":"Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Praha 6, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111746439","display_name":"Anton\u0131\u0301n Hol\u00fd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210145889","display_name":"Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry","ror":"https://ror.org/04nfjn472","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"A. Hol\u00fd","raw_affiliation_strings":["b  Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Praha 6,  Czech Republic","Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Praha 6, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b  Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Praha 6,  Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]},{"raw_affiliation_string":"Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Praha 6, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.4148,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.96043902,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"24","issue":"5-7","first_page":"331","last_page":"341"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.1264999955892563,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.12070000171661377,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acyclic-nucleoside-phosphonates","display_name":"acyclic nucleoside phosphonates","score":0.9810000061988831},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.8690000176429749},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hiv-2","display_name":"HIV-2","score":0.996999979019165},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cytomegalovirus","display_name":"cytomegalovirus","score":0.800000011920929},{"id":"https://openalex.org/keywords/herpesviruses","display_name":"herpesvirus","score":0.5569999814033508},{"id":"https://openalex.org/keywords/cidofovir","display_name":"cidofovir","score":0.6790000200271606},{"id":"https://openalex.org/keywords/adefovir","display_name":"adefovir","score":0.8550000190734863},{"id":"https://openalex.org/keywords/tenofovir","display_name":"tenofovir","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C2779517838","wikidata":"https://www.wikidata.org/wiki/Q353551","display_name":"Adefovir","level":5,"score":0.9571266174316406},{"id":"https://openalex.org/C2776824251","wikidata":"https://www.wikidata.org/wiki/Q423445","display_name":"Cidofovir","level":3,"score":0.9074450731277466},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7038533091545105},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.5350049734115601},{"id":"https://openalex.org/C2777333352","wikidata":"https://www.wikidata.org/wiki/Q2689559","display_name":"Nucleoside analogue","level":3,"score":0.45402106642723083},{"id":"https://openalex.org/C2777869810","wikidata":"https://www.wikidata.org/wiki/Q422631","display_name":"Lamivudine","level":4,"score":0.4157909154891968},{"id":"https://openalex.org/C2776023528","wikidata":"https://www.wikidata.org/wiki/Q178425","display_name":"Cytosine","level":3,"score":0.4157821238040924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4062998592853546},{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.4000590443611145},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3802057206630707},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.23510083556175232},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07025909423828125}],"mesh":[{"descriptor_ui":"D000077404","descriptor_name":"Cidofovir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000257","descriptor_name":"Adenoviridae Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008980","descriptor_name":"Moloney murine sarcoma virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011212","descriptor_name":"Poxviridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011213","descriptor_name":"Poxviridae Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014615","descriptor_name":"Vaccinia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014616","descriptor_name":"Vaccinia virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1081/ncn-200059772","doi":"https://doi.org/10.1081/ncn-200059772","is_oa":false,"landing_page_url":"https://doi.org/10.1081/ncn-200059772","pdf_url":null,"source":{"id":"https://openalex.org/S111464279","display_name":"Nucleosides Nucleotides & Nucleic Acids","issn_l":"1525-7770","issn":["1525-7770","1532-2335"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides, Nucleotides & Nucleic Acids","raw_type":"journal-article"},{"id":"pmid:16247948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16247948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides, nucleotides & nucleic acids","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1964346333","https://openalex.org/W1972241043","https://openalex.org/W1974599773","https://openalex.org/W1999854580","https://openalex.org/W2011006965","https://openalex.org/W2056779298","https://openalex.org/W2069498928","https://openalex.org/W2077704646","https://openalex.org/W2089091270","https://openalex.org/W2113125007","https://openalex.org/W2114677995","https://openalex.org/W2117539616","https://openalex.org/W2126903585","https://openalex.org/W2145335579","https://openalex.org/W2150423201","https://openalex.org/W2167839024","https://openalex.org/W2168652503","https://openalex.org/W2522128155"],"related_works":["https://openalex.org/W2098768441","https://openalex.org/W2114677995","https://openalex.org/W2414160161","https://openalex.org/W2168652503","https://openalex.org/W1969071360","https://openalex.org/W1996014816","https://openalex.org/W1506669191","https://openalex.org/W2316912275","https://openalex.org/W2084517039","https://openalex.org/W2167839024"],"abstract_inverted_index":{"Three":[0],"acyclic":[1],"nucleoside":[2],"phosphonates":[3],"(ANPs)":[4],"have":[5,114],"been":[6],"formally":[7],"approved":[8],"for":[9,251],"clinical":[10],"use":[11],"in":[12,19,125,225,233,243],"the":[13,24,37,51,172,252],"treatment":[14,253],"of":[15,57,64,75,120,149,192,239,254,258],"1)":[16],"cytomegalovirus":[17],"retinitis":[18],"AIDS":[20],"patients":[21],"(cidofovir,":[22],"by":[23,36,50],"intravenous":[25],"route),":[26,39],"2)":[27],"chronic":[28],"hepatitis":[29],"B":[30],"virus":[31,44,177,228],"(HBV)":[32],"infections":[33,46],"(adefovir":[34],"dipivoxil,":[35],"oral":[38,52],"and":[40,67,83,88,100,111,133,142,152,157,162,171,180,189,204,236,263],"3)":[41],"human":[42],"immunodeficiency":[43],"(HIV)":[45],"(tenofovir":[47],"disoproxil":[48],"fumarate,":[49],"route).":[53],"The":[54,246],"activity":[55,108,140,185],"spectrum":[56,74,141],"cidofovir":[58,224],"{(S)-":[59],"1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine":[60],"[(S)-HPMPC)]},":[61],"like":[62],"that":[63,144,148],"(S)-HPMPA":[65],"[(S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine)":[66],"(S)-HPMPDAP":[68],"[(S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,":[69],"6-diaminopurine),":[70],"encompasses":[71],"a":[72,117,207,255],"broad":[73,256],"DNA":[76],"viruses,":[77],"including":[78],"polyoma-,":[79],"papilloma-,":[80],"adeno-,":[81,262],"herpes-,":[82,261],"poxviruses.":[84,112],"Adefovir":[85],"{9-[2-(phosphonomethoxy)ethyl]adenine":[86],"(PMEA)}":[87],"tenofovir":[89],"[(R)-9-[2-(phosphonomethoxy)":[90],"propyl]adenine":[91],"[(R)-PMPA)]}":[92],"are":[93],"particularly":[94,165],"active":[95,166,215],"against":[96,109,167,186,216],"retroviruses":[97],"(ie.,":[98,102,201],"HIV)":[99],"hepadnaviruses":[101],"HBV);":[103],"additionally,":[104],"PMEA":[105,161],"also":[106,182,213],"shows":[107],"herpes-":[110],"We":[113],"recently":[115],"identified":[116],"new":[118],"class":[119],"ANPs,":[121],"namely":[122],"6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines,":[123],"named,":[124],"analogy":[126],"with":[127],"their":[128],"alkylpurine":[129],"counterparts,":[130],"HPMPO-DAPy,":[131],"PMEO-DAPy,":[132],"(R)-PMPO-DAPy.":[134],"These":[135],"compounds":[136],"exhibit":[137],"an":[138],"antiviral":[139],"potency":[143,209],"is":[145],"similar":[146,208],"to":[147,160,197,223],"(S)-HPMPDAP,":[150],"PMEA,":[151],"(R)-PMPA,":[153,163],"respectively.":[154],"Thus,":[155],"PMEO-DAPy":[156,179],"(R)-PMPO-DAPy,":[158],"akin":[159],"proved":[164,214,221],"HIV-":[168],"1,":[169],"HIV-2,":[170],"murine":[173],"retrovirus":[174],"Moloney":[175],"sarcoma":[176],"(MSV).":[178],"(R)-PMPO-DAPy":[181],"showed":[183],"potent":[184],"both":[187],"wild-type":[188],"lamivudine-resistant":[190],"strains":[191],"HBV.":[193],"HPMPO-DAPy":[194,212,220],"was":[195],"found":[196],"inhibit":[198],"different":[199],"poxviruses":[200],"vaccinia,":[202],"cowpox,":[203],"orf)":[205],"at":[206],"as":[210],"cidofovir.":[211],"adenoviruses.":[217],"In":[218],"vivo,":[219],"equipotent":[222],"suppressing":[226],"vaccinia":[227,241],"infection":[229],"(tail":[230],"lesion":[231],"formation)":[232],"immunocompetent":[234],"mice":[235],"promoting":[237],"healing":[238],"disseminated":[240],"lesions":[242],"athymic-nude":[244],"mice.":[245],"6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines":[247],"offer":[248],"substantial":[249],"potential":[250],"range":[257],"retro-,":[259],"hepadna-,":[260],"poxvirus":[264],"infections.":[265]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}