{"id":"https://openalex.org/W2061663786","doi":"https://doi.org/10.1002/dvdy.20011","title":"Enteric nervous system patterning in the avian hindgut","display_name":"Enteric nervous system patterning in the avian hindgut","publication_year":2004,"publication_date":"2004-02-09","ids":{"openalex":"https://openalex.org/W2061663786","doi":"https://doi.org/10.1002/dvdy.20011","mag":"2061663786","pmid":"https://pubmed.ncbi.nlm.nih.gov/14991727"},"language":"en","primary_location":{"id":"doi:10.1002/dvdy.20011","doi":"https://doi.org/10.1002/dvdy.20011","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dvdy.20011","pdf_url":null,"source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010758959","display_name":"Adele M. Doyle","orcid":"https://orcid.org/0000-0003-4204-3642","observed_orcids":["https://orcid.org/0000-0003-4204-3642"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adele M. Doyle","raw_affiliation_strings":["Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA","\u2021Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"\u2021Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027859165","display_name":"Drucilla Jane Roberts","orcid":"https://orcid.org/0000-0002-9104-6674","observed_orcids":["https://orcid.org/0000-0002-9104-6674"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Drucilla J. Roberts","raw_affiliation_strings":["Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027979899","display_name":"Allan M. Goldstein","orcid":"https://orcid.org/0000-0003-2106-847X","observed_orcids":["https://orcid.org/0000-0003-2106-847X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allan M. Goldstein","raw_affiliation_strings":["Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027979899"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":2.5263,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.89167065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"229","issue":"3","first_page":"708","last_page":"712"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enteric-nervous-system","display_name":"enteric nervous system","score":0.9819999933242798},{"id":"https://openalex.org/keywords/neural-crest-cells","display_name":"neural crest cells","score":0.8299999833106995},{"id":"https://openalex.org/keywords/myenteric-plexus","display_name":"myenteric plexus","score":0.8840000033378601},{"id":"https://openalex.org/keywords/submucosal-plexus","display_name":"submucosal plexus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cloaca","display_name":"cloaca","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hirschsprung-disease","display_name":"Hirschsprung disease","score":0.972000002861023},{"id":"https://openalex.org/keywords/intestinal-motility","display_name":"intestinal motility","score":0.5580000281333923},{"id":"https://openalex.org/keywords/avian-embryo","display_name":"avian embryo","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2776942755","wikidata":"https://www.wikidata.org/wiki/Q5766006","display_name":"Hindgut","level":4,"score":0.97124183177948},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.9038592576980591},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8913034200668335},{"id":"https://openalex.org/C2777439022","wikidata":"https://www.wikidata.org/wiki/Q586582","display_name":"Enteric nervous system","level":2,"score":0.875056266784668},{"id":"https://openalex.org/C2776907353","wikidata":"https://www.wikidata.org/wiki/Q1890233","display_name":"Myenteric plexus","level":3,"score":0.6762688159942627},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5717208385467529},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.5289136171340942},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.5119927525520325},{"id":"https://openalex.org/C138981284","wikidata":"https://www.wikidata.org/wiki/Q19035","display_name":"Cloaca","level":2,"score":0.49569976329803467},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4308394193649292},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4023343324661255},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.22342786192893982},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.12037971615791321},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11694461107254028},{"id":"https://openalex.org/C150149183","wikidata":"https://www.wikidata.org/wiki/Q1940081","display_name":"Midgut","level":3,"score":0.06164109706878662},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017615","descriptor_name":"Enteric Nervous System","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/dvdy.20011","doi":"https://doi.org/10.1002/dvdy.20011","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dvdy.20011","pdf_url":null,"source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},{"id":"pmid:14991727","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14991727","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental dynamics : an official publication of the American Association of Anatomists","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G253680483","display_name":null,"funder_award_id":"HD 39942","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G5886441598","display_name":null,"funder_award_id":"HD34448","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7029354313","display_name":"COMPARATIVE GENOMICS TO CORRECT HUMAN LUNG HYPOPLASIA","funder_award_id":"P01HD039942","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1819730896","https://openalex.org/W1985454482","https://openalex.org/W2013252621","https://openalex.org/W2024594938","https://openalex.org/W2027723326","https://openalex.org/W2038754749","https://openalex.org/W2068073686","https://openalex.org/W2075945988","https://openalex.org/W2080245014","https://openalex.org/W2087042452","https://openalex.org/W2100939730","https://openalex.org/W2111524583","https://openalex.org/W2134094991","https://openalex.org/W2140034535","https://openalex.org/W2151600206","https://openalex.org/W2181892845","https://openalex.org/W2403359512","https://openalex.org/W2983353149","https://openalex.org/W4244253403"],"related_works":["https://openalex.org/W3211907728","https://openalex.org/W1984930337","https://openalex.org/W2023718751","https://openalex.org/W4387972015","https://openalex.org/W2570429698","https://openalex.org/W2095591360","https://openalex.org/W2059237864","https://openalex.org/W1990132499","https://openalex.org/W2056969356","https://openalex.org/W164094626"],"abstract_inverted_index":{"The":[0,127],"enteric":[1],"nervous":[2,167],"system":[3,160],"(ENS)":[4],"is":[5],"principally":[6],"derived":[7],"from":[8],"vagal":[9],"and":[10,25,35,40,139],"sacral":[11],"neural":[12],"crest":[13,88],"cells":[14,28,89,108],"that":[15],"migrate":[16],"throughout":[17],"the":[18,62,76,81,84,93,111,115,165],"gastrointestinal":[19],"tract":[20],"before":[21,114],"differentiating":[22],"into":[23],"neurons":[24],"glia.":[26],"These":[27,56],"form":[29],"two":[30],"concentric":[31],"rings":[32],"of":[33,43,50,70,80,99,143,147,157,164],"ganglia":[34],"regulate":[36],"intestinal":[37,51,166],"motility,":[38],"absorption,":[39],"secretion.":[41],"Abnormalities":[42],"ENS":[44,82,151],"development":[45,69,79,152],"can":[46],"lead":[47],"to":[48,61,68,91,122,161],"disorders":[49,57],"function,":[52],"including":[53],"Hirschsprung's":[54],"disease.":[55],"are":[58],"generally":[59],"limited":[60],"distal":[63],"hindgut,":[64],"suggesting":[65],"unique":[66,131],"features":[67],"this":[71,158],"region.":[72],"This":[73],"study":[74,162],"characterized":[75,133],"normal":[77,148],"spatiotemporal":[78],"within":[83],"avian":[85,149],"hindgut.":[86],"Neural":[87],"begin":[90],"populate":[92],"hindgut":[94,150],"at":[95],"E8,":[96],"with":[97],"patterning":[98],"both":[100],"plexuses":[101],"complete":[102],"by":[103,134],"embryonic":[104],"day":[105],"9.":[106],"Crest-derived":[107],"arrive":[109],"in":[110],"submucosal":[112],"layer":[113],"myenteric":[116,137],"layer,":[117],"as":[118,120],"well":[119],"differentiate":[121],"a":[123,130,135,140],"neuronal":[124],"phenotype":[125],"first.":[126],"cloaca":[128],"demonstrates":[129],"pattern,":[132],"disorganized":[136],"plexus":[138],"flattened":[141],"nerve":[142],"Remak.":[144],"Detailed":[145],"understanding":[146],"will":[153],"allow":[154],"better":[155],"utilization":[156],"model":[159],"abnormalities":[163],"system.":[168]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}