{"id":"https://openalex.org/W2061663169","doi":"https://doi.org/10.1172/jci110374","title":"Oxidant injury of lung parenchymal cells.","display_name":"Oxidant injury of lung parenchymal cells.","publication_year":1981,"publication_date":"1981-11-01","ids":{"openalex":"https://openalex.org/W2061663169","doi":"https://doi.org/10.1172/jci110374","mag":"2061663169","pmid":"https://pubmed.ncbi.nlm.nih.gov/7298852","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/370923"},"language":"en","primary_location":{"id":"doi:10.1172/jci110374","doi":"https://doi.org/10.1172/jci110374","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci110374","pdf_url":"http://www.jci.org/articles/view/110374/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2061663169"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/110374/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107277199","display_name":"William J. Martin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W J Martin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076754561","display_name":"James E. Gadek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J E Gadek","raw_affiliation_strings":["Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090768161","display_name":"Gary W. Hunninghake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G W Hunninghake","raw_affiliation_strings":["Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110151789","display_name":"Ronald G. Crystal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R G Crystal","raw_affiliation_strings":["Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":19.0082,"has_fulltext":true,"cited_by_count":177,"citation_normalized_percentile":{"value":0.99826087,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"68","issue":"5","first_page":"1277","last_page":"1288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13639","display_name":"Paraquat toxicity studies and treatments","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13639","display_name":"Paraquat toxicity studies and treatments","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidant-injury","display_name":"oxidant injury","score":0.796999990940094},{"id":"https://openalex.org/keywords/hyperoxia","display_name":"hyperoxia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/paraquat","display_name":"paraquat","score":0.9589999914169312},{"id":"https://openalex.org/keywords/oxygen-toxicity","display_name":"oxygen toxicity","score":0.5170000195503235},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6549999713897705},{"id":"https://openalex.org/keywords/oxygen-free-radicals","display_name":"oxygen free radicals","score":0.6240000128746033},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/alpha-tocopherol","display_name":"alpha-tocopherol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/species-differences","display_name":"species differences","score":0.7799999713897705},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C2776527163","wikidata":"https://www.wikidata.org/wiki/Q409669","display_name":"Paraquat","level":2,"score":0.9498700499534607},{"id":"https://openalex.org/C2780672939","wikidata":"https://www.wikidata.org/wiki/Q5958429","display_name":"Hyperoxia","level":3,"score":0.9333198070526123},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.8150758743286133},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.7916829586029053},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4859703779220581},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43324440717697144},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40298622846603394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3736816346645355},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3362359404563904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32504355907440186},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16463014483451843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10810795426368713}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002857","descriptor_name":"Chromium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010269","descriptor_name":"Paraquat","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci110374","doi":"https://doi.org/10.1172/jci110374","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci110374","pdf_url":"http://www.jci.org/articles/view/110374/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1460444","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC370923","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:7298852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7298852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:370923","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC370923/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1172/jci110374","doi":"https://doi.org/10.1172/jci110374","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci110374","pdf_url":"http://www.jci.org/articles/view/110374/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2061663169.pdf","grobid_xml":"https://content.openalex.org/works/W2061663169.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W44020636","https://openalex.org/W1161117196","https://openalex.org/W1551094276","https://openalex.org/W1554237512","https://openalex.org/W1576614076","https://openalex.org/W1602423734","https://openalex.org/W1604239422","https://openalex.org/W1768247331","https://openalex.org/W1827324032","https://openalex.org/W1882289051","https://openalex.org/W1921304800","https://openalex.org/W1938846285","https://openalex.org/W1940436875","https://openalex.org/W1968539154","https://openalex.org/W1988641324","https://openalex.org/W1996236557","https://openalex.org/W2005062783","https://openalex.org/W2005864395","https://openalex.org/W2029162953","https://openalex.org/W2037355109","https://openalex.org/W2045287165","https://openalex.org/W2048355305","https://openalex.org/W2050034146","https://openalex.org/W2053045651","https://openalex.org/W2056168344","https://openalex.org/W2057949930","https://openalex.org/W2058388216","https://openalex.org/W2059204971","https://openalex.org/W2061470220","https://openalex.org/W2068679264","https://openalex.org/W2084628332","https://openalex.org/W2103165503","https://openalex.org/W2109131304","https://openalex.org/W2120934231","https://openalex.org/W2126370064","https://openalex.org/W2126543010","https://openalex.org/W2133148052","https://openalex.org/W2146800979","https://openalex.org/W2188088995","https://openalex.org/W2235701907","https://openalex.org/W2283137267","https://openalex.org/W2330436374","https://openalex.org/W2336448312","https://openalex.org/W2338969114","https://openalex.org/W2409600169","https://openalex.org/W2409979800","https://openalex.org/W2411973281","https://openalex.org/W2412246617","https://openalex.org/W2417056688","https://openalex.org/W2435319691","https://openalex.org/W4234925382","https://openalex.org/W4252469144","https://openalex.org/W6805623860","https://openalex.org/W6991463990"],"related_works":["https://openalex.org/W48982459","https://openalex.org/W2075619017","https://openalex.org/W2075838356","https://openalex.org/W2461800858","https://openalex.org/W1647292199","https://openalex.org/W2418329398","https://openalex.org/W1579183639","https://openalex.org/W1980287003","https://openalex.org/W2044395325","https://openalex.org/W48104545"],"abstract_inverted_index":{"Hyperoxia":[0],"and":[1,40,81,95,111,117,131,139,159,201],"paraquat":[2,41,82,140,160],"ingestion":[3],"are":[4,64],"two":[5],"clinical":[6],"examples":[7],"of":[8,38,57,71,137,166,175,196,217],"lung":[9,27,45,72,97,119,145,184,198,215],"injury":[10,76,148,200,216],"thought":[11],"to":[12,34,42,74,124,213],"be":[13],"mediated":[14],"by":[15,77,211],"oxidant":[16,130],"mechanisms.":[17],"An":[18],"in":[19,48,68,143,149,208],"vitro":[20,144,209],"cytotoxicity":[21],"assay":[22,186],"using":[23],"freshly":[24],"explanted":[25],"51Cr-labeled":[26,183],"tissue":[28],"as":[29,55,206],"the":[30,36,69,129,132,142,164,167,173,182,193],"target":[31],"was":[32],"used":[33,187],"quantify":[35],"ability":[37,123],"hyperoxia":[39,78,116,138],"directly":[43,162],"injure":[44,163],"parenchymal":[46,146],"cells":[47,59,165],"an":[49,207],"environment":[50],"where":[51],"indirect":[52],"mechanisms":[53],"such":[54],"recruitment":[56],"inflammatory":[58,178],"were":[60],"not":[61],"possible.":[62],"There":[63],"clear":[65],"species":[66,151],"differences":[67],"susceptibility":[70],"parenchyma":[73],"direct":[75,197],"(95%":[79],"O2)":[80],"(10":[83,113],"microM--10":[84],"mM)":[85],"for":[86,188,192],"18":[87],"h":[88],"at":[89],"37":[90],"degrees":[91],"C,":[92],"with":[93],"human":[94],"rat":[96],"being":[98],"more":[99],"sensitive":[100],"than":[101],"rabbit":[102],"lung.":[103],"Oxygen":[104],"radical":[105],"inhibitors,":[106],"particularly":[107],"catalase":[108],"(1,100":[109],"U/ml)":[110],"alpha-tocopherol":[112],"micrograms/ml),":[114],"reduced":[115],"paraquat-induced":[118],"injury,":[120],"although":[121],"their":[122],"do":[125],"so":[126],"depended":[127],"on":[128],"species.":[133],"The":[134],"simultaneous":[135],"use":[136],"accelerated":[141],"cell":[147,199],"each":[150],"tested.":[152],"These":[153],"studies":[154,190],"demonstrate":[155],"that":[156],"both":[157],"oxygen":[158],"can":[161],"lower":[168],"respiratory":[169],"tract":[170],"without":[171],"enlisting":[172],"aid":[174],"additional":[176],"blood-derived":[177],"cells.":[179],"In":[180],"addition,":[181],"explant":[185],"these":[189],"allows":[191],"quantitative":[194],"assessment":[195],"thus":[202],"may":[203],"prove":[204],"useful":[205],"model":[210],"which":[212],"investigate":[214],"other":[218],"etiologies.":[219]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}