{"id":"https://openalex.org/W2061648074","doi":"https://doi.org/10.1371/journal.ppat.1004401","title":"A Sialic Acid Binding Site in a Human Picornavirus","display_name":"A Sialic Acid Binding Site in a Human Picornavirus","publication_year":2014,"publication_date":"2014-10-16","ids":{"openalex":"https://openalex.org/W2061648074","doi":"https://doi.org/10.1371/journal.ppat.1004401","mag":"2061648074","pmid":"https://pubmed.ncbi.nlm.nih.gov/25329320","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4199766"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1004401","doi":"https://doi.org/10.1371/journal.ppat.1004401","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1004401","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004401&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004401&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062366531","display_name":"Georg Zocher","orcid":"https://orcid.org/0000-0001-8711-2088","observed_orcids":["https://orcid.org/0000-0001-8711-2088"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Georg Zocher","raw_affiliation_strings":["Interfaculty Institute of Biochemistry, University T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interfaculty Institute of Biochemistry, University T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040884836","display_name":"Nitesh Mistry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Nitesh Mistry","raw_affiliation_strings":["Division of Virology, Department of Clinical Microbiology, Ume\u00e5 University, Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Virology, Department of Clinical Microbiology, Ume\u00e5 University, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013580762","display_name":"Martin Frank","orcid":"https://orcid.org/0000-0002-1006-6746","observed_orcids":["https://orcid.org/0000-0002-1006-6746"]},"institutions":[{"id":"https://openalex.org/I4210129625","display_name":"Biognos (Sweden)","ror":"https://ror.org/02pap8190","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210129625"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Martin Frank","raw_affiliation_strings":["Biognos AB, G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biognos AB, G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I4210129625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017560775","display_name":"Irmgard H\u00e4hnlein-Schick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Irmgard H\u00e4hnlein-Schick","raw_affiliation_strings":["Interfaculty Institute of Biochemistry, University T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interfaculty Institute of Biochemistry, University T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001615665","display_name":"Jens\u2010Ola Ekstr\u00f6m","orcid":"https://orcid.org/0009-0005-2590-7324","observed_orcids":["https://orcid.org/0009-0005-2590-7324"]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jens-Ola Ekstr\u00f6m","raw_affiliation_strings":["Department of Molecular Biology, Ume\u00e5 University, Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Ume\u00e5 University, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006500541","display_name":"Niklas Arnberg","orcid":"https://orcid.org/0000-0002-7069-6678","observed_orcids":["https://orcid.org/0000-0002-7069-6678"]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Niklas Arnberg","raw_affiliation_strings":["Division of Virology, Department of Clinical Microbiology, Ume\u00e5 University, Ume\u00e5, Sweden; Laboratory for Molecular Infection Medicine (MIMS), Ume\u00e5 University, Ume\u00e5, Sweden","Division of Virology, Department of Clinical Microbiology, Ume\u00e5 University, Ume\u00e5, Sweden","Laboratory for Molecular Infection Medicine (MIMS), Ume\u00e5 University, Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Virology, Department of Clinical Microbiology, Ume\u00e5 University, Ume\u00e5, Sweden; Laboratory for Molecular Infection Medicine (MIMS), Ume\u00e5 University, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]},{"raw_affiliation_string":"Division of Virology, Department of Clinical Microbiology, Ume\u00e5 University, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]},{"raw_affiliation_string":"Laboratory for Molecular Infection Medicine (MIMS), Ume\u00e5 University, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029265500","display_name":"Thilo Stehle","orcid":"https://orcid.org/0000-0002-4571-8548","observed_orcids":["https://orcid.org/0000-0002-4571-8548"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Thilo Stehle","raw_affiliation_strings":["Interfaculty Institute of Biochemistry, University T\u00fcbingen, T\u00fcbingen, Germany; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America","Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America","Interfaculty Institute of Biochemistry, University T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interfaculty Institute of Biochemistry, University T\u00fcbingen, T\u00fcbingen, Germany; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I8087733"]},{"raw_affiliation_string":"Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Interfaculty Institute of Biochemistry, University T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5006500541","https://openalex.org/A5029265500"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I8087733","https://openalex.org/I90267481"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":1.5787,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.82647254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"10","first_page":"e1004401","last_page":"e1004401"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.44429999589920044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.44429999589920044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.12300000339746475,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.09960000216960907,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sialic-acid-binding-site","display_name":"sialic acid binding site","score":0.8289999961853027},{"id":"https://openalex.org/keywords/coxsackievirus-a24-variant","display_name":"coxsackievirus A24 variant","score":0.9909999966621399},{"id":"https://openalex.org/keywords/enterovirus-70","display_name":"enterovirus 70","score":1.0},{"id":"https://openalex.org/keywords/acute-hemorrhagic-conjunctivitis","display_name":"acute hemorrhagic conjunctivitis","score":0.996999979019165},{"id":"https://openalex.org/keywords/n-acetylneuraminic-acid","display_name":"N-acetylneuraminic acid","score":0.7289999723434448},{"id":"https://openalex.org/keywords/viral-capsid-structure","display_name":"viral capsid structure","score":0.7990000247955322},{"id":"https://openalex.org/keywords/antiviral-drug-design","display_name":"antiviral drug design","score":0.7170000076293945},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C2778009244","wikidata":"https://www.wikidata.org/wiki/Q936600","display_name":"Picornavirus","level":4,"score":0.8007448315620422},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.7884876132011414},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7261645793914795},{"id":"https://openalex.org/C2780115458","wikidata":"https://www.wikidata.org/wiki/Q419311","display_name":"Sialic acid","level":2,"score":0.6335511207580566},{"id":"https://openalex.org/C35693153","wikidata":"https://www.wikidata.org/wiki/Q239762","display_name":"Tropism","level":3,"score":0.6335061192512512},{"id":"https://openalex.org/C2779120600","wikidata":"https://www.wikidata.org/wiki/Q1138287","display_name":"Coxsackievirus","level":4,"score":0.5298711061477661},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4779417812824249},{"id":"https://openalex.org/C2777888124","wikidata":"https://www.wikidata.org/wiki/Q519796","display_name":"Enterovirus","level":3,"score":0.4440392255783081},{"id":"https://openalex.org/C33602714","wikidata":"https://www.wikidata.org/wiki/Q7809666","display_name":"Tissue tropism","level":4,"score":0.4392507076263428},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.42369577288627625},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.15736296772956848},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15399840474128723},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.12642565369606018},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.10412144660949707},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07961916923522949}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010849","descriptor_name":"Picornaviridae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012794","descriptor_name":"Sialic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D030015","descriptor_name":"Enterovirus C, Human","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.ppat.1004401","doi":"https://doi.org/10.1371/journal.ppat.1004401","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1004401","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004401&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3170316","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4199766","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4199766","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4199766","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:25329320","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25329320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.777.45","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.777.45","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/6d/da/ppat.1004401.PMC4199766.pdf","raw_type":"text"},{"id":"pmh:oai:DiVA.org:umu-97242","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-97242","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:4ffbb90981954f88a002bc2c1ee5ccd7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4ffbb90981954f88a002bc2c1ee5ccd7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 10, Iss 10, p e1004401 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1207357","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_A_Sialic_Acid_Binding_Site_in_a_Human_Picornavirus_/1207357","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1004401","doi":"https://doi.org/10.1371/journal.ppat.1004401","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1004401","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004401&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7547544699","display_name":"Virus receptorer: betydelse f\u00f6r tropism och behandling","funder_award_id":"F06-0011","funder_id":"https://openalex.org/F4320320940","funder_display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning"}],"funders":[{"id":"https://openalex.org/F4320313096","display_name":"Diamond Light Source","ror":"https://ror.org/05etxs293"},{"id":"https://openalex.org/F4320320940","display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning","ror":"https://ror.org/044wr7g58"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2061648074.pdf","grobid_xml":"https://content.openalex.org/works/W2061648074.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W44421630","https://openalex.org/W101137769","https://openalex.org/W255996521","https://openalex.org/W1527076274","https://openalex.org/W1680430286","https://openalex.org/W1920037911","https://openalex.org/W1954119403","https://openalex.org/W1965761289","https://openalex.org/W1972628981","https://openalex.org/W1985629904","https://openalex.org/W1992888087","https://openalex.org/W2001641653","https://openalex.org/W2008347236","https://openalex.org/W2016886041","https://openalex.org/W2017727500","https://openalex.org/W2024062560","https://openalex.org/W2024909241","https://openalex.org/W2025829142","https://openalex.org/W2027145049","https://openalex.org/W2029488079","https://openalex.org/W2029582401","https://openalex.org/W2032062137","https://openalex.org/W2033264410","https://openalex.org/W2038840577","https://openalex.org/W2047204461","https://openalex.org/W2052833346","https://openalex.org/W2056711157","https://openalex.org/W2058284656","https://openalex.org/W2060500618","https://openalex.org/W2069123478","https://openalex.org/W2069226008","https://openalex.org/W2080577447","https://openalex.org/W2083799886","https://openalex.org/W2084218406","https://openalex.org/W2090893051","https://openalex.org/W2114622716","https://openalex.org/W2115846714","https://openalex.org/W2122591011","https://openalex.org/W2123652528","https://openalex.org/W2124026197","https://openalex.org/W2125782486","https://openalex.org/W2128941244","https://openalex.org/W2149064406","https://openalex.org/W2156409843","https://openalex.org/W2158534713","https://openalex.org/W2167346118","https://openalex.org/W2180229411","https://openalex.org/W2952554548","https://openalex.org/W4248872320"],"related_works":["https://openalex.org/W7100469654","https://openalex.org/W2128941244","https://openalex.org/W2052833346","https://openalex.org/W7071936001","https://openalex.org/W2033264410","https://openalex.org/W2778474843","https://openalex.org/W7024475112","https://openalex.org/W3192828635","https://openalex.org/W2810984788","https://openalex.org/W2156078535"],"abstract_inverted_index":{"The":[0],"picornaviruses":[1],"coxsackievirus":[2],"A24":[3],"variant":[4],"(CVA24v)":[5],"and":[6,13,47,56,79,82,122,139],"enterovirus":[7],"70":[8],"(EV70)":[9],"cause":[10,39],"continued":[11],"outbreaks":[12],"pandemics":[14],"of":[15,88,98,107,135,143,179],"acute":[16,52],"hemorrhagic":[17],"conjunctivitis":[18],"(AHC),":[19],"a":[20,71,96,141],"highly":[21],"contagious":[22],"eye":[23],"disease":[24],"against":[25],"which":[26],"neither":[27],"vaccines":[28],"nor":[29],"antiviral":[30,180],"drugs":[31],"are":[32,58],"currently":[33],"available.":[34],"Moreover,":[35],"these":[36],"viruses":[37],"can":[38,150,162],"symptoms":[40],"in":[41,93,101],"the":[42,75,86,105,108,133,136,167,177],"cornea,":[43],"upper":[44],"respiratory":[45],"tract,":[46],"neurological":[48],"impairments":[49],"such":[50],"as":[51],"flaccid":[53],"paralysis.":[54],"EV70":[55],"CVA24v":[57,109,120,144],"both":[59],"known":[60],"to":[61,110,182],"use":[62],"5-N-acetylneuraminic":[63],"acid":[64],"(Neu5Ac)":[65],"for":[66,119,145,176],"cell":[67,80],"attachment,":[68],"thus":[69],"providing":[70],"putative":[72],"link":[73],"between":[74],"glycan":[76,128],"receptor":[77],"specificity":[78],"tropism":[81],"disease.":[83],"We":[84,103],"report":[85],"structures":[87],"an":[89,173],"intact":[90],"human":[91],"picornavirus":[92],"complex":[94],"with":[95,126,166],"range":[97],"glycans":[99,116,161],"terminating":[100],"Neu5Ac.":[102],"determined":[104],"structure":[106],"1.40":[111],"\u00c5":[112],"resolution,":[113],"screened":[114],"different":[115],"bearing":[117],"Neu5Ac":[118],"binding,":[121],"structurally":[123],"characterized":[124],"interactions":[125],"candidate":[127],"receptors.":[129],"Biochemical":[130],"studies":[131],"verified":[132],"relevance":[134],"binding":[137],"site":[138],"demonstrated":[140],"preference":[142,149],"\u03b12,6-linked":[146,160],"glycans.":[147],"This":[148],"be":[151],"rationalized":[152],"by":[153],"molecular":[154],"dynamics":[155],"simulations":[156],"that":[157,159],"show":[158],"establish":[163],"more":[164],"contacts":[165],"viral":[168],"capsid.":[169],"Our":[170],"results":[171],"form":[172],"excellent":[174],"platform":[175],"design":[178],"compounds":[181],"prevent":[183],"AHC.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
