{"id":"https://openalex.org/W2061428094","doi":"https://doi.org/10.1172/jci8838","title":"Bad for cats, good for humans? Modified feline immunodeficiency virus for gene therapy","display_name":"Bad for cats, good for humans? Modified feline immunodeficiency virus for gene therapy","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W2061428094","doi":"https://doi.org/10.1172/jci8838","mag":"2061428094","pmid":"https://pubmed.ncbi.nlm.nih.gov/10587510","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/409871"},"language":"en","primary_location":{"id":"doi:10.1172/jci8838","doi":"https://doi.org/10.1172/jci8838","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci8838","pdf_url":"http://www.jci.org/articles/view/8838/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/8838/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064433832","display_name":"Ronald G. Crystal","orcid":"https://orcid.org/0000-0001-6177-6839","observed_orcids":["https://orcid.org/0000-0001-6177-6839"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ronald G. Crystal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5064433832"],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":0.1663,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.50663874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"104","issue":"11","first_page":"1491","last_page":"1493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/feline-immunodeficiency-virus","display_name":"feline immunodeficiency virus","score":0.9789999723434448},{"id":"https://openalex.org/keywords/gene-therapy-vectors","display_name":"gene therapy vectors","score":0.6610000133514404},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.8949999809265137},{"id":"https://openalex.org/keywords/respiratory-epithelium","display_name":"respiratory epithelium","score":0.9449999928474426}],"concepts":[{"id":"https://openalex.org/C2777841672","wikidata":"https://www.wikidata.org/wiki/Q1129598","display_name":"Feline immunodeficiency virus","level":5,"score":0.8625930547714233},{"id":"https://openalex.org/C2779904517","wikidata":"https://www.wikidata.org/wiki/Q5008900","display_name":"CATS","level":2,"score":0.7779743671417236},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.7107669115066528},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6813400983810425},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5098854303359985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46009084582328796},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.43102186918258667},{"id":"https://openalex.org/C2779468541","wikidata":"https://www.wikidata.org/wiki/Q1334408","display_name":"Severe combined immunodeficiency","level":3,"score":0.41197025775909424},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40928328037261963},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3671991527080536},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3419749140739441},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23508664965629578},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.17407643795013428},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13279509544372559}],"mesh":[{"descriptor_ui":"D000229","descriptor_name":"Dependovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014721","descriptor_name":"Vesicular stomatitis Indiana virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016089","descriptor_name":"Immunodeficiency Virus, Feline","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci8838","doi":"https://doi.org/10.1172/jci8838","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci8838","pdf_url":"http://www.jci.org/articles/view/8838/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:409871","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/409871","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:10587510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10587510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Comment"}],"best_oa_location":{"id":"doi:10.1172/jci8838","doi":"https://doi.org/10.1172/jci8838","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci8838","pdf_url":"http://www.jci.org/articles/view/8838/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2061428094.pdf","grobid_xml":"https://content.openalex.org/works/W2061428094.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1967670116","https://openalex.org/W1968469725","https://openalex.org/W1970638821","https://openalex.org/W2009286981","https://openalex.org/W2015617337","https://openalex.org/W2017558860","https://openalex.org/W2026699829","https://openalex.org/W2030220702","https://openalex.org/W2048303863","https://openalex.org/W2060216304","https://openalex.org/W2075350162","https://openalex.org/W2079791074","https://openalex.org/W2090781939","https://openalex.org/W2096576290","https://openalex.org/W2100749737","https://openalex.org/W2106378095","https://openalex.org/W2130263296","https://openalex.org/W2136487808","https://openalex.org/W2151534641","https://openalex.org/W2157646788","https://openalex.org/W2197456826","https://openalex.org/W2261997701","https://openalex.org/W2313269464","https://openalex.org/W2408908640"],"related_works":["https://openalex.org/W1967670116","https://openalex.org/W2288247376","https://openalex.org/W2351282381","https://openalex.org/W2096576290","https://openalex.org/W2070917665","https://openalex.org/W2127279142","https://openalex.org/W2422214611","https://openalex.org/W2415265289","https://openalex.org/W2410817613","https://openalex.org/W2007581277"],"abstract_inverted_index":{"When":[0],"the":[1,9,12,17,26,53,57,60,81,88,97,107,120,128],"concepts":[2],"of":[3,29,49,52,80,90,119,131],"gene":[4,30,55,124],"therapy":[5,125],"were":[6],"evolving":[7],"in":[8,32,122],"late":[10],"1980s,":[11],"focus":[13],"was":[14,21],"primarily":[15],"on":[16],"hereditary":[18,35],"disorders.":[19],"This":[20,62,110],"a":[22,74,113],"logical":[23],"choice":[24],"for":[25],"budding":[27],"community":[28],"therapists,":[31],"that":[33,42],"most":[34],"disorders":[36],"are":[37],"autosomal":[38],"recessive":[39],"deficiency":[40],"diseases":[41],"can":[43],"theoretically":[44],"be":[45,65],"corrected":[46],"by":[47],"transfer":[48,96],"sufficient":[50],"amounts":[51],"normal":[54],"to":[56,95,106,116,126],"cells":[58],"manifesting":[59],"disease.":[61],"concept":[63],"may":[64],"logical,":[66],"but":[67],"putting":[68],"it":[69],"into":[70],"practice":[71],"has":[72],"been":[73],"real":[75],"challenge.":[76],"In":[77],"this":[78],"issue":[79],"JCI,":[82],"Wang":[83],"et":[84],"al.":[85],"(1)":[86],"describe":[87],"adaptation":[89],"feline":[91],"immunodeficiency":[92],"virus":[93],"(FIV)":[94],"cystic":[98],"fibrosis":[99],"(CF)":[100],"transmembrane":[101],"conductance":[102],"regulator":[103],"(CFTR)":[104],"cDNA":[105],"respiratory":[108,129],"epithelium.":[109],"strategy":[111],"represents":[112],"new":[114],"approach":[115],"overcoming":[117],"some":[118],"challenges":[121],"using":[123],"correct":[127],"manifestations":[130],"CF.":[132]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}