{"id":"https://openalex.org/W2061410173","doi":"https://doi.org/10.1152/ajpendo.90784.2008","title":"Role of caveolin-1 in thyroid phenotype, cell homeostasis, and hormone synthesis: in vivo study of caveolin-1 knockout mice","display_name":"Role of caveolin-1 in thyroid phenotype, cell homeostasis, and hormone synthesis: in vivo study of caveolin-1 knockout mice","publication_year":2009,"publication_date":"2009-05-13","ids":{"openalex":"https://openalex.org/W2061410173","doi":"https://doi.org/10.1152/ajpendo.90784.2008","mag":"2061410173","pmid":"https://pubmed.ncbi.nlm.nih.gov/19435853"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.90784.2008","doi":"https://doi.org/10.1152/ajpendo.90784.2008","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.90784.2008","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2061410173"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014315617","display_name":"Maximin S\u00e8nou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Maximin Senou","raw_affiliation_strings":["Unit\u00e9 de Morphologie Exp\u00e9rimentale, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Morphologie Exp\u00e9rimentale, Universit\u00e9 Catholique de Louvain, Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075511988","display_name":"Maria Jos\u00e9 de Carvalho Costa","orcid":"https://orcid.org/0000-0001-6111-7614","observed_orcids":["https://orcid.org/0000-0001-6111-7614"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Maria Jos\u00e9 Costa","raw_affiliation_strings":["","Institut de Recherche Interdisciplinaire, Universite \u00b4Libre de Bruxelles, Brussels, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Institut de Recherche Interdisciplinaire, Universite \u00b4Libre de Bruxelles, Brussels, Belgium;","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011882678","display_name":"Claude Massart","orcid":"https://orcid.org/0000-0002-2680-6788","observed_orcids":["https://orcid.org/0000-0002-2680-6788"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Claude Massart","raw_affiliation_strings":["","Institut de Recherche Interdisciplinaire, Universite \u00b4Libre de Bruxelles, Brussels, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Institut de Recherche Interdisciplinaire, Universite \u00b4Libre de Bruxelles, Brussels, Belgium;","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037776758","display_name":"Matthieu Thimmesch","orcid":"https://orcid.org/0000-0001-6058-3373","observed_orcids":["https://orcid.org/0000-0001-6058-3373"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthieu Thimmesch","raw_affiliation_strings":["","Unite \u00b4de Morphologie Expe \u00b4rimentale,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Unite \u00b4de Morphologie Expe \u00b4rimentale,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070116866","display_name":"C\u00e9line Khalifa","orcid":"https://orcid.org/0000-0003-1431-7183","observed_orcids":["https://orcid.org/0000-0003-1431-7183"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C\u00e9line Khalifa","raw_affiliation_strings":["","Unite \u00b4de Morphologie Expe \u00b4rimentale,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Unite \u00b4de Morphologie Expe \u00b4rimentale,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080581483","display_name":"Sylvie Poncin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sylvie Poncin","raw_affiliation_strings":["","Unite \u00b4de Morphologie Expe \u00b4rimentale,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Unite \u00b4de Morphologie Expe \u00b4rimentale,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020631237","display_name":"Marie Boucquey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie Boucquey","raw_affiliation_strings":["","Unite \u00b4de Morphologie Expe \u00b4rimentale,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Unite \u00b4de Morphologie Expe \u00b4rimentale,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074857565","display_name":"Anne-Catherine G\u00e9rard","orcid":"https://orcid.org/0000-0003-2332-5628","observed_orcids":["https://orcid.org/0000-0003-2332-5628"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne-Catherine G\u00e9rard","raw_affiliation_strings":["","Unite \u00b4de Morphologie Expe \u00b4rimentale,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Unite \u00b4de Morphologie Expe \u00b4rimentale,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090263529","display_name":"Jean\u2010Nicolas Audinot","orcid":"https://orcid.org/0000-0002-4966-7653","observed_orcids":["https://orcid.org/0000-0002-4966-7653"]},"institutions":[{"id":"https://openalex.org/I4405265313","display_name":"Centre de recherche public Gabriel-Lippmann","ror":"https://ror.org/04f391x22","country_code":"LU","type":"nonprofit","lineage":["https://openalex.org/I4405265313"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Jean-Nicolas Audinot","raw_affiliation_strings":["","Laboratoire d'Analyse des Mate \u00b4riaux, Centre de Recherche Public Gabriel Lippmann, Luxembourg; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Laboratoire d'Analyse des Mate \u00b4riaux, Centre de Recherche Public Gabriel Lippmann, Luxembourg; and","institution_ids":["https://openalex.org/I4405265313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051191638","display_name":"Chantal Dessy","orcid":"https://orcid.org/0000-0002-9386-0442","observed_orcids":["https://orcid.org/0000-0002-9386-0442"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chantal Dessy","raw_affiliation_strings":["","Unite \u00b4de Pharmacothe \u00b4rapie,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Unite \u00b4de Pharmacothe \u00b4rapie,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066413368","display_name":"Jean Ruf","orcid":"https://orcid.org/0000-0003-4300-8048","observed_orcids":["https://orcid.org/0000-0003-4300-8048"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean Ruf","raw_affiliation_strings":["","Universite \u00b4de la Me \u00b4diterrane \u00b4e, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Universite \u00b4de la Me \u00b4diterrane \u00b4e, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059376263","display_name":"Olivier F\u00e9ron","orcid":"https://orcid.org/0000-0001-5360-0286","observed_orcids":["https://orcid.org/0000-0001-5360-0286"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olivier Feron","raw_affiliation_strings":["","Unite \u00b4de Pharmacothe \u00b4rapie,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Unite \u00b4de Pharmacothe \u00b4rapie,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033792420","display_name":"Olivier Devuyst","orcid":"https://orcid.org/0000-0003-3744-4767","observed_orcids":["https://orcid.org/0000-0003-3744-4767"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olivier Devuyst","raw_affiliation_strings":["","Unite \u00b4de Ne \u00b4phrologie,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Unite \u00b4de Ne \u00b4phrologie,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029138905","display_name":"Yves Guiot","orcid":"https://orcid.org/0000-0003-4120-0204","observed_orcids":["https://orcid.org/0000-0003-4120-0204"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Yves Guiot","raw_affiliation_strings":["","De \u00b4partement de Pathologie, Universite \u00b4Catholique de Louvain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"De \u00b4partement de Pathologie, Universite \u00b4Catholique de Louvain;","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112251348","display_name":"Jacques E. Dumont","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jacques Emile Dumont","raw_affiliation_strings":["","Institut de Recherche Interdisciplinaire, Universite \u00b4Libre de Bruxelles, Brussels, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Institut de Recherche Interdisciplinaire, Universite \u00b4Libre de Bruxelles, Brussels, Belgium;","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108523995","display_name":"Jacqueline VAN SANDE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jacqueline Van Sande","raw_affiliation_strings":["","Institut de Recherche Interdisciplinaire, Universite \u00b4Libre de Bruxelles, Brussels, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Institut de Recherche Interdisciplinaire, Universite \u00b4Libre de Bruxelles, Brussels, Belgium;","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108532962","display_name":"Marie\u2010Christine Many","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie-Christine Many","raw_affiliation_strings":["","Unite \u00b4de Morphologie Expe \u00b4rimentale,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Unite \u00b4de Morphologie Expe \u00b4rimentale,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7869,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.65247461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"297","issue":"2","first_page":"E438","last_page":"E451"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.6068999767303467,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.6068999767303467,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.33180001378059387,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":1.0},{"id":"https://openalex.org/keywords/thyroid","display_name":"thyroid gland","score":0.7549999952316284},{"id":"https://openalex.org/keywords/caveolin-1-knockout-mice","display_name":"caveolin-1 knockout mice","score":0.8849999904632568},{"id":"https://openalex.org/keywords/thyroid-hormone-synthesis","display_name":"thyroid hormone synthesis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/thyroglobulin","display_name":"thyroglobulin","score":0.7940000295639038},{"id":"https://openalex.org/keywords/iodide-organification","display_name":"iodide organification","score":0.9660000205039978},{"id":"https://openalex.org/keywords/thyroid-peroxidase","display_name":"thyroid peroxidase","score":0.902999997138977},{"id":"https://openalex.org/keywords/dual-oxidase","display_name":"dual oxidase","score":0.828000009059906},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8230000138282776},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/iodide-uptake","display_name":"iodide uptake","score":0.7250000238418579},{"id":"https://openalex.org/keywords/goiter","display_name":"goiter","score":0.7850000262260437},{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":0.9129999876022339},{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tsh-regulation","display_name":"TSH regulation","score":0.5809999704360962},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C2778835679","wikidata":"https://www.wikidata.org/wiki/Q412228","display_name":"Thyroglobulin","level":3,"score":0.7843740582466125},{"id":"https://openalex.org/C2779123554","wikidata":"https://www.wikidata.org/wiki/Q7101880","display_name":"Organification","level":3,"score":0.704670250415802},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6477440595626831},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6474149227142334},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6229950189590454},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4747781455516815},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.4608213007450104},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4252912402153015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3613629937171936},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3557620048522949},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12000134587287903},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10667186975479126}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051242","descriptor_name":"Caveolin 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051242","descriptor_name":"Caveolin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051242","descriptor_name":"Caveolin 1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054879","descriptor_name":"Halogenation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajpendo.90784.2008","doi":"https://doi.org/10.1152/ajpendo.90784.2008","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.90784.2008","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmid:19435853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19435853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Endocrinology and metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:dial.uclouvain.be:boreal:22417","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2078.1/22417","pdf_url":null,"source":{"id":"https://openalex.org/S4306401902","display_name":"Digital Access to Libraries (Universit\u00e9 catholique de Louvain (UCL), l'Universit\u00e9 de Namur (UNamur) and the Universit\u00e9 Saint-Louis (USL-B))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I95674353","host_organization_name":"UCLouvain","host_organization_lineage":["https://openalex.org/I95674353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Physiology: Endocrinology and Metabolism, Vol. 297, no. 2, p. E438-451 (2009)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/53082","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/53082","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American journal of physiology: endocrinology and metabolism, 297 (2","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321008","display_name":"Universiteit van Amsterdam","ror":"https://ror.org/04dkp9463"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W140941701","https://openalex.org/W1643087207","https://openalex.org/W1969030806","https://openalex.org/W1971920681","https://openalex.org/W1972286690","https://openalex.org/W1974586979","https://openalex.org/W1985216167","https://openalex.org/W1987441461","https://openalex.org/W1987799567","https://openalex.org/W1990973489","https://openalex.org/W1993484902","https://openalex.org/W2000917584","https://openalex.org/W2005472789","https://openalex.org/W2007470455","https://openalex.org/W2011845988","https://openalex.org/W2013041347","https://openalex.org/W2013592035","https://openalex.org/W2016109584","https://openalex.org/W2019259772","https://openalex.org/W2025950997","https://openalex.org/W2034979282","https://openalex.org/W2036438041","https://openalex.org/W2038884679","https://openalex.org/W2039452667","https://openalex.org/W2040123627","https://openalex.org/W2040548499","https://openalex.org/W2052870974","https://openalex.org/W2059230652","https://openalex.org/W2060481671","https://openalex.org/W2060593058","https://openalex.org/W2066915426","https://openalex.org/W2068800887","https://openalex.org/W2069444054","https://openalex.org/W2072010512","https://openalex.org/W2074267073","https://openalex.org/W2075584603","https://openalex.org/W2075796682","https://openalex.org/W2078510550","https://openalex.org/W2080106089","https://openalex.org/W2084723599","https://openalex.org/W2096797584","https://openalex.org/W2101235425","https://openalex.org/W2101692904","https://openalex.org/W2102194654","https://openalex.org/W2104139918","https://openalex.org/W2108588969","https://openalex.org/W2111833940","https://openalex.org/W2113940512","https://openalex.org/W2115239727","https://openalex.org/W2118160936","https://openalex.org/W2118994238","https://openalex.org/W2121936687","https://openalex.org/W2125380410","https://openalex.org/W2133982632","https://openalex.org/W2140366931","https://openalex.org/W2141156292","https://openalex.org/W2142640185","https://openalex.org/W2148102136","https://openalex.org/W2155083127","https://openalex.org/W2156605591","https://openalex.org/W2158905604","https://openalex.org/W2161484620","https://openalex.org/W2419676871","https://openalex.org/W4249025211"],"related_works":["https://openalex.org/W1700555745","https://openalex.org/W1972286690","https://openalex.org/W7064579510","https://openalex.org/W4294591789","https://openalex.org/W2160479442","https://openalex.org/W4415190376","https://openalex.org/W2805053653","https://openalex.org/W7213542085","https://openalex.org/W2034979282","https://openalex.org/W3158838522"],"abstract_inverted_index":{"In":[0],"human":[1,238,254],"thyroid,":[2],"caveolin-1":[3,35,166,188,194,221,233,245],"is":[4],"localized":[5],"at":[6,89],"the":[7,58,67,74,78,90,102,106,115,118,141,146,156,181,214,223,227,253],"apex":[8],"of":[9,29,45,60,66,105,121,134,148,158,220,232],"thyrocytes,":[10],"but":[11],"its":[12,123],"role":[13,197],"there":[14],"remains":[15],"unknown.":[16],"Using":[17],"immunohistochemistry,":[18],"(127)I":[19],"imaging,":[20],"transmission":[21],"electron":[22,25],"microscopy,":[23,26],"immunogold":[24],"and":[27,50,62,70,81,125,151,178,229,239],"quantification":[28],"H(2)O(2),":[30],"we":[31],"found":[32],"that":[33,77,193],"in":[34,64,73,114,165,187,198,206,222,244],"knockout":[36,167,189,246],"mice":[37,247],"thyroid":[38,107,128,200,224],"cell":[39,48,207],"homeostasis":[40],"was":[41,57,184],"disrupted,":[42],"with":[43],"evidence":[44],"oxidative":[46],"stress,":[47],"damage,":[49],"apoptosis.":[51],"An":[52],"even":[53],"more":[54,185],"striking":[55],"phenotype":[56],"absence":[59],"thyroglobulin":[61,84],"iodine":[63],"one-half":[65],"follicular":[68],"lumina":[69],"their":[71],"presence":[72],"cytosol,":[75],"suggesting":[76,137],"iodide":[79],"organification":[80],"binding":[82],"to":[83,101,132,252],"were":[85,130,153,173,234],"intracellular":[86],"rather":[87],"than":[88],"apical":[91],"membrane/extracellular":[92],"colloid":[93],"interface.":[94],"The":[95],"latter":[96],"abnormality":[97],"may":[98,248],"be":[99],"secondary":[100],"observed":[103],"mislocalization":[104],"hormone":[108,201],"synthesis":[109,202],"machinery":[110],"(dual":[111],"oxidases,":[112],"thyroperoxidase)":[113],"cytosol.":[116],"Nevertheless,":[117],"overall":[119],"uptake":[120],"radioiodide,":[122],"organification,":[124],"secretion":[126],"as":[127,203,205],"hormones":[129],"comparable":[131],"those":[133],"wild-type":[135],"mice,":[136],"adequate":[138],"compensation":[139],"by":[140],"normal":[142,237],"TSH":[143,152,171],"retrocontrol.":[144],"Accordingly,":[145],"levels":[147,157,172],"free":[149,159],"thyroxine":[150],"normal.":[154],"Only":[155],"triiodothyronine":[160],"showed":[161],"a":[162,196,217],"slight":[163],"decrease":[164],"mice.":[168,190],"However,":[169],"when":[170],"increased":[174],"through":[175],"low-iodine":[176],"chow":[177],"sodium":[179],"perchlorate,":[180],"induced":[182],"goiter":[183],"prominent":[186],"We":[191],"conclude":[192],"plays":[195],"proper":[199],"well":[204],"number":[208],"homeostasis.":[209],"Our":[210],"study":[211],"demonstrates":[212],"for":[213],"first":[215],"time":[216],"physiological":[218],"function":[219],"gland.":[225],"Because":[226],"expression":[228],"subcellular":[230],"localization":[231],"similar":[235],"between":[236],"murine":[240],"thyroids,":[241],"our":[242],"findings":[243],"have":[249],"direct":[250],"relevance":[251],"counterpart.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}