{"id":"https://openalex.org/W2061128951","doi":"https://doi.org/10.1245/s10434-012-2259-9","title":"Ex Vivo Evaluation of Preoperatively Treated Rectal Cancer Specimens of Patients Undergoing Radical Resection","display_name":"Ex Vivo Evaluation of Preoperatively Treated Rectal Cancer Specimens of Patients Undergoing Radical Resection","publication_year":2012,"publication_date":"2012-02-13","ids":{"openalex":"https://openalex.org/W2061128951","doi":"https://doi.org/10.1245/s10434-012-2259-9","mag":"2061128951","pmid":"https://pubmed.ncbi.nlm.nih.gov/22350598"},"language":"en","primary_location":{"id":"doi:10.1245/s10434-012-2259-9","doi":"https://doi.org/10.1245/s10434-012-2259-9","is_oa":false,"landing_page_url":"https://doi.org/10.1245/s10434-012-2259-9","pdf_url":null,"source":{"id":"https://openalex.org/S177486402","display_name":"Annals of Surgical Oncology","issn_l":"1068-9265","issn":["1068-9265","1534-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Surgical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064573365","display_name":"Sebasti\u00e1n G. de la Fuente","orcid":"https://orcid.org/0000-0002-9508-4168","observed_orcids":["https://orcid.org/0000-0002-9508-4168"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sebastian G. de la Fuente","raw_affiliation_strings":["Department of Surgery, H. Lee Moffitt Cancer Center, Tampa, FL, USA. sebastian.delafuente@moffitt.org","H. Lee Moffitt Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, H. Lee Moffitt Cancer Center, Tampa, FL, USA. sebastian.delafuente@moffitt.org","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"H. Lee Moffitt Cancer Center","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kirk A. Ludwig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirk A. Ludwig","raw_affiliation_strings":["Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA","Medical College of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015827608","display_name":"Douglas S. Tyler","orcid":"https://orcid.org/0000-0002-7434-846X","observed_orcids":["https://orcid.org/0000-0002-7434-846X"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas S. Tyler","raw_affiliation_strings":["Department of Surgery, Duke University Medical Center, Durham, NC, USA","Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke University Medical Center, Durham, NC, USA","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037064887","display_name":"Christopher R. Mantyh","orcid":"https://orcid.org/0000-0003-0361-7252","observed_orcids":["https://orcid.org/0000-0003-0361-7252"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher R. Mantyh","raw_affiliation_strings":["Department of Surgery, Duke University Medical Center, Durham, NC, USA","Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke University Medical Center, Durham, NC, USA","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5064573365"],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.1657,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.56243117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"19","issue":"6","first_page":"1954","last_page":"1958"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rectal-cancer","display_name":"rectal cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neoadjuvant-chemoradiotherapy","display_name":"neoadjuvant chemoradiotherapy","score":0.8930000066757202},{"id":"https://openalex.org/keywords/radical-resection","display_name":"radical resection","score":0.699999988079071},{"id":"https://openalex.org/keywords/total-mesorectal-excision","display_name":"total mesorectal excision","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tumor-downstaging","display_name":"tumor downstaging","score":0.7369999885559082},{"id":"https://openalex.org/keywords/lymph-node-status","display_name":"lymph node status","score":0.7059999704360962},{"id":"https://openalex.org/keywords/stage-ii-rectal-cancer","display_name":"stage II rectal cancer","score":0.7730000019073486},{"id":"https://openalex.org/keywords/stage-iii-rectal-cancer","display_name":"stage III rectal cancer","score":0.9679999947547913},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.5199999809265137},{"id":"https://openalex.org/keywords/surgical-margins","display_name":"surgical margins","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9142275452613831},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.8624429702758789},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.7138794660568237},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5958207845687866},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.5441277623176575},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.452304869890213},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.4403912425041199},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4395962953567505},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3492197096347809},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.299815833568573},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26991403102874756},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011300","descriptor_name":"Preoperative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1245/s10434-012-2259-9","doi":"https://doi.org/10.1245/s10434-012-2259-9","is_oa":false,"landing_page_url":"https://doi.org/10.1245/s10434-012-2259-9","pdf_url":null,"source":{"id":"https://openalex.org/S177486402","display_name":"Annals of Surgical Oncology","issn_l":"1068-9265","issn":["1068-9265","1534-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Surgical Oncology","raw_type":"journal-article"},{"id":"pmid:22350598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22350598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of surgical oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W48622785","https://openalex.org/W1973101195","https://openalex.org/W1975783562","https://openalex.org/W1976874797","https://openalex.org/W1985914447","https://openalex.org/W1992625388","https://openalex.org/W1997537972","https://openalex.org/W2003706429","https://openalex.org/W2005937579","https://openalex.org/W2008141117","https://openalex.org/W2012946790","https://openalex.org/W2014355159","https://openalex.org/W2017634829","https://openalex.org/W2032043324","https://openalex.org/W2044852602","https://openalex.org/W2047443904","https://openalex.org/W2052724907","https://openalex.org/W2102583333","https://openalex.org/W2120388938","https://openalex.org/W2127699440","https://openalex.org/W2131491002","https://openalex.org/W2136443415","https://openalex.org/W2137332632","https://openalex.org/W2138576565","https://openalex.org/W2159919969","https://openalex.org/W2165022003","https://openalex.org/W2210160876"],"related_works":["https://openalex.org/W2112493073","https://openalex.org/W2124732991","https://openalex.org/W2009417706","https://openalex.org/W2011583022","https://openalex.org/W1974493669","https://openalex.org/W1495429271","https://openalex.org/W7053553747","https://openalex.org/W2077086851","https://openalex.org/W1865989257","https://openalex.org/W1979642977"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}