{"id":"https://openalex.org/W2061106944","doi":"https://doi.org/10.1021/bc950093n","title":"Hypersensitization of Multidrug Resistant Human Ovarian Carcinoma Cells by Pluronic P85 Block Copolymer","display_name":"Hypersensitization of Multidrug Resistant Human Ovarian Carcinoma Cells by Pluronic P85 Block Copolymer","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2061106944","doi":"https://doi.org/10.1021/bc950093n","mag":"2061106944","pmid":"https://pubmed.ncbi.nlm.nih.gov/8983343"},"language":"en","primary_location":{"id":"doi:10.1021/bc950093n","doi":"https://doi.org/10.1021/bc950093n","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc950093n","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110388972","display_name":"Valery Yu. Alakhov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100220","display_name":"Russian Research Center for Molecular Diagnostics and Therapy","ror":"https://ror.org/0138w4412","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210100220"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Valery Yu. Alakhov","raw_affiliation_strings":["Moscow Institute of Biotechnology, Inc., and Russian Research Center of Molecular Diagnostics and Therapy, Simpheropolskii Boulevard 8, Moscow 113149, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moscow Institute of Biotechnology, Inc., and Russian Research Center of Molecular Diagnostics and Therapy, Simpheropolskii Boulevard 8, Moscow 113149, Russia","institution_ids":["https://openalex.org/I4210100220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105504731","display_name":"E. Yu. Moskaleva","orcid":"https://orcid.org/0000-0001-9942-4476","observed_orcids":["https://orcid.org/0000-0001-9942-4476"]},"institutions":[{"id":"https://openalex.org/I4210100220","display_name":"Russian Research Center for Molecular Diagnostics and Therapy","ror":"https://ror.org/0138w4412","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210100220"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elizaveta Yu. Moskaleva","raw_affiliation_strings":["Moscow Institute of Biotechnology, Inc., and Russian Research Center of Molecular Diagnostics and Therapy, Simpheropolskii Boulevard 8, Moscow 113149, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moscow Institute of Biotechnology, Inc., and Russian Research Center of Molecular Diagnostics and Therapy, Simpheropolskii Boulevard 8, Moscow 113149, Russia","institution_ids":["https://openalex.org/I4210100220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006955096","display_name":"Elena V. Batrakova","orcid":"https://orcid.org/0000-0002-9386-3790","observed_orcids":["https://orcid.org/0000-0002-9386-3790"]},"institutions":[{"id":"https://openalex.org/I4210100220","display_name":"Russian Research Center for Molecular Diagnostics and Therapy","ror":"https://ror.org/0138w4412","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210100220"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elena V. Batrakova","raw_affiliation_strings":["Moscow Institute of Biotechnology, Inc., and Russian Research Center of Molecular Diagnostics and Therapy, Simpheropolskii Boulevard 8, Moscow 113149, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moscow Institute of Biotechnology, Inc., and Russian Research Center of Molecular Diagnostics and Therapy, Simpheropolskii Boulevard 8, Moscow 113149, Russia","institution_ids":["https://openalex.org/I4210100220"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060362637","display_name":"Alexander V. Kabanov","orcid":"https://orcid.org/0000-0002-3665-946X","observed_orcids":["https://orcid.org/0000-0002-3665-946X"]},"institutions":[{"id":"https://openalex.org/I4210100220","display_name":"Russian Research Center for Molecular Diagnostics and Therapy","ror":"https://ror.org/0138w4412","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210100220"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander V. Kabanov","raw_affiliation_strings":["Moscow Institute of Biotechnology, Inc., and Russian Research Center of Molecular Diagnostics and Therapy, Simpheropolskii Boulevard 8, Moscow 113149, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moscow Institute of Biotechnology, Inc., and Russian Research Center of Molecular Diagnostics and Therapy, Simpheropolskii Boulevard 8, Moscow 113149, Russia","institution_ids":["https://openalex.org/I4210100220"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210100220"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.0917,"has_fulltext":false,"cited_by_count":304,"citation_normalized_percentile":{"value":0.92299459,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"7","issue":"2","first_page":"209","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pluronic-p85","display_name":"Pluronic P85","score":0.9900000095367432},{"id":"https://openalex.org/keywords/block-copolymers","display_name":"block copolymers","score":0.875},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9259999990463257},{"id":"https://openalex.org/keywords/ovarian-carcinoma","display_name":"ovarian carcinoma","score":0.949999988079071},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.9229999780654907},{"id":"https://openalex.org/keywords/daunorubicin","display_name":"daunorubicin","score":0.8989999890327454},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9200000166893005},{"id":"https://openalex.org/keywords/drug-efflux-inhibition","display_name":"drug efflux inhibition","score":0.6110000014305115},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.6340000033378601},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.8460000157356262},{"id":"https://openalex.org/keywords/skov-3-cells","display_name":"SKOV3 cells","score":0.7160000205039978},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C2781021840","wikidata":"https://www.wikidata.org/wiki/Q411659","display_name":"Daunorubicin","level":3,"score":0.804401159286499},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7788469791412354},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.6151131391525269},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5741534233093262},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5464283227920532},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5119284391403198},{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.42039254307746887},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.27055683732032776},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2635818123817444},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1733320951461792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14852115511894226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10107186436653137},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011060","descriptor_name":"Poloxalene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011060","descriptor_name":"Poloxalene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011060","descriptor_name":"Poloxalene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018432","descriptor_name":"Drug Resistance, Multiple","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018432","descriptor_name":"Drug Resistance, Multiple","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018432","descriptor_name":"Drug Resistance, Multiple","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bc950093n","doi":"https://doi.org/10.1021/bc950093n","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc950093n","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},{"id":"pmid:8983343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8983343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.800000011920929}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1528514916","https://openalex.org/W1925665128","https://openalex.org/W1963649673","https://openalex.org/W2017731672","https://openalex.org/W2044050922","https://openalex.org/W2068960363","https://openalex.org/W2073786769","https://openalex.org/W2078317923","https://openalex.org/W2087760996","https://openalex.org/W2103970111"],"related_works":["https://openalex.org/W2435078746","https://openalex.org/W4389020517","https://openalex.org/W2417263408","https://openalex.org/W2413236155","https://openalex.org/W2055830737","https://openalex.org/W4206695961","https://openalex.org/W2015158439","https://openalex.org/W2374053201","https://openalex.org/W2062278702","https://openalex.org/W2074950338"],"abstract_inverted_index":{"The":[0,29,100,134,218,239],"chemosensitizing":[1],"effect":[2],"of":[3,46,58,96,106,120,132,142,151,165,185,190,202,215,221,257],"Pluronic":[4,92,244],"P85":[5,245],"block":[6],"copolymer":[7,54,64,101,171,187,231],"were":[8],"studied":[9],"using":[10],"two":[11],"human":[12],"ovarian":[13],"carcinoma":[14],"sublines:":[15],"the":[16,37,44,56,63,72,81,90,97,103,138,149,152,163,166,170,178,182,186,200,222,230,236,255],"glycoprotein":[17],"P":[18],"(P-gp)":[19],"multidrug":[20],"resistant":[21],"(MDR)":[22],"SKVLB":[23,59,143],"cells":[24,144,168,204,226],"and":[25,114,122,127,140],"non-MDR":[26,98,123,208],"SKOV3":[27,76,156],"cells.":[28,60,77,99,217],"dramatic":[30],"increase":[31,70],"(up":[32],"to":[33,50,89,94,207,253],"700":[34],"times)":[35],"in":[36,43,55,71,75,137,148,155,188,224],"daunorubicin":[38,135],"cytotoxic":[39,104],"activity":[40,74,256],"was":[41,145],"observed":[42],"presence":[45,150],"0.01%":[47],"(22":[48],"microM)":[49],"1%":[51],"(2.2":[52],"mM)":[53],"case":[57],"By":[61],"contrast,":[62],"induced":[65],"a":[66,79,118,130,250],"less":[67],"than":[68],"3-fold":[69],"drug":[73,192],"As":[78],"result,":[80],"MDR":[82,108,167,203,225,261],"subline":[83],"demonstrated":[84],"much":[85],"higher":[86],"response":[87],"(\"hypersensitivity\")":[88],"daunorubicin/":[91],"compared":[93],"that":[95,228,243],"increased":[102,147],"effects":[105],"other":[107],"type":[109,124,209],"drugs":[110,125,210],"(doxorubicin,":[111],"epirubicin,":[112],"vinblastine,":[113],"mitomycin":[115],"C)":[116],"by":[117,129,169,177],"factor":[119,131],"20-1000":[121],"(methotrexate":[126],"cisplatin)":[128],"2-5.5.":[133],"influx":[136],"cytoplasm":[139],"nuclei":[141],"also":[146,198],"copolymer,":[153],"while":[154],"cells,":[157],"it":[158],"remained":[159],"practically":[160],"unchanged.":[161],"However,":[162],"hypersensitization":[164,237],"could":[172],"not":[173],"be":[174,247],"merely":[175],"explained":[176],"P-gp":[179],"modulation.":[180],"Therefore,":[181],"possible":[183],"role":[184],"inhibition":[189],"non-P-gp":[191],"resistance":[193],"is":[194],"hypothesized,":[195],"which":[196],"may":[197],"explain":[199],"sensitization":[201,214],"with":[205],"respect":[206],"as":[211,213,249],"well":[212],"parental":[216],"concentration":[219],"dependence":[220],"IC50":[223],"indicates":[227],"just":[229],"unimers":[232],"are":[233],"responsible":[234],"for":[235],"effect.":[238],"results":[240],"obtained":[241],"suggest":[242],"can":[246],"used":[248],"delivery":[251],"system":[252],"enhance":[254],"antineoplastic":[258],"agents":[259],"against":[260],"tumors.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":13}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
