{"id":"https://openalex.org/W2061014752","doi":"https://doi.org/10.1111/j.1476-5381.1980.tb10970.x","title":"EFFECT OF VARIATION IN ENDOGENOUS LEVELS OF ASCORBIC ACID ON THE in vitro IMMUNOLOGICAL RELEASE OF HISTAMINE AND SLOW REACTING SUBSTANCE OF ANAPHYLAXIS FROM ACTIVELY SENSITIZED GUINEA\u2010PIG LUNG FRAGMENTS","display_name":"EFFECT OF VARIATION IN ENDOGENOUS LEVELS OF ASCORBIC ACID ON THE in vitro IMMUNOLOGICAL RELEASE OF HISTAMINE AND SLOW REACTING SUBSTANCE OF ANAPHYLAXIS FROM ACTIVELY SENSITIZED GUINEA\u2010PIG LUNG FRAGMENTS","publication_year":1980,"publication_date":"1980-02-01","ids":{"openalex":"https://openalex.org/W2061014752","doi":"https://doi.org/10.1111/j.1476-5381.1980.tb10970.x","mag":"2061014752","pmid":"https://pubmed.ncbi.nlm.nih.gov/6162499","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2044460"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.1980.tb10970.x","doi":"https://doi.org/10.1111/j.1476-5381.1980.tb10970.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1980.tb10970.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1980.tb10970.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1980.tb10970.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041553454","display_name":"Margaret Hitchcock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210098204","display_name":"John B. Pierce Laboratory","ror":"https://ror.org/00fq5ev96","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"MARGARET HITCHCOCK","raw_affiliation_strings":["John B. Pierce Foundation Laboratory, Yale University School of Medicine, 290 Congress Avenue, New Haven, Connecticut 06519, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John B. Pierce Foundation Laboratory, Yale University School of Medicine, 290 Congress Avenue, New Haven, Connecticut 06519, U.S.A","institution_ids":["https://openalex.org/I32971472","https://openalex.org/I4210098204"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041553454"],"corresponding_institution_ids":["https://openalex.org/I32971472","https://openalex.org/I4210098204"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.8758,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.70576889,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"2","first_page":"539","last_page":"543"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12554","display_name":"Vitamin C and Antioxidants Research","score":0.6195999979972839,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12554","display_name":"Vitamin C and Antioxidants Research","score":0.6195999979972839,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.37059998512268066,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9819999933242798},{"id":"https://openalex.org/keywords/vitamin-c-deficiency","display_name":"scurvy","score":0.9079999923706055},{"id":"https://openalex.org/keywords/histamine-release","display_name":"histamine release","score":0.9190000295639038},{"id":"https://openalex.org/keywords/slow-reacting-substance-of-anaphylaxis","display_name":"slow reacting substance of anaphylaxis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lung-tissue","display_name":"lung tissue","score":0.6000000238418579},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.6000000238418579},{"id":"https://openalex.org/keywords/vitamin-c-intake","display_name":"vitamin C intake","score":0.5289999842643738},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.972423255443573},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.8777508735656738},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.7256296277046204},{"id":"https://openalex.org/C2775933838","wikidata":"https://www.wikidata.org/wiki/Q168800","display_name":"Anaphylaxis","level":3,"score":0.5434837341308594},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5279877781867981},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5016582012176514},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4814550280570984},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.46541857719421387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4466469883918762},{"id":"https://openalex.org/C2909345572","wikidata":"https://www.wikidata.org/wiki/Q163865","display_name":"Ascorbic Acid Deficiency","level":3,"score":0.4311926066875458},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4302586317062378},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3789489269256592},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.328827828168869},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3244972825050354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28101545572280884},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19621825218200684},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.18815916776657104},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.12806344032287598}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013189","descriptor_name":"SRS-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1476-5381.1980.tb10970.x","doi":"https://doi.org/10.1111/j.1476-5381.1980.tb10970.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1980.tb10970.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1980.tb10970.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:6162499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6162499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2044460","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2044460/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/j.1476-5381.1980.tb10970.x","doi":"https://doi.org/10.1111/j.1476-5381.1980.tb10970.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1980.tb10970.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1980.tb10970.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.40450000762939453}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2061014752.pdf","grobid_xml":"https://content.openalex.org/works/W2061014752.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1931867546","https://openalex.org/W1981757269","https://openalex.org/W1987178974","https://openalex.org/W2027233484","https://openalex.org/W2028607481","https://openalex.org/W2035933690","https://openalex.org/W2064971088","https://openalex.org/W2078552720","https://openalex.org/W2087729043","https://openalex.org/W2151153202","https://openalex.org/W2254746452","https://openalex.org/W2407891764"],"related_works":["https://openalex.org/W1977233851","https://openalex.org/W2332477275","https://openalex.org/W2253809824","https://openalex.org/W2415092814","https://openalex.org/W2801247645","https://openalex.org/W2062646876","https://openalex.org/W2341329386","https://openalex.org/W2414147984","https://openalex.org/W2333627015","https://openalex.org/W1989976248"],"abstract_inverted_index":{"1.":[0],"The":[1,83,122],"in":[2,53,60,69],"vitro":[3,61],"immunological":[4,62,127],"release":[5,44,128],"of":[6,12,37,50,56,72,96,107,111,118,129,131,142],"histamine":[7,63,80],"and":[8,109],"slow":[9],"reacting":[10],"substance":[11],"anaphylaxis":[13],"(SRS-A)":[14],"from":[15,133],"actively":[16],"sensitized":[17],"guinea-pig":[18,134],"lung":[19,79,84,99,135],"fragments":[20],"was":[21,88,102,116],"greatly":[22],"reduced":[23],"when":[24],"the":[25,54,91,97,105,112,126],"animals":[26],"were":[27],"maintained":[28],"on":[29,78,138],"an":[30],"ascorbic":[31,38,51,73,85,100,143],"acid-deficient":[32],"diet.":[33],"Excessive":[34],"dietary":[35,70,92,119],"levels":[36,71,141],"acid":[39,52,74,86,101],"did":[40],"not":[41],"increase":[42],"mediator":[43],"above":[45],"normal":[46,65],"levels.":[47,66],"2.":[48],"Restoration":[49],"diet":[55],"scorbutic":[57],"guinea-pigs":[58],"restored":[59],"to":[64,90],"3.":[67],"Variation":[68],"had":[75],"no":[76],"effect":[77],"content.":[81],"4.":[82],"content":[87],"proportional":[89],"intake.":[93,120],"Approximately":[94],"60%":[95],"total":[98],"removed":[103],"by":[104],"process":[106],"chopping":[108],"washing":[110],"tissue.":[113],"This":[114],"relationship":[115],"independent":[117],"5.":[121],"results":[123],"indicate":[124],"that":[125],"mediators":[130],"inflammation":[132],"is":[136],"dependent":[137],"adequate":[139],"endogenous":[140],"acid.":[144]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}