{"id":"https://openalex.org/W2060936868","doi":"https://doi.org/10.1159/000126231","title":"Inhibin/Activin Subunits Are Costored with FSH and LH in Secretory Granules of the Rat Anterior Pituitary Gland","display_name":"Inhibin/Activin Subunits Are Costored with FSH and LH in Secretory Granules of the Rat Anterior Pituitary Gland","publication_year":2008,"publication_date":"2008-04-07","ids":{"openalex":"https://openalex.org/W2060936868","doi":"https://doi.org/10.1159/000126231","mag":"2060936868","pmid":"https://pubmed.ncbi.nlm.nih.gov/1407376"},"language":"en","primary_location":{"id":"doi:10.1159/000126231","doi":"https://doi.org/10.1159/000126231","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000126231","pdf_url":null,"source":{"id":"https://openalex.org/S84102376","display_name":"Neuroendocrinology","issn_l":"0028-3835","issn":["0028-3835","1423-0194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074244172","display_name":"Veronica J. Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronica J. Roberts","raw_affiliation_strings":["Laboratory of Neuronal Structure and Function, Salk Institute, La Jolla, Calif","Laboratory of Neuronal Structure and Function, and","The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, Calif., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuronal Structure and Function, Salk Institute, La Jolla, Calif","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"Laboratory of Neuronal Structure and Function, and","institution_ids":[]},{"raw_affiliation_string":"The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, Calif., USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013516543","display_name":"Charles A. Peto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles A. Peto","raw_affiliation_strings":["Laboratory of Neuronal Structure and Function, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuronal Structure and Function, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110215203","display_name":"Wylie Vale","orcid":"https://orcid.org/0009-0000-2655-7200","observed_orcids":["https://orcid.org/0009-0000-2655-7200"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wylie Vale","raw_affiliation_strings":["The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, Calif., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, Calif., USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028880120","display_name":"Paul E. Sawchenko","orcid":"https://orcid.org/0000-0002-8258-1296","observed_orcids":["https://orcid.org/0000-0002-8258-1296"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul E. Sawchenko","raw_affiliation_strings":["Laboratory of Neuronal Structure and Function, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuronal Structure and Function, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6229,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.81873567,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"56","issue":"2","first_page":"214","last_page":"224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.37209999561309814,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.37209999561309814,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.323199987411499,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.030799999833106995,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inhibin","display_name":"inhibin","score":0.9020000100135803},{"id":"https://openalex.org/keywords/activin","display_name":"activin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inhibin-alpha","display_name":"inhibin alpha subunit","score":0.9240000247955322},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.6759999990463257},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.9229999780654907},{"id":"https://openalex.org/keywords/gonadotrophs","display_name":"gonadotrophs","score":0.9110000133514404},{"id":"https://openalex.org/keywords/secretory-granules","display_name":"secretory granules","score":0.9829999804496765},{"id":"https://openalex.org/keywords/anterior-pituitary","display_name":"anterior pituitary","score":0.7760000228881836},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.7099999785423279},{"id":"https://openalex.org/keywords/colocalization","display_name":"colocalization","score":0.8999999761581421},{"id":"https://openalex.org/keywords/corelease","display_name":"corelease","score":0.7860000133514404},{"id":"https://openalex.org/keywords/immunogold-labeling","display_name":"immunogold labeling","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.8065040111541748},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8037338256835938},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7947770357131958},{"id":"https://openalex.org/C197012351","wikidata":"https://www.wikidata.org/wiki/Q3099316","display_name":"Gonadotropic cell","level":4,"score":0.6579087376594543},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.6471177339553833},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.610404908657074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6017366051673889},{"id":"https://openalex.org/C30030713","wikidata":"https://www.wikidata.org/wiki/Q17029513","display_name":"Immunogold labelling","level":3,"score":0.5428810119628906},{"id":"https://openalex.org/C2779029589","wikidata":"https://www.wikidata.org/wiki/Q356002","display_name":"Anterior pituitary","level":3,"score":0.537543535232544},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.4187503159046173},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3713456392288208},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.23645907640457153},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21724766492843628},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1328181028366089},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10860934853553772},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06376934051513672},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028341","descriptor_name":"Activins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000126231","doi":"https://doi.org/10.1159/000126231","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000126231","pdf_url":null,"source":{"id":"https://openalex.org/S84102376","display_name":"Neuroendocrinology","issn_l":"0028-3835","issn":["0028-3835","1423-0194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"journal-article"},{"id":"pmid:1407376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1407376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1001079888","display_name":"Activin and Inhibin Signaling and Reproduction","funder_award_id":"P01HD013527","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2387454712","display_name":null,"funder_award_id":"HD-07172","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6284661572","display_name":"THYROID HORMONE RECEPTOR DISTRIBUTION","funder_award_id":"F32HD007172","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1967999113","https://openalex.org/W135067637","https://openalex.org/W1971270971","https://openalex.org/W2087779280","https://openalex.org/W2054434369","https://openalex.org/W1968586789","https://openalex.org/W2127316885","https://openalex.org/W4255579839","https://openalex.org/W1014924652","https://openalex.org/W1967987025"],"abstract_inverted_index":{"We":[0],"recently":[1],"reported":[2],"that":[3,95,195,215,231],"pituitary":[4],"gonadotropes,":[5],"major":[6],"targets":[7],"of":[8,16,36,80,128,146,151,173,199,218,221],"circulating":[9],"inhibins":[10],"and":[11,22,68,84,123,167,189,233,238],"activins,":[12],"are":[13,223,235],"also":[14,96],"capable":[15],"synthesizing":[17],"the":[18,28,33,45,54,78,106,147,152,174,186,190,219,242],"inhibin":[19,232],"(I)":[20],"alpha-":[21,188],"inhibin/activin":[23],"(I/A)":[24],"beta":[25,135,192],"B-subunits.":[26],"In":[27],"present":[29],"study,":[30],"we":[31],"examined":[32],"subcellular":[34],"distribution":[35],"these":[37,216,228],"subunits,":[38],"with":[39,53,119,124,139,177,210,241],"special":[40],"attention":[41],"given":[42],"to":[43,47,75,105,213,225],"determinating":[44],"extent":[46,220],"which":[48,178],"they":[49],"might":[50],"be":[51,226],"colocalized":[52,118],"gonadotropins":[55],"in":[56,93,103,121,126,143],"secretory":[57,113],"granules.":[58,114,132,148],"Pituitaries":[59],"from":[60],"adult":[61],"male":[62],"rats":[63],"were":[64,73,90,108,160],"cryofixed,":[65],"molecular":[66],"distillation-dried,":[67],"resin-embedded.":[69],"Immunogold":[70],"staining":[71,184],"methods":[72],"used":[74],"examine":[76],"concurrently":[77],"distributions":[79],"an":[81,164],"I/A":[82,88,134,165,191],"subunit":[83],"FSH":[85,120,140,155],"or":[86,141,156],"LH.":[87],"subunits":[89],"detected":[91],"only":[92,162],"cells":[94],"labeled":[97],"positively":[98,130],"for":[99,163,185,206],"a":[100,171],"gonadotropin,":[101],"and,":[102],"contrast":[104],"gonadotropins,":[107],"sequestered":[109],"almost":[110],"exclusively":[111],"within":[112],"The":[115,133],"I":[116,187],"alpha-subunit":[117],"31%,":[122],"LH":[125,142,157],"36%,":[127],"all":[129,200],"stained":[131],"B-subunit":[136],"was":[137,180],"found":[138],"about":[144],"25%":[145],"Approximately":[149],"52-69%":[150],"granules":[153,202],"contained":[154],"alone;":[158],"7-18%":[159],"positive":[161,204],"subunit,":[166],"this":[168],"varied":[169],"as":[170],"function":[172],"particular":[175],"gonadotropin":[176],"costaining":[179],"carried":[181],"out.":[182],"Dual":[183],"B-subunits":[193],"indicated":[194],"at":[196],"least":[197],"35%":[198],"immunolabeled":[201],"showed":[203],"signals":[205],"both":[207],"subunits.":[208],"Coupled":[209],"methodological":[211],"considerations":[212],"indicate":[214],"estimates":[217],"colocalization":[222],"likely":[224],"conservative,":[227],"data":[229],"suggest":[230],"activin":[234],"characteristically":[236],"copackaged,":[237],"presumably":[239],"coreleased,":[240],"gonadotropins.":[243]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
