{"id":"https://openalex.org/W2060793205","doi":"https://doi.org/10.1097/shk.0b013e31815cfd5a","title":"INHIBITION OF MYOCARDIAL APOPTOSIS BY POSTCONDITIONING IS ASSOCIATED WITH ATTENUATION OF OXIDATIVE STRESS-MEDIATED NUCLEAR FACTOR-\u03ba\u03baB TRANSLOCATION AND TNF\u03b1\u03b1 RELEASE","display_name":"INHIBITION OF MYOCARDIAL APOPTOSIS BY POSTCONDITIONING IS ASSOCIATED WITH ATTENUATION OF OXIDATIVE STRESS-MEDIATED NUCLEAR FACTOR-\u03ba\u03baB TRANSLOCATION AND TNF\u03b1\u03b1 RELEASE","publication_year":2008,"publication_date":"2008-05-13","ids":{"openalex":"https://openalex.org/W2060793205","doi":"https://doi.org/10.1097/shk.0b013e31815cfd5a","mag":"2060793205","pmid":"https://pubmed.ncbi.nlm.nih.gov/18496137"},"language":"en","primary_location":{"id":"doi:10.1097/shk.0b013e31815cfd5a","doi":"https://doi.org/10.1097/shk.0b013e31815cfd5a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/shk.0b013e31815cfd5a","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022392450","display_name":"Hajime Kin","orcid":"https://orcid.org/0000-0002-2701-8257","observed_orcids":["https://orcid.org/0000-0002-2701-8257"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2800194297","display_name":"Emory University Hospital Midtown","ror":"https://ror.org/02aknh966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I2800194297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hajime Kin","raw_affiliation_strings":["Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, GA 30308-2225, USA","Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, GA 30308-2225, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]},{"raw_affiliation_string":"Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]},{"raw_affiliation_string":"Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021351308","display_name":"Ning-Ping Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2800194297","display_name":"Emory University Hospital Midtown","ror":"https://ror.org/02aknh966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I2800194297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ning-Ping Wang","raw_affiliation_strings":["Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]},{"raw_affiliation_string":"Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018615160","display_name":"James Mykytenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2800194297","display_name":"Emory University Hospital Midtown","ror":"https://ror.org/02aknh966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I2800194297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Mykytenko","raw_affiliation_strings":["Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]},{"raw_affiliation_string":"Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051544633","display_name":"James G. Reeves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2800194297","display_name":"Emory University Hospital Midtown","ror":"https://ror.org/02aknh966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I2800194297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Reeves","raw_affiliation_strings":["Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]},{"raw_affiliation_string":"Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034098590","display_name":"Jeremiah Deneve","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2800194297","display_name":"Emory University Hospital Midtown","ror":"https://ror.org/02aknh966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I2800194297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremiah Deneve","raw_affiliation_strings":["Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]},{"raw_affiliation_string":"Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103539437","display_name":"Rong Jiang","orcid":"https://orcid.org/0009-0008-9305-4978","observed_orcids":["https://orcid.org/0009-0008-9305-4978"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2800194297","display_name":"Emory University Hospital Midtown","ror":"https://ror.org/02aknh966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I2800194297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Jiang","raw_affiliation_strings":["Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]},{"raw_affiliation_string":"Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054209777","display_name":"Amanda J. Zatta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2800194297","display_name":"Emory University Hospital Midtown","ror":"https://ror.org/02aknh966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I2800194297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda J. Zatta","raw_affiliation_strings":["Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]},{"raw_affiliation_string":"Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081858829","display_name":"Robert A. Guyton","orcid":"https://orcid.org/0000-0002-7171-8904","observed_orcids":["https://orcid.org/0000-0002-7171-8904"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2800194297","display_name":"Emory University Hospital Midtown","ror":"https://ror.org/02aknh966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I2800194297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Guyton","raw_affiliation_strings":["Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]},{"raw_affiliation_string":"Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017018658","display_name":"Jakob Vinten\u2010Johansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2800194297","display_name":"Emory University Hospital Midtown","ror":"https://ror.org/02aknh966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I2800194297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jakob Vinten-Johansen","raw_affiliation_strings":["Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]},{"raw_affiliation_string":"Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109173433","display_name":"and Zhi-Qing Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2800194297","display_name":"Emory University Hospital Midtown","ror":"https://ror.org/02aknh966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I2800194297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"and Zhi-Qing Zhao","raw_affiliation_strings":["Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address reprint requests to Zhi-Qing Zhao, Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree St, NE, Atlanta, GA 30308-2225. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]},{"raw_affiliation_string":"Cardiothoracic Research Laboratory, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800194297"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.2589,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.97894686,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"29","issue":"6","first_page":"761","last_page":"768"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.8930000066757202},{"id":"https://openalex.org/keywords/postconditioning","display_name":"postconditioning","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cardiomyocyte-apoptosis","display_name":"cardiomyocyte apoptosis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/tnf-alpha-release","display_name":"TNF-alpha release","score":0.9150000214576721},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9959999918937683},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.8619999885559082},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9879999756813049},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9179999828338623},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9879999756813049},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.5899999737739563},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8059999942779541},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.8536440134048462},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8129870891571045},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7009813785552979},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6399391293525696},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.5771051049232483},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.491356760263443},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47592833638191223},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.4666229486465454},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.45820239186286926},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.370355486869812},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34888774156570435},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33924400806427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26024532318115234},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2019048035144806},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.048295944929122925},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019194","descriptor_name":"Ischemic Preconditioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/shk.0b013e31815cfd5a","doi":"https://doi.org/10.1097/shk.0b013e31815cfd5a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/shk.0b013e31815cfd5a","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},{"id":"pmid:18496137","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18496137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock (Augusta, Ga.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G458617690","display_name":"Tissue Factor in Myocardial Reperfusion","funder_award_id":"R01HL069487","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5163974382","display_name":" MYOCYTE CELL DEATH DURING EARLY AND LATE PHASES","funder_award_id":"R01HL064886","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W144506950","https://openalex.org/W1528594194","https://openalex.org/W1967184826","https://openalex.org/W1975081780","https://openalex.org/W1978855921","https://openalex.org/W1990931110","https://openalex.org/W2011506135","https://openalex.org/W2012643251","https://openalex.org/W2013965008","https://openalex.org/W2024007859","https://openalex.org/W2049043910","https://openalex.org/W2054010485","https://openalex.org/W2056668196","https://openalex.org/W2062224045","https://openalex.org/W2074272236","https://openalex.org/W2086309499","https://openalex.org/W2090831588","https://openalex.org/W2091958169","https://openalex.org/W2092914889","https://openalex.org/W2106908530","https://openalex.org/W2117344826","https://openalex.org/W2120202791","https://openalex.org/W2124007377","https://openalex.org/W2126636055","https://openalex.org/W2134704000","https://openalex.org/W2135596846","https://openalex.org/W2135981165","https://openalex.org/W2137445925","https://openalex.org/W2147137546","https://openalex.org/W2152828327","https://openalex.org/W2154937731","https://openalex.org/W2167866149","https://openalex.org/W2182141197","https://openalex.org/W2298004435","https://openalex.org/W2404387463"],"related_works":["https://openalex.org/W78287596","https://openalex.org/W1979954124","https://openalex.org/W2125647866","https://openalex.org/W2393864105","https://openalex.org/W2135596846","https://openalex.org/W2381021083","https://openalex.org/W1964808756","https://openalex.org/W2085977736","https://openalex.org/W3028726138","https://openalex.org/W2004870491"],"abstract_inverted_index":{"Oxidative":[0],"stress-stimulated":[1],"nuclear":[2],"factor-kappa":[3],"B":[4,36,126,241],"(NF-kappa":[5],"B)":[6],"activation":[7],"has":[8],"been":[9],"associated":[10],"with":[11,118,182,217,236],"rapid":[12],"transcription":[13],"of":[14,18,34,39,45,57,62,73,83,107,124,139,163,185,198,239,248,250],"TNF-alpha":[15,40,141,251],"and":[16,31,37,59,64,76,103,150,201,213,223,246,261,284,299],"induction":[17],"apoptosis.":[19],"This":[20],"study":[21],"tested":[22],"the":[23,81,92,105,137,196],"hypothesis":[24],"that":[25,232,276],"postconditioning":[26],"(Postcon)":[27],"reduces":[28,281],"myocardial":[29,279],"apoptosis":[30],"inhibits":[32],"translocation":[33,123],"NF-kappa":[35,125,240,291],"release":[38,200,249],"secondary":[41],"to":[42,54,67,88,127,227,231],"an":[43,237],"attenuation":[44],"oxidant":[46,191],"generation":[47,106,192,222],"during":[48],"reperfusion.":[49,215],"Anesthetized":[50],"rats":[51],"were":[52,267],"subjected":[53],"30":[55],"min":[56],"ischemia":[58,212],"3":[60],"h":[61],"reperfusion":[63,75],"divided":[65],"randomly":[66],"Control":[68],"or":[69],"Postcon":[70,90,120,277,298],"(three":[71],"cycles":[72],"10-s":[74,77],"reocclusion":[78],"applied":[79],"at":[80,112,214],"onset":[82],"reperfusion)":[84],"group,":[85],"respectively.":[86],"Relative":[87],"Control,":[89,119],"reduced":[91,173,183,270],"plasma":[93,140,225],"malondialdehyde":[94,226],"(1.21":[95],"+/-":[96,100,130,134,143,147,155,159,175,179,244,253,259,265],"0.08":[97],"vs.":[98,132,145,157,177,301],"0.8":[99],"0.06*":[101],"microM/mL)":[102],"decreased":[104,136,224],"superoxide":[108,220],"radical":[109,221],"in":[110,169,195,233],"area":[111],"risk":[113],"myocardium":[114,171],"(dihydroethidium":[115],"staining).":[116],"Compared":[117],"also":[121,268],"inhibited":[122,151,219],"nuclei":[128],"(167%":[129],"21%":[131],"142%":[133],"18%*),":[135],"level":[138,230],"(1,994":[142],"447":[144],"667":[146],"130*":[148],"pg/mL),":[149],"caspase-3":[152,282],"activity":[153,257],"(0.57%":[154],"0.1%":[156],"0.21%":[158],"0.1%*).":[160],"The":[161],"number":[162],"apoptotic":[164,262],"cells":[165,263],"(percent":[166],"total":[167],"nuclei)":[168],"ischemic":[170],"was":[172,209],"(20%":[174],"1%":[176],"11%":[178],"2%*),":[180],"consistent":[181],"appearance":[184],"DNA":[186],"fragmentation.":[187],"To":[188],"support":[189],"whether":[190],"is":[193,285],"important":[194],"triggering":[197],"cytokine":[199],"apoptosis,":[202,280],"N-acetylcysteine":[203],"(NAC),":[204],"a":[205,228],"potent":[206],"antioxidant":[207],"agent,":[208],"administered":[210],"before":[211],"Treatment":[216],"NAC":[218,300],"comparable":[229],"Postcon,":[234],"concomitant":[235],"inhibition":[238],"expression":[242],"(42%":[243],"8%*)":[245],"reduction":[247],"(231":[252],"72*":[254],"pg/mL).":[255],"Caspase-3":[256],"(0.33%":[258],"0.1%*)":[260],"(12%":[264],"1%*)":[266],"comparably":[269],"by":[271,288],"NAC.":[272],"These":[273],"data":[274],"suggest":[275],"attenuates":[278],"activity,":[283],"potentially":[286],"mediated":[287],"inhibiting":[289],"oxidant-activated":[290],"B-TNF-alpha":[292],"signaling":[293],"pathway.":[294],"*P":[295],"<":[296],"0.05":[297],"Control.":[302]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}