{"id":"https://openalex.org/W2060758992","doi":"https://doi.org/10.1016/0143-4179(90)90149-s","title":"Bulbospinal and intraspinal thyrotropin releasing hormone systems: Modulation of spinal cord pain transmission","display_name":"Bulbospinal and intraspinal thyrotropin releasing hormone systems: Modulation of spinal cord pain transmission","publication_year":1990,"publication_date":"1990-03-01","ids":{"openalex":"https://openalex.org/W2060758992","doi":"https://doi.org/10.1016/0143-4179(90)90149-s","mag":"2060758992","pmid":"https://pubmed.ncbi.nlm.nih.gov/2174521"},"language":"en","primary_location":{"id":"doi:10.1016/0143-4179(90)90149-s","doi":"https://doi.org/10.1016/0143-4179(90)90149-s","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0143-4179(90)90149-s","pdf_url":null,"source":{"id":"https://openalex.org/S86238769","display_name":"Neuropeptides","issn_l":"0143-4179","issn":["0143-4179","1532-2785"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropeptides","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111897644","display_name":"Michael M. Behbehani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M.M. Behbehani","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Cincinnati College of Medicine, Ohio 45267-0576","Department of Physiology and Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267-0576, USA","Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267-0576, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Cincinnati College of Medicine, Ohio 45267-0576","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267-0576, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267-0576, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110100846","display_name":"Frank P. Zemlan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F.P. Zemlan","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267-0576, USA","Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267-0576, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267-0576, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267-0576, USA","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111897644"],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":{"value":3530,"currency":"USD","value_usd":3530},"apc_paid":null,"fwci":0.8067,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.7687909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"15","issue":"3","first_page":"161","last_page":"168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyrotropin-releasing-hormone","display_name":"thyrotropin-releasing hormone","score":0.9449999928474426},{"id":"https://openalex.org/keywords/spinal-nociceptive-neurons","display_name":"spinal nociceptive neurons","score":0.7179999947547913},{"id":"https://openalex.org/keywords/spinal-cord-dorsal-horn","display_name":"dorsal horn","score":0.7570000290870667},{"id":"https://openalex.org/keywords/pain-modulation","display_name":"pain modulation","score":0.746999979019165},{"id":"https://openalex.org/keywords/descending-pain-modulation","display_name":"descending pain modulation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/pain-facilitation","display_name":"pain facilitation","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6440110802650452},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.6430968642234802},{"id":"https://openalex.org/C2776216936","wikidata":"https://www.wikidata.org/wiki/Q24726011","display_name":"Thyrotropin-releasing hormone","level":3,"score":0.6279616951942444},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.5182780623435974},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5066249966621399},{"id":"https://openalex.org/C2777659854","wikidata":"https://www.wikidata.org/wiki/Q3857077","display_name":"Rostral ventromedial medulla","level":5,"score":0.46592164039611816},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.45630329847335815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4452628791332245},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.41032010316848755},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35131803154945374},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2991156280040741},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29407423734664917},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2135210931301117},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18507009744644165},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1411171853542328},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.10161760449409485}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008526","descriptor_name":"Medulla Oblongata","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008526","descriptor_name":"Medulla Oblongata","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008526","descriptor_name":"Medulla Oblongata","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013973","descriptor_name":"Thyrotropin-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013973","descriptor_name":"Thyrotropin-Releasing Hormone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0143-4179(90)90149-s","doi":"https://doi.org/10.1016/0143-4179(90)90149-s","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0143-4179(90)90149-s","pdf_url":null,"source":{"id":"https://openalex.org/S86238769","display_name":"Neuropeptides","issn_l":"0143-4179","issn":["0143-4179","1532-2785"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropeptides","raw_type":"journal-article"},{"id":"pmid:2174521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2174521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropeptides","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7300000190734863,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2614659379","display_name":null,"funder_award_id":"NS 18326","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4646590434","display_name":"NEUROPEPTIDES AND PAIN INHIBITION","funder_award_id":"5r01ns020643-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6173847155","display_name":"PEPTIDE/MONOAMINE CONTROL OF SPINAL PAIN TRANSMISSION","funder_award_id":"5r01ns018326-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G807764364","display_name":null,"funder_award_id":"NS 20643","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1029293373","https://openalex.org/W1547399881","https://openalex.org/W1974164498","https://openalex.org/W1974782548","https://openalex.org/W1975582429","https://openalex.org/W1977080308","https://openalex.org/W1980501091","https://openalex.org/W1990241746","https://openalex.org/W1990378654","https://openalex.org/W1995499904","https://openalex.org/W2009030798","https://openalex.org/W2010216377","https://openalex.org/W2012096282","https://openalex.org/W2012407522","https://openalex.org/W2020461010","https://openalex.org/W2025477120","https://openalex.org/W2030691825","https://openalex.org/W2031161852","https://openalex.org/W2032766740","https://openalex.org/W2035078135","https://openalex.org/W2035790108","https://openalex.org/W2048068039","https://openalex.org/W2048090958","https://openalex.org/W2050276803","https://openalex.org/W2061296589","https://openalex.org/W2070415577","https://openalex.org/W2072125978","https://openalex.org/W2081860395","https://openalex.org/W2087309586","https://openalex.org/W2112145069","https://openalex.org/W2742181128"],"related_works":["https://openalex.org/W1984459952","https://openalex.org/W2341656352","https://openalex.org/W2058371437","https://openalex.org/W2012096282","https://openalex.org/W1967920226","https://openalex.org/W2273258504","https://openalex.org/W4366729486","https://openalex.org/W2084944385","https://openalex.org/W2371285970","https://openalex.org/W2055803457"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}