{"id":"https://openalex.org/W2060523967","doi":"https://doi.org/10.1523/jneurosci.0175-05.2005","title":"Postpubertal Sex Differentiation of Forebrain Structures and Functions Depend on Transforming Growth Factor-\u03b1","display_name":"Postpubertal Sex Differentiation of Forebrain Structures and Functions Depend on Transforming Growth Factor-\u03b1","publication_year":2005,"publication_date":"2005-04-13","ids":{"openalex":"https://openalex.org/W2060523967","doi":"https://doi.org/10.1523/jneurosci.0175-05.2005","mag":"2060523967","pmid":"https://pubmed.ncbi.nlm.nih.gov/15829639","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6724926"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.0175-05.2005","doi":"https://doi.org/10.1523/jneurosci.0175-05.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0175-05.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/15/3870.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/25/15/3870.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034254491","display_name":"Kyoko Koshibu","orcid":"https://orcid.org/0000-0002-9809-0299","observed_orcids":["https://orcid.org/0000-0002-9809-0299"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210086114","display_name":"Center for the Neural Basis of Cognition","ror":"https://ror.org/00jfeg660","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210086114","https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyoko Koshibu","raw_affiliation_strings":["Department of Neurobiology and Center for Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. koshibu@hifo.unizh.ch","Department of Neurobiology and Center for Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Center for Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. koshibu@hifo.unizh.ch","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210086114"]},{"raw_affiliation_string":"Department of Neurobiology and Center for Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210086114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025533535","display_name":"Eric T. Ahrens","orcid":"https://orcid.org/0000-0001-6131-9304","observed_orcids":["https://orcid.org/0000-0001-6131-9304"]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric T. Ahrens","raw_affiliation_strings":["Department of Biological Sciences and Pittsburgh Nuclear Magnetic Resonance Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and Pittsburgh Nuclear Magnetic Resonance Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, and","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039497420","display_name":"Pat R. Levitt","orcid":"https://orcid.org/0000-0002-9717-1695","observed_orcids":["https://orcid.org/0000-0002-9717-1695"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pat Levitt","raw_affiliation_strings":["Department of Pharmacology , Vanderbilt University , Nashville , Tennessee 37203","Vanderbilt Kennedy Center for Research on Human Development and","Vanderbilt Kennedy Center for Research on Human Development and Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37203"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology , Vanderbilt University , Nashville , Tennessee 37203","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Kennedy Center for Research on Human Development and","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Kennedy Center for Research on Human Development and Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37203","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8589,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.91968966,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"25","issue":"15","first_page":"3870","last_page":"3880"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.3628000020980835,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.3628000020980835,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.28999999165534973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.08839999884366989,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sexual-differentiation","display_name":"sexual differentiation","score":0.6179999709129333},{"id":"https://openalex.org/keywords/forebrain","display_name":"forebrain","score":0.8119999766349792},{"id":"https://openalex.org/keywords/ventricular-dilation","display_name":"ventriculomegaly","score":0.7540000081062317},{"id":"https://openalex.org/keywords/hippocampal-volume","display_name":"hippocampal volume","score":0.9900000095367432},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.9900000095367432},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2779715522","wikidata":"https://www.wikidata.org/wiki/Q507027","display_name":"Forebrain","level":3,"score":0.9134522080421448},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.7146085500717163},{"id":"https://openalex.org/C63405245","wikidata":"https://www.wikidata.org/wiki/Q9076644","display_name":"Sexual differentiation","level":3,"score":0.6045044660568237},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.534984290599823},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5211060643196106},{"id":"https://openalex.org/C146539212","wikidata":"https://www.wikidata.org/wiki/Q5611740","display_name":"Growth differentiation factor","level":4,"score":0.4232461750507355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4046609103679657},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.3557993769645691},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.28223368525505066},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24055954813957214},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12993589043617249},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.05701100826263428},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000161","descriptor_name":"Acoustic Stimulation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002755","descriptor_name":"Choice Behavior","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003213","descriptor_name":"Conditioning, Psychological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005106","descriptor_name":"Exploratory Behavior","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005239","descriptor_name":"Fear","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008818","descriptor_name":"Mice, Neurologic Mutants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012733","descriptor_name":"Sex Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.0175-05.2005","doi":"https://doi.org/10.1523/jneurosci.0175-05.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0175-05.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/15/3870.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6724926","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6724926","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:15829639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15829639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.0175-05.2005","doi":"https://doi.org/10.1523/jneurosci.0175-05.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0175-05.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/15/3870.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1238779506","display_name":"Eunice Kennedy Shriver Intellectual and Developmental Disability Research Center","funder_award_id":"P30HD015052","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G1544766391","display_name":"Factors Regulating Limbic System Assembly","funder_award_id":"R01MH045507","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G1713713073","display_name":null,"funder_award_id":"MH45507","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2360538541","display_name":"A MULTIDISCIPLINARY NMR CENTER FOR BIOMEDICAL RESEARCH","funder_award_id":"P41EB001977","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G2475247966","display_name":null,"funder_award_id":"HD015052","funder_id":"https://openalex.org/F4320337364","funder_display_name":"National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6441028046","display_name":null,"funder_award_id":"P50-AR049617","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7218854950","display_name":null,"funder_award_id":"HD015052","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7596995479","display_name":"IGERT Full Proposal: Innovative Cross-Disciplinary Training in Neuroscience and Computation","funder_award_id":"9987588","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G840130349","display_name":"19F MRI probes and autoimmune disease","funder_award_id":"R01EB003453","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G9000049790","display_name":null,"funder_award_id":"HD015052","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337368","display_name":"Division of Graduate Education","ror":"https://ror.org/00whkrf32"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2060523967.pdf","grobid_xml":"https://content.openalex.org/works/W2060523967.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1537802913","https://openalex.org/W1557179886","https://openalex.org/W1608290918","https://openalex.org/W1633118497","https://openalex.org/W1770729033","https://openalex.org/W1970402412","https://openalex.org/W1972036696","https://openalex.org/W1977249405","https://openalex.org/W1980103022","https://openalex.org/W1981402761","https://openalex.org/W1982353374","https://openalex.org/W1993475532","https://openalex.org/W1995465899","https://openalex.org/W1996004317","https://openalex.org/W1996473312","https://openalex.org/W2000292265","https://openalex.org/W2000533601","https://openalex.org/W2002091526","https://openalex.org/W2005098171","https://openalex.org/W2012819521","https://openalex.org/W2016095773","https://openalex.org/W2025879458","https://openalex.org/W2031038187","https://openalex.org/W2031414482","https://openalex.org/W2031541200","https://openalex.org/W2032781543","https://openalex.org/W2035287594","https://openalex.org/W2037749209","https://openalex.org/W2038263974","https://openalex.org/W2040054355","https://openalex.org/W2044134173","https://openalex.org/W2045845042","https://openalex.org/W2054287484","https://openalex.org/W2058148588","https://openalex.org/W2059631901","https://openalex.org/W2059738973","https://openalex.org/W2059917807","https://openalex.org/W2067140282","https://openalex.org/W2071794819","https://openalex.org/W2072008263","https://openalex.org/W2074142727","https://openalex.org/W2074964096","https://openalex.org/W2086589412","https://openalex.org/W2087287750","https://openalex.org/W2095437134","https://openalex.org/W2096872135","https://openalex.org/W2099583536","https://openalex.org/W2110506736","https://openalex.org/W2120032880","https://openalex.org/W2123927100","https://openalex.org/W2153979740","https://openalex.org/W2160353897","https://openalex.org/W2293244897","https://openalex.org/W2436254572","https://openalex.org/W4243810761","https://openalex.org/W4299325671"],"related_works":["https://openalex.org/W2035287594","https://openalex.org/W1980103022","https://openalex.org/W2016785972","https://openalex.org/W2092501696","https://openalex.org/W2034117833","https://openalex.org/W2059917807","https://openalex.org/W2091756467","https://openalex.org/W2758913798","https://openalex.org/W2811084193","https://openalex.org/W2782959346"],"abstract_inverted_index":{"Sex-":[0],"and":[1,7,19,55,61,100,106,137,155,188,191,210,216],"age-associated":[2],"deficits":[3,163,245],"in":[4,11,34,78,82,103,127,141,186,203,229,246],"brain":[5],"structure":[6],"behavior":[8],"are":[9,22,30],"reported":[10],"a":[12,79,92,115,220,223],"number":[13],"of":[14,58,88,213,222,236],"neuropsychiatric":[15],"disorders.":[16],"Although":[17],"genetic":[18],"environmental":[20],"factors":[21],"thought":[23],"to":[24,26],"contribute":[25],"the":[27,121,199],"pathogenesis,":[28],"there":[29],"only":[31,126],"few":[32],"examples":[33],"clinical":[35],"or":[36],"experimental":[37],"systems":[38],"that":[39,47,76,179,234],"have":[40],"identified":[41],"specific":[42],"causes.":[43],"Here,":[44],"we":[45],"report":[46],"transforming":[48],"growth":[49],"factor-alpha":[50],"(TGFalpha)":[51],"may":[52,181,206,242],"regulate":[53,182],"sex-":[54],"age-dependent":[56],"development":[57],"forebrain":[59,89,173],"structures":[60,90],"associated":[62,192],"neural":[63],"functions":[64],"after":[65],"puberty.":[66],"Waved-1":[67],"(Wa-1)":[68],"mice":[69],"inherit":[70],"an":[71,208],"autosomal":[72],"recessive,":[73],"spontaneous":[74],"mutation":[75],"results":[77,177],"postnatal":[80],"reduction":[81,102,202],"TGFalpha":[83,180],"gene":[84],"expression.":[85],"The":[86],"assessment":[87],"using":[91],"three-dimensional":[93],"magnetic":[94],"resonance":[95],"microscopy":[96],"indicated":[97],"ventricular":[98,187],"enlargement":[99],"striatal":[101],"both":[104,153],"male":[105,154],"female":[107,156],"Wa-1":[108,112,129,143,158,231],"adult":[109,128,142,157,200],"mice,":[110,232],"with":[111],"males":[113,144],"exhibiting":[114],"more":[116],"severe":[117],"phenotype.":[118],"In":[119,197],"contrast,":[120],"hippocampal":[122,204],"volume":[123,205],"was":[124,150],"reduced":[125],"males.":[130,196],"Similarly,":[131],"behavioral":[132,162,224],"analyses":[133],"showed":[134],"impaired":[135],"auditory":[136],"contextual":[138],"fear":[139,217],"learning":[140],"only,":[145],"whereas":[146],"abnormal":[147],"stress":[148,214],"response":[149],"expressed":[151],"by":[152],"mice.":[159],"Interestingly,":[160],"all":[161],"were":[164],"absent":[165],"before":[166],"full":[167],"sexual":[168],"maturation,":[169],"despite":[170,226],"some":[171],"slight":[172],"structural":[174],"abnormalities.":[175],"These":[176],"suggest":[178],"postpubertal,":[183],"sex":[184],"differentiation":[185],"periventricular":[189],"anatomy":[190],"behavior,":[193],"affecting":[194],"predominantly":[195],"particular,":[198],"male-specific":[201],"reflect":[207],"age-":[209],"sex-specific":[211],"regulation":[212],"homeostasis":[215],"learning.":[218],"Furthermore,":[219],"lack":[221],"phenotype,":[225],"anatomical":[227],"alterations":[228],"peripubertal":[230],"suggests":[233],"analysis":[235],"certain":[237],"neuroanatomical":[238],"features":[239],"at":[240],"puberty":[241],"predict":[243],"neurobehavioral":[244],"adulthood.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}