{"id":"https://openalex.org/W2060469293","doi":"https://doi.org/10.1002/bies.950190408","title":"Cyclins, cyclin\u2010dependent kinases and differentiation","display_name":"Cyclins, cyclin\u2010dependent kinases and differentiation","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W2060469293","doi":"https://doi.org/10.1002/bies.950190408","mag":"2060469293","pmid":"https://pubmed.ncbi.nlm.nih.gov/9136628"},"language":"en","primary_location":{"id":"doi:10.1002/bies.950190408","doi":"https://doi.org/10.1002/bies.950190408","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bies.950190408","pdf_url":null,"source":{"id":"https://openalex.org/S27819959","display_name":"BioEssays","issn_l":"0265-9247","issn":["0265-9247","1521-1878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089309011","display_name":"Chun Gao","orcid":"https://orcid.org/0000-0003-3477-5886","observed_orcids":["https://orcid.org/0000-0003-3477-5886"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chun Y. Gao","raw_affiliation_strings":["Laboratory of Molecular and Developmental Biology, National Eye Institute, NIH, Bethesda, MD 20892-2730, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Developmental Biology, National Eye Institute, NIH, Bethesda, MD 20892-2730, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108453115","display_name":"Peggy S. Zelenka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peggy S. Zelenka","raw_affiliation_strings":["Laboratory of Molecular and Developmental Biology, National Eye Institute, NIH, Bethesda, MD 20892-2730, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Developmental Biology, National Eye Institute, NIH, Bethesda, MD 20892-2730, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108453115"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":1.8333,"has_fulltext":false,"cited_by_count":140,"citation_normalized_percentile":{"value":0.8913649,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"19","issue":"4","first_page":"307","last_page":"315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclins","display_name":"cyclins","score":0.996999979019165},{"id":"https://openalex.org/keywords/cyclin-dependent-kinases","display_name":"cyclin-dependent kinases","score":1.0},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/kinase-independent-function","display_name":"kinase-independent function","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.7823761701583862},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7218366265296936},{"id":"https://openalex.org/C16438837","wikidata":"https://www.wikidata.org/wiki/Q5198260","display_name":"Cyclin A","level":5,"score":0.666723370552063},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.629396915435791},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6036760807037354},{"id":"https://openalex.org/C11882975","wikidata":"https://www.wikidata.org/wiki/Q24781041","display_name":"Cyclin D","level":5,"score":0.5673648118972778},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5268358588218689},{"id":"https://openalex.org/C28179978","wikidata":"https://www.wikidata.org/wiki/Q5198263","display_name":"Cyclin A2","level":5,"score":0.5230706334114075},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5051606297492981},{"id":"https://openalex.org/C94561458","wikidata":"https://www.wikidata.org/wiki/Q24724860","display_name":"Cyclin E","level":5,"score":0.42260074615478516},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.17825102806091309},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.17516225576400757},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16292396187782288},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.12668120861053467}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/bies.950190408","doi":"https://doi.org/10.1002/bies.950190408","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bies.950190408","pdf_url":null,"source":{"id":"https://openalex.org/S27819959","display_name":"BioEssays","issn_l":"0265-9247","issn":["0265-9247","1521-1878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays","raw_type":"journal-article"},{"id":"pmid:9136628","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9136628","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays : news and reviews in molecular, cellular and developmental biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W14542710","https://openalex.org/W75583122","https://openalex.org/W134790102","https://openalex.org/W140919178","https://openalex.org/W1245662471","https://openalex.org/W1501914448","https://openalex.org/W1536451770","https://openalex.org/W1571117507","https://openalex.org/W1578955626","https://openalex.org/W1616778816","https://openalex.org/W1785240290","https://openalex.org/W1880994255","https://openalex.org/W1928725833","https://openalex.org/W1964317501","https://openalex.org/W1967148378","https://openalex.org/W1967341367","https://openalex.org/W1967624789","https://openalex.org/W1967724361","https://openalex.org/W1969692213","https://openalex.org/W1972132222","https://openalex.org/W1985625969","https://openalex.org/W1989198741","https://openalex.org/W1996741456","https://openalex.org/W1999158509","https://openalex.org/W1999250917","https://openalex.org/W1999330214","https://openalex.org/W2000157312","https://openalex.org/W2005222967","https://openalex.org/W2008903147","https://openalex.org/W2009810944","https://openalex.org/W2012293213","https://openalex.org/W2017091696","https://openalex.org/W2018537155","https://openalex.org/W2019166987","https://openalex.org/W2020314983","https://openalex.org/W2021528704","https://openalex.org/W2021958350","https://openalex.org/W2022502588","https://openalex.org/W2028312132","https://openalex.org/W2028571471","https://openalex.org/W2047235280","https://openalex.org/W2047953965","https://openalex.org/W2048646985","https://openalex.org/W2048672429","https://openalex.org/W2052651806","https://openalex.org/W2053648381","https://openalex.org/W2055085859","https://openalex.org/W2061369072","https://openalex.org/W2061479669","https://openalex.org/W2065797900","https://openalex.org/W2075280050","https://openalex.org/W2085721192","https://openalex.org/W2086082161","https://openalex.org/W2094138646","https://openalex.org/W2123995833","https://openalex.org/W2131503165","https://openalex.org/W2132503351","https://openalex.org/W2162741492","https://openalex.org/W2166300250","https://openalex.org/W2169295539","https://openalex.org/W2170542245","https://openalex.org/W2170793285","https://openalex.org/W2171386133","https://openalex.org/W2184302823","https://openalex.org/W2221759958","https://openalex.org/W2403898849","https://openalex.org/W2406153885","https://openalex.org/W2409639617","https://openalex.org/W2411812181","https://openalex.org/W2432798315","https://openalex.org/W4246253484"],"related_works":["https://openalex.org/W7096749095","https://openalex.org/W2142872328","https://openalex.org/W3134560106","https://openalex.org/W2330968055","https://openalex.org/W7096220149","https://openalex.org/W4239094609","https://openalex.org/W2036853065","https://openalex.org/W2039175174","https://openalex.org/W2041003951","https://openalex.org/W7023901284"],"abstract_inverted_index":{"Cyclin-dependent":[0],"kinases":[1,38],"and":[2,36,42],"their":[3],"regulatory":[4],"subunits,":[5],"the":[6,14,31,44],"cyclins,":[7],"are":[8,21,54],"known":[9],"to":[10],"regulate":[11],"progression":[12],"through":[13],"cell":[15,57],"cycle.":[16],"Yet":[17],"these":[18,47],"same":[19],"proteins":[20,48],"often":[22],"expressed":[23],"in":[24,39],"non-cycling,":[25],"differentiated":[26,40],"cells.":[27],"This":[28],"review":[29],"surveys":[30],"available":[32],"information":[33],"about":[34],"cyclins":[35],"cyclin-dependent":[37],"cells":[41],"explores":[43],"possibility":[45],"that":[46,53],"may":[49],"have":[50],"important":[51],"functions":[52],"independent":[55],"of":[56],"cycle":[58],"regulation.":[59]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}