{"id":"https://openalex.org/W2060418372","doi":"https://doi.org/10.1111/j.1440-1827.1988.tb02282.x","title":"HISTO\u2010 and IMMUNOPATHOLOGIGAL FEATURES OF TERMINAL AIDS. An Autopsy Case of a Japanese Man with Neurological Signs as Initial Symptoms","display_name":"HISTO\u2010 and IMMUNOPATHOLOGIGAL FEATURES OF TERMINAL AIDS. An Autopsy Case of a Japanese Man with Neurological Signs as Initial Symptoms","publication_year":1988,"publication_date":"1988-10-01","ids":{"openalex":"https://openalex.org/W2060418372","doi":"https://doi.org/10.1111/j.1440-1827.1988.tb02282.x","mag":"2060418372","pmid":"https://pubmed.ncbi.nlm.nih.gov/3218510"},"language":"en","primary_location":{"id":"doi:10.1111/j.1440-1827.1988.tb02282.x","doi":"https://doi.org/10.1111/j.1440-1827.1988.tb02282.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1827.1988.tb02282.x","pdf_url":null,"source":{"id":"https://openalex.org/S4390963336","display_name":"Acta Pathologica Japonica","issn_l":"0001-6632","issn":["0001-6632"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pathologica Japonica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088355556","display_name":"Haruhiko Miyayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Haruhiko Miyayama","raw_affiliation_strings":["Second Department of Pathology, Kumamoto University Medical School, Japan","Second Department of Pathology, Kumamoto University Medical School, Kumamoto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Pathology, Kumamoto University Medical School, Japan","institution_ids":["https://openalex.org/I96036126"]},{"raw_affiliation_string":"Second Department of Pathology, Kumamoto University Medical School, Kumamoto","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026409331","display_name":"Motohiro Takeya","orcid":"https://orcid.org/0000-0003-3694-1294","observed_orcids":["https://orcid.org/0000-0003-3694-1294"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motohiro Takeya","raw_affiliation_strings":["Second Department of Pathology, Kumamoto University Medical School, Kumamoto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Pathology, Kumamoto University Medical School, Kumamoto","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110046808","display_name":"Kiyoshi Takahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Takahashi","raw_affiliation_strings":["Second Department of Pathology, Kumamoto University Medical School, Kumamoto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Pathology, Kumamoto University Medical School, Kumamoto","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027809412","display_name":"Atushi Koito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atushi Koito","raw_affiliation_strings":["Second Department of Internal Medicine, Kumamoto University Medical School, Kumamoto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Kumamoto University Medical School, Kumamoto","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009650856","display_name":"Toshio Hattori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshio Hattori","raw_affiliation_strings":["Second Department of Internal Medicine, Kumamoto University Medical School, Kumamoto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Kumamoto University Medical School, Kumamoto","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110392962","display_name":"Kiyoshi Takatsuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Takatsuki","raw_affiliation_strings":["Second Department of Internal Medicine, Kumamoto University Medical School, Kumamoto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Kumamoto University Medical School, Kumamoto","institution_ids":["https://openalex.org/I96036126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088355556"],"corresponding_institution_ids":["https://openalex.org/I96036126"],"apc_list":null,"apc_paid":null,"fwci":0.1058,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.40598448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"10","first_page":"1313","last_page":"1327"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.7179999947547913},{"id":"https://openalex.org/keywords/opportunistic-infections","display_name":"opportunistic infections","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cytomegalovirus-infection","display_name":"cytomegalovirus infection","score":0.9769999980926514},{"id":"https://openalex.org/keywords/pneumocystis-jirovecii-pneumonia","display_name":"Pneumocystis carinii pneumonia","score":0.9810000061988831},{"id":"https://openalex.org/keywords/candidiasis","display_name":"candidiasis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/nontuberculous-mycobacterial-infection","display_name":"nontuberculous mycobacterial infection","score":0.9909999966621399},{"id":"https://openalex.org/keywords/dendritic-reticulum-cells","display_name":"dendritic reticulum cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mediastinal-lymph-nodes","display_name":"mediastinal lymph nodes","score":0.8560000061988831},{"id":"https://openalex.org/keywords/kaposi-sarcoma","display_name":"Kaposi's sarcoma","score":0.8299999833106995},{"id":"https://openalex.org/keywords/autopsy-findings","display_name":"autopsy findings","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.7303122282028198},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6883417963981628},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.6310786604881287},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.630314290523529},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.577208399772644},{"id":"https://openalex.org/C2993443204","wikidata":"https://www.wikidata.org/wiki/Q134478","display_name":"Pneumocystis carinii","level":4,"score":0.4757373332977295},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43790191411972046},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07605791091918945},{"id":"https://openalex.org/C2777559004","wikidata":"https://www.wikidata.org/wiki/Q134478","display_name":"Pneumocystis jirovecii","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009894","descriptor_name":"Opportunistic Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009894","descriptor_name":"Opportunistic Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1440-1827.1988.tb02282.x","doi":"https://doi.org/10.1111/j.1440-1827.1988.tb02282.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1827.1988.tb02282.x","pdf_url":null,"source":{"id":"https://openalex.org/S4390963336","display_name":"Acta Pathologica Japonica","issn_l":"0001-6632","issn":["0001-6632"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pathologica Japonica","raw_type":"journal-article"},{"id":"pmid:3218510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3218510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pathologica japonica","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W37528782","https://openalex.org/W74632471","https://openalex.org/W1529259838","https://openalex.org/W1555738835","https://openalex.org/W1974060304","https://openalex.org/W1974905296","https://openalex.org/W1976745468","https://openalex.org/W1977282539","https://openalex.org/W1979485830","https://openalex.org/W1991670386","https://openalex.org/W1992216122","https://openalex.org/W2010754922","https://openalex.org/W2033475307","https://openalex.org/W2042413287","https://openalex.org/W2042695720","https://openalex.org/W2042874111","https://openalex.org/W2046435330","https://openalex.org/W2090431802","https://openalex.org/W2110411605","https://openalex.org/W2131286622","https://openalex.org/W2137267461","https://openalex.org/W2149251500","https://openalex.org/W2157622324","https://openalex.org/W2169211575","https://openalex.org/W2171933443","https://openalex.org/W2334860476","https://openalex.org/W2334923455","https://openalex.org/W2336576432","https://openalex.org/W2396700132","https://openalex.org/W2397202651","https://openalex.org/W2410444912","https://openalex.org/W2440541237","https://openalex.org/W2727802646"],"related_works":["https://openalex.org/W2042874111","https://openalex.org/W4302064910","https://openalex.org/W2253230198","https://openalex.org/W1529259838","https://openalex.org/W2004991454","https://openalex.org/W2039083031","https://openalex.org/W2283573281","https://openalex.org/W2028479382","https://openalex.org/W2288528766","https://openalex.org/W2010754922"],"abstract_inverted_index":{"An":[0],"autopsy":[1],"case":[2,30],"of":[3,18,25,37,54,141,155],"a":[4,51,79],"37-year-old":[5],"Japanese":[6],"man,":[7],"confirmed":[8],"as":[9],"an":[10,15],"AIDS":[11,27],"patient":[12,35],"infected":[13],"by":[14],"undetermined":[16],"route":[17],"transmission,":[19],"is":[20],"presented.":[21],"The":[22,44],"initial":[23],"symptoms":[24],"full-blown":[26],"in":[28,62,89,100,118,127,137],"this":[29,146],"were":[31,50,87],"neurological,":[32],"and":[33,47,58,68,104,121,124],"the":[34,63,90,119,128,138],"died":[36],"severe":[38,103],"pneumonia":[39],"9":[40],"months":[41],"after":[42],"onset.":[43],"main":[45],"histo-":[46],"immunopathological":[48],"features":[49],"marked":[52],"depletion":[53],"helper-inducer":[55],"T":[56],"cells":[57,61],"dendritic":[59],"reticulum":[60],"lymphoid":[64],"tissues,":[65],"opportunistic":[66,98],"infections,":[67],"some":[69,142],"neuropathologic":[70],"changes.":[71],"Very":[72],"few":[73],"cells,":[74],"possibly":[75],"macrophages,":[76],"immunoreactive":[77],"with":[78,153],"monoclonal":[80],"antibody":[81],"(VAK-5)":[82],"against":[83],"HIV-gag":[84],"protein":[85],"P24":[86],"found":[88,136],"mediastinal":[91],"lymph":[92,131,143],"nodes.":[93,132],"Numerous":[94],"pathogens":[95],"had":[96],"induced":[97],"infections":[99],"many":[101],"organs:":[102],"generalized":[105],"cytomegalovirus":[106],"infection,":[107],"Pneumocystis":[108],"carinii":[109],"pneumonia,":[110],"bronchopneumonia":[111],"(possibly":[112],"due":[113],"to":[114],"Pseudomonas":[115],"aeruginosa),":[116],"candidiasis":[117],"tongue":[120],"oral":[122],"cavity,":[123],"atypical":[125],"mycobacteriosis":[126],"pulmonic":[129],"hilar":[130],"Vascular":[133],"proliferation":[134,151],"was":[135,147],"perinodal":[139],"regions":[140],"nodes,":[144],"but":[145],"not":[148],"neoplastic":[149],"vascular":[150],"compatible":[152],"that":[154],"localized":[156],"Kaposi's":[157],"sarcoma.":[158]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
