{"id":"https://openalex.org/W2060406376","doi":"https://doi.org/10.1054/tube.2001.0317","title":"Decreased IFN- \u03b3 and increased IL-4 production by human CD8+ T cells in response toMycobacterium tuberculosis in tuberculosis patients","display_name":"Decreased IFN- \u03b3 and increased IL-4 production by human CD8+ T cells in response toMycobacterium tuberculosis in tuberculosis patients","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W2060406376","doi":"https://doi.org/10.1054/tube.2001.0317","mag":"2060406376","pmid":"https://pubmed.ncbi.nlm.nih.gov/11914057"},"language":"en","primary_location":{"id":"doi:10.1054/tube.2001.0317","doi":"https://doi.org/10.1054/tube.2001.0317","is_oa":false,"landing_page_url":"https://doi.org/10.1054/tube.2001.0317","pdf_url":null,"source":{"id":"https://openalex.org/S29633479","display_name":"Tuberculosis","issn_l":"1472-9792","issn":["1472-9792","1873-281X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tuberculosis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S.M. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S.M. Smith","raw_affiliation_strings":["Immunology Unit, London School of Hygiene & Tropical Medicine, UK","Immunology Unit, London School of Hygiene and Tropical Medicine, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Unit, London School of Hygiene & Tropical Medicine, UK","institution_ids":["https://openalex.org/I4210089966"]},{"raw_affiliation_string":"Immunology Unit, London School of Hygiene and Tropical Medicine, London, UK","institution_ids":["https://openalex.org/I4210089966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103412499","display_name":"Mich\u00e8l R. Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M.R. Klein","raw_affiliation_strings":["Tuberculosis Research Programme, MRC Laboratories, Fajara, The Gambia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tuberculosis Research Programme, MRC Laboratories, Fajara, The Gambia","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108435573","display_name":"Adam S. Malin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A.S. Malin","raw_affiliation_strings":["Immunology Unit, London School of Hygiene & Tropical Medicine, London, UK","Immunology Unit, London School of Hygiene and Tropical Medicine, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Unit, London School of Hygiene & Tropical Medicine, London, UK","institution_ids":["https://openalex.org/I4210089966"]},{"raw_affiliation_string":"Immunology Unit, London School of Hygiene and Tropical Medicine, London, UK","institution_ids":["https://openalex.org/I4210089966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111987339","display_name":"Jainaba Sillah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Sillah","raw_affiliation_strings":["Tuberculosis Research Programme, MRC Laboratories, Fajara, The Gambia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tuberculosis Research Programme, MRC Laboratories, Fajara, The Gambia","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108225125","display_name":"K. P. W. J. Mcadam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K.P.W.J. McAdam","raw_affiliation_strings":["Tuberculosis Research Programme, MRC Laboratories, Fajara, The Gambia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tuberculosis Research Programme, MRC Laboratories, Fajara, The Gambia","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089522455","display_name":"Hazel M. Dockrell","orcid":"https://orcid.org/0000-0003-1869-9107","observed_orcids":["https://orcid.org/0000-0003-1869-9107"]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H.M. Dockrell","raw_affiliation_strings":["Immunology Unit, London School of Hygiene & Tropical Medicine, London, UK","Immunology Unit, London School of Hygiene and Tropical Medicine, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Unit, London School of Hygiene & Tropical Medicine, London, UK","institution_ids":["https://openalex.org/I4210089966"]},{"raw_affiliation_string":"Immunology Unit, London School of Hygiene and Tropical Medicine, London, UK","institution_ids":["https://openalex.org/I4210089966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":null,"fwci":3.1152,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.91483769,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"82","issue":"1","first_page":"7","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9599999785423279},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7820000052452087},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/mhc-class-i-restricted-t-cells","display_name":"MHC class I-restricted T cells","score":0.7419999837875366},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mycobacterium-bovis-bcg","display_name":"Mycobacterium bovis BCG","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pulmonary-tuberculosis","display_name":"pulmonary tuberculosis","score":0.6019999980926514},{"id":"https://openalex.org/keywords/disease-markers","display_name":"disease markers","score":0.3889999985694885},{"id":"https://openalex.org/keywords/gambia","display_name":"Gambia","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.7863221764564514},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7289682626724243},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6939296722412109},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6596148014068604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5120261311531067},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4996802806854248},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4712018668651581},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.46959128975868225},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41409504413604736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3234909176826477},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12544989585876465},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11116626858711243},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1054/tube.2001.0317","doi":"https://doi.org/10.1054/tube.2001.0317","is_oa":false,"landing_page_url":"https://doi.org/10.1054/tube.2001.0317","pdf_url":null,"source":{"id":"https://openalex.org/S29633479","display_name":"Tuberculosis","issn_l":"1472-9792","issn":["1472-9792","1873-281X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tuberculosis","raw_type":"journal-article"},{"id":"pmid:11914057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11914057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tuberculosis (Edinburgh, Scotland)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1494918516","https://openalex.org/W1521353535","https://openalex.org/W1552622113","https://openalex.org/W1819607739","https://openalex.org/W1877277475","https://openalex.org/W1898764189","https://openalex.org/W1915893748","https://openalex.org/W1924972785","https://openalex.org/W1966333025","https://openalex.org/W2008209529","https://openalex.org/W2016336432","https://openalex.org/W2063696360","https://openalex.org/W2065704868","https://openalex.org/W2082386765","https://openalex.org/W2086281370","https://openalex.org/W2104904969","https://openalex.org/W2105101886","https://openalex.org/W2106462617","https://openalex.org/W2108811173","https://openalex.org/W2111354206","https://openalex.org/W2130873748","https://openalex.org/W2136447805","https://openalex.org/W2141507915","https://openalex.org/W2146614103","https://openalex.org/W2148234810","https://openalex.org/W2149349606","https://openalex.org/W2151825158","https://openalex.org/W2152776307","https://openalex.org/W2157157664","https://openalex.org/W2158035277","https://openalex.org/W2161415222","https://openalex.org/W2163895833","https://openalex.org/W2325215003","https://openalex.org/W2338591221","https://openalex.org/W2418150095","https://openalex.org/W3154196951","https://openalex.org/W4313347805","https://openalex.org/W6629765204"],"related_works":["https://openalex.org/W2120813027","https://openalex.org/W2125774942","https://openalex.org/W1742089665","https://openalex.org/W2105101886","https://openalex.org/W2146614103","https://openalex.org/W1819607739","https://openalex.org/W2339210422","https://openalex.org/W1991070292","https://openalex.org/W2115846220","https://openalex.org/W2147495461"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}