{"id":"https://openalex.org/W2060347472","doi":"https://doi.org/10.1371/journal.pone.0112541","title":"Correlations of Differentially Expressed Gap Junction Connexins Cx26, Cx30, Cx32, Cx43 and Cx46 with Breast Cancer Progression and Prognosis","display_name":"Correlations of Differentially Expressed Gap Junction Connexins Cx26, Cx30, Cx32, Cx43 and Cx46 with Breast Cancer Progression and Prognosis","publication_year":2014,"publication_date":"2014-11-10","ids":{"openalex":"https://openalex.org/W2060347472","doi":"https://doi.org/10.1371/journal.pone.0112541","mag":"2060347472","pmid":"https://pubmed.ncbi.nlm.nih.gov/25383624"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0112541","doi":"https://doi.org/10.1371/journal.pone.0112541","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0112541","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112541&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112541&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042838020","display_name":"Ivett Teleki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Ivett Teleki","raw_affiliation_strings":["1st Department of Pathology & Experimental Cancer Research, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Pathology & Experimental Cancer Research, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080901690","display_name":"Attila Marcell Sz\u00e1sz","orcid":"https://orcid.org/0000-0003-2739-4196","observed_orcids":["https://orcid.org/0000-0003-2739-4196"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Attila Marcell Szasz","raw_affiliation_strings":["2nd Department of Pathology, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Pathology, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008029296","display_name":"Mate Elod Maros","orcid":"https://orcid.org/0000-0002-1589-8699","observed_orcids":["https://orcid.org/0000-0002-1589-8699"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Mate Elod Maros","raw_affiliation_strings":["1st Department of Pathology & Experimental Cancer Research, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Pathology & Experimental Cancer Research, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023340072","display_name":"Bal\u00e1zs Gy\u0151rffy","orcid":"https://orcid.org/0000-0002-5772-3766","observed_orcids":["https://orcid.org/0000-0002-5772-3766"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Balazs Gyorffy","raw_affiliation_strings":["MTA TTK Lendulet Cancer Biomarker Research Group, Budapest, Hungary; 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary; MTA-SE Pediatrics and Nephrology Research Group, Budapest, Hungary","2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary","MTA TTK Lendulet Cancer Biomarker Research Group, Budapest, Hungary","MTA-SE Pediatrics and Nephrology Research Group, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MTA TTK Lendulet Cancer Biomarker Research Group, Budapest, Hungary; 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary; MTA-SE Pediatrics and Nephrology Research Group, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996","https://openalex.org/I80251312"]},{"raw_affiliation_string":"2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]},{"raw_affiliation_string":"MTA TTK Lendulet Cancer Biomarker Research Group, Budapest, Hungary","institution_ids":["https://openalex.org/I7597260","https://openalex.org/I80251312"]},{"raw_affiliation_string":"MTA-SE Pediatrics and Nephrology Research Group, Budapest, Hungary","institution_ids":["https://openalex.org/I7597260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039788677","display_name":"Janina Kulka","orcid":"https://orcid.org/0000-0001-8884-8337","observed_orcids":["https://orcid.org/0000-0001-8884-8337"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Janina Kulka","raw_affiliation_strings":["2nd Department of Pathology, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Pathology, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053258528","display_name":"N\u00f3ra Meggyesh\u00e1zi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Nora Meggyeshazi","raw_affiliation_strings":["1st Department of Pathology & Experimental Cancer Research, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Pathology & Experimental Cancer Research, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085566093","display_name":"Gerg\u0151 Kiszner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Gergo Kiszner","raw_affiliation_strings":["1st Department of Pathology & Experimental Cancer Research, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Pathology & Experimental Cancer Research, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019407930","display_name":"P\u00e9ter Balla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Peter Balla","raw_affiliation_strings":["1st Department of Pathology & Experimental Cancer Research, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Pathology & Experimental Cancer Research, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073584175","display_name":"Samu Aliz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Aliz Samu","raw_affiliation_strings":["1st Department of Pathology & Experimental Cancer Research, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Pathology & Experimental Cancer Research, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054757986","display_name":"Tibor Kren\u00e1cs","orcid":"https://orcid.org/0000-0001-9164-065X","observed_orcids":["https://orcid.org/0000-0001-9164-065X"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"Tibor Krenacs","raw_affiliation_strings":["1st Department of Pathology & Experimental Cancer Research, Semmelweis University, Budapest, Hungary; MTA-SE Tumor Progression Research Group, Budapest, Hungary","1st Department of Pathology & Experimental Cancer Research, Semmelweis University, Budapest, Hungary","MTA-SE Tumor Progression Research Group, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Pathology & Experimental Cancer Research, Semmelweis University, Budapest, Hungary; MTA-SE Tumor Progression Research Group, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996","https://openalex.org/I7597260"]},{"raw_affiliation_string":"1st Department of Pathology & Experimental Cancer Research, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]},{"raw_affiliation_string":"MTA-SE Tumor Progression Research Group, Budapest, Hungary","institution_ids":["https://openalex.org/I7597260"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054757986"],"corresponding_institution_ids":["https://openalex.org/I101202996","https://openalex.org/I7597260"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.5655,"has_fulltext":true,"cited_by_count":91,"citation_normalized_percentile":{"value":0.90242944,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"9","issue":"11","first_page":"e112541","last_page":"e112541"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/connexins","display_name":"connexins","score":0.8690000176429749},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7200000286102295},{"id":"https://openalex.org/keywords/connexin-43","display_name":"connexin 43","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cx30","display_name":"Cx30","score":0.9929999709129333},{"id":"https://openalex.org/keywords/connexin-26","display_name":"connexin 26","score":0.9279999732971191},{"id":"https://openalex.org/keywords/connexin-32","display_name":"connexin 32","score":0.9589999914169312},{"id":"https://openalex.org/keywords/gja3","display_name":"GJA3","score":0.8709999918937683},{"id":"https://openalex.org/keywords/gjb2","display_name":"GJB2","score":0.9610000252723694},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8420000076293945},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.968999981880188},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.7919999957084656},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.996999979019165},{"id":"https://openalex.org/keywords/gap-junction-channels","display_name":"gap junction channels","score":0.6269999742507935},{"id":"https://openalex.org/keywords/mammary-carcinogenesis","display_name":"mammary carcinogenesis","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2780228694","wikidata":"https://www.wikidata.org/wiki/Q423489","display_name":"Connexin","level":4,"score":0.8573367595672607},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.7881454229354858},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5827157497406006},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47054392099380493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4117122292518616},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4091774523258209},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33952856063842773},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33268338441848755},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1531417965888977},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072259","descriptor_name":"Connexin 26","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072259","descriptor_name":"Connexin 26","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072259","descriptor_name":"Connexin 26","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072259","descriptor_name":"Connexin 26","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075302","descriptor_name":"Connexin 30","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075302","descriptor_name":"Connexin 30","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075302","descriptor_name":"Connexin 30","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075302","descriptor_name":"Connexin 30","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097002","descriptor_name":"Gap Junction beta-1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097002","descriptor_name":"Gap Junction beta-1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097002","descriptor_name":"Gap Junction beta-1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097002","descriptor_name":"Gap Junction beta-1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018031","descriptor_name":"Connexin 43","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018031","descriptor_name":"Connexin 43","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018031","descriptor_name":"Connexin 43","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018031","descriptor_name":"Connexin 43","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018031","descriptor_name":"Connexin 43","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018031","descriptor_name":"Connexin 43","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018031","descriptor_name":"Connexin 43","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018031","descriptor_name":"Connexin 43","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0112541","doi":"https://doi.org/10.1371/journal.pone.0112541","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0112541","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112541&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:25383624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25383624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:real.mtak.hu:21439","doi":null,"is_oa":false,"landing_page_url":"http://real.mtak.hu/21439/1/Teleki-PlosOne.pdf","pdf_url":"http://real.mtak.hu/21439/1/Teleki-PlosOne.pdf","source":{"id":"https://openalex.org/S4306400081","display_name":"Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210140733","host_organization_name":"Library and Information Centre of the Hungarian Academy of Sciences","host_organization_lineage":["https://openalex.org/I4210140733"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:3199010","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4226536","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4226536","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4226536","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:200043035d4e458c95765e37b27e1e6f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/200043035d4e458c95765e37b27e1e6f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 11, p e112541 (2014)","raw_type":"article"},{"id":"pmh:oai:repo.lib.semmelweis.hu:123456789/1286","doi":null,"is_oa":false,"landing_page_url":"http://repo.lib.semmelweis.hu//handle/123456789/1286","pdf_url":null,"source":{"id":"https://openalex.org/S4306402199","display_name":"Semmelweis University Repository (Semmelweis University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I101202996","host_organization_name":"Semmelweis University","host_organization_lineage":["https://openalex.org/I101202996"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0112541","doi":"https://doi.org/10.1371/journal.pone.0112541","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0112541","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112541&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6000000238418579,"id":"https://metadata.un.org/sdg/1","display_name":"No poverty"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2122184555","display_name":null,"funder_award_id":"-2012-0001","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2276364982","display_name":null,"funder_award_id":"A/2-11-1-2012-0001","funder_id":"https://openalex.org/F4320321994","funder_display_name":"Hungarian Scientific Research Fund"},{"id":"https://openalex.org/G2309511876","display_name":null,"funder_award_id":"K 108655","funder_id":"https://openalex.org/F4320321994","funder_display_name":"Hungarian Scientific Research Fund"},{"id":"https://openalex.org/G2311459128","display_name":null,"funder_award_id":"A/2\u201311/1-2012-0001","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G3326222259","display_name":null,"funder_award_id":"A/2-11-1-2012-0001","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5106337722","display_name":null,"funder_award_id":"-2012-0001","funder_id":"https://openalex.org/F4320322192","funder_display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia"},{"id":"https://openalex.org/G5453020616","display_name":null,"funder_award_id":"4.2.4.A/2-11-1-2012-0001","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6978788099","display_name":null,"funder_award_id":"-2012-0001","funder_id":"https://openalex.org/F4320321994","funder_display_name":"Hungarian Scientific Research Fund"},{"id":"https://openalex.org/G70412324","display_name":null,"funder_award_id":"4.2.4.A/2-11-1-2012-0001","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G7648729802","display_name":null,"funder_award_id":"A/2-11-1-2012-0001","funder_id":"https://openalex.org/F4320322192","funder_display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia"},{"id":"https://openalex.org/G945463265","display_name":null,"funder_award_id":"-2012-0001","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321994","display_name":"Hungarian Scientific Research Fund","ror":"https://ror.org/00v349e63"},{"id":"https://openalex.org/F4320322192","display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","ror":"https://ror.org/02ks8qq67"},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2060347472.pdf","grobid_xml":"https://content.openalex.org/works/W2060347472.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W1703705190","https://openalex.org/W1941282326","https://openalex.org/W1964586143","https://openalex.org/W1969806380","https://openalex.org/W1971911970","https://openalex.org/W1973180811","https://openalex.org/W1975666468","https://openalex.org/W1977248675","https://openalex.org/W1981940030","https://openalex.org/W1982118505","https://openalex.org/W1982937883","https://openalex.org/W1987594610","https://openalex.org/W1992547890","https://openalex.org/W1997406039","https://openalex.org/W2003217138","https://openalex.org/W2004781536","https://openalex.org/W2005307774","https://openalex.org/W2005895632","https://openalex.org/W2008588133","https://openalex.org/W2011859836","https://openalex.org/W2013109332","https://openalex.org/W2013147142","https://openalex.org/W2014222083","https://openalex.org/W2020015129","https://openalex.org/W2023454558","https://openalex.org/W2027049042","https://openalex.org/W2028909681","https://openalex.org/W2039606117","https://openalex.org/W2051152724","https://openalex.org/W2051367002","https://openalex.org/W2052103975","https://openalex.org/W2052340847","https://openalex.org/W2053385718","https://openalex.org/W2058622049","https://openalex.org/W2063650806","https://openalex.org/W2063804661","https://openalex.org/W2065738044","https://openalex.org/W2068023769","https://openalex.org/W2072377248","https://openalex.org/W2075007700","https://openalex.org/W2076275590","https://openalex.org/W2080702640","https://openalex.org/W2081886885","https://openalex.org/W2084527887","https://openalex.org/W2084828724","https://openalex.org/W2085934079","https://openalex.org/W2086117273","https://openalex.org/W2092312267","https://openalex.org/W2092853998","https://openalex.org/W2093491816","https://openalex.org/W2096743863","https://openalex.org/W2099257018","https://openalex.org/W2099406205","https://openalex.org/W2102672852","https://openalex.org/W2106292881","https://openalex.org/W2106787323","https://openalex.org/W2108739220","https://openalex.org/W2108923445","https://openalex.org/W2112953993","https://openalex.org/W2112979829","https://openalex.org/W2118450542","https://openalex.org/W2119625199","https://openalex.org/W2143017330","https://openalex.org/W2154307972","https://openalex.org/W2157162039","https://openalex.org/W2157383773","https://openalex.org/W2161426850","https://openalex.org/W2169384011","https://openalex.org/W2224697703","https://openalex.org/W2326037330","https://openalex.org/W4211091257","https://openalex.org/W4304079780"],"related_works":["https://openalex.org/W2050127546","https://openalex.org/W1744239203","https://openalex.org/W4324132893","https://openalex.org/W2078261885","https://openalex.org/W2374420015","https://openalex.org/W2979548918","https://openalex.org/W1996470658","https://openalex.org/W2048275409","https://openalex.org/W2040850663","https://openalex.org/W90909017"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,47],"AIMS:":[2],"Connexins":[3],"and":[4,16,22,40,57,64,93,105,111,116,125,133,143,154,211,233,250,269,280,287],"their":[5,23,147],"cell":[6,14],"membrane":[7],"channels":[8],"contribute":[9],"to":[10,27,33],"the":[11,62,77,108,129,160,171,242],"control":[12],"of":[13,50,55,83,122,244,278,297],"proliferation":[15],"compartmental":[17],"functions":[18],"in":[19,42,80,102,114,138],"breast":[20,28,44,59,144,187,298],"glands":[21,142],"deregulation":[24],"is":[25],"linked":[26,183],"carcinogenesis.":[29],"Our":[30],"aim":[31],"was":[32,69,135],"correlate":[34],"connexin":[35,51],"expression":[36,53,121,277],"with":[37,170,184,216],"tumor":[38,89],"progression":[39],"prognosis":[41],"primary":[43],"cancers.":[45,299],"MATERIALS":[46],"METHODS:":[48],"Meta-analysis":[49],"isotype":[52],"data":[54],"1809":[56],"1899":[58],"cancers":[60],"from":[61],"Affymetrix":[63],"Illumina":[65],"array":[66,161],"platforms,":[67],"respectively,":[68,291],"performed.":[70],"Expressed":[71],"connexins":[72,150],"were":[73,100,182,214],"also":[74],"monitored":[75],"at":[76,175],"protein":[78,180,192,212,223,239],"level":[79],"tissue":[81],"microarrays":[82],"127":[84],"patients":[85,266],"equally":[86],"representing":[87],"all":[88],"grades,":[90],"using":[91,107],"immunofluorescence":[92],"multilayer,":[94],"multichannel":[95],"digital":[96],"microscopy.":[97],"Prognostic":[98],"correlations":[99,173],"plotted":[101],"Kaplan-Meier":[103],"curves":[104],"tested":[106],"log-rank":[109],"test":[110],"cox-regression":[112],"analysis":[113],"univariate":[115],"multivariate":[117],"models.":[118],"RESULTS:":[119],"The":[120],"GJA1/Cx43,":[123],"GJA3/Cx46":[124],"GJB2/Cx26":[126],"and,":[127],"for":[128,292],"first":[130],"time,":[131],"GJA6/Cx30":[132],"GJB1/Cx32":[134],"revealed":[136],"both":[137],"normal":[139],"human":[140],"mammary":[141],"carcinomas.":[145],"Within":[146],"subfamilies":[148],"these":[149],"can":[151],"form":[152],"homo-":[153],"heterocellular":[155],"epithelial":[156],"channels.":[157],"In":[158,168],"cancer,":[159],"datasets":[162],"cross-validated":[163],"each":[164],"other's":[165],"prognostic":[166,197,228,289],"results.":[167],"line":[169],"significant":[172],"found":[174],"mRNA":[176,210],"level,":[177],"elevated":[178,208,258],"Cx43":[179,191,238,279],"levels":[181,213,240,262],"significantly":[185],"improved":[186],"cancer":[188],"outcome,":[189],"offering":[190,221],"detection":[193,224],"as":[194,225,284],"an":[195,226],"independent":[196,227],"marker":[198,229],"stronger":[199],"than":[200],"vascular":[201],"invasion":[202],"or":[203],"necrosis.":[204,234],"As":[205],"a":[206,217,293],"contrary,":[207],"Cx30":[209,222,261,281],"associated":[215],"reduced":[218],"disease":[219],"outcome":[220],"outperforming":[230],"mitotic":[231],"index":[232],"Elevated":[235],"versus":[236,259],"low":[237,260],"allowed":[241],"stratification":[243,296],"grade":[245,264],"2":[246],"tumors":[247],"into":[248,267],"good":[249,270],"poor":[251,268],"relapse":[252],"free":[253],"survival":[254,272],"subgroups,":[255,273],"respectively.":[256,274],"Also,":[257],"stratified":[263],"3":[265],"overall":[271],"CONCLUSION:":[275],"Differential":[276],"may":[282],"serve":[283],"potential":[285],"positive":[286],"negative":[288],"markers,":[290],"clinically":[294],"relevant":[295]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}