{"id":"https://openalex.org/W2060197770","doi":"https://doi.org/10.1007/s00299-010-0995-5","title":"Plant-made vaccines in support of the Millennium Development Goals","display_name":"Plant-made vaccines in support of the Millennium Development Goals","publication_year":2011,"publication_date":"2011-01-17","ids":{"openalex":"https://openalex.org/W2060197770","doi":"https://doi.org/10.1007/s00299-010-0995-5","mag":"2060197770","pmid":"https://pubmed.ncbi.nlm.nih.gov/21243362","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3075396"},"language":"en","primary_location":{"id":"doi:10.1007/s00299-010-0995-5","doi":"https://doi.org/10.1007/s00299-010-0995-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00299-010-0995-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00299-010-0995-5.pdf","source":{"id":"https://openalex.org/S196783408","display_name":"Plant Cell Reports","issn_l":"0721-7714","issn":["0721-7714","1432-203X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Cell Reports","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00299-010-0995-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045529354","display_name":"Claire A. Penney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Claire A. Penney","raw_affiliation_strings":["Department of Biological Sciences, Monash University, Clayton, VIC, Australia. claire.penney@monash.edu","Department of Biological Sciences, Monash University, Clayton, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Monash University, Clayton, VIC, Australia. claire.penney@monash.edu","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Department of Biological Sciences, Monash University, Clayton, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019921720","display_name":"David Rhys Thomas","orcid":"https://orcid.org/0000-0002-6259-0881","observed_orcids":["https://orcid.org/0000-0002-6259-0881"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"David R. Thomas","raw_affiliation_strings":["Department of Biological Sciences, Monash University, Clayton, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Monash University, Clayton, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045744818","display_name":"Sadia S. Deen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Sadia S. Deen","raw_affiliation_strings":["Department of Biological Sciences, Monash University, Clayton, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Monash University, Clayton, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028062856","display_name":"Amanda Maree Walmsley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Amanda M. Walmsley","raw_affiliation_strings":["Department of Biological Sciences, Monash University, Clayton, Australia","Monash university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Monash University, Clayton, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Monash university","institution_ids":["https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019921720","https://openalex.org/A5028062856","https://openalex.org/A5045529354","https://openalex.org/A5045744818"],"corresponding_institution_ids":["https://openalex.org/I56590836"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":{"value":4590,"currency":"USD","value_usd":4590},"fwci":1.145,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.73684211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"30","issue":"5","first_page":"789","last_page":"798"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plant-based-vaccines","display_name":"plant-made vaccines","score":1.0},{"id":"https://openalex.org/keywords/plant-based-vaccine-production","display_name":"plant-based vaccine production","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cold-chain","display_name":"cold chain","score":0.625},{"id":"https://openalex.org/keywords/vaccine-production-cost","display_name":"vaccine production cost","score":0.5609999895095825},{"id":"https://openalex.org/keywords/developing-countries","display_name":"developing countries","score":0.546999990940094},{"id":"https://openalex.org/keywords/pandemic-preparedness","display_name":"pandemic preparedness","score":0.7860000133514404},{"id":"https://openalex.org/keywords/millennium-development-goals","display_name":"Millennium Development Goals","score":0.7979999780654907},{"id":"https://openalex.org/keywords/greenhouse-cultivation","display_name":"greenhouse cultivation","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6151027679443359},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.5323646068572998},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5301163196563721},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.5034584403038025},{"id":"https://openalex.org/C2779503283","wikidata":"https://www.wikidata.org/wiki/Q81737","display_name":"Millennium Development Goals","level":3,"score":0.4907604157924652},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.4907601773738861},{"id":"https://openalex.org/C2780114722","wikidata":"https://www.wikidata.org/wiki/Q592197","display_name":"Cold chain","level":2,"score":0.47347843647003174},{"id":"https://openalex.org/C83864248","wikidata":"https://www.wikidata.org/wiki/Q177323","display_name":"Developing country","level":2,"score":0.46562570333480835},{"id":"https://openalex.org/C118518473","wikidata":"https://www.wikidata.org/wiki/Q11451","display_name":"Agriculture","level":2,"score":0.4454590976238251},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.3851056694984436},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.37048202753067017},{"id":"https://openalex.org/C175605778","wikidata":"https://www.wikidata.org/wiki/Q3299701","display_name":"Natural resource economics","level":1,"score":0.3284696936607361},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.2901306748390198},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.18945783376693726},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1262345314025879},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10406020283699036},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.10335922241210938},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003140","descriptor_name":"Communicable Disease Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003906","descriptor_name":"Developing Countries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004356","descriptor_name":"Drug Storage","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004356","descriptor_name":"Drug Storage","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010944","descriptor_name":"Plants","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010944","descriptor_name":"Plants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013678","descriptor_name":"Technology, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013678","descriptor_name":"Technology, Pharmaceutical","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00299-010-0995-5","doi":"https://doi.org/10.1007/s00299-010-0995-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00299-010-0995-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00299-010-0995-5.pdf","source":{"id":"https://openalex.org/S196783408","display_name":"Plant Cell Reports","issn_l":"0721-7714","issn":["0721-7714","1432-203X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Cell Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3075396","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3075396","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Cell Rep","raw_type":"Text"},{"id":"pmid:21243362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21243362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/271495","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/271495","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s00299-010-0995-5","doi":"https://doi.org/10.1007/s00299-010-0995-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00299-010-0995-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00299-010-0995-5.pdf","source":{"id":"https://openalex.org/S196783408","display_name":"Plant Cell Reports","issn_l":"0721-7714","issn":["0721-7714","1432-203X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/2","score":0.6875,"display_name":"Zero hunger"},{"id":"https://metadata.un.org/sdg/9","score":0.5378999710083008,"display_name":"Industry, innovation and infrastructure"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2060197770.pdf","grobid_xml":"https://content.openalex.org/works/W2060197770.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W52189606","https://openalex.org/W1577852666","https://openalex.org/W1590397189","https://openalex.org/W1678067306","https://openalex.org/W1758536372","https://openalex.org/W1967993205","https://openalex.org/W1971308430","https://openalex.org/W1972526061","https://openalex.org/W1976039989","https://openalex.org/W1977294998","https://openalex.org/W1981540119","https://openalex.org/W1983514420","https://openalex.org/W1986845650","https://openalex.org/W1987496713","https://openalex.org/W1991504103","https://openalex.org/W1992757631","https://openalex.org/W1996786545","https://openalex.org/W1997328630","https://openalex.org/W1997968787","https://openalex.org/W1999615285","https://openalex.org/W2001018234","https://openalex.org/W2003126535","https://openalex.org/W2003275346","https://openalex.org/W2008472051","https://openalex.org/W2008779574","https://openalex.org/W2009087758","https://openalex.org/W2013574284","https://openalex.org/W2016541049","https://openalex.org/W2021142943","https://openalex.org/W2025104339","https://openalex.org/W2027807090","https://openalex.org/W2027876836","https://openalex.org/W2029164954","https://openalex.org/W2029765937","https://openalex.org/W2029793786","https://openalex.org/W2031865804","https://openalex.org/W2034550565","https://openalex.org/W2037739015","https://openalex.org/W2040004884","https://openalex.org/W2041652700","https://openalex.org/W2044099066","https://openalex.org/W2045641681","https://openalex.org/W2046739387","https://openalex.org/W2052690594","https://openalex.org/W2054770708","https://openalex.org/W2055802294","https://openalex.org/W2057652073","https://openalex.org/W2062391473","https://openalex.org/W2065035248","https://openalex.org/W2067319971","https://openalex.org/W2069501506","https://openalex.org/W2070627367","https://openalex.org/W2071657440","https://openalex.org/W2073406666","https://openalex.org/W2074886451","https://openalex.org/W2075515367","https://openalex.org/W2076067924","https://openalex.org/W2078716988","https://openalex.org/W2081550858","https://openalex.org/W2090338614","https://openalex.org/W2095139007","https://openalex.org/W2097043803","https://openalex.org/W2098425163","https://openalex.org/W2101357255","https://openalex.org/W2103351543","https://openalex.org/W2111359724","https://openalex.org/W2113014022","https://openalex.org/W2114409495","https://openalex.org/W2115975647","https://openalex.org/W2118552684","https://openalex.org/W2122096836","https://openalex.org/W2127890221","https://openalex.org/W2133723912","https://openalex.org/W2135916248","https://openalex.org/W2143986020","https://openalex.org/W2147782391","https://openalex.org/W2148995643","https://openalex.org/W2150946801","https://openalex.org/W2152159080","https://openalex.org/W2156801977","https://openalex.org/W2158310952","https://openalex.org/W2160608817","https://openalex.org/W2164321625","https://openalex.org/W2171936932","https://openalex.org/W2347134342","https://openalex.org/W2577240621","https://openalex.org/W4211164442","https://openalex.org/W4245792343"],"related_works":["https://openalex.org/W7100541750","https://openalex.org/W565250739","https://openalex.org/W2169978362","https://openalex.org/W2092688835","https://openalex.org/W2326073927","https://openalex.org/W2289129384","https://openalex.org/W2138917929","https://openalex.org/W4313216748","https://openalex.org/W1571660773","https://openalex.org/W1551374961"],"abstract_inverted_index":{"Vaccines":[0],"are":[1,30,74,149],"one":[2],"of":[3,10,21,110,124,130,138,170],"the":[4,11,19,33,48,54,108,121,125,128,155,168,171],"most":[5,75],"successful":[6],"public":[7],"health":[8],"achievements":[9],"last":[12],"century.":[13],"Systematic":[14],"immunisation":[15],"programs":[16],"have":[17],"reduced":[18],"burden":[20],"infectious":[22],"diseases":[23],"on":[24],"a":[25,86,117,150],"global":[26,164],"scale.":[27],"However,":[28],"there":[29],"limitations":[31],"to":[32,50,98,119,133,157],"current":[34],"technology,":[35],"which":[36],"often":[37,62],"requires":[38],"costly":[39],"infrastructure":[40],"and":[41,59,64,94,176],"long":[42],"lead":[43],"times":[44],"for":[45],"production.":[46],"Furthermore,":[47],"requirement":[49],"keep":[51],"vaccines":[52,73,80,114],"within":[53,101],"cold-chain":[55],"throughout":[56],"manufacture,":[57],"transport":[58],"storage":[60],"is":[61],"impractical":[63],"prohibitively":[65],"expensive":[66],"in":[67,145,162,167],"developing":[68,111],"countries-the":[69],"very":[70],"regions":[71],"where":[72],"needed.":[76],"In":[77],"contrast,":[78],"plant-made":[79],"(PMVs)":[81],"can":[82],"be":[83,99],"produced":[84],"at":[85,116],"lower":[87],"cost":[88],"using":[89],"basic":[90],"greenhouse":[91],"agricultural":[92],"methods,":[93],"do":[95],"not":[96],"need":[97],"kept":[100],"such":[102],"narrow":[103],"temperature":[104],"ranges.":[105],"This":[106],"increases":[107],"feasibility":[109],"countries":[112],"producing":[113],"locally":[115],"small-scale":[118],"target":[120],"specific":[122],"needs":[123],"region.":[126],"Additionally,":[127],"ability":[129],"plant-production":[131],"technologies":[132],"rapidly":[134],"produce":[135],"large":[136],"quantities":[137],"strain-specific":[139],"vaccine":[140],"demonstrates":[141],"their":[142],"potential":[143,156],"use":[144],"combating":[146],"pandemics.":[147],"PMVs":[148],"proven":[151],"technology":[152],"that":[153],"has":[154],"play":[158],"an":[159],"important":[160],"role":[161],"increasing":[163],"health,":[165],"both":[166],"context":[169],"2015":[172],"Millennium":[173],"Development":[174],"Goals":[175],"beyond.":[177]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
