{"id":"https://openalex.org/W2060179948","doi":"https://doi.org/10.1021/np0102253","title":"Isolation and Structure Determination of Obyanamide, a Novel Cytotoxic Cyclic Depsipeptide from the Marine Cyanobacterium Lyngbya confervoides","display_name":"Isolation and Structure Determination of Obyanamide, a Novel Cytotoxic Cyclic Depsipeptide from the Marine Cyanobacterium Lyngbya confervoides","publication_year":2001,"publication_date":"2001-12-21","ids":{"openalex":"https://openalex.org/W2060179948","doi":"https://doi.org/10.1021/np0102253","mag":"2060179948","pmid":"https://pubmed.ncbi.nlm.nih.gov/11809060"},"language":"en","primary_location":{"id":"doi:10.1021/np0102253","doi":"https://doi.org/10.1021/np0102253","is_oa":false,"landing_page_url":"https://doi.org/10.1021/np0102253","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047930678","display_name":"Philip G. Williams","orcid":"https://orcid.org/0000-0001-8987-0683","observed_orcids":["https://orcid.org/0000-0001-8987-0683"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I80276326","display_name":"University of Guam","ror":"https://ror.org/00376bg92","country_code":"GU","type":"education","lineage":["https://openalex.org/I80276326"]}],"countries":["GU","US"],"is_corresponding":false,"raw_author_name":"Philip G. Williams","raw_affiliation_strings":["Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, and University of Guam Marine Laboratory, UOG Station, Mangilao, Guam 96913"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, and University of Guam Marine Laboratory, UOG Station, Mangilao, Guam 96913","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I80276326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000957727","display_name":"Wesley Y. Yoshida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I80276326","display_name":"University of Guam","ror":"https://ror.org/00376bg92","country_code":"GU","type":"education","lineage":["https://openalex.org/I80276326"]}],"countries":["GU","US"],"is_corresponding":false,"raw_author_name":"Wesley Y. Yoshida","raw_affiliation_strings":["Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, and University of Guam Marine Laboratory, UOG Station, Mangilao, Guam 96913"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, and University of Guam Marine Laboratory, UOG Station, Mangilao, Guam 96913","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I80276326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107595054","display_name":"Richard E. Moore","orcid":"https://orcid.org/0000-0002-5328-9018","observed_orcids":["https://orcid.org/0000-0002-5328-9018"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I80276326","display_name":"University of Guam","ror":"https://ror.org/00376bg92","country_code":"GU","type":"education","lineage":["https://openalex.org/I80276326"]}],"countries":["GU","US"],"is_corresponding":true,"raw_author_name":"Richard E. Moore","raw_affiliation_strings":["Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, and University of Guam Marine Laboratory, UOG Station, Mangilao, Guam 96913"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, and University of Guam Marine Laboratory, UOG Station, Mangilao, Guam 96913","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I80276326"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016411275","display_name":"Valerie Jean Paul","orcid":"https://orcid.org/0000-0002-4691-1569","observed_orcids":["https://orcid.org/0000-0002-4691-1569"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I80276326","display_name":"University of Guam","ror":"https://ror.org/00376bg92","country_code":"GU","type":"education","lineage":["https://openalex.org/I80276326"]}],"countries":["GU","US"],"is_corresponding":true,"raw_author_name":"Valerie J. Paul","raw_affiliation_strings":["Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, and University of Guam Marine Laboratory, UOG Station, Mangilao, Guam 96913"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, and University of Guam Marine Laboratory, UOG Station, Mangilao, Guam 96913","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I80276326"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016411275","https://openalex.org/A5107595054"],"corresponding_institution_ids":["https://openalex.org/I117965899","https://openalex.org/I80276326"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.0712,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.77169756,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"65","issue":"1","first_page":"29","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclic-depsipeptides","display_name":"cyclic depsipeptides","score":0.9419999718666077},{"id":"https://openalex.org/keywords/marine-cyanobacteria","display_name":"marine cyanobacteria","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8379999995231628},{"id":"https://openalex.org/keywords/kb-cells","display_name":"KB cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/absolute-configuration","display_name":"absolute configuration","score":0.9700000286102295},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/saipan","display_name":"Saipan","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C168831097","wikidata":"https://www.wikidata.org/wiki/Q413248","display_name":"Depsipeptide","level":2,"score":0.9477545022964478},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.7097355723381042},{"id":"https://openalex.org/C2777403737","wikidata":"https://www.wikidata.org/wiki/Q310362","display_name":"Lyngbya","level":4,"score":0.6271931529045105},{"id":"https://openalex.org/C60984968","wikidata":"https://www.wikidata.org/wiki/Q389172","display_name":"Cyclic peptide","level":3,"score":0.6025114059448242},{"id":"https://openalex.org/C25170562","wikidata":"https://www.wikidata.org/wiki/Q2052053","display_name":"Absolute configuration","level":2,"score":0.4610634744167328},{"id":"https://openalex.org/C51724486","wikidata":"https://www.wikidata.org/wiki/Q908955","display_name":"Column chromatography","level":2,"score":0.4483022093772888},{"id":"https://openalex.org/C19549132","wikidata":"https://www.wikidata.org/wiki/Q11141463","display_name":"Two-dimensional nuclear magnetic resonance spectroscopy","level":2,"score":0.44554978609085083},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.4393312931060791},{"id":"https://openalex.org/C2779669040","wikidata":"https://www.wikidata.org/wiki/Q93315","display_name":"Cyanobacteria","level":3,"score":0.40414226055145264},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4038310945034027},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3846958875656128},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.31006956100463867},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.19257333874702454},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.1888139843940735},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.16211402416229248},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14343911409378052},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10849452018737793},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000458","descriptor_name":"Cyanobacteria","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002845","descriptor_name":"Chromatography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007624","descriptor_name":"KB Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008849","descriptor_name":"Micronesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047630","descriptor_name":"Depsipeptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/np0102253","doi":"https://doi.org/10.1021/np0102253","is_oa":false,"landing_page_url":"https://doi.org/10.1021/np0102253","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},{"id":"pmid:11809060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11809060","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of natural products","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G497553939","display_name":null,"funder_award_id":"CA-53001","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W171199456","https://openalex.org/W1997846715","https://openalex.org/W2019701027","https://openalex.org/W2068272229","https://openalex.org/W2074536661","https://openalex.org/W2089700127","https://openalex.org/W2949678003"],"related_works":["https://openalex.org/W43459599","https://openalex.org/W2580180420","https://openalex.org/W2079316190","https://openalex.org/W2039199489","https://openalex.org/W1978318726","https://openalex.org/W4400203643","https://openalex.org/W2095090147","https://openalex.org/W2092228221","https://openalex.org/W2511870781","https://openalex.org/W1986746504"],"abstract_inverted_index":{"Obyanamide":[0,57],"(1)":[1,58],"was":[2,41,59],"isolated":[3],"from":[4],"a":[5],"variety":[6],"of":[7,17,25,34,46,67],"the":[8,18,47],"marine":[9],"cyanobacterium":[10],"Lyngbya":[11],"confervoides":[12],"collected":[13],"in":[14],"Saipan,":[15],"Commonwealth":[16],"Northern":[19],"Mariana":[20],"Islands.":[21],"Gross":[22],"structure":[23],"elucidation":[24],"this":[26],"novel":[27],"cyclic":[28],"depsipeptide":[29],"relied":[30],"on":[31],"extensive":[32],"application":[33],"2D":[35],"NMR":[36],"techniques.":[37],"The":[38],"absolute":[39],"stereochemistry":[40],"deduced":[42],"by":[43],"chiral":[44],"chromatography":[45],"hydrolysis":[48],"products":[49],"and":[50,54],"comparison":[51],"with":[52,64],"authentic":[53],"synthetic":[55],"standards.":[56],"cytotoxic":[60],"against":[61],"KB":[62],"cells":[63],"an":[65],"IC(50)":[66],"0.58":[68],"microg/mL.":[69]},"counts_by_year":[{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}