{"id":"https://openalex.org/W2060168154","doi":"https://doi.org/10.1111/j.1755-3768.2013.2772.x","title":"The role of wound healing in cornea","display_name":"The role of wound healing in cornea","publication_year":2013,"publication_date":"2013-08-01","ids":{"openalex":"https://openalex.org/W2060168154","doi":"https://doi.org/10.1111/j.1755-3768.2013.2772.x","mag":"2060168154"},"language":"en","primary_location":{"id":"doi:10.1111/j.1755-3768.2013.2772.x","doi":"https://doi.org/10.1111/j.1755-3768.2013.2772.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1755-3768.2013.2772.x","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007551999","display_name":"Roger Wilmer Beuerman","orcid":"https://orcid.org/0000-0002-0725-9336","observed_orcids":["https://orcid.org/0000-0002-0725-9336"]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"R BEUERMAN","raw_affiliation_strings":["Department of Ophthalmology, Tampere","Singapore Eye Research Institute, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Tampere","institution_ids":[]},{"raw_affiliation_string":"Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007551999"],"corresponding_institution_ids":["https://openalex.org/I4210116917"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"91","issue":"s252","first_page":"0","last_page":"0"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corneal-fibrosis","display_name":"corneal fibrosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/corneal-wound-healing","display_name":"corneal wound healing","score":0.9020000100135803},{"id":"https://openalex.org/keywords/myofibroblast-transformation","display_name":"myofibroblast transformation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/keratocytes","display_name":"keratocytes","score":0.8999999761581421},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/moesin","display_name":"moesin","score":0.9639999866485596},{"id":"https://openalex.org/keywords/pseudomonas-infection","display_name":"Pseudomonas infection","score":0.8629999756813049},{"id":"https://openalex.org/keywords/corneal-injury","display_name":"corneal injury","score":0.7960000038146973},{"id":"https://openalex.org/keywords/topical-therapy","display_name":"topical treatment","score":0.6269999742507935},{"id":"https://openalex.org/keywords/corneal-blindness","display_name":"corneal blindness","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.8836913704872131},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.6362067461013794},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6268947124481201},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5482190847396851},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.5109926462173462},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5072343349456787},{"id":"https://openalex.org/C2780246058","wikidata":"https://www.wikidata.org/wiki/Q18032329","display_name":"Ezrin","level":4,"score":0.5053842067718506},{"id":"https://openalex.org/C2776292417","wikidata":"https://www.wikidata.org/wiki/Q18029442","display_name":"Moesin","level":5,"score":0.46575719118118286},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41587918996810913},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.3782583475112915},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33494052290916443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3218497633934021},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2819509208202362},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.23128360509872437},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.21507805585861206},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07406452298164368}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1111/j.1755-3768.2013.2772.x","doi":"https://doi.org/10.1111/j.1755-3768.2013.2772.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1755-3768.2013.2772.x","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1997953362","https://openalex.org/W2052798376","https://openalex.org/W2322368541","https://openalex.org/W2266483087","https://openalex.org/W4327520710","https://openalex.org/W2211480987","https://openalex.org/W2625985824","https://openalex.org/W4287377065","https://openalex.org/W2219429396","https://openalex.org/W3090920307"],"abstract_inverted_index":{"Abstract":[0],"Corneal":[1],"fibrosis":[2,60,88,160],"contributes":[3],"to":[4,10,68,76,156],"the":[5,23,38,40,46,62,65,107,121,137],"substantial":[6],"health":[7],"burden":[8],"due":[9],"\u201ccorneal":[11],"blindness\u201d,":[12],"a":[13,84,118,149],"leading":[14],"cause":[15],"of":[16,22,29,48,64,87,120,130],"blindness":[17],"world\u2010wide.":[18],"Molecular":[19],"intra\u2010cellular":[20],"regulators":[21,109],"cytoskeleton,":[24],"suggests":[25],"that":[26,110,136,151],"this":[27],"class":[28],"proteins":[30],"may":[31,72],"be":[32,153],"targets":[33],"for":[34,106],"therapeutic":[35],"development.":[36],"In":[37],"transformation":[39,70],"usually":[41],"quiet":[42],"fibroblast\u2010to\u2010a":[43],"myofibroblast":[44,69],"morphology,":[45],"expression":[47],"\u03b1\u2010smooth":[49],"muscle":[50],"actin":[51],"(SMA)":[52],"is":[53,61],"characteristic.":[54],"As":[55],"an":[56,104],"excessive":[57],"healing":[58],"response,":[59],"result":[63],"corneal":[66,162],"keratocyte":[67],"and":[71,94],"occur":[73],"in":[74],"response":[75],"trauma,":[77],"infection":[78,91],"as":[79,81,142],"well":[80],"surgery.":[82],"Using":[83],"mouse":[85],"model":[86],"following":[89],"both":[90],"with":[92],"Pseudomonas":[93],"by":[95,133],"trauma":[96],"(an":[97],"anterior":[98],"keratectomy)":[99],"it":[100],"was":[101,114,125],"shown":[102],"using":[103],"array":[105],"cytoskeletal":[108],"one":[111],"key":[112],"molecule":[113],"highly":[115,126],"unregulated.":[116,127],"Moesin":[117],"member":[119],"ERM":[122],"Complex":[123],"(ezrin/radixin/moesin)":[124],"The":[128,144],"use":[129],"siRNA":[131],"applied":[132,154],"iontophoresis":[134],"showed":[135],"molecules":[138],"characterizing":[139],"fibrosis,":[140],"such":[141],"alpha\u2010SMA.":[143],"clinical":[145],"development":[146],"focuses":[147],"on":[148],"method":[150],"can":[152],"topically":[155],"lessen":[157],"or":[158],"prevent":[159],"after":[161],"insult.":[163]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}