{"id":"https://openalex.org/W2060163289","doi":"https://doi.org/10.1016/j.molimm.2009.01.014","title":"Vav1 and PI3K are required for phagocytosis of \u03b2-glucan and subsequent superoxide generation by microglia","display_name":"Vav1 and PI3K are required for phagocytosis of \u03b2-glucan and subsequent superoxide generation by microglia","publication_year":2009,"publication_date":"2009-02-22","ids":{"openalex":"https://openalex.org/W2060163289","doi":"https://doi.org/10.1016/j.molimm.2009.01.014","mag":"2060163289","pmid":"https://pubmed.ncbi.nlm.nih.gov/19232731"},"language":"en","primary_location":{"id":"doi:10.1016/j.molimm.2009.01.014","doi":"https://doi.org/10.1016/j.molimm.2009.01.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molimm.2009.01.014","pdf_url":null,"source":{"id":"https://openalex.org/S92126311","display_name":"Molecular Immunology","issn_l":"0161-5890","issn":["0161-5890","1872-9142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113840076","display_name":"Vaibhav B. Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vaibhav B. Shah","raw_affiliation_strings":["Division of Pharmacology, College of Pharmacy, The Ohio State University, 500W 12th Avenue, Columbus, OH 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology, College of Pharmacy, The Ohio State University, 500W 12th Avenue, Columbus, OH 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057346697","display_name":"Tammy R. Ozment-Skelton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tammy R. Ozment-Skelton","raw_affiliation_strings":["Department of Surgery, College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033677559","display_name":"David L. Williams","orcid":"https://orcid.org/0000-0002-4586-9290","observed_orcids":["https://orcid.org/0000-0002-4586-9290"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Williams","raw_affiliation_strings":["Department of Surgery, College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079687580","display_name":"Lakhu M. Keshvara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lakhu Keshvara","raw_affiliation_strings":["Division of Pharmacology, College of Pharmacy, The Ohio State University, 500W 12th Avenue, Columbus, OH 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology, College of Pharmacy, The Ohio State University, 500W 12th Avenue, Columbus, OH 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079687580"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":3340,"currency":"USD","value_usd":3340},"apc_paid":null,"fwci":2.6513,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.87594937,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"46","issue":"8-9","first_page":"1845","last_page":"1853"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.5102999806404114,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.5102999806404114,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.3621000051498413,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vav1","display_name":"Vav1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9259999990463257},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8920000195503235},{"id":"https://openalex.org/keywords/beta-glucan","display_name":"\u03b2-glucan","score":0.8949999809265137},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.9290000200271606},{"id":"https://openalex.org/keywords/dectin-1","display_name":"Dectin-1","score":0.9440000057220459},{"id":"https://openalex.org/keywords/guanine-nucleotide-exchange-factor","display_name":"guanine nucleotide exchange factor","score":0.8100000023841858},{"id":"https://openalex.org/keywords/pi3k-activation","display_name":"PI3K activation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/fungal-pathogen-recognition","display_name":"fungal pathogen recognition","score":0.7300000190734863},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7099999785423279},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.8274035453796387},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.8112744092941284},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7210228443145752},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.6702983379364014},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6550746560096741},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6348668336868286},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.505943238735199},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47905433177948},{"id":"https://openalex.org/C126619667","wikidata":"https://www.wikidata.org/wiki/Q901088","display_name":"Guanine nucleotide exchange factor","level":3,"score":0.4628640115261078},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.412119060754776},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3515397310256958},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3499079644680023},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2577037811279297},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.23146915435791016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1656022071838379},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D047071","descriptor_name":"beta-Glucans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051567","descriptor_name":"Proto-Oncogene Proteins c-vav","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051567","descriptor_name":"Proto-Oncogene Proteins c-vav","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.molimm.2009.01.014","doi":"https://doi.org/10.1016/j.molimm.2009.01.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molimm.2009.01.014","pdf_url":null,"source":{"id":"https://openalex.org/S92126311","display_name":"Molecular Immunology","issn_l":"0161-5890","issn":["0161-5890","1872-9142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Immunology","raw_type":"journal-article"},{"id":"pmid:19232731","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19232731","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular immunology","raw_type":"Journal Article"},{"id":"pmh:oai:dc.etsu.edu:etsu-works-18384","doi":null,"is_oa":false,"landing_page_url":"https://dc.etsu.edu/etsu-works/17118","pdf_url":null,"source":{"id":"https://openalex.org/S4377196424","display_name":"Digital Commons - East Tennessee State University (East Tennessee State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119443389","host_organization_name":"East Tennessee State University","host_organization_lineage":["https://openalex.org/I119443389"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ETSU Faculty Works","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3702555361","display_name":"Amelioration of Sepsis by Macrophage Activation","funder_award_id":"R01GM053522","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W1495813857","https://openalex.org/W1498673365","https://openalex.org/W1503511302","https://openalex.org/W1517631297","https://openalex.org/W1533457677","https://openalex.org/W1545383294","https://openalex.org/W1575242432","https://openalex.org/W1582842326","https://openalex.org/W1646206347","https://openalex.org/W1895473399","https://openalex.org/W1930867397","https://openalex.org/W1934347187","https://openalex.org/W1934467632","https://openalex.org/W1970417260","https://openalex.org/W1972641293","https://openalex.org/W1972976060","https://openalex.org/W1976925504","https://openalex.org/W1977604451","https://openalex.org/W1981408589","https://openalex.org/W1987216284","https://openalex.org/W1988822418","https://openalex.org/W1990111262","https://openalex.org/W1994334475","https://openalex.org/W1995441274","https://openalex.org/W1995629350","https://openalex.org/W1995900983","https://openalex.org/W1996120942","https://openalex.org/W2001349268","https://openalex.org/W2003319634","https://openalex.org/W2009230499","https://openalex.org/W2013592169","https://openalex.org/W2024410241","https://openalex.org/W2025326971","https://openalex.org/W2025960625","https://openalex.org/W2037971418","https://openalex.org/W2038438278","https://openalex.org/W2041789288","https://openalex.org/W2044356299","https://openalex.org/W2047225913","https://openalex.org/W2047422738","https://openalex.org/W2050069950","https://openalex.org/W2050662417","https://openalex.org/W2052590794","https://openalex.org/W2058238427","https://openalex.org/W2058977272","https://openalex.org/W2067530904","https://openalex.org/W2067724310","https://openalex.org/W2070732456","https://openalex.org/W2072360147","https://openalex.org/W2073925712","https://openalex.org/W2074885149","https://openalex.org/W2075595064","https://openalex.org/W2082390177","https://openalex.org/W2095570273","https://openalex.org/W2101368523","https://openalex.org/W2104033155","https://openalex.org/W2107531246","https://openalex.org/W2108119532","https://openalex.org/W2109759840","https://openalex.org/W2109860344","https://openalex.org/W2115993724","https://openalex.org/W2116756714","https://openalex.org/W2122806101","https://openalex.org/W2123076431","https://openalex.org/W2123333009","https://openalex.org/W2124334590","https://openalex.org/W2126924404","https://openalex.org/W2128049587","https://openalex.org/W2134115181","https://openalex.org/W2140333814","https://openalex.org/W2142977472","https://openalex.org/W2143498880","https://openalex.org/W2147897016","https://openalex.org/W2150568244","https://openalex.org/W2153048580","https://openalex.org/W2156539075","https://openalex.org/W2158373279","https://openalex.org/W2159584083","https://openalex.org/W2163018106","https://openalex.org/W2163751922","https://openalex.org/W2168064391","https://openalex.org/W2171432125","https://openalex.org/W2406965583","https://openalex.org/W4245376573"],"related_works":["https://openalex.org/W22321849","https://openalex.org/W1495813857","https://openalex.org/W7100206259","https://openalex.org/W1019261432","https://openalex.org/W7099026147","https://openalex.org/W2001349268","https://openalex.org/W2004336750","https://openalex.org/W107873773","https://openalex.org/W2782929718","https://openalex.org/W2952903742"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}