{"id":"https://openalex.org/W2060155932","doi":"https://doi.org/10.1016/0014-2999(88)90064-7","title":"Apparent loss of Gi protein activity in the diabetic retina","display_name":"Apparent loss of Gi protein activity in the diabetic retina","publication_year":1988,"publication_date":"1988-04-01","ids":{"openalex":"https://openalex.org/W2060155932","doi":"https://doi.org/10.1016/0014-2999(88)90064-7","mag":"2060155932","pmid":"https://pubmed.ncbi.nlm.nih.gov/3135197"},"language":"en","primary_location":{"id":"doi:10.1016/0014-2999(88)90064-7","doi":"https://doi.org/10.1016/0014-2999(88)90064-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-2999(88)90064-7","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112710104","display_name":"Maria Hadjiconstantinou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Hadjiconstantinou","raw_affiliation_strings":["Department of Pharmacology, Ohio State University College of Medicine, Columbus 43120","a. Numbers and letters correspond to the affiliation list. Click to expose these in author workspace"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Ohio State University College of Medicine, Columbus 43120","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"a. Numbers and letters correspond to the affiliation list. Click to expose these in author workspace","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065745832","display_name":"Zhi Xiang Qu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z.-X. Qu","raw_affiliation_strings":["Department of Pharmacology, The Ohio State University College of Medicine, Columbus, OH 43120, U.S.A","a. Numbers and letters correspond to the affiliation list. Click to expose these in author workspace"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, The Ohio State University College of Medicine, Columbus, OH 43120, U.S.A","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"a. Numbers and letters correspond to the affiliation list. Click to expose these in author workspace","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090443674","display_name":"Sayoko Eileen Moroi","orcid":"https://orcid.org/0000-0002-0418-0657","observed_orcids":["https://orcid.org/0000-0002-0418-0657","https://orcid.org/0000-0002-9640-1786"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.E. Moroi-Fetters","raw_affiliation_strings":["Department of Pathology, The Ohio State University College of Medicine, Columbus, OH 43120, U.S.A","1. Numbers and letters correspond to the affiliation list. Click to expose these in author workspace"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Ohio State University College of Medicine, Columbus, OH 43120, U.S.A","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"1. Numbers and letters correspond to the affiliation list. Click to expose these in author workspace","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111447017","display_name":"Norton H. Neff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"N.H. Neff","raw_affiliation_strings":["Department of Pharmacology, The Ohio State University College of Medicine, Columbus, OH 43120, U.S.A","a. Numbers and letters correspond to the affiliation list. Click to expose these in author workspace"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, The Ohio State University College of Medicine, Columbus, OH 43120, U.S.A","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"a. Numbers and letters correspond to the affiliation list. Click to expose these in author workspace","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111447017"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":2.0633,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.88778331,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"149","issue":"1-2","first_page":"193","last_page":"194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gi-protein","display_name":"Gi protein","score":0.8130000233650208},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9860000014305115},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.8679999709129333},{"id":"https://openalex.org/keywords/eicosanoids","display_name":"eicosanoids","score":0.9309999942779541},{"id":"https://openalex.org/keywords/endothelin","display_name":"endothelin","score":0.9179999828338623},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endothelium-derived-hyperpolarizing-factor","display_name":"endothelium-derived hyperpolarizing factor","score":0.953000009059906},{"id":"https://openalex.org/keywords/vascular-disease","display_name":"vascular disease","score":0.6600000262260437},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6539999842643738},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.7499337196350098},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.7387968301773071},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.6691509485244751},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.620390772819519},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.608444094657898},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5962504148483276},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5107455253601074},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5093106031417847},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4918115437030792},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46942999958992004},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.4667375981807709},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.44283390045166016},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.43804627656936646},{"id":"https://openalex.org/C2780310817","wikidata":"https://www.wikidata.org/wiki/Q5376433","display_name":"Endothelium-derived relaxing factor","level":3,"score":0.4104015529155731},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.09530270099639893},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07870706915855408}],"mesh":[{"descriptor_ui":"D000067956","descriptor_name":"Adenylyl Cyclase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010566","descriptor_name":"Virulence Factors, Bordetella","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-2999(88)90064-7","doi":"https://doi.org/10.1016/0014-2999(88)90064-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-2999(88)90064-7","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:3135197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3135197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2042567893","https://openalex.org/W2043390449","https://openalex.org/W2062105646","https://openalex.org/W2073342650"],"related_works":["https://openalex.org/W2052244174","https://openalex.org/W2007880055","https://openalex.org/W7043379154","https://openalex.org/W2418702515","https://openalex.org/W1973479401","https://openalex.org/W2316015817","https://openalex.org/W2069294586","https://openalex.org/W2412109670","https://openalex.org/W2050091397","https://openalex.org/W7220047730"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
