{"id":"https://openalex.org/W2060152253","doi":"https://doi.org/10.1111/j.1600-0714.2009.00827.x","title":"Expression and role of metalloproteinase-2 and endogenous tissue regulator in ameloblastoma","display_name":"Expression and role of metalloproteinase-2 and endogenous tissue regulator in ameloblastoma","publication_year":2009,"publication_date":"2009-08-26","ids":{"openalex":"https://openalex.org/W2060152253","doi":"https://doi.org/10.1111/j.1600-0714.2009.00827.x","mag":"2060152253","pmid":"https://pubmed.ncbi.nlm.nih.gov/19709349"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0714.2009.00827.x","doi":"https://doi.org/10.1111/j.1600-0714.2009.00827.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0714.2009.00827.x","pdf_url":null,"source":{"id":"https://openalex.org/S86809486","display_name":"Journal of Oral Pathology and Medicine","issn_l":"0300-9777","issn":["0300-9777","0904-2512","1600-0714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oral Pathology & Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100392798","display_name":"Bin Zhang","orcid":"https://orcid.org/0000-0001-9903-083X","observed_orcids":["https://orcid.org/0000-0001-9903-083X"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Zhang","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou","These authors contributed equally to this study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"These authors contributed equally to this study","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Zhang","raw_affiliation_strings":["Department of Internal Medicine, the Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou","These authors contributed equally to this study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, the Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"These authors contributed equally to this study","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087948235","display_name":"Hongzhang Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Zhang Huang","raw_affiliation_strings":["Department of Oral and Maxillofacial surgery, Guanghua College of Stomatology, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial surgery, Guanghua College of Stomatology, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110968531","display_name":"Zhi-Ying Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Ying Xu","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100611747","display_name":"Hongliang Xie","orcid":"https://orcid.org/0000-0002-6866-2807","observed_orcids":["https://orcid.org/0000-0002-6866-2807"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Liang Xie","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I157773358"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":1.5044,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.80598814,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"39","issue":"3","first_page":"219","last_page":"222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11787","display_name":"Oral and Maxillofacial Pathology","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11787","display_name":"Oral and Maxillofacial Pathology","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ameloblastoma","display_name":"ameloblastoma","score":1.0},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/timp-2","display_name":"TIMP-2","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6549999713897705},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.8339999914169312},{"id":"https://openalex.org/keywords/odontogenic-tumors","display_name":"odontogenic tumors","score":0.7730000019073486},{"id":"https://openalex.org/keywords/type-iv-collagen-degradation","display_name":"type IV collagen degradation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.640999972820282},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.6539999842643738},{"id":"https://openalex.org/keywords/solid-multicystic-ameloblastoma","display_name":"solid/multicystic ameloblastoma","score":0.8379999995231628},{"id":"https://openalex.org/keywords/unicystic-ameloblastoma","display_name":"unicystic ameloblastoma","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2775876115","wikidata":"https://www.wikidata.org/wiki/Q461857","display_name":"Ameloblastoma","level":3,"score":0.9743077754974365},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.7924570441246033},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6432758569717407},{"id":"https://openalex.org/C2777610189","wikidata":"https://www.wikidata.org/wiki/Q7077953","display_name":"Odontogenic tumor","level":3,"score":0.5383419394493103},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.5359889268875122},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.48188263177871704},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.4576003849506378},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.402218759059906},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3339931070804596},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30563461780548096},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1942823827266693},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13563674688339233},{"id":"https://openalex.org/C2778125672","wikidata":"https://www.wikidata.org/wiki/Q769266","display_name":"Odontogenic","level":2,"score":0.11909633874893188},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.11680686473846436},{"id":"https://openalex.org/C122246415","wikidata":"https://www.wikidata.org/wiki/Q350956","display_name":"Maxilla","level":2,"score":0.08278173208236694},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06552848219871521}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000564","descriptor_name":"Ameloblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003795","descriptor_name":"Dental Sac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019716","descriptor_name":"Tissue Inhibitor of Metalloproteinase-2","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D053511","descriptor_name":"Matrix Metalloproteinase 14","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0714.2009.00827.x","doi":"https://doi.org/10.1111/j.1600-0714.2009.00827.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0714.2009.00827.x","pdf_url":null,"source":{"id":"https://openalex.org/S86809486","display_name":"Journal of Oral Pathology and Medicine","issn_l":"0300-9777","issn":["0300-9777","0904-2512","1600-0714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oral Pathology & Medicine","raw_type":"journal-article"},{"id":"pmid:19709349","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19709349","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1978818883","https://openalex.org/W1986261908","https://openalex.org/W2023786025","https://openalex.org/W2053192881","https://openalex.org/W2053582267","https://openalex.org/W2064376964","https://openalex.org/W2083406037","https://openalex.org/W2088125557","https://openalex.org/W2094083611","https://openalex.org/W2101514945","https://openalex.org/W2104981238","https://openalex.org/W2105087414","https://openalex.org/W2113056676","https://openalex.org/W2118052037","https://openalex.org/W2128531359","https://openalex.org/W2145494310","https://openalex.org/W2155256293","https://openalex.org/W4230628886","https://openalex.org/W6629756581","https://openalex.org/W7168255562"],"related_works":["https://openalex.org/W2390090398","https://openalex.org/W2312361414","https://openalex.org/W2094083611","https://openalex.org/W2086289978","https://openalex.org/W2356269862","https://openalex.org/W2105087414","https://openalex.org/W2075974791","https://openalex.org/W2102550071","https://openalex.org/W2155256293","https://openalex.org/W2171807179"],"abstract_inverted_index":{"BACKGROUND:":[0],"Ameloblastoma":[1],"is":[2,44,225],"a":[3,199,230],"frequently":[4],"encountered":[5],"odontogenic":[6],"benign":[7],"tumor":[8,40],"characterized":[9],"by":[10,72],"local":[11,111,213,220],"invasiveness":[12],"and":[13,54,75,85,93,104,110,118,140,143,158,175,182,189,205,236],"high":[14,200,231],"risk":[15],"of":[16,27,39,48,58,63,82,90,113,136,155,173,202,216,223,234],"recurrence.":[17],"Matrix":[18],"metalloproteinase":[19],"(MMP)-2":[20],"can":[21],"degrade":[22],"type":[23,52,109],"IV":[24],"collagen,":[25],"one":[26],"the":[28,32,37,46,55,196,212,219],"major":[29],"components":[30],"in":[31,36,77,87,107,123,134,148,163,167,180,187],"basement":[33],"membrane,":[34],"resulting":[35],"promotion":[38],"invasion,":[41],"whereas":[42,218],"it":[43],"under":[45],"influence":[47],"an":[49],"activator,":[50],"membrane":[51],"1-MMP-14":[53],"tissue":[56,88],"inhibitor":[57],"metalloproteases":[59],"(TIMP)-2.":[60],"The":[61,152,170],"aim":[62],"this":[64],"study":[65],"was":[66,97,131],"to":[67,211,229],"investigate":[68],"combinatorial":[69],"role":[70],"played":[71],"MMP-2,":[73,83,116,156,203],"TIMP-2":[74,84,117,157,174,204,235],"MMP-14":[76,86,119,144,159,176,206],"ameloblastoma.":[78,114],"METHODS:":[79],"Transcriptional":[80],"expression":[81,154,201],"extracts":[89],"42":[91],"ameloblastomas":[92],"10":[94,137],"dental":[95],"follicles":[96],"detected":[98,122],"using":[99],"reverse":[100],"transcription-polymerase":[101],"chain":[102],"reaction,":[103],"compared":[105],"difference":[106],"clinical":[108],"recurrence":[112],"RESULTS:":[115],"mRNA":[120,130,153,171,207],"were":[121,145,160,177],"all":[124,149],"investigated":[125],"ameloblastoma":[126,164,184,191,224],"tissues.":[127,151,169],"While":[128],"MMP-2":[129],"only":[132],"expressed":[133],"eight":[135],"odontotheca":[138,150,168],"tissues":[139,165,185,192],"TIMP-":[141],"2":[142],"not":[146],"found":[147],"significantly":[161,178],"higher":[162,179],"than":[166,186],"levels":[172,208,233],"recurrent":[181],"solid/multicystic":[183],"primary":[188],"unicystic":[190],"respectively.":[193],"CONCLUSIONS:":[194],"Of":[195],"MMP-2/TIMP-2/MMP-14":[197],"complex,":[198],"may":[209],"contribute":[210],"invasive":[214,221],"characteristics":[215],"ameloblastoma,":[217],"capacity":[222],"more":[226],"likely":[227],"related":[228],"transcriptional":[232],"MMP-14.":[237]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}