{"id":"https://openalex.org/W2060151779","doi":"https://doi.org/10.1128/aac.31.10.1457","title":"In vitro antistaphylococcal activity of pefloxacin alone and in combination with other antistaphylococcal drugs","display_name":"In vitro antistaphylococcal activity of pefloxacin alone and in combination with other antistaphylococcal drugs","publication_year":1987,"publication_date":"1987-10-01","ids":{"openalex":"https://openalex.org/W2060151779","doi":"https://doi.org/10.1128/aac.31.10.1457","mag":"2060151779","pmid":"https://pubmed.ncbi.nlm.nih.gov/3481244","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/174970"},"language":"en","primary_location":{"id":"doi:10.1128/aac.31.10.1457","doi":"https://doi.org/10.1128/aac.31.10.1457","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.31.10.1457","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/174970","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109313287","display_name":"Robert J. Fass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R J Fass","raw_affiliation_strings":["Department of Internal Medicine, Ohio State University College of Medicine, Columbus 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Ohio State University College of Medicine, Columbus 43210","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059744574","display_name":"Valerie L. Helsel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V L Helsel","raw_affiliation_strings":["Department of Internal Medicine, Ohio State University College of Medicine, Columbus 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Ohio State University College of Medicine, Columbus 43210","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":3.4456,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.92789053,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"10","first_page":"1457","last_page":"1460"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pefloxacin","display_name":"pefloxacin","score":1.0},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9470000267028809},{"id":"https://openalex.org/keywords/staphylococcus-epidermidis","display_name":"Staphylococcus epidermidis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/staphylococcus-haemolyticus","display_name":"Staphylococcus haemolyticus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/staphylococcus-hominis","display_name":"Staphylococcus hominis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/staphylococcus-saprophyticus","display_name":"Staphylococcus saprophyticus","score":1.0},{"id":"https://openalex.org/keywords/oxacillin-resistance","display_name":"oxacillin resistance","score":0.8610000014305115},{"id":"https://openalex.org/keywords/gentamicin-resistance","display_name":"gentamicin resistance","score":0.7749999761581421},{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.703000009059906},{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/combination-antibiotic-therapy","display_name":"combination antibiotic therapy","score":0.5870000123977661},{"id":"https://openalex.org/keywords/bactericidal-activity","display_name":"bactericidal activity","score":0.9269999861717224},{"id":"https://openalex.org/keywords/time-kill-kinetics","display_name":"time-kill kinetics","score":0.9169999957084656},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.7950000166893005},{"id":"https://openalex.org/keywords/fluoroquinolones","display_name":"fluoroquinolones","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C2781166304","wikidata":"https://www.wikidata.org/wiki/Q2601859","display_name":"Pefloxacin","level":5,"score":0.9836670160293579},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.8022639751434326},{"id":"https://openalex.org/C2777949923","wikidata":"https://www.wikidata.org/wiki/Q131915","display_name":"Staphylococcus epidermidis","level":4,"score":0.6665557026863098},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.6484568119049072},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.5835192799568176},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.5769580006599426},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.5573874711990356},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5031790137290955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34276920557022095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29536867141723633},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.15425974130630493},{"id":"https://openalex.org/C2778049240","wikidata":"https://www.wikidata.org/wiki/Q411447","display_name":"Ofloxacin","level":4,"score":0.1266002058982849},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1198263168334961},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009643","descriptor_name":"Norfloxacin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009643","descriptor_name":"Norfloxacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013210","descriptor_name":"Staphylococcus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015366","descriptor_name":"Pefloxacin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.31.10.1457","doi":"https://doi.org/10.1128/aac.31.10.1457","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.31.10.1457","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:9002","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/174970","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:174970","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/174970","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:3481244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3481244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:9002","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/174970","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W65113315","https://openalex.org/W1581962345","https://openalex.org/W1931658698","https://openalex.org/W1966138471","https://openalex.org/W1974853023","https://openalex.org/W1984451793","https://openalex.org/W1990471590","https://openalex.org/W2001847772","https://openalex.org/W2010327844","https://openalex.org/W2011798244","https://openalex.org/W2030993013","https://openalex.org/W2035748953","https://openalex.org/W2043157310","https://openalex.org/W2057178954","https://openalex.org/W2058341549","https://openalex.org/W2064967510","https://openalex.org/W2072181091","https://openalex.org/W2093531974","https://openalex.org/W2096757168","https://openalex.org/W2098092303","https://openalex.org/W2099903919","https://openalex.org/W2103739563","https://openalex.org/W2126874955","https://openalex.org/W2155198260","https://openalex.org/W2162676187","https://openalex.org/W2164668487","https://openalex.org/W2322381039"],"related_works":["https://openalex.org/W2410088259","https://openalex.org/W2046860455","https://openalex.org/W2116973178","https://openalex.org/W2107975342","https://openalex.org/W2145273291","https://openalex.org/W2143298601","https://openalex.org/W2417911543","https://openalex.org/W2066774883","https://openalex.org/W2437386700","https://openalex.org/W1969285019"],"abstract_inverted_index":{"MICs":[0],"of":[1,12,64,77,131,145],"pefloxacin":[2,87,116,124,140],"and":[3,21,32,41,53,69],"nine":[4],"antistaphylococcal":[5,165],"drugs":[6],"were":[7,27,36,42,56],"determined":[8],"for":[9],"200":[10],"isolates":[11],"Staphylococcus":[13,15,17,19,22],"aureus,":[14,66],"epidermidis,":[16,68],"haemolyticus,":[18],"hominis,":[20],"saprophyticus.":[23],"All":[24],"the":[25,74,127,142],"strains":[26,35,63],"susceptible":[28],"to":[29,39,45,48,86],"pefloxacin,":[30],"vancomycin,":[31,122,138],"rifampin.":[33,96],"Oxacillin-resistant":[34],"uniformly":[37],"resistant":[38,47],"cephalothin":[40],"more":[43,105],"likely":[44],"be":[46],"gentamicin,":[49],"erythromycin,":[50],"clindamycin,":[51],"doxycycline,":[52],"trimethoprim-sulfamethoxazole":[54],"than":[55,83,89,92,95,107,115],"oxacillin-susceptible":[57],"strains.":[58,133],"Time-kill":[59],"studies":[60],"with":[61,99,120,136,157],"23":[62],"S.":[65,67,70],"haemolyticus":[71],"indicated":[72],"that":[73],"relative":[75],"order":[76],"bactericidal":[78,143],"activities":[79,144],"was":[80,151,156],"gentamicin":[81],"greater":[82,88,91,94],"or":[84,101,109,123,139],"equal":[85],"oxacillin":[90,100,108],"vancomycin":[93,102,110],"Pefloxacin":[97,160],"combined":[98,119,135],"killed":[103],"staphylococci":[104],"rapidly":[106,114],"alone":[111],"but":[112,148],"less":[113],"alone.":[117,159],"Gentamicin":[118],"oxacillin,":[121,137],"resulted":[125],"in":[126],"most":[128],"rapid":[129],"killing":[130],"gentamicin-susceptible":[132],"Rifampin":[134],"reduced":[141],"those":[146],"drugs,":[147],"rifampin":[149,158],"resistance":[150],"not":[152],"observed":[153],"as":[154],"it":[155],"is":[161],"a":[162],"potentially":[163],"useful":[164],"agent.":[166]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}