{"id":"https://openalex.org/W2060132792","doi":"https://doi.org/10.1213/00000539-198407000-00007","title":"Pulmonary Aspiration???Effects of Volume and pH in the Rat","display_name":"Pulmonary Aspiration???Effects of Volume and pH in the Rat","publication_year":1984,"publication_date":"1984-07-01","ids":{"openalex":"https://openalex.org/W2060132792","doi":"https://doi.org/10.1213/00000539-198407000-00007","mag":"2060132792","pmid":"https://pubmed.ncbi.nlm.nih.gov/6731893"},"language":"en","primary_location":{"id":"doi:10.1213/00000539-198407000-00007","doi":"https://doi.org/10.1213/00000539-198407000-00007","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-198407000-00007","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111868053","display_name":"Christopher F. James","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I61515104","display_name":"University of Florida Health Science Center","ror":"https://ror.org/0419bgt07","country_code":"US","type":"education","lineage":["https://openalex.org/I61515104"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher F. James","raw_affiliation_strings":["Recived from the Departments of Anesthesiology and Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida. Presented in part at the annual meeting of the International Anesthesia Research Society, New Orleans, Louisiana, March 1983","to Dr. James, Department of Anesthesiology, Box J-254, J. Hillis Miller Health Center, Gainesville, FL 32610"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Recived from the Departments of Anesthesiology and Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida. Presented in part at the annual meeting of the International Anesthesia Research Society, New Orleans, Louisiana, March 1983","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"to Dr. James, Department of Anesthesiology, Box J-254, J. Hillis Miller Health Center, Gainesville, FL 32610","institution_ids":["https://openalex.org/I61515104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105986607","display_name":"Jerome H. Modell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I61515104","display_name":"University of Florida Health Science Center","ror":"https://ror.org/0419bgt07","country_code":"US","type":"education","lineage":["https://openalex.org/I61515104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerome H. Modell","raw_affiliation_strings":["Recived from the Departments of Anesthesiology and Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida. Presented in part at the annual meeting of the International Anesthesia Research Society, New Orleans, Louisiana, March 1983","to Dr. James, Department of Anesthesiology, Box J-254, J. Hillis Miller Health Center, Gainesville, FL 32610"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Recived from the Departments of Anesthesiology and Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida. Presented in part at the annual meeting of the International Anesthesia Research Society, New Orleans, Louisiana, March 1983","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"to Dr. James, Department of Anesthesiology, Box J-254, J. Hillis Miller Health Center, Gainesville, FL 32610","institution_ids":["https://openalex.org/I61515104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103395840","display_name":"Charles Parker Gibbs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I61515104","display_name":"University of Florida Health Science Center","ror":"https://ror.org/0419bgt07","country_code":"US","type":"education","lineage":["https://openalex.org/I61515104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles P. Gibbs","raw_affiliation_strings":["Recived from the Departments of Anesthesiology and Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida. Presented in part at the annual meeting of the International Anesthesia Research Society, New Orleans, Louisiana, March 1983","to Dr. James, Department of Anesthesiology, Box J-254, J. Hillis Miller Health Center, Gainesville, FL 32610"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Recived from the Departments of Anesthesiology and Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida. Presented in part at the annual meeting of the International Anesthesia Research Society, New Orleans, Louisiana, March 1983","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"to Dr. James, Department of Anesthesiology, Box J-254, J. Hillis Miller Health Center, Gainesville, FL 32610","institution_ids":["https://openalex.org/I61515104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065603106","display_name":"Earlene J. Kuck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I61515104","display_name":"University of Florida Health Science Center","ror":"https://ror.org/0419bgt07","country_code":"US","type":"education","lineage":["https://openalex.org/I61515104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Earlene J. Kuck","raw_affiliation_strings":["Recived from the Departments of Anesthesiology and Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida. Presented in part at the annual meeting of the International Anesthesia Research Society, New Orleans, Louisiana, March 1983","to Dr. James, Department of Anesthesiology, Box J-254, J. Hillis Miller Health Center, Gainesville, FL 32610"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Recived from the Departments of Anesthesiology and Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida. Presented in part at the annual meeting of the International Anesthesia Research Society, New Orleans, Louisiana, March 1983","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"to Dr. James, Department of Anesthesiology, Box J-254, J. Hillis Miller Health Center, Gainesville, FL 32610","institution_ids":["https://openalex.org/I61515104"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013083148","display_name":"Bruce C. Ruiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I61515104","display_name":"University of Florida Health Science Center","ror":"https://ror.org/0419bgt07","country_code":"US","type":"education","lineage":["https://openalex.org/I61515104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce C. Ruiz","raw_affiliation_strings":["Recived from the Departments of Anesthesiology and Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida. Presented in part at the annual meeting of the International Anesthesia Research Society, New Orleans, Louisiana, March 1983","to Dr. James, Department of Anesthesiology, Box J-254, J. Hillis Miller Health Center, Gainesville, FL 32610"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Recived from the Departments of Anesthesiology and Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida. Presented in part at the annual meeting of the International Anesthesia Research Society, New Orleans, Louisiana, March 1983","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"to Dr. James, Department of Anesthesiology, Box J-254, J. Hillis Miller Health Center, Gainesville, FL 32610","institution_ids":["https://openalex.org/I61515104"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111868053"],"corresponding_institution_ids":["https://openalex.org/I33213144","https://openalex.org/I61515104"],"apc_list":null,"apc_paid":null,"fwci":5.873,"has_fulltext":false,"cited_by_count":215,"citation_normalized_percentile":{"value":0.96325549,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"63","issue":"7","first_page":"665???668","last_page":"665???668"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10830","display_name":"Airway Management and Intubation Techniques","score":0.6704000234603882,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10830","display_name":"Airway Management and Intubation Techniques","score":0.6704000234603882,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11358","display_name":"Dysphagia Assessment and Management","score":0.1281999945640564,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.04089999943971634,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-aspiration","display_name":"pulmonary aspiration","score":0.9869999885559082},{"id":"https://openalex.org/keywords/gastric-aspiration","display_name":"gastric aspiration","score":0.49000000953674316},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.7210000157356262},{"id":"https://openalex.org/keywords/hydrochloric-acid","display_name":"hydrochloric acid","score":0.8370000123977661},{"id":"https://openalex.org/keywords/antacids","display_name":"antacids","score":0.9359999895095825},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.5009999871253967},{"id":"https://openalex.org/keywords/cardiorespiratory-failure","display_name":"cardiopulmonary failure","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.943618655204773},{"id":"https://openalex.org/C2777963132","wikidata":"https://www.wikidata.org/wiki/Q737510","display_name":"Pulmonary aspiration","level":2,"score":0.8471226692199707},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.6345123052597046},{"id":"https://openalex.org/C2781338923","wikidata":"https://www.wikidata.org/wiki/Q677449","display_name":"Aspiration pneumonia","level":3,"score":0.4847923815250397},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.4592553973197937},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.44158151745796204},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.42893338203430176},{"id":"https://openalex.org/C2910429360","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Cardiorespiratory arrest","level":2,"score":0.41680359840393066},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4162176847457886},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3705316185951233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2819362282752991},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.09396153688430786},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006851","descriptor_name":"Hydrochloric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011015","descriptor_name":"Pneumonia, Aspiration","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011015","descriptor_name":"Pneumonia, Aspiration","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012972","descriptor_name":"Sodium Hydroxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1213/00000539-198407000-00007","doi":"https://doi.org/10.1213/00000539-198407000-00007","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-198407000-00007","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},{"id":"pmid:6731893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6731893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1627013989","https://openalex.org/W2017008447","https://openalex.org/W2033396318","https://openalex.org/W1986150734","https://openalex.org/W2157189926","https://openalex.org/W2052031554","https://openalex.org/W4399168083","https://openalex.org/W2092663242","https://openalex.org/W2418696366","https://openalex.org/W2069397405"],"abstract_inverted_index":{"To":[0],"evaluate":[1],"the":[2,23,193],"effect":[3],"of":[4,6,25,74,158,196,208,217,219],"volume":[5,107,126,157],"aspirates":[7,109,128],"with":[8,14,83,112,131],"different":[9],"pHs":[10],"on":[11],"mortality":[12,121,145,166],"associated":[13],"pulmonary":[15,108,127],"aspiration,":[16,43,60],"hydrochloric":[17],"acid":[18],"solutions":[19,82],"were":[20,31,37,45,49],"injected":[21],"into":[22,34,51],"tracheas":[24],"336":[26],"Sprague-Dawley":[27],"rats.":[28],"The":[29],"rats":[30],"divided":[32,50],"randomly":[33],"33":[35],"groups,":[36],"observed":[38],"for":[39,72],"96":[40],"hr":[41,66],"after":[42,59,67],"and":[44,61,156,211],"not":[46,213],"resuscitated.":[47],"Deaths":[48],"two":[52],"groups:":[53],"early,":[54],"less":[55,86],"than":[56,64,87,136,184],"30":[57],"min":[58],"late,":[62],"greater":[63],"4":[65],"aspiration.":[68],"Late":[69],"deaths,":[70],"accounting":[71],"22%":[73],"all":[75],"fatalities,":[76],"occurred":[77],"exclusively":[78],"in":[79,118,142,202],"animals":[80],"aspirating":[81],"a":[84,119,132,143,164],"pH":[85,115,134,155,169],"2.5.":[88],"These":[89,148],"late":[90],"deaths":[91,104],"indicated":[92,201],"progressive":[93],"lung":[94],"damage":[95],"as":[96],"opposed":[97],"to":[98,139],"acute":[99],"cardiorespiratory":[100],"failure,":[101],"which":[102],"early":[103],"suggested.":[105],"Low":[106],"(0.3":[110],"ml/kg)":[111,130],"extremely":[113],"low":[114,144,161],"(1.0)":[116],"resulted":[117,141],"high":[120,165],"rate":[122,146,167],"(90%).":[123],"Conversely,":[124],"higher":[125,133,182],"(1.0-2.0":[129],"(greater":[135],"or":[137],"equal":[138],"1.8)":[140],"(14%).":[147],"data":[149],"demonstrate":[150],"an":[151],"important":[152],"interaction":[153],"between":[154],"aspirates:":[159],"even":[160],"volumes":[162,183],"have":[163],"if":[168,174],"is":[170,177],"very":[171],"low,":[172],"whereas":[173],"gastric":[175,221],"fluid":[176],"effectively":[178],"buffered,":[179],"then":[180],"much":[181],"previously":[185],"thought":[186],"can":[187],"be":[188,200,214],"tolerated.":[189],"This":[190],"suggests":[191],"that":[192],"routine":[194],"use":[195],"nonparticulate":[197],"antacids":[198],"may":[199],"patients":[203],"at":[204],"risk":[205],"from":[206],"aspiration":[207],"stomach":[209],"contents":[210],"should":[212],"withheld":[215],"because":[216],"concern":[218],"increasing":[220],"volume.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
