{"id":"https://openalex.org/W2060108798","doi":"https://doi.org/10.1016/j.lungcan.2007.11.006","title":"Hybrid (intravenous and oral) administration of vinorelbine plus cisplatinum followed by oral vinorelbine as first-line therapy of advanced non-small cell lung cancer: A phase II study","display_name":"Hybrid (intravenous and oral) administration of vinorelbine plus cisplatinum followed by oral vinorelbine as first-line therapy of advanced non-small cell lung cancer: A phase II study","publication_year":2008,"publication_date":"2008-01-07","ids":{"openalex":"https://openalex.org/W2060108798","doi":"https://doi.org/10.1016/j.lungcan.2007.11.006","mag":"2060108798","pmid":"https://pubmed.ncbi.nlm.nih.gov/18160123"},"language":"en","primary_location":{"id":"doi:10.1016/j.lungcan.2007.11.006","doi":"https://doi.org/10.1016/j.lungcan.2007.11.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lungcan.2007.11.006","pdf_url":null,"source":{"id":"https://openalex.org/S100767427","display_name":"Lung Cancer","issn_l":"0169-5002","issn":["0169-5002","1872-8332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054546157","display_name":"Andrea Angelo Martoni","orcid":"https://orcid.org/0000-0003-1008-8803","observed_orcids":["https://orcid.org/0000-0003-1008-8803"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"A.A. Martoni","raw_affiliation_strings":["Medical Oncology Unit, S.Orsola-Malpighi Hospital, Bologna, Italy. martoni@aosp.bo.it","Medical Oncology Unit, S.Orsola-Malpighi Hospital, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, S.Orsola-Malpighi Hospital, Bologna, Italy. martoni@aosp.bo.it","institution_ids":["https://openalex.org/I4210097083"]},{"raw_affiliation_string":"Medical Oncology Unit, S.Orsola-Malpighi Hospital, Bologna, Italy","institution_ids":["https://openalex.org/I4210097083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072521541","display_name":"Barbara Melotti","orcid":"https://orcid.org/0000-0003-1041-391X","observed_orcids":["https://orcid.org/0000-0003-1041-391X"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"B. Melotti","raw_affiliation_strings":["Medical Oncology Unit, S.Orsola-Malpighi Hospital, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, S.Orsola-Malpighi Hospital, Bologna, Italy","institution_ids":["https://openalex.org/I4210097083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076616410","display_name":"Francesca Sperandi","orcid":"https://orcid.org/0000-0002-1581-3456","observed_orcids":["https://orcid.org/0000-0002-1581-3456"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Sperandi","raw_affiliation_strings":["Medical Oncology Unit, S.Orsola-Malpighi Hospital, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, S.Orsola-Malpighi Hospital, Bologna, Italy","institution_ids":["https://openalex.org/I4210097083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015823046","display_name":"Stefania Giaquinta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Giaquinta","raw_affiliation_strings":["Medical Oncology Unit, S.Orsola-Malpighi Hospital, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, S.Orsola-Malpighi Hospital, Bologna, Italy","institution_ids":["https://openalex.org/I4210097083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031030028","display_name":"Edera Piana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Piana","raw_affiliation_strings":["Medical Oncology Unit, S.Orsola-Malpighi Hospital, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, S.Orsola-Malpighi Hospital, Bologna, Italy","institution_ids":["https://openalex.org/I4210097083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103032979","display_name":"L. Pavesi","orcid":"https://orcid.org/0009-0006-3530-4276","observed_orcids":["https://orcid.org/0009-0006-3530-4276"]},"institutions":[{"id":"https://openalex.org/I4210091499","display_name":"Istituti Clinici Scientifici Maugeri","ror":"https://ror.org/00mc77d93","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091499","https://openalex.org/I4210105320","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210105320","display_name":"Fondazione Salvatore Maugeri","ror":"https://ror.org/01e8tvg28","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210105320","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Pavesi","raw_affiliation_strings":["Medical Oncology I, S.Maugeri Foundation, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology I, S.Maugeri Foundation, Pavia, Italy","institution_ids":["https://openalex.org/I4210091499","https://openalex.org/I4210105320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111616986","display_name":"G. Da Prada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091499","display_name":"Istituti Clinici Scientifici Maugeri","ror":"https://ror.org/00mc77d93","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091499","https://openalex.org/I4210105320","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210105320","display_name":"Fondazione Salvatore Maugeri","ror":"https://ror.org/01e8tvg28","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210105320","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Da Prada","raw_affiliation_strings":["Medical Oncology I, S.Maugeri Foundation, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology I, S.Maugeri Foundation, Pavia, Italy","institution_ids":["https://openalex.org/I4210091499","https://openalex.org/I4210105320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033030232","display_name":"GIORGIO LELLI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126260","display_name":"Arcispedale Sant'Anna","ror":"https://ror.org/026yzxh70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210126260"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Lelli","raw_affiliation_strings":["Medical Oncology, Arcispedale S.Anna, Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, Arcispedale S.Anna, Ferrara, Italy","institution_ids":["https://openalex.org/I4210126260"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5054546157"],"corresponding_institution_ids":["https://openalex.org/I4210097083"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":null,"fwci":0.5739,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.74966349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"60","issue":"3","first_page":"387","last_page":"392"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5264000296592712,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5264000296592712,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.4675000011920929,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vinorelbine","display_name":"vinorelbine","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9679999947547913},{"id":"https://openalex.org/keywords/oral-vinorelbine","display_name":"oral vinorelbine","score":0.8389999866485596},{"id":"https://openalex.org/keywords/advanced-non-small-cell-lung-cancer","display_name":"advanced non-small cell lung cancer","score":0.9210000038146973},{"id":"https://openalex.org/keywords/first-line-chemotherapy","display_name":"first-line chemotherapy","score":0.9539999961853027},{"id":"https://openalex.org/keywords/consolidation-therapy","display_name":"consolidation therapy","score":0.5839999914169312},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.8220000267028809},{"id":"https://openalex.org/keywords/objective-response","display_name":"objective response","score":0.5130000114440918},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.6620000004768372},{"id":"https://openalex.org/keywords/outpatient-chemotherapy","display_name":"outpatient chemotherapy","score":0.8320000171661377},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6269999742507935},{"id":"https://openalex.org/keywords/time-to-progression","display_name":"time to progression","score":0.8009999990463257},{"id":"https://openalex.org/keywords/treatment-related-mortality","display_name":"non-relapse mortality","score":0.31299999356269836},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.5929999947547913},{"id":"https://openalex.org/keywords/nausea-and-vomiting","display_name":"nausea and vomiting","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9198428988456726},{"id":"https://openalex.org/C2780350996","wikidata":"https://www.wikidata.org/wiki/Q420532","display_name":"Vinorelbine","level":4,"score":0.9071955680847168},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.7400070428848267},{"id":"https://openalex.org/C2778850193","wikidata":"https://www.wikidata.org/wiki/Q3775974","display_name":"Febrile neutropenia","level":4,"score":0.6542176008224487},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6234704256057739},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5920606851577759},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.577136754989624},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.47002482414245605},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.44513237476348877},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.42952868342399597},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4241051971912384},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.41815850138664246},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.3095265328884125}],"mesh":[{"descriptor_ui":"D000077235","descriptor_name":"Vinorelbine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.lungcan.2007.11.006","doi":"https://doi.org/10.1016/j.lungcan.2007.11.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lungcan.2007.11.006","pdf_url":null,"source":{"id":"https://openalex.org/S100767427","display_name":"Lung Cancer","issn_l":"0169-5002","issn":["0169-5002","1872-8332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer","raw_type":"journal-article"},{"id":"pmid:18160123","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18160123","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung cancer (Amsterdam, Netherlands)","raw_type":"Clinical Trial, Phase II"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1837121308","https://openalex.org/W1986773298","https://openalex.org/W1995634658","https://openalex.org/W2014323749","https://openalex.org/W2043173598","https://openalex.org/W2115684400","https://openalex.org/W2125730874","https://openalex.org/W2127405377","https://openalex.org/W2129793485","https://openalex.org/W2136438932","https://openalex.org/W2145653040","https://openalex.org/W2147839112","https://openalex.org/W2166164739","https://openalex.org/W2167959488","https://openalex.org/W2169518833","https://openalex.org/W2256453366","https://openalex.org/W2261464614"],"related_works":["https://openalex.org/W2057190740","https://openalex.org/W2115684400","https://openalex.org/W2136438932","https://openalex.org/W1991425817","https://openalex.org/W2970993716","https://openalex.org/W1983042427","https://openalex.org/W2418235015","https://openalex.org/W2043173598","https://openalex.org/W1994855166","https://openalex.org/W2394575408"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
