{"id":"https://openalex.org/W206010701","doi":null,"title":"TRANSCRIPTIONAL REGULATION OF THE GnRH RECEPTOR GENE IN LINES OF SWINE DIVERGENT FOR OVULATION RATE","display_name":"TRANSCRIPTIONAL REGULATION OF THE GnRH RECEPTOR GENE IN LINES OF SWINE DIVERGENT FOR OVULATION RATE","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W206010701","mag":"206010701"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.unl.edu:animalscidiss-1007","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unl.edu/animalscidiss/8","pdf_url":"https://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1007&context=animalscidiss","source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Animal Science: Dissertations, Theses, and Student Research","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1007&context=animalscidiss","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Emily A. McDonald","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Emily A. McDonald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3484,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.70923932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.058400001376867294,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/ovulation-rate","display_name":"ovulation rate","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.6539999842643738},{"id":"https://openalex.org/keywords/meishan-pig","display_name":"Meishan pig","score":0.8830000162124634},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8370000123977661},{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.7020000219345093},{"id":"https://openalex.org/keywords/gonadotrophs","display_name":"gonadotrophs","score":0.9079999923706055},{"id":"https://openalex.org/keywords/anterior-pituitary","display_name":"anterior pituitary","score":0.8569999933242798},{"id":"https://openalex.org/keywords/reproductive-genetics","display_name":"reproductive genetics","score":0.44999998807907104},{"id":"https://openalex.org/keywords/quantitative-trait-loci","display_name":"quantitative trait loci","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2777702977","wikidata":"https://www.wikidata.org/wiki/Q187082","display_name":"Ovulation","level":3,"score":0.5865737199783325},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5035566687583923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49847984313964844},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3739030957221985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3709988594055176},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33562171459198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23714780807495117},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.18860286474227905}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.unl.edu:animalscidiss-1007","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unl.edu/animalscidiss/8","pdf_url":"https://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1007&context=animalscidiss","source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Animal Science: Dissertations, Theses, and Student Research","raw_type":"text"},{"id":"mag:206010701","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.unl.edu/animalscidiss/8/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.unl.edu:animalscidiss-1007","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unl.edu/animalscidiss/8","pdf_url":"https://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1007&context=animalscidiss","source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Animal Science: Dissertations, Theses, and Student Research","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W206010701.pdf","grobid_xml":"https://content.openalex.org/works/W206010701.grobid-xml"},"referenced_works_count":234,"referenced_works":["https://openalex.org/W28521291","https://openalex.org/W37487597","https://openalex.org/W41868388","https://openalex.org/W51462311","https://openalex.org/W73574910","https://openalex.org/W126692597","https://openalex.org/W196178521","https://openalex.org/W1228798347","https://openalex.org/W1485432800","https://openalex.org/W1489775551","https://openalex.org/W1492242941","https://openalex.org/W1499154937","https://openalex.org/W1501791679","https://openalex.org/W1509644625","https://openalex.org/W1559089042","https://openalex.org/W1559986791","https://openalex.org/W1570551626","https://openalex.org/W1572635906","https://openalex.org/W1578555932","https://openalex.org/W1593444788","https://openalex.org/W1799052444","https://openalex.org/W1833742808","https://openalex.org/W1842943643","https://openalex.org/W1867673000","https://openalex.org/W1963864696","https://openalex.org/W1964512812","https://openalex.org/W1964557297","https://openalex.org/W1964752171","https://openalex.org/W1966384215","https://openalex.org/W1968392281","https://openalex.org/W1968581250","https://openalex.org/W1970336036","https://openalex.org/W1972006317","https://openalex.org/W1972275692","https://openalex.org/W1972536915","https://openalex.org/W1972715709","https://openalex.org/W1973668516","https://openalex.org/W1974020982","https://openalex.org/W1974170731","https://openalex.org/W1974591289","https://openalex.org/W1976875374","https://openalex.org/W1977918766","https://openalex.org/W1978387202","https://openalex.org/W1979337429","https://openalex.org/W1982565891","https://openalex.org/W1983397972","https://openalex.org/W1985253953","https://openalex.org/W1987131378","https://openalex.org/W1988947995","https://openalex.org/W1989652277","https://openalex.org/W1992377292","https://openalex.org/W1992478303","https://openalex.org/W1994627056","https://openalex.org/W1996523236","https://openalex.org/W1996895789","https://openalex.org/W1997726924","https://openalex.org/W1998186649","https://openalex.org/W1999571693","https://openalex.org/W2000358009","https://openalex.org/W2001998267","https://openalex.org/W2002424855","https://openalex.org/W2002474134","https://openalex.org/W2002526474","https://openalex.org/W2002788608","https://openalex.org/W2005066622","https://openalex.org/W2005363482","https://openalex.org/W2005608222","https://openalex.org/W2005900169","https://openalex.org/W2009909885","https://openalex.org/W2010099444","https://openalex.org/W2010140340","https://openalex.org/W2011687097","https://openalex.org/W2012884526","https://openalex.org/W2013444999","https://openalex.org/W2015268989","https://openalex.org/W2016065996","https://openalex.org/W2017325384","https://openalex.org/W2017399638","https://openalex.org/W2017465212","https://openalex.org/W2018216158","https://openalex.org/W2019625788","https://openalex.org/W2019885719","https://openalex.org/W2020161422","https://openalex.org/W2023539413","https://openalex.org/W2023666553","https://openalex.org/W2023711636","https://openalex.org/W2023750079","https://openalex.org/W2024205683","https://openalex.org/W2024776674","https://openalex.org/W2025589527","https://openalex.org/W2028360008","https://openalex.org/W2029433828","https://openalex.org/W2029602474","https://openalex.org/W2029842855","https://openalex.org/W2030688236","https://openalex.org/W2031532049","https://openalex.org/W2032728378","https://openalex.org/W2033398255","https://openalex.org/W2035209944","https://openalex.org/W2036051154","https://openalex.org/W2036390316","https://openalex.org/W2036423270","https://openalex.org/W2036635876","https://openalex.org/W2037846443","https://openalex.org/W2038101078","https://openalex.org/W2038133272","https://openalex.org/W2039198739","https://openalex.org/W2040688071","https://openalex.org/W2041772151","https://openalex.org/W2043525901","https://openalex.org/W2044613610","https://openalex.org/W2044943380","https://openalex.org/W2046225717","https://openalex.org/W2047211130","https://openalex.org/W2048246231","https://openalex.org/W2049757959","https://openalex.org/W2050689590","https://openalex.org/W2052062764","https://openalex.org/W2052378128","https://openalex.org/W2054378237","https://openalex.org/W2056723048","https://openalex.org/W2056847739","https://openalex.org/W2056967455","https://openalex.org/W2058590901","https://openalex.org/W2058683885","https://openalex.org/W2060990872","https://openalex.org/W2062952618","https://openalex.org/W2063816440","https://openalex.org/W2065358604","https://openalex.org/W2065625184","https://openalex.org/W2065855627","https://openalex.org/W2066007865","https://openalex.org/W2066764799","https://openalex.org/W2066897038","https://openalex.org/W2067808043","https://openalex.org/W2068502127","https://openalex.org/W2068850203","https://openalex.org/W2069002100","https://openalex.org/W2069839260","https://openalex.org/W2072317433","https://openalex.org/W2072386144","https://openalex.org/W2073643727","https://openalex.org/W2074729962","https://openalex.org/W2075123367","https://openalex.org/W2076031582","https://openalex.org/W2076350564","https://openalex.org/W2076844113","https://openalex.org/W2078621832","https://openalex.org/W2078871537","https://openalex.org/W2079574569","https://openalex.org/W2080206379","https://openalex.org/W2080539832","https://openalex.org/W2081670399","https://openalex.org/W2081794745","https://openalex.org/W2082048636","https://openalex.org/W2083347345","https://openalex.org/W2083378898","https://openalex.org/W2083618055","https://openalex.org/W2089296240","https://openalex.org/W2089719946","https://openalex.org/W2089895610","https://openalex.org/W2090306619","https://openalex.org/W2090977762","https://openalex.org/W2091040855","https://openalex.org/W2091371511","https://openalex.org/W2092156741","https://openalex.org/W2092214602","https://openalex.org/W2092279256","https://openalex.org/W2093204516","https://openalex.org/W2093548749","https://openalex.org/W2093827154","https://openalex.org/W2095811197","https://openalex.org/W2095907411","https://openalex.org/W2097890006","https://openalex.org/W2098519379","https://openalex.org/W2100196866","https://openalex.org/W2104765191","https://openalex.org/W2107161940","https://openalex.org/W2107180907","https://openalex.org/W2108402070","https://openalex.org/W2109379227","https://openalex.org/W2112787832","https://openalex.org/W2116931151","https://openalex.org/W2118506472","https://openalex.org/W2118514946","https://openalex.org/W2118533346","https://openalex.org/W2120596322","https://openalex.org/W2122080693","https://openalex.org/W2123704253","https://openalex.org/W2123947048","https://openalex.org/W2124005549","https://openalex.org/W2124995570","https://openalex.org/W2125493768","https://openalex.org/W2125746812","https://openalex.org/W2126350930","https://openalex.org/W2126973348","https://openalex.org/W2127783662","https://openalex.org/W2127797312","https://openalex.org/W2127823059","https://openalex.org/W2129915028","https://openalex.org/W2130320546","https://openalex.org/W2132966314","https://openalex.org/W2134114303","https://openalex.org/W2136819827","https://openalex.org/W2137722297","https://openalex.org/W2139624389","https://openalex.org/W2139981662","https://openalex.org/W2140112004","https://openalex.org/W2140139647","https://openalex.org/W2141582604","https://openalex.org/W2142277736","https://openalex.org/W2143572454","https://openalex.org/W2147908186","https://openalex.org/W2148119611","https://openalex.org/W2148511156","https://openalex.org/W2148896458","https://openalex.org/W2149290295","https://openalex.org/W2149731032","https://openalex.org/W2149937006","https://openalex.org/W2152762661","https://openalex.org/W2158179206","https://openalex.org/W2158709030","https://openalex.org/W2160124934","https://openalex.org/W2162944007","https://openalex.org/W2163173672","https://openalex.org/W2170241485","https://openalex.org/W2170825006","https://openalex.org/W2212861781","https://openalex.org/W2341514891","https://openalex.org/W2412477427","https://openalex.org/W2417772238","https://openalex.org/W2521585434","https://openalex.org/W2735566229","https://openalex.org/W3092975730"],"related_works":["https://openalex.org/W2149833796","https://openalex.org/W2534824044","https://openalex.org/W2466115444","https://openalex.org/W183536903","https://openalex.org/W2099546847","https://openalex.org/W1542972145","https://openalex.org/W7133467369","https://openalex.org/W2148511156","https://openalex.org/W2596364766","https://openalex.org/W2342861278"],"abstract_inverted_index":{"The":[0],"interaction":[1],"between":[2],"GnRH":[3],"and":[4,62,101,132,231],"its":[5],"receptor":[6],"on":[7],"gonadotropes":[8],"within":[9,123,180,308],"the":[10,23,27,51,86,105,110,118,124,137,148,166,174,210,217,222,242,258,269,293,303],"anterior":[11],"pituitary":[12],"gland":[13],"represents":[14],"a":[15,32,41,92,177,249],"central":[16],"point":[17],"for":[18,36,44,128,209,227],"regulation":[19],"of":[20,26,58,70,80,109,117,141,165,176,185,216,245,263,292,306],"reproduction.":[21],"Additionally,":[22],"close":[24],"proximity":[25],"porcine":[28],"GnRHR":[29,52,81,125,295],"gene":[30,53,82,126,296],"to":[31,85,94,113,146,170,213,221,256,282],"quantitative":[33],"trait":[34],"locus":[35],"ovulation":[37,47,66],"rate":[38],"makes":[39],"it":[40],"positional":[42],"candidate":[43],"genes":[45],"influencing":[46],"rate.":[48],"We":[49],"isolated":[50],"promoter":[54,83,112,127,133,151,157,167,219,272,297],"from":[55,168,203],"three":[56,130],"lines":[57,160],"swine":[59],"(Control,":[60],"Index":[61],"Meishan)":[63],"with":[64,74,225,266],"different":[65],"rates.":[67],"Transient":[68,261],"transfection":[69,262],"gonadotrope-derived":[71],"\u03b1T3-1":[72,204,264],"cells":[73,205,265],"vectors":[75,267],"containing":[76,268],"approximately":[77],"5000":[78],"bp":[79,139,191,215],"fused":[84],"cDNA":[87],"encoding":[88],"luciferase":[89,98,279],"resulted":[90,247],"in":[91,97,150,156,248,300],"2-":[93],"4-fold":[95],"difference":[96],"activity":[99,152,158,280,291],"(Index":[100],"Meishan,":[102],"respectively)":[103],"over":[104],"Control":[106],"promoter.":[107],"Reduction":[108],"full-length":[111,270],"1900":[114],"bp,":[115,172],"mutation":[116],"steroidogenic":[119],"factor-1":[120],"binding":[121,208,228],"element":[122,179],"all":[129],"breeds,":[131],"\u201cswap\u201d":[134],"experiments":[135],"using":[136,200,237],"-1900/-1400":[138],"region":[140,187,277],"5\u2019":[142],"flanking":[143],"sequence":[144],"failed":[145,255],"eliminate":[147],"differences":[149],"among":[153,159,193],"lines.":[154,194],"Divergence":[155],"was":[161],"ablated":[162],"following":[163],"reduction":[164],"1400":[169],"1000":[171],"indicating":[173],"presence":[175],"breed-specific":[178],"this":[181,186,276],"region.":[182],"Sequence":[183],"analysis":[184],"revealed":[188],"five":[189],"single":[190],"substitutions":[192],"Electrophoretic":[195],"mobility":[196],"shift":[197],"assays":[198],"(EMSA)":[199],"nuclear":[201],"extracts":[202],"demonstrated":[206],"unique":[207],"oligonucleotide":[211],"corresponding":[212],"-1245/-1225":[214],"Meishan":[218,271,294],"compared":[220,281],"Control/Index":[223],"promoter,":[224],"competition":[226],"by":[229],"NF-\u03baB":[230,246,307],"Sp1":[232],"consensus":[233],"oligonucleotides.":[234],"Furthermore,":[235],"EMSA":[236],"an":[238,252],"antibody":[239,254],"directed":[240],"against":[241],"p65":[243],"subunit":[244],"supershift.":[250],"However,":[251],"Sp1-specific":[253],"supershift":[257],"DNA:protein":[259],"complex.":[260],"harboring":[273],"mutations":[274],"spanning":[275],"reduced":[278],"native":[283],"sequence.":[284],"Our":[285],"results":[286],"demonstrate":[287],"that":[288],"increased":[289],"transcriptional":[290],"is":[298],"conferred":[299],"part":[301],"via":[302],"novel":[304],"utilization":[305],"gonadotropes.":[309]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}