{"id":"https://openalex.org/W2060106005","doi":"https://doi.org/10.1002/anie.200503387","title":"A DNA\u2010Templated Aldol Reaction as a Model for the Formation of Pentose Sugars in the RNA World","display_name":"A DNA\u2010Templated Aldol Reaction as a Model for the Formation of Pentose Sugars in the RNA World","publication_year":2005,"publication_date":"2005-10-20","ids":{"openalex":"https://openalex.org/W2060106005","doi":"https://doi.org/10.1002/anie.200503387","mag":"2060106005","pmid":"https://pubmed.ncbi.nlm.nih.gov/16240312"},"language":"en","primary_location":{"id":"doi:10.1002/anie.200503387","doi":"https://doi.org/10.1002/anie.200503387","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.200503387","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035216350","display_name":"Michael Oberhuber","orcid":"https://orcid.org/0000-0002-9989-7297","observed_orcids":["https://orcid.org/0000-0002-9989-7297"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT","US"],"is_corresponding":false,"raw_author_name":"Michael Oberhuber","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA","Current address: Institute of Organic Chemistry and Center for Molecular Biosciences, Leopold\u2010Franzens University of Innsbruck, 6020 Innsbruck, Austria","Departments of Chemistry and Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA, Fax: (+1)\u2009858\u2010784\u20102943"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Current address: Institute of Organic Chemistry and Center for Molecular Biosciences, Leopold\u2010Franzens University of Innsbruck, 6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]},{"raw_affiliation_string":"Departments of Chemistry and Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA, Fax: (+1)\u2009858\u2010784\u20102943","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064029544","display_name":"Gerald F. Joyce","orcid":"https://orcid.org/0000-0003-0603-2874","observed_orcids":["https://orcid.org/0000-0003-0603-2874"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald F. Joyce","raw_affiliation_strings":["Departments of Chemistry and Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA, Fax: (+1)\u2009858-784-2943"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA, Fax: (+1)\u2009858-784-2943","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":null,"fwci":2.1794,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.8565253,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"44","issue":"46","first_page":"7580","last_page":"7583"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldol-reaction","display_name":"aldol reaction","score":0.8090000152587891},{"id":"https://openalex.org/keywords/dna-template","display_name":"DNA template","score":0.6880000233650208},{"id":"https://openalex.org/keywords/pentoses","display_name":"pentoses","score":0.8600000143051147},{"id":"https://openalex.org/keywords/ribose-synthesis","display_name":"ribose synthesis","score":0.902999997138977},{"id":"https://openalex.org/keywords/rna-world-hypothesis","display_name":"RNA world","score":0.890999972820282},{"id":"https://openalex.org/keywords/glyceraldehyde","display_name":"glyceraldehyde","score":0.753000020980835},{"id":"https://openalex.org/keywords/glycolaldehyde","display_name":"glycolaldehyde","score":1.0},{"id":"https://openalex.org/keywords/oligonucleotide-chemistry","display_name":"oligonucleotide chemistry","score":0.5860000252723694},{"id":"https://openalex.org/keywords/origin-of-life","display_name":"origin of life","score":0.7749999761581421},{"id":"https://openalex.org/keywords/prebiotic-chemistry","display_name":"prebiotic chemistry","score":0.7580000162124634},{"id":"https://openalex.org/keywords/rna-catalysis","display_name":"RNA catalysis","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C2780261296","wikidata":"https://www.wikidata.org/wiki/Q205654","display_name":"Pentose","level":3,"score":0.8608571887016296},{"id":"https://openalex.org/C2776651935","wikidata":"https://www.wikidata.org/wiki/Q899877","display_name":"Glycolaldehyde","level":3,"score":0.7823730707168579},{"id":"https://openalex.org/C2779461342","wikidata":"https://www.wikidata.org/wiki/Q59817493","display_name":"Ribose","level":3,"score":0.7778890132904053},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7058656215667725},{"id":"https://openalex.org/C61156836","wikidata":"https://www.wikidata.org/wiki/Q494392","display_name":"Aldol reaction","level":3,"score":0.6830832958221436},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.624813437461853},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5459553003311157},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5173701643943787},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.47778090834617615},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.253476083278656},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.21764639019966125},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12543156743049622},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.06870520114898682}],"mesh":[{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010429","descriptor_name":"Pentoses","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010429","descriptor_name":"Pentoses","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/anie.200503387","doi":"https://doi.org/10.1002/anie.200503387","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.200503387","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},{"id":"pmid:16240312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16240312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie (International ed. in English)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1507445348","https://openalex.org/W1602417853","https://openalex.org/W1971165765","https://openalex.org/W1975182459","https://openalex.org/W1990220614","https://openalex.org/W2016305899","https://openalex.org/W2034986386","https://openalex.org/W2037357263","https://openalex.org/W2044813549","https://openalex.org/W2048983892","https://openalex.org/W2050110866","https://openalex.org/W2065548742","https://openalex.org/W2088210851","https://openalex.org/W2096661398","https://openalex.org/W2106132690","https://openalex.org/W2120435341","https://openalex.org/W2127467439","https://openalex.org/W2134988785","https://openalex.org/W2164701497","https://openalex.org/W2172075849","https://openalex.org/W4206404641","https://openalex.org/W4210975051","https://openalex.org/W4245388086"],"related_works":["https://openalex.org/W2320978413","https://openalex.org/W2167831452","https://openalex.org/W4306850519","https://openalex.org/W2010692334","https://openalex.org/W2035972791","https://openalex.org/W2911285064","https://openalex.org/W4254293257","https://openalex.org/W2077866448","https://openalex.org/W2072159602","https://openalex.org/W1996007710"],"abstract_inverted_index":{"Sugar":[0],"on":[1,59],"a":[2,25,37,49],"stick:":[3],"A":[4],"DNA":[5],"template":[6],"can":[7],"bind":[8],"two":[9],"complementary":[10],"oligonucleotides,":[11],"one":[12],"derivatized":[13],"with":[14,20],"glyceraldehyde":[15],"(blue)":[16],"and":[17],"the":[18,40,54],"other":[19],"glycolaldehyde":[21],"(red),":[22],"resulting":[23],"in":[24],"cross-aldol":[26],"reaction":[27,33],"that":[28],"forms":[29],"pentose":[30],"sugars.":[31],"This":[32],"system":[34],"serves":[35],"as":[36],"model":[38],"for":[39],"RNA-catalyzed":[41],"synthesis":[42],"of":[43,57],"ribose,":[44],"which":[45],"is":[46],"relevant":[47],"to":[48],"presumed":[50],"RNA-based":[51],"metabolism":[52],"during":[53],"early":[55],"history":[56],"life":[58],"Earth.":[60]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}