{"id":"https://openalex.org/W2060102193","doi":"https://doi.org/10.1161/01.str.27.7.1163","title":"Activated Protein C Resistance in Ischemic Stroke Not Due to Factor V Arginine 506 \u2192Glutamine Mutation","display_name":"Activated Protein C Resistance in Ischemic Stroke Not Due to Factor V Arginine 506 \u2192Glutamine Mutation","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W2060102193","doi":"https://doi.org/10.1161/01.str.27.7.1163","mag":"2060102193","pmid":"https://pubmed.ncbi.nlm.nih.gov/8685921"},"language":"en","primary_location":{"id":"doi:10.1161/01.str.27.7.1163","doi":"https://doi.org/10.1161/01.str.27.7.1163","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.str.27.7.1163","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027852438","display_name":"Mark Fisher","orcid":"https://orcid.org/0000-0001-9802-8826","observed_orcids":["https://orcid.org/0000-0001-9802-8826"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Fisher","raw_affiliation_strings":["the Departments of Neurology (M.F., S.F.A., D.X.) and Preventive Medicine (A.P.-H.), University of Southern California School of Medicine (Los Angeles), and the Departments of Molecular and Experimental Medicine and of Vascular Biology, The Scripps Research Institute, La Jolla, Calif (J.A.F., A.G., J.H.G.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Neurology (M.F., S.F.A., D.X.) and Preventive Medicine (A.P.-H.), University of Southern California School of Medicine (Los Angeles), and the Departments of Molecular and Experimental Medicine and of Vascular Biology, The Scripps Research Institute, La Jolla, Calif (J.A.F., A.G., J.H.G.)","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007019044","display_name":"Jos\u00e9 A. Fern\u00e1ndez","orcid":"https://orcid.org/0000-0002-0804-1865","observed_orcids":["https://orcid.org/0000-0002-0804-1865"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose\u0301 A. Ferna\u0301ndez","raw_affiliation_strings":["the Departments of Neurology (M.F., S.F.A., D.X.) and Preventive Medicine (A.P.-H.), University of Southern California School of Medicine (Los Angeles), and the Departments of Molecular and Experimental Medicine and of Vascular Biology, The Scripps Research Institute, La Jolla, Calif (J.A.F., A.G., J.H.G.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Neurology (M.F., S.F.A., D.X.) and Preventive Medicine (A.P.-H.), University of Southern California School of Medicine (Los Angeles), and the Departments of Molecular and Experimental Medicine and of Vascular Biology, The Scripps Research Institute, La Jolla, Calif (J.A.F., A.G., J.H.G.)","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051881130","display_name":"Sebastian Francisco Ameriso","orcid":"https://orcid.org/0000-0001-8933-0847","observed_orcids":["https://orcid.org/0000-0001-8933-0847"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sebastian F. Ameriso","raw_affiliation_strings":["the Departments of Neurology (M.F., S.F.A., D.X.) and Preventive Medicine (A.P.-H.), University of Southern California School of Medicine (Los Angeles), and the Departments of Molecular and Experimental Medicine and of Vascular Biology, The Scripps Research Institute, La Jolla, Calif (J.A.F., A.G., J.H.G.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Neurology (M.F., S.F.A., D.X.) and Preventive Medicine (A.P.-H.), University of Southern California School of Medicine (Los Angeles), and the Departments of Molecular and Experimental Medicine and of Vascular Biology, The Scripps Research Institute, La Jolla, Calif (J.A.F., A.G., J.H.G.)","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013152980","display_name":"Dangci Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dangci Xie","raw_affiliation_strings":["the Departments of Neurology (M.F., S.F.A., D.X.) and Preventive Medicine (A.P.-H.), University of Southern California School of Medicine (Los Angeles), and the Departments of Molecular and Experimental Medicine and of Vascular Biology, The Scripps Research Institute, La Jolla, Calif (J.A.F., A.G., J.H.G.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Neurology (M.F., S.F.A., D.X.) and Preventive Medicine (A.P.-H.), University of Southern California School of Medicine (Los Angeles), and the Departments of Molecular and Experimental Medicine and of Vascular Biology, The Scripps Research Institute, La Jolla, Calif (J.A.F., A.G., J.H.G.)","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036237322","display_name":"Andr\u00e1s Gruber","orcid":"https://orcid.org/0000-0001-6212-2247","observed_orcids":["https://orcid.org/0000-0001-6212-2247"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andras Gruber","raw_affiliation_strings":["the Departments of Neurology (M.F., S.F.A., D.X.) and Preventive Medicine (A.P.-H.), University of Southern California School of Medicine (Los Angeles), and the Departments of Molecular and Experimental Medicine and of Vascular Biology, The Scripps Research Institute, La Jolla, Calif (J.A.F., A.G., J.H.G.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Neurology (M.F., S.F.A., D.X.) and Preventive Medicine (A.P.-H.), University of Southern California School of Medicine (Los Angeles), and the Departments of Molecular and Experimental Medicine and of Vascular Biology, The Scripps Research Institute, La Jolla, Calif (J.A.F., A.G., J.H.G.)","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065067002","display_name":"Annlia Paganini\u2010Hill","orcid":"https://orcid.org/0000-0003-4106-3334","observed_orcids":["https://orcid.org/0000-0003-4106-3334"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annlia Paganini-Hill","raw_affiliation_strings":["the Departments of Neurology (M.F., S.F.A., D.X.) and Preventive Medicine (A.P.-H.), University of Southern California School of Medicine (Los Angeles), and the Departments of Molecular and Experimental Medicine and of Vascular Biology, The Scripps Research Institute, La Jolla, Calif (J.A.F., A.G., J.H.G.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Neurology (M.F., S.F.A., D.X.) and Preventive Medicine (A.P.-H.), University of Southern California School of Medicine (Los Angeles), and the Departments of Molecular and Experimental Medicine and of Vascular Biology, The Scripps Research Institute, La Jolla, Calif (J.A.F., A.G., J.H.G.)","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102759807","display_name":"John H. Griffin","orcid":"https://orcid.org/0000-0002-4302-2547","observed_orcids":["https://orcid.org/0000-0002-4302-2547"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Griffin","raw_affiliation_strings":["the Departments of Neurology (M.F., S.F.A., D.X.) and Preventive Medicine (A.P.-H.), University of Southern California School of Medicine (Los Angeles), and the Departments of Molecular and Experimental Medicine and of Vascular Biology, The Scripps Research Institute, La Jolla, Calif (J.A.F., A.G., J.H.G.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Neurology (M.F., S.F.A., D.X.) and Preventive Medicine (A.P.-H.), University of Southern California School of Medicine (Los Angeles), and the Departments of Molecular and Experimental Medicine and of Vascular Biology, The Scripps Research Institute, La Jolla, Calif (J.A.F., A.G., J.H.G.)","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.6992,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.98072407,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"27","issue":"7","first_page":"1163","last_page":"1166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/activated-protein-c-resistance","display_name":"activated protein C resistance","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9240000247955322},{"id":"https://openalex.org/keywords/factor-v-leiden","display_name":"factor V Leiden","score":0.8230000138282776},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hispanic-patients","display_name":"Hispanic patients","score":0.6159999966621399},{"id":"https://openalex.org/keywords/anticoagulant-resistance","display_name":"anticoagulant resistance","score":0.6869999766349792},{"id":"https://openalex.org/keywords/stroke-risk-factors","display_name":"stroke risk factors","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8510681390762329},{"id":"https://openalex.org/C2781287897","wikidata":"https://www.wikidata.org/wiki/Q412810","display_name":"Protein C","level":2,"score":0.7516264319419861},{"id":"https://openalex.org/C2779956388","wikidata":"https://www.wikidata.org/wiki/Q296104","display_name":"Activated protein C resistance","level":5,"score":0.7300623059272766},{"id":"https://openalex.org/C2776046644","wikidata":"https://www.wikidata.org/wiki/Q422831","display_name":"Factor V","level":3,"score":0.7131130695343018},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.590599775314331},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.5893529057502747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5771006345748901},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.49832653999328613},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4753396511077881},{"id":"https://openalex.org/C2778261982","wikidata":"https://www.wikidata.org/wiki/Q1755136","display_name":"Partial thromboplastin time","level":3,"score":0.4749172627925873},{"id":"https://openalex.org/C2777175894","wikidata":"https://www.wikidata.org/wiki/Q185986","display_name":"Factor V Leiden","level":4,"score":0.4434199035167694},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4387873113155365},{"id":"https://openalex.org/C15045988","wikidata":"https://www.wikidata.org/wiki/Q419531","display_name":"Factor XI","level":3,"score":0.4290151298046112},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.42129582166671753},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4123991131782532},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.4117595851421356},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33660101890563965},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.3038070499897003},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1412283182144165},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.10922178626060486},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08718329668045044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08481064438819885},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005165","descriptor_name":"Factor V","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005165","descriptor_name":"Factor V","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006630","descriptor_name":"Hispanic or Latino","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010314","descriptor_name":"Partial Thromboplastin Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015141","descriptor_name":"Los Angeles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.str.27.7.1163","doi":"https://doi.org/10.1161/01.str.27.7.1163","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.str.27.7.1163","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},{"id":"pmid:8685921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8685921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3876130284","display_name":null,"funder_award_id":"P01N531945","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G4010074132","display_name":null,"funder_award_id":"NS24456","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7365142983","display_name":"NORTH AMERICAN SYMPTOMATIC CAROTID ENDARTERECTOMY TRIAL","funder_award_id":"R01NS024456","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8974919034","display_name":"STRUCTURE AND FUNCTION OF PROTEIN C","funder_award_id":"R37HL052246","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1578269485","https://openalex.org/W1589420516","https://openalex.org/W1605065455","https://openalex.org/W1696947947","https://openalex.org/W1965958910","https://openalex.org/W1967221315","https://openalex.org/W1977503236","https://openalex.org/W1978668033","https://openalex.org/W1986999852","https://openalex.org/W1988826969","https://openalex.org/W1995474189","https://openalex.org/W2009373062","https://openalex.org/W2010514761","https://openalex.org/W2011895219","https://openalex.org/W2017967816","https://openalex.org/W2044708838","https://openalex.org/W2044790853","https://openalex.org/W2059308063","https://openalex.org/W2068240290","https://openalex.org/W2069343109","https://openalex.org/W2077770912","https://openalex.org/W2081181859","https://openalex.org/W2090368722","https://openalex.org/W2104062454","https://openalex.org/W2105604369","https://openalex.org/W2265785629","https://openalex.org/W2287148382","https://openalex.org/W2328547014","https://openalex.org/W2339305503","https://openalex.org/W2382154612","https://openalex.org/W2401627076","https://openalex.org/W2408188083","https://openalex.org/W2410621809","https://openalex.org/W2412782517","https://openalex.org/W2413241816","https://openalex.org/W2414253260","https://openalex.org/W2417642457","https://openalex.org/W2560269372","https://openalex.org/W3115500913","https://openalex.org/W4323283585"],"related_works":["https://openalex.org/W2171551573","https://openalex.org/W2040572522","https://openalex.org/W2413679964","https://openalex.org/W2405927150","https://openalex.org/W2044790853","https://openalex.org/W2017325681","https://openalex.org/W2044021856","https://openalex.org/W1980206272","https://openalex.org/W2409417821","https://openalex.org/W2077770912"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"PURPOSE:":[2],"Resistance":[3],"to":[4],"activated":[5,77],"protein":[6],"C":[7],"(APC),":[8],"a":[9,61,191],"natural":[10],"plasma":[11,87,97,102],"anticoagulant,":[12],"is":[13,35,171],"the":[14,46,92,108,152,164,175],"most":[15],"common":[16],"identifiable":[17],"risk":[18,192],"factor":[19,29,54,100,105,149,153,176,186,193],"for":[20,194],"venous":[21,41],"thromboembolic":[22],"disease.":[23],"One":[24,82],"point":[25],"mutation":[26,56,188],"in":[27,37,57,116,197],"coagulation":[28],"V":[30,55,154,177,187],"that":[31],"renders":[32],"it":[33],"APC-resistant":[34,40,104,148],"found":[36],">90%":[38],"of":[39,48,52,63,121,126,137,168],"thrombosis":[42],"patients.":[43,66],"To":[44],"determine":[45],"prevalence":[47],"APC":[49,89,132,169,180],"resistance":[50,133,170,181],"and":[51,91],"this":[53,185,198],"stroke,":[58,163],"we":[59],"screened":[60,73],"group":[62],"ischemic":[64,69,162,195],"stroke":[65,70,129,196],"METHODS:":[67],"Hispanic":[68,118,159],"patients":[71,130,160],"were":[72,112],"using":[74,84,95],"two":[75],"different":[76],"partial":[78],"thromboplastin":[79],"time-based":[80],"assays.":[81],"assay":[83,94],"neat":[85],"patient":[86,96,143],"determined":[88,103],"resistance,":[90],"other":[93],"diluted":[98],"into":[99],"V-deficient":[101],"V,":[106,150],"including":[107],"Arg506-->Gln":[109,155,178],"mutation.":[110,156,179],"Results":[111],"compared":[113,134],"with":[114,135,161],"those":[115],"31":[117,138],"control":[119,140,145],"subjects":[120],"similar":[122],"ages.":[123],"RESULTS:":[124],"Six":[125],"63":[127],"(9.5%)":[128],"had":[131,147],"none":[136],"(0%)":[139],"subjects.":[141],"No":[142],"or":[144],"subject":[146],"ie,":[151],"CONCLUSIONS:":[157],"In":[158],"incidence":[165],"(approximately":[166],"10%)":[167],"not":[172,182],"caused":[173,183],"by":[174,184],"may":[189],"be":[190],"population.":[199]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
