{"id":"https://openalex.org/W2060080945","doi":"https://doi.org/10.1007/s11999-008-0323-3","title":"Polymorphisms and Methylation of the Reduced Folate Carrier in Osteosarcoma","display_name":"Polymorphisms and Methylation of the Reduced Folate Carrier in Osteosarcoma","publication_year":2008,"publication_date":"2008-06-04","ids":{"openalex":"https://openalex.org/W2060080945","doi":"https://doi.org/10.1007/s11999-008-0323-3","mag":"2060080945","pmid":"https://pubmed.ncbi.nlm.nih.gov/18528741","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2493020"},"language":"en","primary_location":{"id":"doi:10.1007/s11999-008-0323-3","doi":"https://doi.org/10.1007/s11999-008-0323-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11999-008-0323-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11999-008-0323-3.pdf","source":{"id":"https://openalex.org/S191421250","display_name":"Clinical Orthopaedics and Related Research","issn_l":"0009-921X","issn":["0009-921X","1528-1132"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Orthopaedics and Related Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1007/s11999-008-0323-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059485677","display_name":"Rui Yang","orcid":"https://orcid.org/0000-0001-9126-4957","observed_orcids":["https://orcid.org/0000-0001-9126-4957"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I4210135976","display_name":"Children's Hospital at Montefiore","ror":"https://ror.org/03n0fp725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rui Yang","raw_affiliation_strings":["Department of Pediatrics and Molecular Pharmacology, The Albert Einstein College of Medicine, The Children's Hospital at Montefiore, 3415 Bainbridge Avenue, Rosenthal 3rd Floor, Bronx, NY 10467, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Molecular Pharmacology, The Albert Einstein College of Medicine, The Children's Hospital at Montefiore, 3415 Bainbridge Avenue, Rosenthal 3rd Floor, Bronx, NY 10467, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I4210135976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105937278","display_name":"Jing Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Qin","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077636119","display_name":"Bang H. Hoang","orcid":"https://orcid.org/0000-0002-2950-3221","observed_orcids":["https://orcid.org/0000-0002-2950-3221"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bang H. Hoang","raw_affiliation_strings":["Orthopedic Surgery Service, Weill Medical College of Cornell, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","Department of Orthopaedic Surgery, University of California, Irvine, USA","Orthopedic Surgery Service, Weill Medical College of Cornell, Memorial Sloan-Kettering Cancer Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopedic Surgery Service, Weill Medical College of Cornell, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Orthopedic Surgery Service, Weill Medical College of Cornell, Memorial Sloan-Kettering Cancer Center, New York, USA","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022207361","display_name":"John H. Healey","orcid":"https://orcid.org/0000-0002-0802-1186","observed_orcids":["https://orcid.org/0000-0002-0802-1186"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Healey","raw_affiliation_strings":["Orthopedic Surgery Service, Weill Medical College of Cornell, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","Orthopedic Surgery Service, Weill Medical College of Cornell, Memorial Sloan-Kettering Cancer Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopedic Surgery Service, Weill Medical College of Cornell, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Orthopedic Surgery Service, Weill Medical College of Cornell, Memorial Sloan-Kettering Cancer Center, New York, USA","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032743242","display_name":"Richard Greg Gorlick","orcid":"https://orcid.org/0000-0001-8995-2929","observed_orcids":["https://orcid.org/0000-0001-8995-2929"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I4210135976","display_name":"Children's Hospital at Montefiore","ror":"https://ror.org/03n0fp725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135976"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard Gorlick","raw_affiliation_strings":["Department of Pediatrics and Molecular Pharmacology, The Albert Einstein College of Medicine, The Children\u2019s Hospital at Montefiore, 3415 Bainbridge Avenue, Rosenthal 3rd Floor, Bronx, NY, 10467, USA","Department of Pediatrics and Molecular Pharmacology, The Albert Einstein College of Medicine, The Children\u2019s Hospital at Montefiore, Bronx, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Molecular Pharmacology, The Albert Einstein College of Medicine, The Children\u2019s Hospital at Montefiore, 3415 Bainbridge Avenue, Rosenthal 3rd Floor, Bronx, NY, 10467, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I4210135976"]},{"raw_affiliation_string":"Department of Pediatrics and Molecular Pharmacology, The Albert Einstein College of Medicine, The Children\u2019s Hospital at Montefiore, Bronx, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I4210135976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5032743242"],"corresponding_institution_ids":["https://openalex.org/I129975664","https://openalex.org/I4210135976"],"apc_list":null,"apc_paid":null,"fwci":1.532,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.84271321,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"466","issue":"9","first_page":"2046","last_page":"2051"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reduced-folate-carrier","display_name":"reduced folate carrier","score":0.972000002861023},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.8230000138282776},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/3-untranslated-region-polymorphism","display_name":"3' untranslated region polymorphism","score":0.9169999957084656},{"id":"https://openalex.org/keywords/methotrexate-resistance","display_name":"methotrexate resistance","score":0.9589999914169312},{"id":"https://openalex.org/keywords/methotrexate-uptake","display_name":"methotrexate uptake","score":0.9440000057220459},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.817607045173645},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6771202683448792},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.5990135669708252},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5834110379219055},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.5357770919799805},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5213924050331116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5124669671058655},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.5102975368499756},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43646112084388733},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.4297780394554138},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.4254331886768341},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.31678956747055054},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.29349860548973083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2835019826889038},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2766876816749573},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2714766561985016},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2252117097377777},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17109903693199158},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1607247292995453}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018807","descriptor_name":"Polymorphism, Single-Stranded Conformational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058978","descriptor_name":"Reduced Folate Carrier Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s11999-008-0323-3","doi":"https://doi.org/10.1007/s11999-008-0323-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11999-008-0323-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11999-008-0323-3.pdf","source":{"id":"https://openalex.org/S191421250","display_name":"Clinical Orthopaedics and Related Research","issn_l":"0009-921X","issn":["0009-921X","1528-1132"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Orthopaedics and Related Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2493020","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2493020","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Orthop Relat Res","raw_type":"Text"},{"id":"pmid:18528741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18528741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical orthopaedics and related research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s11999-008-0323-3","doi":"https://doi.org/10.1007/s11999-008-0323-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11999-008-0323-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11999-008-0323-3.pdf","source":{"id":"https://openalex.org/S191421250","display_name":"Clinical Orthopaedics and Related Research","issn_l":"0009-921X","issn":["0009-921X","1528-1132"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Orthopaedics and Related Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309468","display_name":"Memorial Sloan-Kettering Cancer Center","ror":"https://ror.org/02yrq0923"},{"id":"https://openalex.org/F4320309886","display_name":"Rutgers Cancer Institute of New Jersey","ror":"https://ror.org/05vt9qd57"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2060080945.pdf","grobid_xml":"https://content.openalex.org/works/W2060080945.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1504303645","https://openalex.org/W1633962291","https://openalex.org/W1946181835","https://openalex.org/W1973931979","https://openalex.org/W1974658241","https://openalex.org/W2002710745","https://openalex.org/W2005025180","https://openalex.org/W2005930815","https://openalex.org/W2007470097","https://openalex.org/W2022200703","https://openalex.org/W2023452084","https://openalex.org/W2025633862","https://openalex.org/W2055968410","https://openalex.org/W2067372171","https://openalex.org/W2075437346","https://openalex.org/W2092674943","https://openalex.org/W2094075600","https://openalex.org/W2095826659","https://openalex.org/W2101259585","https://openalex.org/W2121417064","https://openalex.org/W2123321988","https://openalex.org/W2124635305","https://openalex.org/W2127532437","https://openalex.org/W2138122497","https://openalex.org/W2147934034","https://openalex.org/W2150920867","https://openalex.org/W2162376831","https://openalex.org/W2162880859","https://openalex.org/W2188910199","https://openalex.org/W2324225179","https://openalex.org/W2416664351","https://openalex.org/W4245103890"],"related_works":["https://openalex.org/W2124635305","https://openalex.org/W2329372490","https://openalex.org/W2013623834","https://openalex.org/W2095826659","https://openalex.org/W2994040119","https://openalex.org/W2035614599","https://openalex.org/W2018780534","https://openalex.org/W2188910199","https://openalex.org/W2025800129","https://openalex.org/W7056844768"],"abstract_inverted_index":{"High-dose":[0],"methotrexate":[1,13,27],"is":[2,22,101,184],"a":[3,23,54,92],"standard":[4],"component":[5],"in":[6,29,40,47,79,103,133,162,175,179],"the":[7,41,86,134,148,163,168],"treatment":[8],"of":[9,26,56,76,81,128,167],"osteogenic":[10,30,58,180],"sarcoma.":[11,181],"Impaired":[12],"uptake":[14],"associated":[15],"with":[16,107,115,119,147],"decreased":[17],"reduced":[18,49,87,97,139,169],"folate":[19,50,88,98,140,170],"carrier":[20,51,89,99,141,171],"expression":[21,100,142],"common":[24],"mechanism":[25],"resistance":[28],"sarcoma":[31,59],"samples.":[32,82],"We":[33,72],"investigated":[34],"whether":[35],"promoter":[36,77,158],"methylation":[37,78,112,159],"and":[38,66,131,151,160],"polymorphisms":[39,127,161],"3'":[42,135,164],"untranslated":[43,136,165],"region":[44,137,166],"are":[45],"involved":[46,174],"regulating":[48],"expression.":[52],"In":[53],"cohort":[55],"66":[57],"specimens,":[60],"quantitative":[61],"methylation-specific":[62],"polymerase":[63],"chain":[64],"reaction":[65],"single-strand":[67],"conformation":[68],"polymorphism":[69],"were":[70],"performed.":[71],"found":[73],"detectable":[74],"levels":[75],"84.3%":[80],"When":[83],"related":[84],"to":[85,186],"mRNA":[90],"levels,":[91],"trend":[93],"was":[94],"observed":[95],"that":[96],"lower":[102],"samples":[104],"(median,":[105,117,143,153],"0.7)":[106],"greater":[108],"than":[109,121],"10%":[110,122],"DNA":[111,123],"as":[113,145],"compared":[114,146],"those":[116],"2.3)":[118],"less":[120],"methylation.":[124],"The":[125,155],"heterozygous":[126],"2582":[129],"T/G":[130],"2617C/T":[132],"showed":[138],"0.9)":[144],"wild-type":[149],"2582T":[150],"2617C":[152],"4.2).":[154],"data":[156],"suggest":[157],"may":[172],"be":[173],"its":[176],"transcriptional":[177],"regulation":[178],"Further":[182],"study":[183],"required":[185],"confirm":[187],"this":[188],"finding.":[189]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}