{"id":"https://openalex.org/W2060076574","doi":"https://doi.org/10.1021/ie1007932","title":"Micronization of p-Aminosalicylic Acid Particles Using High-Gravity Technique","display_name":"Micronization of p-Aminosalicylic Acid Particles Using High-Gravity Technique","publication_year":2010,"publication_date":"2010-08-17","ids":{"openalex":"https://openalex.org/W2060076574","doi":"https://doi.org/10.1021/ie1007932","mag":"2060076574"},"language":"en","primary_location":{"id":"doi:10.1021/ie1007932","doi":"https://doi.org/10.1021/ie1007932","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ie1007932","pdf_url":null,"source":{"id":"https://openalex.org/S202680183","display_name":"Industrial & Engineering Chemistry Research","issn_l":"0888-5885","issn":["0888-5885","1520-5045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Industrial & Engineering Chemistry Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073281236","display_name":"Yu\u2010Shao Chen","orcid":"https://orcid.org/0000-0003-3284-354X","observed_orcids":["https://orcid.org/0000-0003-3284-354X","https://orcid.org/0000-0002-6592-9801"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Shao Chen","raw_affiliation_strings":["Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan Department of Chemical Engineering, Chung Yuan University, Taoyuan 320, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan Department of Chemical Engineering, Chung Yuan University, Taoyuan 320, Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005367532","display_name":"Yao-Hsuan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yao-Hsuan Wang","raw_affiliation_strings":["Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan Department of Chemical Engineering, Chung Yuan University, Taoyuan 320, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan Department of Chemical Engineering, Chung Yuan University, Taoyuan 320, Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111779926","display_name":"Hwai-Shen Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hwai-Shen Liu","raw_affiliation_strings":["Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan Department of Chemical Engineering, Chung Yuan University, Taoyuan 320, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan Department of Chemical Engineering, Chung Yuan University, Taoyuan 320, Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111557441","display_name":"Kuang-Yang Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuang-Yang Hsu","raw_affiliation_strings":["Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan Department of Chemical Engineering, Chung Yuan University, Taoyuan 320, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan Department of Chemical Engineering, Chung Yuan University, Taoyuan 320, Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I47519274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110666356","display_name":"Clifford Yi-Der Tai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Clifford Y. Tai","raw_affiliation_strings":["Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan Department of Chemical Engineering, Chung Yuan University, Taoyuan 320, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan Department of Chemical Engineering, Chung Yuan University, Taoyuan 320, Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I47519274"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110666356"],"corresponding_institution_ids":["https://openalex.org/I16733864","https://openalex.org/I47519274"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.2798,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.49148155,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"49","issue":"18","first_page":"8832","last_page":"8840"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.7612000107765198,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.7612000107765198,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.21850000321865082,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10615","display_name":"Granular flow and fluidized beds","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-aminosalicylic-acid","display_name":"p-aminosalicylic acid","score":0.9959999918937683},{"id":"https://openalex.org/keywords/micronization","display_name":"micronization","score":0.9539999961853027},{"id":"https://openalex.org/keywords/antisolvent-precipitation","display_name":"antisolvent precipitation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/high-pressure-homogenization","display_name":"high-pressure homogenization","score":0.8289999961853027},{"id":"https://openalex.org/keywords/particle-size-reduction","display_name":"particle size reduction","score":0.7519999742507935},{"id":"https://openalex.org/keywords/dispersant-concentration","display_name":"dispersant concentration","score":0.6909999847412109},{"id":"https://openalex.org/keywords/particle-agglomeration","display_name":"particle agglomeration","score":0.8399999737739563},{"id":"https://openalex.org/keywords/dissolution-enhancement","display_name":"dissolution enhancement","score":0.7940000295639038},{"id":"https://openalex.org/keywords/drug-particles","display_name":"drug particles","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C86178769","wikidata":"https://www.wikidata.org/wiki/Q1130789","display_name":"Micronization","level":3,"score":0.862214207649231},{"id":"https://openalex.org/C2908904536","wikidata":"https://www.wikidata.org/wiki/Q5958048","display_name":"High Gravity","level":3,"score":0.590641975402832},{"id":"https://openalex.org/C2776206795","wikidata":"https://www.wikidata.org/wiki/Q2823237","display_name":"Aminosalicylic acid","level":2,"score":0.538987934589386},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43541383743286133},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.37420654296875},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.343711256980896},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.3272906541824341},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.32494187355041504},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.167490154504776},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.14259934425354004},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12454244494438171},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09737074375152588},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09642094373703003},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1021/ie1007932","doi":"https://doi.org/10.1021/ie1007932","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ie1007932","pdf_url":null,"source":{"id":"https://openalex.org/S202680183","display_name":"Industrial & Engineering Chemistry Research","issn_l":"0888-5885","issn":["0888-5885","1520-5045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Industrial & Engineering Chemistry Research","raw_type":"journal-article"},{"id":"pmh:oai:localhost:987654321/47861","doi":null,"is_oa":false,"landing_page_url":"http://libir.tmu.edu.tw/handle/987654321/47861","pdf_url":null,"source":{"id":"https://openalex.org/S4406923063","display_name":"Taipei Medical University Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:libir.tmu.edu.tw:123456789/23531","doi":null,"is_oa":false,"landing_page_url":"https://203.71.86.71/handle/123456789/23531","pdf_url":null,"source":{"id":"https://openalex.org/S4406923063","display_name":"Taipei Medical University Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1517661852","https://openalex.org/W1845028167","https://openalex.org/W1928606408","https://openalex.org/W1977281681","https://openalex.org/W1979526695","https://openalex.org/W1984310605","https://openalex.org/W1988127957","https://openalex.org/W1990524263","https://openalex.org/W1994805566","https://openalex.org/W1997813812","https://openalex.org/W1998580244","https://openalex.org/W2005139629","https://openalex.org/W2013929608","https://openalex.org/W2018937851","https://openalex.org/W2036893240","https://openalex.org/W2051355660","https://openalex.org/W2055444002","https://openalex.org/W2055767033","https://openalex.org/W2060546390","https://openalex.org/W2068133763","https://openalex.org/W2072855654","https://openalex.org/W2075179133","https://openalex.org/W2076858446","https://openalex.org/W2082928799","https://openalex.org/W2083666643","https://openalex.org/W2087050645","https://openalex.org/W2087271701","https://openalex.org/W2088739723","https://openalex.org/W2147268085","https://openalex.org/W4251505294"],"related_works":["https://openalex.org/W7112615892","https://openalex.org/W2045095103","https://openalex.org/W2567003645","https://openalex.org/W2147268085","https://openalex.org/W2068801176","https://openalex.org/W2020304962","https://openalex.org/W2067422015","https://openalex.org/W2026149474","https://openalex.org/W2079024113","https://openalex.org/W7126087704"],"abstract_inverted_index":{"An":[0],"antisolvent":[1],"precipitation":[2,99],"process":[3,141],"was":[4,55,62,90,128],"adopted":[5],"in":[6,35,45,82,108],"this":[7],"study":[8],"to":[9,111],"prepare":[10],"micrometer-sized":[11],"p":[12],"-aminosalicylic":[13],"acid":[14],"(PAS)":[15,48],"particles":[16,107,114],"using":[17],"the":[18,27,36,46,50,72,75,78,83,97,103,106,109,125,131,139],"high-gravity":[19,98,140],"technique.":[20],"The":[21,93,122,135],"effects":[22],"of":[23,53,77,105,119,124],"operating":[24],"variables":[25],"on":[26],"particle":[28,51],"size":[29,52,118],"were":[30],"investigated.":[31],"With":[32],"an":[33],"increase":[34],"dispersant":[37],"concentration":[38],"and":[39,87],"disk":[40],"diameter":[41],"or":[42],"a":[43,59,66,116,143],"decrease":[44],"drug":[47,113,133,148],"concentration,":[49],"PAS":[54],"reduced.":[56],"In":[57],"addition,":[58],"circular-tube":[60],"distributor":[61,68],"more":[63],"effective":[64],"than":[65],"straight-tube":[67],"for":[69,130,146],"micronization.":[70],"On":[71],"other":[73],"hand,":[74],"effect":[76],"liquid":[79],"flow":[80],"rate":[81,127],"range":[84],"between":[85],"0.25":[86],"1":[88,120],"L/min":[89],"less":[91],"significant.":[92],"high-pressure":[94],"homogenization":[95],"following":[96],"would":[100],"effectively":[101],"reduce":[102],"agglomeration":[104],"suspension":[110],"produce":[112],"with":[115],"mean":[117],"\u03bcm.":[121],"enhancement":[123],"dissolution":[126],"significant":[129],"micronized":[132],"particles.":[134,149],"results":[136],"indicate":[137],"that":[138],"is":[142],"promising":[144],"approach":[145],"micronizing":[147]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}