{"id":"https://openalex.org/W2060076563","doi":"https://doi.org/10.3389/fimmu.2013.00337","title":"Eradication of HIV and Cure of AIDS, Now and How?","display_name":"Eradication of HIV and Cure of AIDS, Now and How?","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2060076563","doi":"https://doi.org/10.3389/fimmu.2013.00337","mag":"2060076563","pmid":"https://pubmed.ncbi.nlm.nih.gov/24151495","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3799464"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2013.00337","doi":"https://doi.org/10.3389/fimmu.2013.00337","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2013.00337","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2013.00337/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2013.00337/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109172698","display_name":"Jielin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jielin Zhang","raw_affiliation_strings":["Department of Medicine Beth, Israel Deaconess Medical Center, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Beth, Israel Deaconess Medical Center, Boston, MA, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082691948","display_name":"Clyde S. Crumpacker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Clyde Crumpacker","raw_affiliation_strings":["Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA","Harvard medical school, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA","institution_ids":["https://openalex.org/I1316535847"]},{"raw_affiliation_string":"Harvard medical school, Boston, United States","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082691948"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.5593,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.44836957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"4","issue":null,"first_page":"337","last_page":"337"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-eradication","display_name":"HIV eradication","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hiv-reservoir","display_name":"HIV reservoir","score":0.7099999785423279},{"id":"https://openalex.org/keywords/memory-cd4-t-cells","display_name":"memory CD4+ T cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hiv-reactivation","display_name":"HIV reactivation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.9079999923706055},{"id":"https://openalex.org/keywords/stem-cell-properties","display_name":"stem cell properties","score":0.49399998784065247},{"id":"https://openalex.org/keywords/innate-and-adaptive-immunity","display_name":"innate and adaptive immunity","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.68665611743927},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5272173881530762},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5144672393798828},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3489936888217926},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3274742364883423},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.3262821435928345}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2013.00337","doi":"https://doi.org/10.3389/fimmu.2013.00337","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2013.00337","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2013.00337/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2793537","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3799464","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3799464","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3799464","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:24151495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24151495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4e2ea30880fc46e4a1dd5e86f039086c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4e2ea30880fc46e4a1dd5e86f039086c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 4 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2013.00337","doi":"https://doi.org/10.3389/fimmu.2013.00337","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2013.00337","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2013.00337/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2060076563.pdf","grobid_xml":"https://content.openalex.org/works/W2060076563.grobid-xml"},"referenced_works_count":114,"referenced_works":["https://openalex.org/W26332760","https://openalex.org/W1493822493","https://openalex.org/W1496816690","https://openalex.org/W1507192983","https://openalex.org/W1507573241","https://openalex.org/W1590436404","https://openalex.org/W1592864174","https://openalex.org/W1602780463","https://openalex.org/W1604800926","https://openalex.org/W1674146216","https://openalex.org/W1809324973","https://openalex.org/W1972626855","https://openalex.org/W1973370266","https://openalex.org/W1975438827","https://openalex.org/W1976474059","https://openalex.org/W1983617338","https://openalex.org/W1986222655","https://openalex.org/W1990388100","https://openalex.org/W1992690552","https://openalex.org/W1992761009","https://openalex.org/W1992870543","https://openalex.org/W1994047615","https://openalex.org/W1995391551","https://openalex.org/W1996175658","https://openalex.org/W1999690840","https://openalex.org/W2004458954","https://openalex.org/W2005853315","https://openalex.org/W2008667095","https://openalex.org/W2009626008","https://openalex.org/W2009662369","https://openalex.org/W2010687778","https://openalex.org/W2011729775","https://openalex.org/W2014161666","https://openalex.org/W2019438613","https://openalex.org/W2019563096","https://openalex.org/W2021115043","https://openalex.org/W2023721918","https://openalex.org/W2026004604","https://openalex.org/W2026814484","https://openalex.org/W2028917545","https://openalex.org/W2030355757","https://openalex.org/W2032679752","https://openalex.org/W2032822109","https://openalex.org/W2033467615","https://openalex.org/W2033940098","https://openalex.org/W2034010324","https://openalex.org/W2034819322","https://openalex.org/W2037088576","https://openalex.org/W2039055784","https://openalex.org/W2039777415","https://openalex.org/W2041559190","https://openalex.org/W2051001991","https://openalex.org/W2051044641","https://openalex.org/W2052959758","https://openalex.org/W2054136035","https://openalex.org/W2054217735","https://openalex.org/W2057109822","https://openalex.org/W2060255512","https://openalex.org/W2060446375","https://openalex.org/W2060963592","https://openalex.org/W2063556011","https://openalex.org/W2063563723","https://openalex.org/W2065708749","https://openalex.org/W2067609727","https://openalex.org/W2070190623","https://openalex.org/W2073749024","https://openalex.org/W2075090773","https://openalex.org/W2076534074","https://openalex.org/W2079858542","https://openalex.org/W2082695983","https://openalex.org/W2087865446","https://openalex.org/W2090563308","https://openalex.org/W2092803321","https://openalex.org/W2099143573","https://openalex.org/W2099468505","https://openalex.org/W2101844985","https://openalex.org/W2102264469","https://openalex.org/W2106042343","https://openalex.org/W2106431826","https://openalex.org/W2108210087","https://openalex.org/W2109010689","https://openalex.org/W2110887983","https://openalex.org/W2111945115","https://openalex.org/W2115403023","https://openalex.org/W2118351251","https://openalex.org/W2124058652","https://openalex.org/W2124114936","https://openalex.org/W2125458228","https://openalex.org/W2126960228","https://openalex.org/W2133900645","https://openalex.org/W2134280066","https://openalex.org/W2139250164","https://openalex.org/W2140510294","https://openalex.org/W2146312543","https://openalex.org/W2146789279","https://openalex.org/W2147932979","https://openalex.org/W2148989373","https://openalex.org/W2151217565","https://openalex.org/W2152129968","https://openalex.org/W2153950704","https://openalex.org/W2162606970","https://openalex.org/W2163197744","https://openalex.org/W2163944364","https://openalex.org/W2165578636","https://openalex.org/W2170391560","https://openalex.org/W2178857694","https://openalex.org/W2253959633","https://openalex.org/W2320150009","https://openalex.org/W2336115893","https://openalex.org/W2916182786","https://openalex.org/W2945792041","https://openalex.org/W4232948727","https://openalex.org/W4237038146","https://openalex.org/W6601602020"],"related_works":["https://openalex.org/W7098664164","https://openalex.org/W2063563723","https://openalex.org/W137451722","https://openalex.org/W2410601385","https://openalex.org/W7118163741","https://openalex.org/W2608841238","https://openalex.org/W4407525789","https://openalex.org/W2013554131","https://openalex.org/W2411905979","https://openalex.org/W7100372112"],"abstract_inverted_index":{"Recent":[0],"studies":[1],"have":[2],"highlighted":[3],"the":[4,25,49,64,72,83,107,122],"importance":[5],"of":[6,8,15,48,85,111],"eradication":[7,97],"human":[9],"immunodeficiency":[10,17],"virus":[11],"(HIV)":[12],"and":[13,54,59,92,98],"cure":[14],"acquired":[16],"syndrome":[18],"(AIDS).":[19],"However,":[20],"a":[21,90],"pivotal":[22],"point":[23],"that":[24,51],"patient":[26],"immunity":[27],"controls":[28],"HIV":[29,80],"reactivation":[30],"after":[31],"highly":[32],"active":[33],"anti-retroviral":[34,39],"therapy":[35,40],"[HAART":[36],"or":[37],"combination":[38],"(cART)]":[41],"remains":[42],"less":[43],"well":[44],"addressed.":[45],"In":[46],"spite":[47],"fact":[50],"both":[52],"innate":[53],"adaptive":[55],"immunities":[56],"are":[57,70],"indispensable":[58],"numerous":[60],"cells":[61,74,113],"participate":[62],"in":[63],"anti-HIV":[65,117],"immunity,":[66],"memory":[67,103,118],"CD4":[68,104],"T-cells":[69],"indisputably":[71],"key":[73],"organizing":[75],"all":[76],"immune":[77],"actions":[78],"against":[79],"while":[81],"being":[82],"targets":[84],"HIV.":[86],"Here":[87],"we":[88],"present":[89],"view":[91],"multidisciplinary":[93],"approaches":[94],"to":[95,114,120],"HIV/AIDS":[96],"cure.":[99],"We":[100],"aim":[101],"at":[102],"T-cells,":[105],"utilizing":[106],"stem":[108],"cell":[109],"properties":[110],"these":[112],"reprogram":[115],"an":[116,127],"repertoire":[119],"eliminate":[121],"viral":[123],"reservoir,":[124],"toward":[125],"achieving":[126],"AIDS-free":[128],"world.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
