{"id":"https://openalex.org/W2060069774","doi":"https://doi.org/10.1364/ao.51.008731","title":"Fluorescence molecular tomography using a two-step three-dimensional shape-based reconstruction with graphics processing unit acceleration","display_name":"Fluorescence molecular tomography using a two-step three-dimensional shape-based reconstruction with graphics processing unit acceleration","publication_year":2012,"publication_date":"2012-12-19","ids":{"openalex":"https://openalex.org/W2060069774","doi":"https://doi.org/10.1364/ao.51.008731","mag":"2060069774","pmid":"https://pubmed.ncbi.nlm.nih.gov/23262613"},"language":"en","primary_location":{"id":"doi:10.1364/ao.51.008731","doi":"https://doi.org/10.1364/ao.51.008731","is_oa":false,"landing_page_url":"https://doi.org/10.1364/ao.51.008731","pdf_url":null,"source":{"id":"https://openalex.org/S4210211917","display_name":"Applied Optics","issn_l":"0003-6935","issn":["0003-6935","1539-4522","1540-8981","1559-128X","2155-3165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315679","host_organization_name":"Optica Publishing Group","host_organization_lineage":["https://openalex.org/P4310315679"],"host_organization_lineage_names":["Optica Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Optics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091446947","display_name":"Daifa Wang","orcid":"https://orcid.org/0000-0003-3977-3206","observed_orcids":["https://orcid.org/0000-0003-3977-3206"]},"institutions":[{"id":"https://openalex.org/I4391767781","display_name":"State Key Laboratory of Software Development Environment","ror":"https://ror.org/017r4dj03","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391767781","https://openalex.org/I82880672"]},{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daifa Wang","raw_affiliation_strings":["State Key Laboratory of Software Development Environment, Beihang University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Software Development Environment, Beihang University, Beijing, China","institution_ids":["https://openalex.org/I4391767781","https://openalex.org/I82880672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102576248","display_name":"Huiting Qiao","orcid":"https://orcid.org/0000-0001-8772-069X","observed_orcids":["https://orcid.org/0000-0001-8772-069X"]},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiting Qiao","raw_affiliation_strings":["Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China","Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science & Medical Engineering, Beihang University, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China","institution_ids":["https://openalex.org/I82880672"]},{"raw_affiliation_string":"Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science & Medical Engineering, Beihang University, Beijing 100191, China","institution_ids":["https://openalex.org/I82880672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090414812","display_name":"Xiaolei Song","orcid":"https://orcid.org/0000-0002-0206-1574","observed_orcids":["https://orcid.org/0000-0002-0206-1574"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaolei Song","raw_affiliation_strings":["The Russell H. Morgan Department of Radiology and Radiological Sciences, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Sciences, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066943052","display_name":"Yubo Fan","orcid":"https://orcid.org/0000-0002-3480-4395","observed_orcids":["https://orcid.org/0000-0002-3480-4395"]},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yubo Fan","raw_affiliation_strings":["Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China","Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science & Medical Engineering, Beihang University, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China","institution_ids":["https://openalex.org/I82880672"]},{"raw_affiliation_string":"Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science & Medical Engineering, Beihang University, Beijing 100191, China","institution_ids":["https://openalex.org/I82880672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100698991","display_name":"Deyu Li","orcid":"https://orcid.org/0000-0002-1963-0710","observed_orcids":["https://orcid.org/0000-0002-1963-0710"]},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Deyu Li","raw_affiliation_strings":["Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China","Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science & Medical Engineering, Beihang University, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China","institution_ids":["https://openalex.org/I82880672"]},{"raw_affiliation_string":"Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science & Medical Engineering, Beihang University, Beijing 100191, China","institution_ids":["https://openalex.org/I82880672"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2069,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.78083508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"51","issue":"36","first_page":"8731","last_page":"8731"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluorescence-molecular-tomography","display_name":"fluorescence molecular tomography","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gpu-acceleration","display_name":"GPU acceleration","score":0.6759999990463257},{"id":"https://openalex.org/keywords/two-stage-optimization","display_name":"two-stage optimization","score":0.7120000123977661},{"id":"https://openalex.org/keywords/inverse-problems","display_name":"inverse problems","score":0.6549999713897705},{"id":"https://openalex.org/keywords/constrained-nonlinear-least-squares","display_name":"constrained nonlinear least squares","score":0.8059999942779541},{"id":"https://openalex.org/keywords/finite-element-analysis","display_name":"finite element analysis","score":0.6819999814033508},{"id":"https://openalex.org/keywords/jacobian-computation","display_name":"Jacobian computation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/noise-robustness","display_name":"noise robustness","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C117896860","wikidata":"https://www.wikidata.org/wiki/Q11376","display_name":"Acceleration","level":2,"score":0.5856791138648987},{"id":"https://openalex.org/C164660894","wikidata":"https://www.wikidata.org/wiki/Q2037833","display_name":"Piecewise","level":2,"score":0.5338602662086487},{"id":"https://openalex.org/C135252773","wikidata":"https://www.wikidata.org/wiki/Q1567213","display_name":"Inverse problem","level":2,"score":0.5019078254699707},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48829221725463867},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.48577120900154114},{"id":"https://openalex.org/C141379421","wikidata":"https://www.wikidata.org/wiki/Q6094427","display_name":"Iterative reconstruction","level":2,"score":0.4811069369316101},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.4697471261024475},{"id":"https://openalex.org/C2779851693","wikidata":"https://www.wikidata.org/wiki/Q183484","display_name":"Graphics processing unit","level":2,"score":0.44226786494255066},{"id":"https://openalex.org/C200331156","wikidata":"https://www.wikidata.org/wiki/Q506041","display_name":"Jacobian matrix and determinant","level":2,"score":0.43893009424209595},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4043576717376709},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.29796504974365234},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2889939546585083},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.26828306913375854},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.20482903718948364},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.18868723511695862},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.11979594826698303},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019544","descriptor_name":"Equipment Failure Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D041622","descriptor_name":"Tomography, Optical","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1364/ao.51.008731","doi":"https://doi.org/10.1364/ao.51.008731","is_oa":false,"landing_page_url":"https://doi.org/10.1364/ao.51.008731","pdf_url":null,"source":{"id":"https://openalex.org/S4210211917","display_name":"Applied Optics","issn_l":"0003-6935","issn":["0003-6935","1539-4522","1540-8981","1559-128X","2155-3165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315679","host_organization_name":"Optica Publishing Group","host_organization_lineage":["https://openalex.org/P4310315679"],"host_organization_lineage_names":["Optica Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Optics","raw_type":"journal-article"},{"id":"pmid:23262613","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23262613","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied optics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4837955433","display_name":null,"funder_award_id":"61108084","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5010069382","display_name":"\u57fa\u4e8emicro PET/CT\u5bf9\u80ba\u90e8\u80bf\u7624\u4e0e\u708e\u75c7\u8461\u8404\u7cd6\u4ee3\u8c22\u52a8\u6001\u7279\u5f81\u7684\u7814\u7a76","funder_award_id":"81101123","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7302901134","display_name":null,"funder_award_id":"SKLSDE-2011ZX-12","funder_id":"https://openalex.org/F4320326978","funder_display_name":"State Key Laboratory of Software Development Environment"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326978","display_name":"State Key Laboratory of Software Development Environment","ror":"https://ror.org/017r4dj03"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W18585895","https://openalex.org/W1565229770","https://openalex.org/W1964254493","https://openalex.org/W1969808883","https://openalex.org/W1972532549","https://openalex.org/W1974607771","https://openalex.org/W1977637828","https://openalex.org/W1980257886","https://openalex.org/W1989541248","https://openalex.org/W1996085026","https://openalex.org/W2001771415","https://openalex.org/W2011301737","https://openalex.org/W2027180576","https://openalex.org/W2029606255","https://openalex.org/W2036392698","https://openalex.org/W2043649486","https://openalex.org/W2048584772","https://openalex.org/W2062021463","https://openalex.org/W2066935878","https://openalex.org/W2079180677","https://openalex.org/W2089526563","https://openalex.org/W2106030748","https://openalex.org/W2109662011","https://openalex.org/W2110012738","https://openalex.org/W2120745971","https://openalex.org/W2122294678","https://openalex.org/W2127902336","https://openalex.org/W2144534840","https://openalex.org/W2148121821","https://openalex.org/W2148588305","https://openalex.org/W2161286679","https://openalex.org/W2164719261","https://openalex.org/W2166163757","https://openalex.org/W4235944846"],"related_works":["https://openalex.org/W2049444694","https://openalex.org/W1991323407","https://openalex.org/W250823442","https://openalex.org/W2438730927","https://openalex.org/W1967863802","https://openalex.org/W2654145507","https://openalex.org/W7166699251","https://openalex.org/W2577424456","https://openalex.org/W2220643408","https://openalex.org/W2013917920"],"abstract_inverted_index":{"In":[0,37],"fluorescence":[1,52],"molecular":[2],"tomography,":[3],"the":[4,40,46,76,91,110,113,122,127,132,161,167,171,180,186,201],"accurate":[5],"and":[6,107,126],"stable":[7],"reconstruction":[8,29,164],"of":[9,18,48,78,121,157,182,188],"fluorescence-labeled":[10],"targets":[11,156,189],"remains":[12],"a":[13,25,60,96,104,193],"challenge":[14],"for":[15,118],"wide":[16],"application":[17],"this":[19,38],"imaging":[20],"modality.":[21],"Here":[22],"we":[23,94],"propose":[24],"two-step":[26,97,172],"three-dimensional":[27],"shape-based":[28],"method":[30,151],"using":[31],"graphics":[32],"processing":[33],"unit":[34],"(GPU)":[35],"acceleration.":[36],"method,":[39],"fluorophore":[41],"distribution":[42],"is":[43,57,80,116,190],"assumed":[44],"as":[45,59,75],"sum":[47],"ellipsoids":[49],"with":[50,65],"piecewise-constant":[51],"intensities.":[53],"The":[54,145],"inverse":[55],"problem":[56,64],"formulated":[58],"constrained":[61],"nonlinear":[62],"least-squares":[63],"respect":[66],"to":[67,71,90,100,140],"shape":[68,86],"parameters,":[69],"leading":[70],"much":[72],"less":[73,141],"ill-posedness":[74],"number":[77,187],"unknowns":[79],"greatly":[81],"reduced.":[82],"Considering":[83],"that":[84,149],"various":[85,158],"parameters":[87],"contribute":[88],"differently":[89],"boundary":[92],"measurements,":[93],"use":[95],"optimization":[98,134,173],"algorithm":[99],"handle":[101],"them":[102],"in":[103,179,204],"distinctive":[105],"way":[106],"also":[108],"stabilize":[109],"reconstruction.":[111],"Additionally,":[112],"GPU":[114],"acceleration":[115],"employed":[117],"finite-element-method-based":[119],"calculation":[120],"objective":[123],"function":[124],"value":[125],"Jacobian":[128],"matrix,":[129],"which":[130],"reduces":[131],"total":[133],"time":[135],"from":[136],"around":[137],"10":[138],"min":[139],"than":[142],"1":[143],"min.":[144],"numerical":[146],"simulations":[147],"show":[148],"our":[150],"can":[152,174],"accurately":[153],"reconstruct":[154],"multiple":[155],"shapes":[159],"while":[160],"conventional":[162],"voxel-based":[163],"cannot":[165],"separate":[166],"nearby":[168],"targets.":[169],"Moreover,":[170],"tolerate":[175],"different":[176],"initial":[177],"values":[178],"existence":[181],"noises,":[183],"even":[184],"when":[185],"not":[191],"known":[192],"priori.":[194],"A":[195],"physical":[196],"phantom":[197],"experiment":[198],"further":[199],"demonstrates":[200],"method's":[202],"potential":[203],"practical":[205],"applications.":[206]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}