{"id":"https://openalex.org/W2060037872","doi":"https://doi.org/10.1523/jneurosci.4599-06.2007","title":"Rab5 Mediates an Amyloid Precursor Protein Signaling Pathway That Leads to Apoptosis","display_name":"Rab5 Mediates an Amyloid Precursor Protein Signaling Pathway That Leads to Apoptosis","publication_year":2007,"publication_date":"2007-07-04","ids":{"openalex":"https://openalex.org/W2060037872","doi":"https://doi.org/10.1523/jneurosci.4599-06.2007","mag":"2060037872","pmid":"https://pubmed.ncbi.nlm.nih.gov/17611268","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6794581"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.4599-06.2007","doi":"https://doi.org/10.1523/jneurosci.4599-06.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4599-06.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/27/7141.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/27/27/7141.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112008111","display_name":"Daphna Laifenfeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daphna Laifenfeld","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA. dlaifenfeld@mclean.harvard.edu","Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA. dlaifenfeld@mclean.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]},{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087994742","display_name":"Lucas J. Patzek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucas J. Patzek","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108392347","display_name":"Donna L. McPhie","orcid":"https://orcid.org/0009-0004-6623-5424","observed_orcids":["https://orcid.org/0009-0004-6623-5424"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donna L. McPhie","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034409858","display_name":"Yuzhi Chen","orcid":"https://orcid.org/0000-0002-5975-3053","observed_orcids":["https://orcid.org/0000-0002-5975-3053"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuzhi Chen","raw_affiliation_strings":["Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, and","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009025157","display_name":"Yona Levites","orcid":"https://orcid.org/0000-0001-6925-4525","observed_orcids":["https://orcid.org/0000-0001-6925-4525"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yona Levites","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113656534","display_name":"Anne M. Cataldo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne M. Cataldo","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084260138","display_name":"Rachael L. Neve","orcid":"https://orcid.org/0000-0002-3854-5968","observed_orcids":["https://orcid.org/0000-0002-3854-5968"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachael L. Neve","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478,","MRC 223 , McLean Hospital , 115 Mill Street , Belmont , MA 02478 "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]},{"raw_affiliation_string":"MRC 223 , McLean Hospital , 115 Mill Street , Belmont , MA 02478 ","institution_ids":["https://openalex.org/I2801148111"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0112,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.93211212,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"27","issue":"27","first_page":"7141","last_page":"7153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rab5","display_name":"Rab5","score":0.996999979019165},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9940000176429749},{"id":"https://openalex.org/keywords/familial-alzheimer-s-disease","display_name":"familial Alzheimer's disease","score":0.8989999890327454},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/early-endosomes","display_name":"early endosomes","score":0.8379999995231628},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.7639999985694885},{"id":"https://openalex.org/keywords/dynamin","display_name":"dynamin","score":0.7870000004768372},{"id":"https://openalex.org/keywords/eps15","display_name":"Eps15","score":0.9670000076293945},{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.7789999842643738},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7260000109672546},{"id":"https://openalex.org/keywords/protein-trafficking","display_name":"protein trafficking","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6910182237625122},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5958008170127869},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5624163746833801},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.5584713816642761},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.47819140553474426},{"id":"https://openalex.org/C36103677","wikidata":"https://www.wikidata.org/wiki/Q4749551","display_name":"Amyloid precursor protein secretase","level":5,"score":0.47050875425338745},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4293718934059143},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41478171944618225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32947707176208496},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.24134162068367004},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2359984815120697},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14692354202270508},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11950421333312988},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.113697350025177},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020696","descriptor_name":"rab5 GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020696","descriptor_name":"rab5 GTP-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.4599-06.2007","doi":"https://doi.org/10.1523/jneurosci.4599-06.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4599-06.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/27/7141.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6794581","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6794581","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:17611268","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17611268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.4599-06.2007","doi":"https://doi.org/10.1523/jneurosci.4599-06.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4599-06.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/27/7141.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2047000999","display_name":"APP-BP1, The Cell Cycle, and Alzheimer Disease","funder_award_id":"R01AG021185","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4559867606","display_name":null,"funder_award_id":"AG12954","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5275661767","display_name":null,"funder_award_id":"AG021185","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8216535212","display_name":"MOLECULAR BIOLOGY OF ALZHEIMER DISEASE NEURODEGENERATION","funder_award_id":"R01AG012954","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2060037872.pdf","grobid_xml":"https://content.openalex.org/works/W2060037872.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W58149416","https://openalex.org/W282408398","https://openalex.org/W1500435375","https://openalex.org/W1504283291","https://openalex.org/W1505339870","https://openalex.org/W1552824037","https://openalex.org/W1580332068","https://openalex.org/W1606338704","https://openalex.org/W1911014954","https://openalex.org/W1969271586","https://openalex.org/W1975510716","https://openalex.org/W1976609069","https://openalex.org/W1980859319","https://openalex.org/W1981008691","https://openalex.org/W1987020520","https://openalex.org/W1987210689","https://openalex.org/W1992484817","https://openalex.org/W2001839227","https://openalex.org/W2008087702","https://openalex.org/W2009023024","https://openalex.org/W2013082189","https://openalex.org/W2019061059","https://openalex.org/W2019843044","https://openalex.org/W2019987740","https://openalex.org/W2021109304","https://openalex.org/W2030013085","https://openalex.org/W2030854565","https://openalex.org/W2038924652","https://openalex.org/W2040732053","https://openalex.org/W2044635087","https://openalex.org/W2054662911","https://openalex.org/W2058330451","https://openalex.org/W2060632687","https://openalex.org/W2069478975","https://openalex.org/W2071420516","https://openalex.org/W2075179181","https://openalex.org/W2076184221","https://openalex.org/W2077828507","https://openalex.org/W2080284013","https://openalex.org/W2080647249","https://openalex.org/W2081881251","https://openalex.org/W2100835617","https://openalex.org/W2129280965","https://openalex.org/W2129597014","https://openalex.org/W2133966135","https://openalex.org/W2135841642","https://openalex.org/W2135990814","https://openalex.org/W2136825556","https://openalex.org/W2139849649","https://openalex.org/W2142623337","https://openalex.org/W2146113273","https://openalex.org/W2147268537","https://openalex.org/W2149117501","https://openalex.org/W2153723509","https://openalex.org/W2155259994","https://openalex.org/W2159018562","https://openalex.org/W2159367229","https://openalex.org/W2161335932","https://openalex.org/W2163915292","https://openalex.org/W2171776741","https://openalex.org/W2339157592"],"related_works":["https://openalex.org/W2026696338","https://openalex.org/W2163915292","https://openalex.org/W1946603937","https://openalex.org/W2318541701","https://openalex.org/W3108584570","https://openalex.org/W2532480688","https://openalex.org/W2781684601","https://openalex.org/W2077828507","https://openalex.org/W2159367229","https://openalex.org/W4410152720"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1],"(AD)":[2],"involves":[3],"activation":[4,211],"of":[5,35,44,50,53,63,81,113,133,140,163,170,175,194,202,224],"apoptotic":[6],"pathways":[7],"that":[8,41,190,209,238],"may":[9],"be":[10],"regulated":[11],"through":[12],"signaling":[13,215,237],"cascades":[14],"initiated":[15],"by":[16,155,221],"the":[17,36,54],"amyloid":[18],"precursor":[19],"protein":[20,57],"(APP).":[21],"Enlarged":[22],"endosomes":[23,90],"have":[24],"been":[25],"observed":[26],"in":[27,59,88,91,99,109,184,236,248],"postmortem":[28,110],"AD":[29,47],"brains":[30],"at":[31],"very":[32],"early":[33,64,89],"stages":[34],"disease.":[37],"We":[38],"show":[39],"here":[40],"exogenous":[42],"expression":[43,174],"a":[45,70,176,198,233],"familial":[46],"(FAD)":[48],"mutant":[49,179],"APP":[51,55,225],"or":[52,97,135,158,165],"binding":[56,75],"APP-BP1":[58,74,83],"neurons":[60,94,151],"causes":[61],"enlargement":[62,196],"endosomes,":[65],"increased":[66],"receptor-mediated":[67],"endocytosis":[68],"via":[69,173,197,212],"pathway":[71,146,216],"dependent":[72],"on":[73],"to":[76,121,124,181,192],"APP,":[77],"and":[78,84,108,130,226],"apoptosis.":[79],"Levels":[80],"both":[82],"Rab5":[85,118,134,171,210,231],"are":[86],"elevated":[87],"cortical":[92],"embryonic":[93],"expressing":[95],"APP(V642I)":[96,157],"APP-BP1,":[98,125,159],"cultured":[100],"skin":[101],"fibroblast":[102],"cells":[103],"from":[104,152],"Down":[105],"syndrome":[106],"subjects,":[107],"hippocampal":[111],"tissue":[112],"individuals":[114],"with":[115],"AD.":[116],"Indeed,":[117],"was":[119],"found":[120],"bind":[122],"specifically":[123],"between":[126],"amino":[127],"acids":[128],"443":[129],"479.":[131],"Inhibition":[132],"dynamin":[136],"activity,":[137,149],"but":[138],"not":[139,243],"Eps15":[141],"(epidermal":[142],"growth":[143],"factor":[144],"receptor":[145],"substrate":[147],"15)":[148],"rescued":[150],"apoptosis":[153,186,219],"induced":[154],"either":[156],"without":[160],"affecting":[161],"levels":[162],"intracellular":[164],"secreted":[166],"amyloid-beta":[167],"(Abeta).":[168],"Induction":[169],"activity":[172],"constitutively":[177],"active":[178],"led":[180],"an":[182,213],"increase":[183],"neuronal":[185,218],"more":[187],"than":[188],"twice":[189],"attributable":[191],"induction":[193],"endosome":[195],"Rab5-independent":[199],"mechanism,":[200],"regardless":[201],"Abeta":[203],"production.":[204],"Together,":[205],"these":[206],"findings":[207],"suggest":[208],"APP/APP-BP1-initiated":[214],"mediates":[217],"caused":[220],"FAD":[222],"mutants":[223],"that,":[227],"within":[228],"this":[229],"pathway,":[230],"has":[232],"specific":[234],"role":[235,247],"is":[239],"distinct":[240],"from,":[241],"although":[242],"independent":[244],"of,":[245],"its":[246],"trafficking.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}