{"id":"https://openalex.org/W2060029296","doi":"https://doi.org/10.2165/00003088-200544020-00005","title":"Pharmacokinetic/Pharmacodynamic Modelling of Antibacterials In Vitro and In Vivo Using Bacterial Growth and Kill Kinetics","display_name":"Pharmacokinetic/Pharmacodynamic Modelling of Antibacterials In Vitro and In Vivo Using Bacterial Growth and Kill Kinetics","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2060029296","doi":"https://doi.org/10.2165/00003088-200544020-00005","mag":"2060029296","pmid":"https://pubmed.ncbi.nlm.nih.gov/15656698"},"language":"en","primary_location":{"id":"doi:10.2165/00003088-200544020-00005","doi":"https://doi.org/10.2165/00003088-200544020-00005","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00003088-200544020-00005","pdf_url":null,"source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002934725","display_name":"Johan Willem Mouton","orcid":"https://orcid.org/0000-0001-6736-4149","observed_orcids":["https://orcid.org/0000-0001-6736-4149"]},"institutions":[{"id":"https://openalex.org/I4210113935","display_name":"Canisius-Wilhelmina Ziekenhuis","ror":"https://ror.org/027vts844","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210113935"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Johan W Mouton","raw_affiliation_strings":["Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands. Mouton@cwz.nl","Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands. Mouton@cwz.nl","institution_ids":["https://openalex.org/I4210113935"]},{"raw_affiliation_string":"Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210113935"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040060343","display_name":"Alexander A. T. M. M. Vinks","orcid":"https://orcid.org/0000-0003-4224-2967","observed_orcids":["https://orcid.org/0000-0003-4224-2967"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander A Vinks","raw_affiliation_strings":["Pediatric Pharmacology Research Unit, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, USA","CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Pharmacology Research Unit, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002934725"],"corresponding_institution_ids":["https://openalex.org/I4210113935"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":5.021,"has_fulltext":false,"cited_by_count":157,"citation_normalized_percentile":{"value":0.95856678,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"44","issue":"2","first_page":"201","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacokinetic-pharmacodynamic-modeling","display_name":"pharmacokinetic-pharmacodynamic modeling","score":0.9369999766349792},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.8370000123977661},{"id":"https://openalex.org/keywords/time-kill-kinetics","display_name":"time-kill kinetics","score":0.8059999942779541},{"id":"https://openalex.org/keywords/hill-equation","display_name":"Hill equation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.8560000061988831},{"id":"https://openalex.org/keywords/ceftazidime","display_name":"ceftazidime","score":0.9869999885559082},{"id":"https://openalex.org/keywords/meropenem","display_name":"meropenem","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tobramycin","display_name":"tobramycin","score":1.0},{"id":"https://openalex.org/keywords/beta-lactam-antibiotics","display_name":"beta-lactam antibiotics","score":0.8610000014305115},{"id":"https://openalex.org/keywords/aminoglycosides","display_name":"aminoglycosides","score":0.9789999723434448},{"id":"https://openalex.org/keywords/sub-mic-effects","display_name":"sub-MIC effects","score":0.781000018119812},{"id":"https://openalex.org/keywords/bacterial-regrowth","display_name":"bacterial regrowth","score":0.824999988079071},{"id":"https://openalex.org/keywords/kill-rate","display_name":"kill rate","score":0.4869999885559082},{"id":"https://openalex.org/keywords/growth-rate","display_name":"growth rate","score":0.625}],"concepts":[{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.7520591616630554},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6977193355560303},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6530218720436096},{"id":"https://openalex.org/C2778974779","wikidata":"https://www.wikidata.org/wiki/Q1758380","display_name":"Tobramycin","level":4,"score":0.6451869010925293},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5383990406990051},{"id":"https://openalex.org/C17741926","wikidata":"https://www.wikidata.org/wiki/Q762045","display_name":"Bacterial growth","level":3,"score":0.5341647267341614},{"id":"https://openalex.org/C26381139","wikidata":"https://www.wikidata.org/wiki/Q1158816","display_name":"Minimum bactericidal concentration","level":4,"score":0.5266960859298706},{"id":"https://openalex.org/C2776968632","wikidata":"https://www.wikidata.org/wiki/Q808845","display_name":"Ceftazidime","level":4,"score":0.5237514972686768},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5171191692352295},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.47744280099868774},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.47530683875083923},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4571220576763153},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4368543028831482},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38985228538513184},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3798900246620178},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3213112950325012},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.10104203224182129},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.05426529049873352},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2165/00003088-200544020-00005","doi":"https://doi.org/10.2165/00003088-200544020-00005","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00003088-200544020-00005","pdf_url":null,"source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},{"id":"pmid:15656698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15656698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacokinetics","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W31121744","https://openalex.org/W611976593","https://openalex.org/W1581962345","https://openalex.org/W1607091142","https://openalex.org/W2061614232","https://openalex.org/W2076387592","https://openalex.org/W2110910316","https://openalex.org/W2113717321","https://openalex.org/W2117014230","https://openalex.org/W2123435197","https://openalex.org/W2130946094","https://openalex.org/W2132963724","https://openalex.org/W2135719561","https://openalex.org/W2143470880","https://openalex.org/W2154885361","https://openalex.org/W2155770029","https://openalex.org/W2164113452","https://openalex.org/W2170093763","https://openalex.org/W2171185194"],"related_works":["https://openalex.org/W2095833414","https://openalex.org/W4299458250","https://openalex.org/W2014674546","https://openalex.org/W7098383517","https://openalex.org/W2022235425","https://openalex.org/W2557634135","https://openalex.org/W2155758003","https://openalex.org/W4225567971","https://openalex.org/W2086678216","https://openalex.org/W2151739450"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
