{"id":"https://openalex.org/W2059999122","doi":"https://doi.org/10.3892/ijo.9.2.217","title":"Anti-tumor and cell cycle responses in KB cells treated with a chimeric anti-EGFR monoclonal antibody in combination with cisplatin","display_name":"Anti-tumor and cell cycle responses in KB cells treated with a chimeric anti-EGFR monoclonal antibody in combination with cisplatin","publication_year":1996,"publication_date":"1996-08-01","ids":{"openalex":"https://openalex.org/W2059999122","doi":"https://doi.org/10.3892/ijo.9.2.217","mag":"2059999122","pmid":"https://pubmed.ncbi.nlm.nih.gov/21541503"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.9.2.217","doi":"https://doi.org/10.3892/ijo.9.2.217","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijo.9.2.217","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088455715","display_name":"Marie C. Prewett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Prewett","raw_affiliation_strings":["IMCLONE SYST INC,DEPT IMMUNOL,NEW YORK,NY 10014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMCLONE SYST INC,DEPT IMMUNOL,NEW YORK,NY 10014","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108500881","display_name":"Patricia Rockwell","orcid":"https://orcid.org/0000-0002-4621-961X","observed_orcids":["https://orcid.org/0000-0002-4621-961X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Rockwell","raw_affiliation_strings":["IMCLONE SYST INC,DEPT IMMUNOL,NEW YORK,NY 10014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMCLONE SYST INC,DEPT IMMUNOL,NEW YORK,NY 10014","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"C Rose","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Rose","raw_affiliation_strings":["IMCLONE SYST INC,DEPT IMMUNOL,NEW YORK,NY 10014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMCLONE SYST INC,DEPT IMMUNOL,NEW YORK,NY 10014","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056970679","display_name":"Neil I. Goldstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Goldstein","raw_affiliation_strings":["IMCLONE SYST INC,DEPT IMMUNOL,NEW YORK,NY 10014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMCLONE SYST INC,DEPT IMMUNOL,NEW YORK,NY 10014","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6001,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.70118323,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"2","first_page":"217","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.8650000095367432},{"id":"https://openalex.org/keywords/c225","display_name":"C225","score":0.7879999876022339},{"id":"https://openalex.org/keywords/chimeric-monoclonal-antibody","display_name":"chimeric monoclonal antibody","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6489999890327454},{"id":"https://openalex.org/keywords/kb-cells","display_name":"KB cells","score":0.8159999847412109},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.9240000247955322},{"id":"https://openalex.org/keywords/xenograft-tumor-growth-inhibition","display_name":"xenograft tumor growth inhibition","score":0.824999988079071},{"id":"https://openalex.org/keywords/cell-cycle-regulatory-proteins","display_name":"cell cycle regulatory proteins","score":0.8949999809265137},{"id":"https://openalex.org/keywords/egfr-phosphorylation","display_name":"EGFR phosphorylation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/egfr-overexpression","display_name":"EGFR overexpression","score":0.6940000057220459},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.7996773719787598},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.7419120073318481},{"id":"https://openalex.org/C47170353","wikidata":"https://www.wikidata.org/wiki/Q4649310","display_name":"A431 cells","level":5,"score":0.7158942222595215},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.7038658261299133},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6705319881439209},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6480048894882202},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5684366226196289},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5649099349975586},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5277260541915894},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5109288096427917},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4970085918903351},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.4561123847961426},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4431711435317993},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4382089674472809},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.4325258731842041},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.42337071895599365},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3200188875198364},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2754197120666504},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23350095748901367},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22961097955703735},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2252483069896698},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.21308696269989014},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.21215325593948364},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09715303778648376},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.07466486096382141},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3892/ijo.9.2.217","doi":"https://doi.org/10.3892/ijo.9.2.217","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijo.9.2.217","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmid:21541503","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21541503","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5699999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2439513927","https://openalex.org/W2066684373","https://openalex.org/W2106764013","https://openalex.org/W2016142439","https://openalex.org/W2164686711","https://openalex.org/W2129432386","https://openalex.org/W2109960839","https://openalex.org/W2064022140","https://openalex.org/W2153534791","https://openalex.org/W1984559226"],"abstract_inverted_index":{"Overexpression":[0],"of":[1,36,44,60,63,78,104,144,152],"the":[2,37,58,64,76,88,100,105,122,130,147],"epidermal":[3],"growth":[4,31,59],"factor":[5],"receptor":[6],"(EGFR)":[7],"has":[8],"been":[9],"found":[10,117],"to":[11,23],"correlate":[12],"with":[13,121],"a":[14,42,82,142],"poor":[15],"prognosis":[16],"for":[17,146],"many":[18],"cancers.":[19],"The":[20],"EGFR":[21,106,135],"appears":[22],"play":[24],"an":[25],"important":[26,111],"role":[27],"in":[28,99,118,138,148],"regulating":[29],"cell":[30,46,68,112],"during":[32],"tumorigenesis":[33],"and":[34],"blockade":[35],"EGFR/ligand":[38],"interaction":[39],"may":[40],"be":[41,72],"means":[43],"inducing":[45],"cytotoxicity,":[47],"terminal":[48],"differentiation,":[49],"or":[50],"apoptosis.":[51],"In":[52,124],"this":[53],"report,":[54],"we":[55],"show":[56],"that":[57],"well-established":[61],"xenografts":[62],"human":[65],"epidermoid":[66],"carcinoma":[67],"line":[69],"KB":[70],"could":[71],"significantly":[73],"inhibited":[74,129],"by":[75],"combination":[77],"cisplatin":[79,126],"plus":[80,127,154],"C225,":[81],"chimeric":[83],"anti-EGFR":[84],"monoclonal":[85],"antibody,":[86],"whereas":[87],"individual":[89],"treatments":[90],"had":[91],"no":[92],"effect":[93],"on":[94],"tumor":[95],"growth.":[96],"Substantive":[97],"changes":[98],"protein":[101],"expression":[102],"levels":[103],"as":[107,109],"well":[108],"several":[110],"cycle":[113],"regulatory":[114],"proteins":[115],"were":[116],"cells":[119],"treated":[120],"combination.":[123],"addition,":[125],"C225":[128,153],"overall":[131],"phosphorylation":[132],"patterns":[133],"including":[134],"activation.":[136],"These":[137],"vitro":[139],"data":[140],"suggest":[141],"mechanism":[143],"action":[145],"vivo":[149],"therapeutic":[150],"effects":[151],"cisplatin.":[155]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}