{"id":"https://openalex.org/W2059982307","doi":"https://doi.org/10.1016/j.clpt.2004.12.164","title":"Adverse events in a behavioral treatment trial in methadone maintenance","display_name":"Adverse events in a behavioral treatment trial in methadone maintenance","publication_year":2005,"publication_date":"2005-02-01","ids":{"openalex":"https://openalex.org/W2059982307","doi":"https://doi.org/10.1016/j.clpt.2004.12.164","mag":"2059982307"},"language":"en","primary_location":{"id":"doi:10.1016/j.clpt.2004.12.164","doi":"https://doi.org/10.1016/j.clpt.2004.12.164","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clpt.2004.12.164","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056255102","display_name":"John P. Schmittner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J SCHMITTNER","raw_affiliation_strings":["National Institutes of Drug Abuse IRP, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Drug Abuse IRP, Baltimore, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"J SCHROEDER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J SCHROEDER","raw_affiliation_strings":["National Institutes of Drug Abuse IRP, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Drug Abuse IRP, Baltimore, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040672500","display_name":"David H. Epstein","orcid":"https://orcid.org/0000-0001-8147-0386","observed_orcids":["https://orcid.org/0000-0001-8147-0386"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D EPSTEIN","raw_affiliation_strings":["National Institutes of Drug Abuse IRP, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Drug Abuse IRP, Baltimore, MD","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060972692","display_name":"Kenzie L. Preston","orcid":"https://orcid.org/0000-0003-0603-2479","observed_orcids":["https://orcid.org/0000-0003-0603-2479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K PRESTON","raw_affiliation_strings":["National Institutes of Drug Abuse IRP, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Drug Abuse IRP, Baltimore, MD","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19675721,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"2","first_page":"P71","last_page":"P71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.18119999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.09030000120401382,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.9760000109672546},{"id":"https://openalex.org/keywords/methadone-maintenance-treatment","display_name":"methadone maintenance treatment","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cocaine-dependence","display_name":"cocaine dependence","score":0.7419999837875366},{"id":"https://openalex.org/keywords/behavioral-therapy","display_name":"behavior therapy","score":0.7570000290870667},{"id":"https://openalex.org/keywords/clinical-trial-safety","display_name":"clinical trial safety","score":0.6230000257492065},{"id":"https://openalex.org/keywords/incidence-density-ratio","display_name":"incidence density ratio","score":0.7129999995231628},{"id":"https://openalex.org/keywords/people-who-use-drugs","display_name":"drug users","score":0.4650000035762787},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.5339999794960022},{"id":"https://openalex.org/keywords/adverse-event-reporting","display_name":"adverse event reporting","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8075270652770996},{"id":"https://openalex.org/C2778767360","wikidata":"https://www.wikidata.org/wiki/Q179996","display_name":"Methadone","level":2,"score":0.7958078384399414},{"id":"https://openalex.org/C199475168","wikidata":"https://www.wikidata.org/wiki/Q1539689","display_name":"MedDRA","level":4,"score":0.7041688561439514},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6526092886924744},{"id":"https://openalex.org/C2778140631","wikidata":"https://www.wikidata.org/wiki/Q2026938","display_name":"Opiate","level":3,"score":0.6467227935791016},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6319282054901123},{"id":"https://openalex.org/C167704817","wikidata":"https://www.wikidata.org/wiki/Q7295548","display_name":"Rate ratio","level":3,"score":0.5827222466468811},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.48696836829185486},{"id":"https://openalex.org/C2778903061","wikidata":"https://www.wikidata.org/wiki/Q17156814","display_name":"Methadone maintenance","level":3,"score":0.48640087246894836},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46834298968315125},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.4546944200992584},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.4423038363456726},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4382810592651367},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.38417884707450867},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3223009705543518},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.1556047797203064},{"id":"https://openalex.org/C57658597","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Pharmacovigilance","level":3,"score":0.11949700117111206},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.clpt.2004.12.164","doi":"https://doi.org/10.1016/j.clpt.2004.12.164","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clpt.2004.12.164","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology &amp; Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1986204527","https://openalex.org/W2313524130","https://openalex.org/W2386374165","https://openalex.org/W2352249606","https://openalex.org/W2150108524","https://openalex.org/W7081970388","https://openalex.org/W2733176399","https://openalex.org/W2063054113","https://openalex.org/W2100642235","https://openalex.org/W2983608146"],"abstract_inverted_index":{"Background/Aims":[0],"Drug":[1],"users":[2,49],"in":[3,34,46,51,104,140,188],"clinical":[4],"trials":[5,191],"have":[6],"morbidity":[7,60],"unrelated":[8],"to":[9,86,173],"the":[10,30,88,183],"intervention":[11],"being":[12],"studied":[13],"and":[14,73,96,121,124,147,175],"little":[15],"is":[16],"known":[17],"about":[18],"rates":[19],"of":[20,32,37,55,90,186],"adverse":[21],"events":[22],"(AEs)":[23],"from":[24],"behavioral":[25,57],"interventions.":[26],"This":[27],"study":[28,54],"investigated":[29],"rate":[31],"AEs":[33,42,103,129,136,166,187],"a":[35,52],"trial":[36],"methadone":[38],"maintained":[39],"patients.":[40],"Methods":[41],"were":[43,61,64,84,133,137,167],"collected":[44],"weekly":[45],"methadone-maintained":[47],"cocaine":[48,163],"participating":[50],"randomized":[53],"two":[56],"treatments.":[58],"Pre-existing":[59],"excluded.":[62],"Events":[63],"assigned":[65],"MedDRA":[66],"codes":[67],"(Medical":[68],"Dictionary":[69],"for":[70],"Regulatory":[71],"Activities)":[72],"categorized":[74],"as":[75],"opiate-related":[76],"or":[77,162],"not":[78,155,171,177],"related.":[79],"Incidence":[80,153],"density":[81],"ratios":[82],"(IDRs)":[83],"calculated":[85],"determine":[87],"association":[89],"AE":[91,195],"incidence":[92],"with":[93,157],"participant":[94],"characteristics":[95],"intervention.":[97],"Results":[98],"286":[99],"participants":[100],"reported":[101],"884":[102],"7680":[105],"person-weeks.":[106],"The":[107],"most":[108,169],"common":[109,139],"were:":[110],"infections":[111],"(26.8%),":[112],"gastrointestinal":[113],"(20.5%),":[114],"musculoskeletal/connective":[115],"tissue":[116],"(12.3%),":[117],"general":[118],"disorders":[119],"(10.0%),":[120],"injury,":[122],"poisoning":[123],"procedural":[125],"complications":[126],"(7.6%).":[127],"Fourteen":[128],"required":[130],"hospitalization.":[131],"136":[132],"likely":[134,170],"opiate-related.":[135],"more":[138],"females":[141],"(IDR=1.38,":[142],"p<0.0001),":[143,146],"Caucasians":[144],"(IDR=0.73,":[145],"under":[148],"age":[149],"40":[150],"(IDR=0.84,":[151],"p=0.0047).":[152],"did":[154,176],"differ":[156,178],"treatment":[158,180],"group,":[159],"psychiatric":[160],"comorbidity,":[161],"use.":[164],"Conclusions":[165],"common,":[168],"related":[172],"methadone,":[174],"across":[179],"groups.":[181],"Knowing":[182],"expected":[184],"rate/nature":[185],"substance":[189],"abuse":[190],"may":[192],"help":[193],"improve":[194],"reporting.":[196],"Clinical":[197],"Pharmacology":[198],"&":[199],"Therapeutics":[200],"(2005)":[201],"77,":[202],"P71\u2013P71;":[203],"doi:":[204],"10.1016/j.clpt.2004.12.164":[205]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}