{"id":"https://openalex.org/W2059968418","doi":"https://doi.org/10.1016/s0014-5793(02)03834-6","title":"Protein kinase C\u2010dependent phosphorylation and mitochondrial translocation of aldose reductase","display_name":"Protein kinase C\u2010dependent phosphorylation and mitochondrial translocation of aldose reductase","publication_year":2003,"publication_date":"2003-01-08","ids":{"openalex":"https://openalex.org/W2059968418","doi":"https://doi.org/10.1016/s0014-5793(02)03834-6","mag":"2059968418","pmid":"https://pubmed.ncbi.nlm.nih.gov/12527382"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-5793(02)03834-6","doi":"https://doi.org/10.1016/s0014-5793(02)03834-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0014-5793(02)03834-6","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2802%2903834-6","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2802%2903834-6","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069837519","display_name":"Tushar K. Varma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tushar Varma","raw_affiliation_strings":["Division of Anesthesiology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77550, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Anesthesiology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77550, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033077468","display_name":"Si-Qi Liu","orcid":"https://orcid.org/0000-0001-9727-9498","observed_orcids":["https://orcid.org/0000-0001-9727-9498"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Si-Qi Liu","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, Jewish Cardiovascular Center, 500 South Floyd Street, University of Louisville, Louisville, KY 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, Jewish Cardiovascular Center, 500 South Floyd Street, University of Louisville, Louisville, KY 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086141649","display_name":"Matthew West","orcid":"https://orcid.org/0000-0003-3247-1774","observed_orcids":["https://orcid.org/0000-0003-3247-1774"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew West","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, Jewish Cardiovascular Center, 500 South Floyd Street, University of Louisville, Louisville, KY 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, Jewish Cardiovascular Center, 500 South Floyd Street, University of Louisville, Louisville, KY 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091140339","display_name":"Visith Thongboonkerd","orcid":"https://orcid.org/0000-0001-7865-0765","observed_orcids":["https://orcid.org/0000-0001-7865-0765"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Visith Thongboonkerd","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, University of Louisville, Louisville, KY 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, University of Louisville, Louisville, KY 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041671683","display_name":"Peter P. Ruvolo","orcid":"https://orcid.org/0000-0002-8574-1531","observed_orcids":["https://orcid.org/0000-0002-8574-1531"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter P. Ruvolo","raw_affiliation_strings":["Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112501365","display_name":"William Stratford May","orcid":"https://orcid.org/0009-0004-8573-224X","observed_orcids":["https://orcid.org/0009-0004-8573-224X"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W.Stratford May","raw_affiliation_strings":["Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012248310","display_name":"Aruni Bhatnagar","orcid":"https://orcid.org/0000-0001-6818-0384","observed_orcids":["https://orcid.org/0000-0001-6818-0384"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aruni Bhatnagar","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, Jewish Cardiovascular Center, 500 South Floyd Street, University of Louisville, Louisville, KY 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, Jewish Cardiovascular Center, 500 South Floyd Street, University of Louisville, Louisville, KY 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5012248310"],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.6056,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.63565746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"534","issue":"1-3","first_page":"175","last_page":"179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldose-reductase","display_name":"aldose reductase","score":1.0},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":1.0},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mitochondrial-translocation","display_name":"mitochondrial translocation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/post-translational-regulation","display_name":"post-translational regulation","score":0.871999979019165},{"id":"https://openalex.org/keywords/osmoregulation","display_name":"osmoregulation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.8880000114440918},{"id":"https://openalex.org/keywords/aldehyde-metabolism","display_name":"aldehyde metabolism","score":0.8629999756813049},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C2776439734","wikidata":"https://www.wikidata.org/wiki/Q414213","display_name":"Aldose reductase","level":3,"score":0.916716456413269},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.8068674802780151},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6957736015319824},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.588119387626648},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5140572786331177},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.512773334980011},{"id":"https://openalex.org/C173990801","wikidata":"https://www.wikidata.org/wiki/Q910492","display_name":"Substrate-level phosphorylation","level":3,"score":0.5001380443572998},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.48820048570632935},{"id":"https://openalex.org/C2910800646","wikidata":"https://www.wikidata.org/wiki/Q414213","display_name":"Aldehyde Reductase","level":4,"score":0.48814210295677185},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.4808957576751709},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47269749641418457},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4620724320411682},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.43436264991760254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3996894657611847},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.371417373418808},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010761","descriptor_name":"Phosphorus Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018942","descriptor_name":"Macrolides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054713","descriptor_name":"Bryostatins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0014-5793(02)03834-6","doi":"https://doi.org/10.1016/s0014-5793(02)03834-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0014-5793(02)03834-6","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2802%2903834-6","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:12527382","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12527382","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0014-5793(02)03834-6","doi":"https://doi.org/10.1016/s0014-5793(02)03834-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0014-5793(02)03834-6","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2802%2903834-6","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","score":0.5,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2037318493","display_name":"IL3 Growth Factor Signaling","funder_award_id":"R01CA044649","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2276200497","display_name":null,"funder_award_id":"HL 59378","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3115833039","display_name":"The Role of PKR in a Novel IL-3 Signal Transduction Pathway","funder_award_id":"5r01hl054083-11","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4003598344","display_name":"Cardiac Metabolism of Enals","funder_award_id":"R01HL059378","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5603472889","display_name":null,"funder_award_id":"CA 44649","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5931960095","display_name":"Toxicity and Detoxification of 4 Hydroxyalkenals in Heart","funder_award_id":"R01HL055477","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6160033664","display_name":null,"funder_award_id":"HL54083","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6471611709","display_name":null,"funder_award_id":"HL55477","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2059968418.pdf","grobid_xml":"https://content.openalex.org/works/W2059968418.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W93019692","https://openalex.org/W1529592271","https://openalex.org/W1601924230","https://openalex.org/W1770562442","https://openalex.org/W1969150166","https://openalex.org/W1969868126","https://openalex.org/W1969870204","https://openalex.org/W1970834072","https://openalex.org/W1996182204","https://openalex.org/W2021861995","https://openalex.org/W2025701628","https://openalex.org/W2035349175","https://openalex.org/W2048012950","https://openalex.org/W2050138059","https://openalex.org/W2057522312","https://openalex.org/W2061407410","https://openalex.org/W2063018977","https://openalex.org/W2072616787","https://openalex.org/W2074488178","https://openalex.org/W2111793581","https://openalex.org/W2140354392","https://openalex.org/W2155217360","https://openalex.org/W2163411908","https://openalex.org/W2473336210"],"related_works":["https://openalex.org/W3014264523","https://openalex.org/W2008646227","https://openalex.org/W1255864955","https://openalex.org/W2040771421","https://openalex.org/W2021856515","https://openalex.org/W1967259169","https://openalex.org/W2401924875","https://openalex.org/W2045410696","https://openalex.org/W2005879489","https://openalex.org/W2291473834"],"abstract_inverted_index":{"Although":[0],"aldose":[1],"reductase":[2],"(AR)":[3],"is":[4],"a":[5,83],"critical":[6],"participant":[7],"in":[8,42,75],"osmoregulation,":[9],"and":[10,15,50,89,94],"the":[11,53,57,90],"metabolism":[12],"of":[13,37,48,52,92],"glucose":[14,93],"aldehydes":[16],"derived":[17],"from":[18],"lipid":[19],"peroxidation,":[20],"post-translational":[21],"mechanisms":[22],"regulating":[23],"its":[24],"activity":[25],"have":[26],"not":[27],"been":[28],"identified.":[29],"In":[30,59],"this":[31],"paper,":[32],"we":[33],"report":[34],"that":[35,70],"stimulation":[36],"protein":[38,55],"kinase":[39],"C":[40],"(PKC)":[41],"several":[43],"cell":[44],"types":[45],"induces":[46],"phosphorylation":[47],"AR":[49,62,71],"translocation":[51],"phosphorylated":[54,65],"to":[56],"mitochondria.":[58],"vitro,":[60],"recombinant":[61],"was":[63],"directly":[64],"by":[66],"activated":[67],"PKC,":[68],"suggesting":[69],"may":[72],"be":[73],"an":[74],"vivo":[76],"PKC":[77,87],"substrate.":[78],"Together,":[79],"these":[80],"observations":[81],"reveal":[82],"novel":[84],"link":[85],"between":[86],"activation":[88],"regulation":[91],"aldehyde":[95],"metabolism.":[96]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}