{"id":"https://openalex.org/W2059965787","doi":"https://doi.org/10.1021/bc049709b","title":"Synthesis and Biological Evaluation of EC72: A New Folate-Targeted Chemotherapeutic","display_name":"Synthesis and Biological Evaluation of EC72: A New Folate-Targeted Chemotherapeutic","publication_year":2005,"publication_date":"2005-06-11","ids":{"openalex":"https://openalex.org/W2059965787","doi":"https://doi.org/10.1021/bc049709b","mag":"2059965787","pmid":"https://pubmed.ncbi.nlm.nih.gov/16029021"},"language":"en","primary_location":{"id":"doi:10.1021/bc049709b","doi":"https://doi.org/10.1021/bc049709b","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc049709b","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085542989","display_name":"Christopher P. Leamon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher P. Leamon","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906","Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906","institution_ids":["https://openalex.org/I906832008"]},{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906, USA","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109996340","display_name":"Joseph A. Reddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. Reddy","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109371739","display_name":"Iontcho R. Vlahov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iontcho R. Vlahov","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043457997","display_name":"Marilynn Vetzel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marilynn Vetzel","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015130724","display_name":"Nikki L. Parker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikki Parker","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024296693","display_name":"Jeffrey S. Nicoson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey S. Nicoson","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083624807","display_name":"Le-Cun Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Le-Cun Xu","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906","institution_ids":["https://openalex.org/I906832008"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002632070","display_name":"Elaine M. Westrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I906832008","display_name":"Endocyte (United States)","ror":"https://ror.org/058dk4619","country_code":"US","type":"company","lineage":["https://openalex.org/I906832008"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine Westrick","raw_affiliation_strings":["Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocyte, Inc., 3000 Kent Avenue, West Lafayette, Indiana 47906","institution_ids":["https://openalex.org/I906832008"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085542989"],"corresponding_institution_ids":["https://openalex.org/I906832008"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.812,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.93998048,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":"4","first_page":"803","last_page":"811"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.28220000863075256,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.28220000863075256,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.1200999990105629,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.10119999945163727,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/folate-receptor","display_name":"folate receptor","score":0.7149999737739563},{"id":"https://openalex.org/keywords/mitomycin-c","display_name":"mitomycin C","score":0.902999997138977},{"id":"https://openalex.org/keywords/folate-conjugates","display_name":"folate conjugates","score":0.7599999904632568},{"id":"https://openalex.org/keywords/targeted-chemotherapy","display_name":"targeted chemotherapy","score":0.8479999899864197},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.8159999847412109},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.5460000038146973},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.8489999771118164},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.6840000152587891},{"id":"https://openalex.org/keywords/syngeneic-mouse-model","display_name":"syngeneic mouse model","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.815804123878479},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8053626418113708},{"id":"https://openalex.org/C2780306303","wikidata":"https://www.wikidata.org/wiki/Q24784504","display_name":"Folate receptor","level":4,"score":0.7969157695770264},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6621400713920593},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6139714121818542},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5871968269348145},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.543973982334137},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.4775053858757019},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.46086040139198303},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.44176167249679565},{"id":"https://openalex.org/C2779338040","wikidata":"https://www.wikidata.org/wiki/Q19856779","display_name":"Mitomycin C","level":2,"score":0.43137669563293457},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30596762895584106},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23932087421417236},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.20207685232162476},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19944286346435547},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09456980228424072},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08771860599517822},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.07451507449150085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07080307602882385},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bc049709b","doi":"https://doi.org/10.1021/bc049709b","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc049709b","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},{"id":"pmid:16029021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16029021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1594606204","https://openalex.org/W1916273603","https://openalex.org/W1969855337","https://openalex.org/W1971341208","https://openalex.org/W2004017298","https://openalex.org/W2036342934","https://openalex.org/W2082650965","https://openalex.org/W2111030915","https://openalex.org/W2116725368","https://openalex.org/W2149933943","https://openalex.org/W4232914070"],"related_works":["https://openalex.org/W2127168225","https://openalex.org/W2734620733","https://openalex.org/W2090540963","https://openalex.org/W2055954943","https://openalex.org/W2023298707","https://openalex.org/W3045965460","https://openalex.org/W2052004281","https://openalex.org/W2740051881","https://openalex.org/W2341670115","https://openalex.org/W2048945971"],"abstract_inverted_index":{"A":[0],"novel":[1,199],"folate":[2,63],"conjugate":[3,41],"of":[4,62,119,131,142],"mitomycin":[5],"C,":[6],"herein":[7],"referred":[8],"to":[9,31,44,72,95,146,169,173,177],"as":[10],"EC72,":[11],"was":[12,25,42,70],"designed":[13],"and":[14,22,51,75,88,108,111,176,190],"evaluated":[15],"for":[16,48,77,133,204],"biological":[17,86],"activity":[18,56,69,104,113],"against":[19,59],"FR-positive":[20,49,151],"cells":[21],"tumors.":[23],"EC72":[24,132],"produced":[26,53],"by":[27],"coupling":[28],"folic":[29,83],"acid-gamma-cysteine":[30],"7-N-modified":[32],"MMC":[33],"via":[34],"a":[35,60],"disulfide":[36],"bond.":[37],"This":[38],"water":[39],"soluble":[40],"found":[43],"retain":[45],"high":[46],"affinity":[47],"cells,":[50],"it":[52],"dose":[54],"responsive":[55],"in":[57,99,105,115,188,191],"vitro":[58,189],"panel":[61],"receptor":[64],"(FR)-positive":[65],"cell":[66,91],"lines.":[67],"EC72's":[68,103,186],"considered":[71,203],"be":[73],"targeted":[74,200],"specific":[76],"the":[78,116,150,161],"FR":[79],"since":[80,128],"(i)":[81],"excess":[82],"acid":[84],"blocked":[85],"activity,":[87],"(ii)":[89],"FR-negative":[90],"lines":[92],"were":[93],"unresponsive":[94],"this":[96,112,198],"drug.":[97],"Initial":[98],"vivo":[100,192],"tests":[101],"confirmed":[102],"both":[106],"syngeneic":[107],"xenograft":[109],"models,":[110],"occurred":[114],"apparent":[117],"absence":[118],"gross":[120],"or":[121,144],"pathological":[122],"toxicity.":[123],"These":[124],"results":[125],"are":[126],"significant,":[127],"daily":[129],"dosing":[130],"more":[134],"than":[135],"30":[136],"consecutive":[137],"days":[138],"yielded":[139],"no":[140],"evidence":[141],"myelosuppression":[143],"toxicity":[145],"major":[147],"organs,":[148],"including":[149],"kidneys.":[152],"The":[153],"latter":[154],"observation":[155],"supports":[156],"published":[157],"data,":[158],"indicating":[159],"that":[160],"apically":[162],"oriented":[163],"kidney":[164],"proximal":[165],"tubule":[166],"FRs":[167],"function":[168],"salvage":[170],"folates":[171],"prior":[172],"their":[174],"excretion":[175],"return":[178],"these":[179],"molecules":[180],"back":[181],"into":[182],"systemic":[183],"circulation.":[184],"Overall,":[185],"performance":[187],"warrants":[193],"further":[194],"preclinical":[195],"study":[196],"before":[197],"chemotherapeutic":[201],"is":[202],"clinical":[205],"investigation.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}