{"id":"https://openalex.org/W2059940170","doi":"https://doi.org/10.1016/j.arr.2007.07.003","title":"Hormesis: A promising strategy to sustain endogenous neuronal survival pathways against neurodegenerative disorders","display_name":"Hormesis: A promising strategy to sustain endogenous neuronal survival pathways against neurodegenerative disorders","publication_year":2007,"publication_date":"2007-08-27","ids":{"openalex":"https://openalex.org/W2059940170","doi":"https://doi.org/10.1016/j.arr.2007.07.003","mag":"2059940170","pmid":"https://pubmed.ncbi.nlm.nih.gov/17889623"},"language":"en","primary_location":{"id":"doi:10.1016/j.arr.2007.07.003","doi":"https://doi.org/10.1016/j.arr.2007.07.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.arr.2007.07.003","pdf_url":null,"source":{"id":"https://openalex.org/S117312820","display_name":"Ageing Research Reviews","issn_l":"1568-1637","issn":["1568-1637","1872-9649"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ageing Research Reviews","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031454261","display_name":"Ann M. Marini","orcid":"https://orcid.org/0000-0003-1444-7180","observed_orcids":["https://orcid.org/0000-0003-1444-7180"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ann M. Marini","raw_affiliation_strings":["Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. amarini@usuhs.mil","Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda MD 20814, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. amarini@usuhs.mil","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda MD 20814, USA","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100739577","display_name":"Hong Jiang","orcid":"https://orcid.org/0000-0001-9481-9807","observed_orcids":["https://orcid.org/0000-0001-9481-9807","https://orcid.org/0000-0002-6026-6068","https://orcid.org/0000-0003-2075-3272","https://orcid.org/0009-0002-4982-445X"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Jiang","raw_affiliation_strings":["Department of Neurology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111462694","display_name":"Hongna Pan","orcid":"https://orcid.org/0000-0001-8862-2987","observed_orcids":["https://orcid.org/0000-0001-8862-2987"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongna Pan","raw_affiliation_strings":["Department of Neurology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062642936","display_name":"Xuan Wu","orcid":"https://orcid.org/0000-0002-5622-1908","observed_orcids":["https://orcid.org/0000-0002-5622-1908","https://orcid.org/0009-0003-3007-7535"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuan Wu","raw_affiliation_strings":["Department of Neurology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021708761","display_name":"Robert H. Lipsky","orcid":"https://orcid.org/0000-0001-7753-1473","observed_orcids":["https://orcid.org/0000-0001-7753-1473"]},"institutions":[{"id":"https://openalex.org/I4210121815","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Lipsky","raw_affiliation_strings":["Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, United States","institution_ids":["https://openalex.org/I4210121815"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031454261"],"corresponding_institution_ids":["https://openalex.org/I148314036"],"apc_list":{"value":5520,"currency":"USD","value_usd":5520},"apc_paid":null,"fwci":0.3191,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.2732475,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"1","first_page":"21","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.788100004196167,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.788100004196167,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.13819999992847443,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hormesis","display_name":"hormesis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7990000247955322},{"id":"https://openalex.org/keywords/glutamate-receptors","display_name":"glutamate receptors","score":0.6840000152587891},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9300000071525574},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8659999966621399},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.8259999752044678},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.5099999904632568},{"id":"https://openalex.org/keywords/status-epilepticus","display_name":"status epilepticus","score":1.0},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.7692939043045044},{"id":"https://openalex.org/C115955781","wikidata":"https://www.wikidata.org/wiki/Q6063798","display_name":"Ionotropic effect","level":4,"score":0.7355980277061462},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6249904632568359},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5929923057556152},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.5359021425247192},{"id":"https://openalex.org/C87247309","wikidata":"https://www.wikidata.org/wiki/Q6590338","display_name":"Metabotropic glutamate receptor 7","level":5,"score":0.4773447811603546},{"id":"https://openalex.org/C2129178","wikidata":"https://www.wikidata.org/wiki/Q6590408","display_name":"Metabotropic glutamate receptor 8","level":5,"score":0.46507784724235535},{"id":"https://openalex.org/C41653306","wikidata":"https://www.wikidata.org/wiki/Q6589190","display_name":"Metabotropic glutamate receptor 5","level":5,"score":0.4547001123428345},{"id":"https://openalex.org/C189184402","wikidata":"https://www.wikidata.org/wiki/Q3454536","display_name":"Kainate receptor","level":5,"score":0.4343096911907196},{"id":"https://openalex.org/C207951395","wikidata":"https://www.wikidata.org/wiki/Q288431","display_name":"Metabotropic glutamate receptor 1","level":5,"score":0.4101629853248596},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3806058466434479},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.35929784178733826},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.3157975971698761},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11075511574745178}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.arr.2007.07.003","doi":"https://doi.org/10.1016/j.arr.2007.07.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.arr.2007.07.003","pdf_url":null,"source":{"id":"https://openalex.org/S117312820","display_name":"Ageing Research Reviews","issn_l":"1568-1637","issn":["1568-1637","1872-9649"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ageing Research Reviews","raw_type":"journal-article"},{"id":"pmid:17889623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17889623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ageing research reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":148,"referenced_works":["https://openalex.org/W31370813","https://openalex.org/W133296140","https://openalex.org/W170973748","https://openalex.org/W1492349549","https://openalex.org/W1494401713","https://openalex.org/W1504583940","https://openalex.org/W1529774113","https://openalex.org/W1539043236","https://openalex.org/W1542152284","https://openalex.org/W1542202136","https://openalex.org/W1562796888","https://openalex.org/W1567576394","https://openalex.org/W1584917605","https://openalex.org/W1598726068","https://openalex.org/W1627593641","https://openalex.org/W1656928430","https://openalex.org/W1720681720","https://openalex.org/W1767114057","https://openalex.org/W1784311570","https://openalex.org/W1896045165","https://openalex.org/W1913599140","https://openalex.org/W1921003572","https://openalex.org/W1928374558","https://openalex.org/W1937085587","https://openalex.org/W1956227640","https://openalex.org/W1964504843","https://openalex.org/W1966418219","https://openalex.org/W1966785609","https://openalex.org/W1967475748","https://openalex.org/W1969125125","https://openalex.org/W1971261279","https://openalex.org/W1974790521","https://openalex.org/W1975572257","https://openalex.org/W1978215017","https://openalex.org/W1980166683","https://openalex.org/W1982776595","https://openalex.org/W1987615735","https://openalex.org/W1989051882","https://openalex.org/W1990626252","https://openalex.org/W1991437921","https://openalex.org/W1994611219","https://openalex.org/W1998164097","https://openalex.org/W1998347917","https://openalex.org/W1999012962","https://openalex.org/W1999157780","https://openalex.org/W2000024512","https://openalex.org/W2000082154","https://openalex.org/W2000668716","https://openalex.org/W2002217566","https://openalex.org/W2002482239","https://openalex.org/W2002637584","https://openalex.org/W2002959507","https://openalex.org/W2004107819","https://openalex.org/W2005254595","https://openalex.org/W2006777504","https://openalex.org/W2010050518","https://openalex.org/W2010675706","https://openalex.org/W2013394705","https://openalex.org/W2013966390","https://openalex.org/W2014599626","https://openalex.org/W2014855335","https://openalex.org/W2016575029","https://openalex.org/W2016843660","https://openalex.org/W2020567039","https://openalex.org/W2022419428","https://openalex.org/W2027443706","https://openalex.org/W2027973075","https://openalex.org/W2029603067","https://openalex.org/W2030332988","https://openalex.org/W2032057219","https://openalex.org/W2032060995","https://openalex.org/W2032794324","https://openalex.org/W2033027472","https://openalex.org/W2034182513","https://openalex.org/W2034861130","https://openalex.org/W2035131786","https://openalex.org/W2036068742","https://openalex.org/W2039524747","https://openalex.org/W2041969644","https://openalex.org/W2043884992","https://openalex.org/W2044704316","https://openalex.org/W2044868069","https://openalex.org/W2045441934","https://openalex.org/W2046539223","https://openalex.org/W2048121649","https://openalex.org/W2051493425","https://openalex.org/W2053239700","https://openalex.org/W2054031594","https://openalex.org/W2057855503","https://openalex.org/W2058861807","https://openalex.org/W2061894701","https://openalex.org/W2061903251","https://openalex.org/W2063537428","https://openalex.org/W2064253775","https://openalex.org/W2067430765","https://openalex.org/W2068412840","https://openalex.org/W2069249812","https://openalex.org/W2071957609","https://openalex.org/W2073507621","https://openalex.org/W2074340804","https://openalex.org/W2074783627","https://openalex.org/W2077088537","https://openalex.org/W2078167209","https://openalex.org/W2079472132","https://openalex.org/W2079966712","https://openalex.org/W2080274663","https://openalex.org/W2081524299","https://openalex.org/W2082249282","https://openalex.org/W2091744001","https://openalex.org/W2093421538","https://openalex.org/W2093612739","https://openalex.org/W2097293665","https://openalex.org/W2098719212","https://openalex.org/W2100338501","https://openalex.org/W2102527735","https://openalex.org/W2105752803","https://openalex.org/W2105976044","https://openalex.org/W2109399660","https://openalex.org/W2109922354","https://openalex.org/W2111062311","https://openalex.org/W2114827971","https://openalex.org/W2119420631","https://openalex.org/W2125403403","https://openalex.org/W2128960139","https://openalex.org/W2129242841","https://openalex.org/W2129928823","https://openalex.org/W2135357607","https://openalex.org/W2138497185","https://openalex.org/W2139565721","https://openalex.org/W2141750111","https://openalex.org/W2144232114","https://openalex.org/W2147114673","https://openalex.org/W2148880706","https://openalex.org/W2154553662","https://openalex.org/W2154727263","https://openalex.org/W2163388234","https://openalex.org/W2163638464","https://openalex.org/W2166052438","https://openalex.org/W2166781237","https://openalex.org/W2167091449","https://openalex.org/W2169053713","https://openalex.org/W2170891211","https://openalex.org/W2316580498","https://openalex.org/W2335925695","https://openalex.org/W2415766950","https://openalex.org/W2470223656","https://openalex.org/W4300503127","https://openalex.org/W4322703208"],"related_works":["https://openalex.org/W2033264001","https://openalex.org/W1971274544","https://openalex.org/W2002863436","https://openalex.org/W2018907328","https://openalex.org/W2032444015","https://openalex.org/W1542202136","https://openalex.org/W2415383885","https://openalex.org/W4233484258","https://openalex.org/W2276287788","https://openalex.org/W2200873332"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}